Hub : Genes

HMGB1P31

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0770 0.0410 7.2e-03 -0.003 NA 0.006 NA -0.003 9.7e-01 NA 9.6e-02 NA 9.1e-01
2 GTEx Adrenal Gland 0.1867 0.0752 1.6e-04 0.113 NA 0.070 NA 0.071 7.4e-05 NA 1.7e-03 NA 1.6e-03
3 GTEx Artery Aorta 0.1680 0.0600 2.8e-05 0.051 NA 0.073 NA 0.014 8.7e-04 NA 7.4e-05 NA 5.3e-02
4 GTEx Artery Coronary 0.0960 0.0460 6.3e-03 0.023 NA 0.004 NA 0.029 5.8e-02 NA 2.3e-01 NA 3.6e-02
5 GTEx Artery Tibial 0.1671 0.0618 6.3e-04 0.005 NA 0.060 NA 0.023 1.3e-01 NA 1.8e-05 NA 6.0e-03
6 GTEx Brain Caudate basal ganglia 0.3100 0.1060 6.4e-04 0.226 NA 0.123 NA 0.190 4.0e-07 NA 2.2e-04 NA 3.8e-06
7 GTEx Brain Cerebellar Hemisphere 0.2820 0.0990 3.6e-03 0.117 NA 0.052 NA 0.076 6.5e-04 NA 1.8e-02 NA 5.5e-03
8 GTEx Brain Cortex 0.1360 0.0630 7.7e-03 0.001 NA 0.016 NA -0.003 3.0e-01 NA 1.1e-01 NA 4.1e-01
9 GTEx Brain Frontal Cortex BA9 0.1713 0.0782 4.7e-03 0.035 NA 0.068 NA 0.053 4.2e-02 NA 7.3e-03 NA 1.6e-02
10 GTEx Brain Hippocampus 0.2258 0.0887 6.8e-04 0.178 NA 0.182 NA 0.229 5.9e-05 NA 4.6e-05 NA 4.4e-06
11 GTEx Brain Hypothalamus 0.2170 0.0850 4.5e-03 0.015 NA 0.046 NA -0.013 1.4e-01 NA 3.1e-02 NA 9.9e-01
12 GTEx Brain Putamen basal ganglia 0.2360 0.0870 2.2e-03 0.070 NA 0.081 NA 0.079 9.9e-03 NA 5.8e-03 NA 6.2e-03
13 GTEx Breast Mammary Tissue 0.1460 0.0510 4.6e-05 0.080 NA 0.036 NA 0.097 6.8e-05 NA 5.8e-03 NA 1.1e-05
14 GTEx Breast Mammary Tissue (Male) 0.1662 0.0655 3.0e-03 0.094 NA 0.062 NA 0.066 3.5e-03 NA 1.5e-02 NA 1.3e-02
15 GTEx Breast Mammary Tissue (Female) 0.1898 0.0781 3.8e-03 0.056 NA 0.067 NA 0.062 9.0e-03 NA 4.7e-03 NA 6.5e-03
16 GTEx Cells Transformed fibroblasts 0.1220 0.0400 3.7e-05 0.032 NA 0.052 NA 0.060 1.8e-03 NA 9.4e-05 NA 2.6e-05
17 GTEx Esophagus Mucosa 0.0620 0.0290 3.5e-03 0.012 NA 0.017 NA -0.003 5.0e-02 NA 2.5e-02 NA 5.5e-01
18 GTEx Esophagus Muscularis 0.1370 0.0740 7.9e-03 0.000 NA 0.011 NA 0.003 3.2e-01 NA 6.5e-02 NA 2.0e-01
19 GTEx Heart Atrial Appendage 0.1180 0.0500 2.9e-03 0.013 NA 0.027 NA 0.042 8.1e-02 NA 2.2e-02 NA 5.6e-03
20 GTEx Liver 0.1780 0.0810 8.0e-03 0.031 NA 0.047 NA 0.047 4.6e-02 NA 1.9e-02 NA 1.9e-02
21 GTEx Muscle Skeletal 0.2570 0.0517 1.8e-15 0.174 NA 0.217 NA 0.215 9.1e-17 NA 4.8e-21 NA 8.0e-21
