Best TWAS P=5.3e-46 · Best GWAS P=1.4e-169 conditioned to 9.98e-79
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FTO | 0.11 | 0.00 | bslmm | 739 | 0.02 | 1.6e-03 | -0.89 | 13.7 | 1.9e-42 | 0.38 | 0.09 | 0.55 | TRUE |
| 2 | GTEx | Brain Cortex | RBL2 | 0.51 | 0.45 | enet | 12 | 0.46 | 3.5e-14 | 3.60 | -5.2 | 2.4e-07 | 0.02 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Muscle Skeletal | RBL2 | 0.11 | 0.00 | lasso | 5 | 0.00 | 2.9e-01 | 5.61 | -9.0 | 1.5e-19 | -0.10 | 0.28 | 0.23 | FALSE |
| 4 | GTEx | Spleen | RBL2 | 0.59 | 0.47 | enet | 51 | 0.46 | 3.2e-13 | 4.01 | -5.7 | 1.6e-08 | -0.06 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Testis | AKTIP | 0.19 | 0.00 | enet | 26 | 0.00 | 1.9e-01 | 3.60 | 14.2 | 5.3e-46 | 0.51 | 0.03 | 0.40 | TRUE |
| 6 | YFS | Blood | AKTIP | 0.19 | 0.27 | lasso | 13 | 0.30 | 3.3e-99 | 6.19 | 5.3 | 1.3e-07 | -0.01 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Glioblastoma Multiforme | FTO | 0.27 | 0.16 | enet | 13 | 0.14 | 6.7e-05 | -2.39 | 10.8 | 2.5e-27 | 0.33 | 0.11 | 0.32 | TRUE |
| 8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RBL2 | 0.11 | 0.08 | blup | 44 | 0.06 | 1.5e-03 | 5.61 | -5.5 | 4.9e-08 | -0.03 | 0.01 | 0.79 | FALSE |