TWAS
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chr16:19,178,437-21,147,999
Best TWAS P=3.95e-12 · Best GWAS P=4.3e-12 conditioned to 7.65e-08
19.5M
20M
20.5M
21M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Adipose Subcutaneous
GPRC5B
0.07
0.04
lasso
4
0.03
1.3e-03
-6.38
6.9
3.9e-12
-0.08
0.15
0.63
TRUE
2
GTEx
Skin Sun Exposed Lower leg
ACSM5
0.21
0.04
lasso
9
0.07
3.6e-06
0.95
-5.2
2.0e-07
0.22
0.34
0.16
TRUE
4
The Cancer Genome Atlas
Thyroid Carcinoma
GPRC5B
0.06
0.01
blup
38
0.01
2.4e-02
-3.51
-5.6
2.7e-08
0.05
0.01
0.08
FALSE
3
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
IQCK
0.03
0.03
lasso
3
0.02
7.2e-04
-4.99
-5.3
1.3e-07
0.07
0.02
0.96
FALSE