22 GTEx Nerve Tibial 0.1357 0.0481 4.8e-05 0.019 NA 0.087 NA 0.072 1.6e-02 NA 9.1e-07 NA 7.8e-06
23 GTEx Pancreas 0.3040 0.0840 5.5e-07 0.153 NA 0.134 NA 0.140 5.1e-07 NA 2.9e-06 NA 1.7e-06
24 GTEx Prostate 0.5350 0.1000 1.8e-07 0.193 NA 0.273 NA 0.246 1.4e-05 NA 1.5e-07 NA 7.3e-07
25 GTEx Skin Not Sun Exposed Suprapubic 0.1800 0.0690 6.4e-04 0.010 NA 0.090 NA 0.042 8.3e-02 NA 1.2e-05 NA 2.3e-03
26 GTEx Stomach 0.1060 0.0450 2.6e-03 0.068 NA 0.068 NA 0.070 3.7e-04 NA 3.6e-04 NA 3.1e-04
27 GTEx Testis 0.1680 0.0650 4.4e-04 0.010 NA 0.019 NA 0.019 1.1e-01 NA 4.6e-02 NA 4.6e-02
28 GTEx Thyroid 0.0510 0.0260 9.0e-03 0.058 NA 0.041 NA 0.031 3.0e-05 NA 4.3e-04 NA 2.0e-03
29 ROSMAP Brain Pre-frontal Cortex 0.0664 0.0205 1.1e-06 0.073 0.048 0.061 0.052 0.075 1.1e-09 7.3e-07 2.7e-08 2.7e-07 7.3e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
Bipolar Disorder (2018) 1.5 2.4 12.7 -0.8 0.1 -0.3 0.2 -1.3 -2.1 -2.4 -1.1 -1.7 -0.9 0.2 -1.7 -1.6 -1.8 -1.0 -2.3 -0.6 -1.1 -1.1 0.7 -2.0 -1.1 -1.1 -2.1 -3.6 -2.5 -1.2 -1.1 -1.5
Bipolar Disorder or Schizophrenia 1.2 2.8 11.4 0.6 -0.7 0.0 0.7 -0.1 -1.4 -1.5 -1.4 -2.2 -2.5 -0.5 -2.4 -2.7 -2.9 -0.8 -2.1 -1.2 -1.2 -1.6 0.2 -1.2 -0.3 -1.9 -2.3 -3.4 -2.2 -0.4 -1.1 -1.7
Depressed Affect (Nagel 2018) 0.2 0.4 1.6 -0.4 0.9 0.1 -0.8 -1.3 -1.0 -0.4 0.7 -0.7 0.5 1.0 -0.0 0.3 0.7 -0.9 -0.2 1.1 -0.1 0.3 0.8 -1.0 -0.4 0.4 -0.6 -0.7 -0.1 -0.6 -0.6 -0.1
Depression (Nagel 2018) 0.6 0.9 5.8 1.1 2.4 0.3 -2.0 -1.2 0.0 -0.3 0.7 0.7 0.6 1.0 1.1 0.5 1.1 -1.0 0.7 1.7 -0.7 0.0 -1.4 -0.1 0.1 0.2 0.4 0.1 0.1 -0.2 -0.3 0.5
Intelligence (Savage-Jansen 2018) 2.1 6.4 15.6 -2.2 -3.3 -1.7 2.9 -1.5 -2.5 -0.7 -3.3 -3.9 -3.7 -3.3 -3.6 -3.6 -3.3 -2.1 -2.3 -2.9 -0.7 -1.1 -2.5 -1.9 -0.4 -2.3 -2.1 -1.6 -2.0 -1.6 -2.5 -2.8
Neuroticism (Nagel 2018) 1.0 2.4 5.9 -1.8 -0.5 -1.0 0.1 -2.0 -2.1 -0.8 -0.9 -1.8 -1.4 -1.1 -1.9 -1.5 -0.6 -1.8 -1.8 -0.5 -1.3 -1.2 1.1 -2.4 -1.9 -0.7 -2.1 -1.8 -0.9 -1.7 -2.3 -1.9
Schizophrenia (2018) 0.6 1.3 6.4 1.0 -1.0 0.2 0.8 0.9 -0.1 -0.0 -1.0 -1.4 -2.5 -0.9 -1.7 -2.1 -2.3 -0.3 -0.9 -1.1 -0.7 -1.2 -0.4 0.0 0.5 -1.5 -1.2 -1.5 -0.9 0.4 -0.6 -1.0
Schizophrenia vs Biploar Disorder 0.3 0.4 4.2 1.0 0.0 -0.8 -0.1 0.8 -0.2 0.9 -0.8 0.3 -2.1 -0.7 -0.6 -0.9 -0.5 0.4 -0.4 -0.0 -0.5 0.5 -0.5 0.4 0.6 -0.3 0.4 0.6 -0.4 0.0 -0.1 -0.0
