Best TWAS P=1.04e-10 · Best GWAS P=7.9e-10 conditioned to 0.0156
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ACYP2 | 0.06 | 0.02 | blup | 561 | 0.03 | 4.8e-05 | -5.2 | 6.5 | 1.0e-10 | -0.68 | 0.01 | 0.98 | TRUE |
| 7 | GTEx | Testis | HMGB1P31 | 0.17 | 0.01 | enet | 21 | 0.02 | 4.6e-02 | -3.0 | -6.1 | 8.2e-10 | 0.60 | 0.12 | 0.65 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | HMGB1P31 | 0.19 | 0.06 | enet | 32 | 0.07 | 4.7e-03 | -2.9 | -6.0 | 2.2e-09 | 0.74 | 0.03 | 0.84 | FALSE |
| 4 | GTEx | Colon Sigmoid | ACYP2 | 0.35 | 0.09 | enet | 21 | 0.18 | 4.6e-07 | -3.0 | 5.6 | 2.1e-08 | -0.70 | 0.10 | 0.89 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | ERLEC1 | 0.03 | 0.00 | blup | 467 | 0.01 | 5.1e-03 | -4.5 | -5.6 | 2.3e-08 | 0.71 | 0.23 | 0.56 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ACYP2 | 0.06 | 0.04 | lasso | 3 | 0.03 | 1.3e-04 | -6.1 | 5.6 | 2.7e-08 | -0.96 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | ACYP2 | 0.15 | 0.09 | enet | 8 | 0.12 | 2.0e-11 | 3.7 | 5.5 | 4.0e-08 | -0.85 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Thyroid | HMGB1P31 | 0.05 | 0.06 | enet | 13 | 0.04 | 4.3e-04 | -6.0 | -5.5 | 4.5e-08 | 0.78 | 0.01 | 0.97 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | HMGB1P31 | 0.07 | 0.07 | lasso | 7 | 0.07 | 7.3e-10 | -4.4 | -5.5 | 4.6e-08 | 0.82 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Artery Tibial | HMGB1P31 | 0.17 | 0.00 | enet | 21 | 0.06 | 1.8e-05 | -6.1 | -5.5 | 5.0e-08 | 0.57 | 0.01 | 0.94 | FALSE |
| 6 | GTEx | Prostate | HMGB1P31 | 0.53 | 0.19 | enet | 25 | 0.27 | 1.5e-07 | -6.0 | -5.2 | 2.0e-07 | 0.80 | 0.02 | 0.97 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | AC008280.3 | 0.13 | 0.00 | enet | 21 | 0.08 | 2.4e-04 | -3.0 | 5.2 | 2.1e-07 | -0.45 | 0.08 | 0.05 | FALSE |