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chr16:14,229,099-15,946,778

Best TWAS P=2.3e-12 · Best GWAS P=2.52e-08 conditioned to 0.541

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	NTR	Blood	PDXDC1	0.12	0.12	enet	26	0.15	1.3e-46	-5.4	7.0	2.3e-12	0.74	0.01	0.99	TRUE
11	GTEx	Heart Left Ventricle	RRN3	0.24	0.12	lasso	7	0.17	2.2e-09	5.4	-6.5	8.4e-11	-0.87	0.01	0.99	FALSE
15	GTEx	Nerve Tibial	NTAN1	0.07	0.00	enet	14	0.00	1.7e-01	5.6	6.2	7.0e-10	0.46	0.01	0.34	FALSE
6	GTEx	Cells Transformed fibroblasts	RRN3	0.10	0.12	enet	13	0.13	6.3e-10	5.6	6.1	1.2e-09	0.95	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	NTAN1	0.05	0.03	lasso	2	0.04	6.7e-04	-5.5	6.0	1.5e-09	0.69	0.01	0.96	FALSE
13	GTEx	Muscle Skeletal	RRN3	0.18	0.03	enet	17	0.11	5.7e-11	4.1	-6.0	1.8e-09	-0.49	0.16	0.73	FALSE
19	NTR	Blood	NTAN1	0.01	0.00	bslmm	110	0.00	4.2e-02	5.6	6.0	2.1e-09	0.72	0.01	0.44	FALSE
3	GTEx	Cells EBV-transformed lymphocytes	RRN3	0.36	0.14	lasso	5	0.20	4.5e-07	5.6	5.9	4.7e-09	0.97	0.01	0.99	FALSE
7	GTEx	Colon Transverse	RRN3	0.13	0.00	lasso	5	0.00	1.9e-01	5.4	-5.8	6.1e-09	-0.68	0.02	0.56	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	NTAN1	0.12	0.10	lasso	3	0.11	1.4e-13	5.4	5.8	7.5e-09	0.97	0.01	0.99	FALSE
12	GTEx	Heart Left Ventricle	NTAN1	0.09	0.04	lasso	3	0.02	2.0e-02	5.6	5.7	1.0e-08	0.99	0.01	0.86	FALSE
9	GTEx	Heart Atrial Appendage	NOMO1	0.19	0.12	lasso	6	0.10	3.7e-05	5.4	5.7	1.3e-08	0.98	0.01	0.96	FALSE
14	GTEx	Muscle Skeletal	NTAN1	0.12	0.07	lasso	6	0.09	1.4e-09	5.4	5.7	1.3e-08	0.90	0.01	0.99	FALSE
16	GTEx	Skin Sun Exposed Lower leg	RRN3	0.10	0.12	lasso	1	0.11	4.5e-09	5.6	5.6	2.5e-08	1.00	0.01	0.99	FALSE
17	GTEx	Testis	RRN3	0.10	0.10	lasso	2	0.07	3.9e-04	5.6	5.6	2.5e-08	1.00	0.01	0.93	FALSE
18	METSIM	Adipose	NTAN1	0.07	0.06	enet	12	0.06	1.7e-09	5.6	5.5	4.1e-08	0.88	0.01	0.99	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	RP11-958N24.1	0.22	0.02	lasso	5	0.06	4.8e-03	-2.9	5.4	5.3e-08	0.72	0.01	0.54	FALSE
10	GTEx	Heart Atrial Appendage	NTAN1	0.10	0.09	lasso	1	0.07	3.7e-04	5.4	5.4	5.7e-08	1.00	0.01	0.86	FALSE
2	GTEx	Artery Tibial	RRN3	0.11	0.06	lasso	2	0.07	2.0e-06	5.6	5.2	1.6e-07	0.99	0.01	0.99	FALSE
8	GTEx	Esophagus Mucosa	RRN3	0.13	0.13	lasso	4	0.13	3.2e-09	5.4	5.2	2.6e-07	0.98	0.01	0.99	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	PKD1P6	0.14	0.00	lasso	5	0.00	2.7e-01	4.1	5.1	2.9e-07	0.39	0.02	0.10	FALSE