Worry (Nagel 2018) 1.6 3.3 8.3 -2.1 -1.6 -1.0 1.0 -1.8 -2.3 -1.0 -1.5 -2.0 -2.4 -2.3 -2.3 -1.7 -0.5 -1.7 -1.8 -1.5 -1.4 -1.6 0.8 -2.9 -2.0 -0.7 -2.7 -2.7 -0.4 -1.9 -2.0 -1.8
Alzheimer’s Disease (in mother) 0.6 0.7 4.8 -0.1 -0.5 0.6 0.3 -1.1 -0.5 -1.9 -1.1 -0.3 -1.1 -0.2 -1.0 -1.0 -1.0 -0.4 -1.1 -0.1 2.2 -0.6 -0.1 -0.1 0.0 -0.7 -0.3 -0.9 -1.1 -0.6 0.4 -0.2
Alzheimer’s Disease (in father) 0.7 0.7 2.8 0.7 0.4 0.7 -0.4 0.8 1.5 0.8 0.1 1.2 1.0 1.3 0.8 0.4 -0.0 0.3 0.7 0.6 1.2 0.3 0.9 1.5 0.2 0.5 0.8 1.0 1.1 1.7 0.4 0.3
Alzheimer’s Disease (including proxy) 0.4 0.5 6.4 0.5 -0.5 0.7 0.3 -0.5 0.5 -1.0 -1.2 0.2 -0.3 0.3 -0.4 -0.5 -1.0 -0.0 -0.4 0.1 2.5 0.0 0.0 1.0 0.3 -0.1 0.5 0.1 -0.2 0.7 0.7 0.1
Crohns Disease (2017) 0.4 0.9 2.8 -0.6 0.9 -0.8 -1.2 -1.0 -1.7 -1.4 -1.2 -1.6 -0.5 0.5 -0.7 -0.7 -0.7 0.3 -1.5 0.6 1.2 1.2 -0.8 -0.5 -0.3 -0.8 -0.3 -1.1 -1.1 -0.7 -0.0 0.0
Irritable Bowel Disease (IBD) 0.3 0.7 2.8 0.1 1.2 -0.4 -1.1 -0.6 -0.5 -0.9 -0.3 -0.5 0.2 0.7 0.2 0.4 0.3 1.7 -0.3 1.0 1.6 1.7 0.2 0.3 0.4 0.6 0.5 -0.7 0.0 0.3 1.5 0.9
Ulcerative Colitis (UC) 0.4 0.7 2.8 0.2 0.7 -0.3 -0.3 -0.4 0.5 -0.0 0.3 0.5 0.6 0.0 0.7 1.0 0.9 1.6 0.9 0.6 1.0 1.1 1.1 0.8 0.7 1.4 0.7 -0.2 1.2 0.9 1.7 1.0
Major Depression (MDD) 0.3 0.4 2.3 -0.2 0.3 0.4 0.5 -0.7 0.2 1.2 0.9 -0.6 0.2 0.4 0.1 0.6 1.0 -0.8 0.3 0.6 0.0 0.6 1.0 0.3 -0.3 1.5 0.2 0.7 0.8 -0.3 0.1 0.3
Reaction Time 0.4 0.7 4.4 -1.1 -0.3 -0.0 0.4 -1.3 0.9 -0.3 0.6 0.0 0.2 -0.6 -0.3 0.2 0.7 -0.5 0.1 -0.4 -2.1 0.2 1.5 -0.3 -1.7 -0.1 -0.9 0.0 0.6 -0.1 -1.8 -1.2
Verbal and Numeric Reasoning (VNR) 3.7 8.8 17.0 -2.3 -3.5 -1.1 3.5 -1.5 -3.1 -0.3 -3.8 -4.0 -4.1 -3.1 -3.7 -4.1 -3.5 -3.1 -2.9 -3.6 -2.0 -1.8 -2.5 -2.7 -1.4 -3.2 -2.4 -1.4 -2.4 -2.2 -4.1 -3.7
Breast Cancer 0.1 0.3 1.4 -0.4 -0.2 -0.9 0.3 -0.4 0.9 0.4 0.9 1.1 0.2 0.2 0.2 0.4 0.4 0.0 0.5 -0.4 -0.8 -0.3 -0.1 -0.4 -1.2 -0.1 -0.3 -0.5 0.3 0.3 -0.7 -0.1
Ovarian Cancer 0.3 0.4 2.0 -0.0 0.8 -0.1 -0.9 0.6 1.1 0.6 0.5 1.4 0.3 0.7 0.7 0.4 0.4 -0.1 0.9 0.5 1.4 0.8 -0.5 0.6 0.2 0.1 -0.5 -0.5 1.0 -0.3 0.1 -0.0
Prostate Cancer 1.2 1.7 5.6 -1.6 0.0 -1.2 0.2 -2.4 -1.8 -0.7 -1.2 -1.0 -0.8 -1.0 -0.7 -0.7 -0.1 -1.8 -1.0 -0.3 0.4 -1.0 -2.0 -1.9 -1.2 -0.7 -2.1 -1.6 -0.5 -2.1 -1.6 -0.7
Age at First Birth 0.6 0.9 4.2 0.7 -0.9 0.4 0.3 -0.0 -1.4 -1.7 -1.2 -1.9 -0.5 -0.6 -1.1 -0.9 -1.2 -0.2 -1.7 -0.4 0.5 -0.6 0.2 -0.0 0.4 -0.8 0.5 0.3 -2.1 -0.7 0.2 -0.0
Bipolar Disorder (2011) 0.9 0.9 3.0 -0.8 -0.8 -0.2 1.0 -0.3 -0.4 0.1 -0.3 -0.4 -0.4 -0.1 -1.1 -1.1 -0.9 -1.0 -0.6 -0.7 -1.4 -1.5 0.8 -1.2 -1.7 -1.1 -1.4 -0.9 -0.5 -0.6 -1.6 -1.5
Body Mass Index (BMI) (2010) 3.6 5.0 10.1 -2.3 -2.6 -2.2 2.9 -1.6 -1.8 -1.3 -2.8 -1.4 -2.2 -2.7 -2.1 -2.1 -1.7 -1.8 -2.2 -3.0 -1.0 -2.5 -2.1 -2.4 -1.5 -2.3 -2.3 -2.0 -2.0 -3.2 -2.3 -2.5
Coronary Artery Disease (CAD) 0.5 0.5 4.0 -0.1 -0.1 -0.4 0.2 -1.3 -0.8 -1.1 -0.6 -0.7 0.2 -1.1 -0.2 0.7 0.2 -0.4 -1.0 -0.2 -1.1 -1.0 -2.0 -0.1 -0.3 0.8 0.3 -0.4 -0.5 -0.9 0.3 0.4
Crohns Disease (2012) 0.2 0.4 2.2 0.3 1.1 0.3 -1.5 -0.2 -0.5 0.3 -0.2 -0.4 0.3 1.5 0.3 0.0 0.2 0.7 0.1 1.1 0.7 1.2 -0.5 0.2 0.1 -0.4 0.2 0.3 0.1 0.2 0.2 0.6
Mean Putamen Volume 0.3 0.3 1.6 0.3 0.2 1.0 1.0 -0.3 0.9 1.2 -0.0 1.1 -0.0 -0.2 0.7 0.3 0.1 0.2 0.7 -0.1 0.5 -0.4 0.1 0.8 0.7 -0.2 0.2 0.6 0.4 0.2 -0.4 0.0
Fasting Glucose 2.4 2.9 7.7 1.2 -0.8 0.2 -0.9 2.5 1.9 1.4 1.9 2.0 1.8 1.3 1.8 2.4 2.7 1.6 2.1 1.4 0.4 0.9 0.7 1.1 0.6 2.8 2.0 1.4 2.0 1.8 2.0 1.8
HbA1C 1.2 1.3 2.4 -1.4 1.2 -0.8 1.2 -0.7 -1.2 0.2 -1.4 -1.3 -1.4 -0.7 -0.8 -1.3 -1.2 -1.4 -1.1 -1.1 -1.1 -0.8 -1.4 -0.8 -1.3 -1.5 -1.4 -0.6 -1.0 -0.8 -1.4 -1.4
HDL Cholesterol 3.8 6.4 11.8 3.1 2.9 2.0 -3.4 2.2 1.3 1.9 3.4 1.1 2.2 2.6 2.6 2.6 2.0 2.5 2.3 3.1 1.8 3.1 1.6 2.3 2.7 2.5 2.5 1.8 2.5 2.7 3.0 3.4
LDL Cholesterol 0.6 0.9 3.0 0.7 1.7 0.9 -1.6 0.5 -0.3 1.0 1.3 0.3 0.7 0.6 1.0 1.0 0.7 1.3 0.3 1.4 -0.8 1.4 0.5 -0.2 1.0 0.5 1.0 1.1 0.2 0.6 0.3 1.3
Lupus 0.2 0.2 1.0 -0.5 0.5 0.5 -0.7 0.1 -0.7 0.4 0.2 -1.0 -0.3 -0.4 -0.1 -0.6 -0.4 -0.5 0.1 0.5 -0.6 1.0 -0.8 -0.2 0.2 -0.1 -0.1 0.1 0.2 0.2 -0.4 -0.2
Neuroticism (2016) 1.8 2.6 5.2 -1.7 -1.2 -1.9 1.0 -1.4 -1.2 -1.5 -1.3 -1.0 -1.7 -2.3 -2.2 -1.9 -1.8 -0.9 -2.0 -1.5 -1.9 -2.0 -0.6 -1.2 -1.9 -2.2 -1.8 -1.1 -0.9 -1.6 -1.7 -1.9
Primary Biliary Cirrhosis 1.8 2.6 6.4 1.7 1.7 1.7 -1.0 1.8 2.5 1.8 1.7 1.5 1.4 1.7 2.1 1.5 1.2 1.3 2.3 1.2 0.9 1.6 0.2 2.0 1.4 1.0 1.5 1.7 1.6 1.7 1.1 1.5
Rheumatoid Arthritis 1.3 1.8 6.1 1.4 1.4 0.7 -2.5 0.7 0.4 -0.1 1.1 1.0 1.7 1.8 1.3 1.5 0.9 1.7 0.5 1.9 1.0 1.3 0.2 1.3 0.6 0.9 2.3 2.2 -0.2 0.6 1.2 1.7
Schizophrenia (2014) 1.4 3.1 11.9 1.5 -1.3 0.2 1.2 1.3 -0.7 0.0 -1.7 -1.9 -3.4 -1.2 -2.7 -3.2 -3.5 -0.5 -1.7 -1.7 -1.8 -1.6 -0.7 -0.4 0.2 -2.7 -1.7 -1.8 -1.8 0.4 -1.4 -1.7
Triglycerides 2.8 4.6 10.6 -2.1 -1.9 -1.4 2.2 -1.7 -2.0 -1.3 -2.5 -1.6 -2.0 -2.2 -2.4 -2.3 -2.2 -1.5 -2.7 -2.2 -1.1 -1.9 -3.3 -2.3 -1.7 -2.3 -2.1 -1.8 -2.5 -2.7 -2.7 -2.5
Type 2 Diabetes (T2D) (2012) 0.1 0.2 0.6 -0.2 -0.4 -0.4 0.6 0.2 0.0 0.4 -0.3 -0.5 -0.7 -0.6 -0.1 0.1 0.2 -0.4 -0.3 -0.2 -0.7 -0.0 -0.8 -0.3 0.0 0.2 -0.7 -0.1 -0.2 -0.3 -0.6 -0.4
Ulcerative Colitis 0.4 0.6 3.2 0.6 0.3 0.1 0.1 -0.3 0.7 -0.2 0.0 0.5 0.2 0.1 0.5 0.6 -0.0 1.6 0.6 0.3 1.3 0.3 0.9 1.0 1.0 0.5 0.8 -0.2 0.4 1.2 1.8 0.7
Blood Eosinophil Count 0.7 5.7 17.4 0.4 -1.9 -0.8 1.2 0.1 -2.4 -2.0 -3.2 -3.4 -3.4 -2.1 -2.8 -3.6 -4.2 -1.9 -2.8 -2.5 0.4 -2.2 -2.0 -1.5 0.1 -4.1 -2.3 -2.6 -3.5 -0.8 -0.5 -1.7
Blood Platelet Count 0.1 1.6 6.9 -0.3 0.3 -0.3 -0.3 -1.4 -2.1 -2.6 -0.4 -0.4 -0.7 -1.0 -1.2 -1.0 -1.5 -0.2 -2.6 -0.0 -0.6 -1.0 0.6 -1.3 -0.2 -1.4 -1.1 -2.5 -2.2 -1.3 -0.2 -0.2
Blood Red Count 0.6 5.8 13.5 0.7 1.0 0.1 -0.9 1.4 2.1 2.4 2.4 2.4 2.4 0.7 2.8 3.4 3.7 2.9 2.7 1.7 2.0 2.0 1.1 2.3 2.5 3.7 3.2 3.1 3.5 2.0 2.6 2.7
Blood White Count 0.2 1.4 5.2 0.4 0.1 -1.5 -0.3 -0.3 -1.9 -2.3 -1.5 -0.9 -1.5 0.1 -0.9 -1.2 -1.4 -0.7 -2.0 -0.6 1.0 -0.5 -1.7 -0.6 -0.7 -1.9 -0.8 -0.8 -2.1 -1.1 -0.1 -0.2
Heel T-Score 2.4 19.1 156.2 -4.7 -1.5 5.3 0.7 -1.2 1.2 -5.2 1.9 1.4 3.7 2.3 2.0 3.5 2.6 1.1 -0.8 -4.2 0.2 -1.2 9.2 -4.2 -4.1 -0.5 -12.5 -11.0 2.0 -1.0 0.8 -0.0
BMI 2.6 15.3 32.4 -4.8 -4.4 -5.5 4.0 -5.7 -2.6 -1.0 -3.1 -1.8 -3.2 -3.0 -3.6 -3.4 -1.7 -5.0 -3.1 -4.5 -2.3 -4.5 -1.9 -4.0 -5.2 -2.7 -5.3 -2.3 -1.7 -5.5 -5.1 -5.5
Height 1.6 30.0 74.1 -3.1 -2.6 -2.7 2.6 -3.6 -8.3 -4.9 -7.3 -8.1 -6.6 -3.9 -6.2 -7.0 -6.9 -4.8 -6.9 -3.7 -2.0 -1.9 -8.1 -5.7 -2.1 -6.1 -4.5 -3.9 -8.6 -6.3 -4.7 -4.5
Waist Hip Ratio (WHR) 0.1 0.6 2.9 0.7 -0.2 0.6 -0.1 0.4 0.8 1.3 -0.2 0.1 -0.2 0.7 0.3 -0.4 -0.2 -0.7 1.1 0.8 1.7 0.3 -0.7 1.4 1.5 0.3 1.0 1.4 0.7 0.4 -0.1 -0.0
Systolic Blood Pressure 0.5 2.7 8.4 2.3 1.9 1.8 -2.6 -0.3 1.0 0.1 2.0 1.0 1.7 2.0 1.5 1.5 1.3 0.9 0.9 2.9 1.0 1.1 1.8 1.1 1.4 1.0 2.9 2.5 1.1 1.1 1.1 1.6
Smoking Status 1.3 3.1 10.4 -0.3 -2.0 -1.1 1.5 -0.7 -1.2 -0.3 -2.1 -1.4 -1.9 -0.5 -2.3 -2.9 -2.3 -1.9 -1.8 -1.4 -1.9 -1.7 -1.9 -0.9 -2.2 -2.4 -1.8 -0.3 -1.4 -0.7 -2.0 -3.2
Allergy or Eczema 1.0 2.6 7.2 -1.0 -1.7 0.5 1.2 0.2 -1.6 -1.6 -1.3 -1.7 -1.7 -0.5 -2.0 -2.5 -2.7 -1.3 -2.1 -1.6 0.3 -2.2 0.4 -2.2 -0.4 -2.3 -1.5 -1.6 -2.2 -0.8 -1.1 -1.7
Cardiovascular Disease 0.1 0.5 3.9 0.5 -0.1 -0.3 -0.9 -2.0 0.0 1.2 -0.1 -0.5 -1.0 1.0 -0.2 -0.7 0.2 -1.0 0.0 0.5 -0.2 -0.3 -0.1 0.1 0.1 0.0 0.3 1.0 0.2 -0.7 -0.8 -1.0
Hypothyroidism (self reported) 0.1 0.3 1.6 0.1 -0.2 0.2 0.2 0.6 -1.0 0.4 -0.3 -1.2 -1.0 -0.1 -0.4 -0.6 0.1 -0.5 -0.3 -0.1 0.1 0.3 -0.9 -1.0 0.2 -0.1 0.3 -0.1 -0.2 -1.0 -0.6 -0.2
Respiratory disease 1.4 3.1 12.5 -0.2 -1.4 -1.1 1.3 -0.0 -1.3 -0.9 -2.0 -1.6 -2.3 -1.1 -2.2 -2.9 -3.5 -1.8 -1.8 -2.0 0.7 -2.8 -0.2 -0.7 -0.5 -2.8 -2.4 -1.2 -1.9 -0.1 -0.8 -2.0
Type 2 Diabetes (T2D) (2018) 0.6 1.1 3.8 -1.3 -2.0 0.2 1.5 -0.7 -0.7 -0.1 -0.4 -1.4 -1.3 -0.7 -1.2 -1.2 -0.4 -1.3 -0.8 -1.3 -0.0 -1.4 -1.1 -0.6 -0.9 -0.3 -1.7 0.2 -0.3 -1.3 -1.1 -1.5
Lung FEV1/FVC ratio 0.5 2.7 7.7 0.4 2.6 0.8 -2.6 -0.5 0.5 2.0 2.0 0.6 2.4 2.8 2.0 1.6 2.4 0.3 1.4 2.4 -0.2 2.5 -0.7 0.4 -1.9 1.6 1.2 2.2 1.3 -0.6 -0.5 0.7
Lung FVC 1.0 5.3 11.7 1.2 2.2 1.1 -1.3 1.1 1.5 0.8 2.1 2.2 3.2 1.9 2.9 3.4 3.0 2.3 2.2 2.4 2.1 2.5 2.7 2.1 2.2 3.3 2.2 0.2 2.2 2.3 3.3 3.1
Neuroticism 1.2 2.9 6.0 -2.2 -1.3 -1.1 1.1 -1.6 -2.1 -1.3 -0.9 -2.2 -2.1 -1.3 -2.2 -1.8 -0.9 -1.6 -1.9 -1.2 -1.8 -1.0 1.0 -2.4 -1.6 -1.0 -2.2 -2.1 -1.0 -1.7 -2.4 -1.9
Chronotype (morning person) 1.9 4.5 12.0 1.2 2.6 1.3 -2.4 2.1 1.5 2.7 3.5 1.1 2.7 2.1 2.3 2.3 3.0 2.1 2.3 2.4 1.7 2.4 1.1 1.0 -0.0 3.0 2.2 0.4 2.5 1.6 1.5 2.2
Hair Pigment 0.0 1.1 4.2 1.2 -0.6 1.5 -0.0 2.1 1.1 -0.5 0.4 0.5 0.0 1.2 0.2 0.0 -0.9 0.7 0.6 0.6 1.9 0.5 0.9 1.6 1.6 -0.4 0.9 -0.2 -0.3 1.5 1.8 1.0
Tanning 0.1 1.5 5.5 1.3 1.3 -1.8 -1.5 0.2 0.4 -0.2 0.8 0.9 1.7 1.7 1.4 1.5 1.9 -0.1 1.0 1.3 0.0 0.2 -2.3 0.3 -0.1 1.7 1.9 1.1 0.7 0.2 1.3 1.1
Hand grip strength (left) 1.6 4.3 11.7 0.6 2.8 0.9 -3.0 -0.4 0.9 0.2 1.8 1.2 2.8 2.3 2.7 2.8 3.0 1.1 1.6 3.2 2.1 2.7 1.1 1.8 1.2 3.4 1.9 1.0 2.3 0.6 2.1 2.2
Number of treatments/medications taken 0.2 0.3 1.0 0.9 0.4 0.5 -1.0 -0.8 -0.2 -0.3 0.3 0.2 0.0 0.8 0.2 -0.1 -0.5 0.0 -0.1 0.8 0.8 0.0 0.2 0.3 0.7 -0.8 -0.1 0.1 -0.6 0.7 0.8 0.5
Average weekly spirits intake 1.1 1.4 3.9 -1.8 -1.5 -1.1 1.7 -2.0 -0.5 0.2 -0.8 -0.2 -0.7 -1.8 -0.2 -0.0 0.9 -1.7 0.1 -1.7 0.1 -0.8 -0.7 -0.8 -1.3 1.3 -1.3 -1.8 1.2 -1.0 -1.4 -1.0
Sensitivity / hurt feelings 0.6 1.0 2.4 -1.2 -0.4 -1.6 0.2 -0.9 -1.3 -1.2 -0.8 -1.4 -1.5 -1.4 -1.4 -0.8 -0.4 -0.5 -1.5 -0.5 -1.2 -0.5 -0.3 -0.9 -0.8 -0.4 -0.7 -0.4 -1.2 -1.1 -0.6 -0.9
Frequency of depressed mood in last 2 weeks 0.2 0.2 1.3 0.4 1.1 0.6 -0.7 -0.2 0.4 -0.1 0.3 0.2 -0.5 0.6 0.2 -0.2 0.3 -0.6 0.7 0.8 -0.5 -0.3 -0.1 0.3 0.0 0.2 -0.5 0.2 0.4 0.3 -0.4 -0.0
Hearing difficulty/problems: Yes 0.5 0.7 2.5 -0.1 1.6 -1.1 -0.7 1.4 0.4 0.5 0.5 1.1 1.1 1.1 1.1 1.1 1.0 0.7 0.7 0.6 -0.3 1.1 -1.3 0.3 -0.4 0.2 0.6 0.7 0.0 -0.3 -0.2 0.9
Relative age of first facial hair 0.5 1.1 5.2 -0.4 -0.1 -0.7 -0.2 -0.1 -1.2 -0.6 0.0 -0.9 -1.1 -0.4 -1.3 -1.3 -0.8 -0.6 -1.4 -0.3 -2.3 -0.3 0.8 -2.0 -0.7 -1.3 -1.4 -1.6 -1.6 -0.6 -0.5 -1.0
Other serious medical condition/disability diagnosed by doctor 5.2 6.8 17.6 3.8 3.6 2.1 -3.4 2.3 1.1 4.2 2.9 0.8 1.1 2.5 2.5 2.0 2.5 1.3 3.0 3.4 1.1 3.4 0.4 2.2 3.9 2.5 2.9 2.3 2.4 2.2 1.8 2.8
Ever used hormone-replacement therapy (HRT) 0.6 0.7 2.5 0.4 0.3 -0.6 -0.4 0.9 0.9 0.9 -0.1 1.3 0.5 0.6 1.2 0.7 1.0 0.0 1.0 0.8 -0.2 1.2 -1.6 0.9 0.1 0.5 1.5 0.9 1.2 0.4 1.1 0.7
Ever had hysterectomy (womb removed) 0.5 0.5 7.5 0.6 0.7 0.5 -0.4 -0.0 -0.5 0.2 -0.0 -0.5 -0.6 0.5 0.6 0.2 0.5 -0.3 0.0 0.6 0.6 1.0 -2.7 0.1 1.2 0.6 0.1 0.5 -0.1 -0.7 0.6 0.6
Systolic blood pressure, automated reading 0.2 0.5 2.4 1.0 0.8 0.6 -0.8 -0.9 0.4 -0.4 0.2 0.8 0.7 1.1 0.6 0.5 0.3 0.1 0.3 1.2 0.4 0.0 -1.1 0.2 -0.2 -0.2 1.1 1.6 0.7 -0.2 0.0 0.3
Eye problems/disorders: Diabetes related eye disease 4.4 4.8 11.8 1.4 2.5 1.5 -2.3 1.2 2.6 3.1 2.5 2.6 2.0 2.4 2.8 1.8 2.6 -0.1 3.4 2.2 1.1 1.4 2.5 2.2 0.6 2.5 1.5 2.2 3.2 2.8 1.2 1.4
Angina 0.2 0.2 0.7 0.7 0.5 0.4 -0.8 -0.1 0.0 -0.5 -0.1 -0.1 -0.6 0.8 -0.0 -0.8 -0.4 -0.7 -0.1 0.4 0.6 -0.4 0.3 -0.2 0.3 -0.4 -0.0 -0.5 -0.3 0.7 -0.2 -0.4
Medication for hormone replacement therapy 0.6 0.7 2.5 0.3 0.3 0.0 0.2 1.0 0.8 -0.6 -0.1 1.3 0.6 0.4 1.1 1.2 0.3 1.6 0.6 0.5 1.0 0.7 0.6 0.9 1.3 0.4 1.2 0.1 0.1 0.9 1.3 1.3
Vitamin and mineral supplements 1.4 1.9 4.9 0.7 1.3 1.2 -0.9 0.5 1.7 1.0 0.7 0.8 0.8 0.9 1.6 1.9 2.0 1.0 1.5 1.5 0.2 0.8 1.0 1.7 1.1 1.8 1.6 2.0 2.2 2.0 1.2 1.7
Supplements: Zinc 0.3 0.3 1.2 -0.0 -0.4 -0.3 0.4 -0.6 -0.7 -0.7 -0.7 -1.1 -0.1 -0.4 -0.3 -0.5 -0.8 0.4 -0.7 -0.3 0.8 0.8 -0.5 -0.3 0.4 -0.3 0.6 0.2 -0.6 -0.5 -0.2 -0.0
Medication: Co-codamol 0.6 0.7 2.2 0.7 0.6 0.2 -0.4 -1.5 -1.1 -0.8 -0.9 -0.6 -0.7 1.0 -0.6 -0.9 -1.1 -1.4 -1.2 0.3 0.1 -0.7 -1.4 -0.5 -0.2 -0.7 -0.6 0.6 -1.1 -0.5 0.0 -0.5
Medication: Metformin 0.2 0.3 1.7 0.5 0.2 1.0 -0.4 -0.0 -0.4 0.6 1.0 -0.6 0.1 -0.0 -0.0 -0.2 0.2 -0.4 0.1 0.1 0.5 -0.3 -1.0 -0.1 -0.7 -0.2 -0.5 1.3 0.0 -0.3 -0.3 -0.0
Diabetes (father) 0.2 0.2 1.1 -0.3 0.4 0.0 -0.1 -0.6 0.2 0.3 0.4 -0.0 -0.0 -0.1 0.4 0.7 1.0 -0.7 0.7 0.1 0.1 0.2 -0.4 0.1 -0.1 1.0 -0.9 -0.5 0.6 0.5 0.2 0.3
Diabetes (mother) 0.2 0.2 1.6 -1.3 0.6 0.0 -0.5 -0.8 -0.0 -0.1 0.3 -0.3 0.2 0.3 0.2 -0.4 -0.1 -0.4 0.4 0.2 0.3 -0.8 0.9 -0.5 -0.1 -0.2 -0.1 0.1 0.4 -0.1 -0.8 -0.3
Severe depression (siblings) 0.3 0.3 1.7 -0.5 -0.6 -0.4 0.9 -0.0 0.9 -0.0 -0.0 0.9 -0.0 -0.5 0.4 0.5 0.6 -0.7 0.5 -0.4 -1.1 -0.2 -1.3 0.1 0.0 0.3 0.6 -0.1 0.4 0.1 -0.6 -0.3
Pack years adult smoking proportion 0.2 0.4 1.9 0.4 0.7 0.2 -1.3 -0.4 0.8 0.0 0.1 1.4 0.4 1.2 0.6 0.4 0.6 -0.7 0.6 0.8 0.2 0.0 0.4 0.9 -0.0 0.4 -0.3 0.0 0.5 0.6 -0.4 0.0
Impedance of leg (right) 0.4 1.8 11.0 1.6 0.5 2.2 -0.4 3.3 1.0 1.1 -0.3 0.3 0.0 1.4 0.4 0.2 -0.6 2.3 1.0 0.6 0.3 0.9 -1.0 1.8 1.4 -0.1 1.2 0.9 0.6 2.6 1.4 1.4
Leg fat-free mass (left) 2.3 12.4 28.0 -3.4 -2.5 -3.7 2.2 -4.5 -4.4 -2.2 -3.3 -3.8 -3.5 -3.2 -3.4 -3.7 -2.6 -4.7 -3.9 -3.1 -1.4 -2.8 -2.7 -4.6 -2.5 -2.8 -3.8 -3.1 -3.9 -5.3 -4.0 -4.1
Trunk fat percentage 2.9 11.4 22.7 -3.9 -3.1 -4.2 3.5 -3.3 -2.5 -0.6 -3.6 -2.5 -3.9 -2.8 -3.2 -3.6 -2.2 -4.5 -2.5 -3.8 -1.4 -3.5 -4.4 -3.0 -3.6 -2.9 -4.1 -2.0 -2.3 -4.8 -4.3 -4.4
Hand grip strength (right) 1.2 3.3 10.5 0.9 2.5 1.1 -3.2 0.3 0.1 -0.1 1.6 0.7 2.1 2.3 2.0 1.6 1.4 1.1 0.9 3.0 2.8 2.2 1.4 1.5 2.3 2.6 1.9 0.6 1.0 0.6 2.4 2.0
Townsend deprivation index at recruitment 2.8 3.9 10.2 -2.4 -2.8 -1.2 2.2 -2.3 -1.0 -1.2 -1.5 -1.0 -2.3 -2.0 -2.2 -2.5 -1.6 -2.5 -1.8 -2.0 -2.4 -3.0 -0.2 -1.6 -0.5 -1.1 -2.3 -1.6 -1.0 -1.3 -2.5 -3.2
Current tobacco smoking 0.2 0.3 1.3 0.5 -0.7 0.4 -0.4 -0.2 0.4 -0.1 -0.6 -0.0 -0.5 1.2 -0.3 -0.8 -0.4 -0.9 -0.3 0.6 1.1 -0.7 -0.4 0.8 0.1 0.4 -0.0 0.6 0.3 -0.0 -0.0 -1.1
Average weekly fortified wine intake 1.6 1.9 4.2 0.6 1.4 0.5 -1.2 0.5 1.2 1.5 1.7 1.7 1.6 1.3 2.0 1.6 1.7 1.1 2.1 1.4 0.8 1.5 1.0 1.3 1.2 1.6 1.1 0.0 1.5 1.2 2.1 1.4
Maternal smoking around birth 0.4 0.6 2.8 1.7 0.0 1.6 -0.3 1.1 -0.3 0.0 0.4 -0.2 0.1 0.4 0.2 0.1 -0.4 1.6 0.2 0.1 -0.4 -0.3 1.6 0.0 0.8 -0.3 1.3 1.0 -0.9 0.4 1.0 0.5
Fed-up feelings 0.3 0.6 3.9 -1.1 0.1 -0.3 0.3 -2.0 -0.9 -0.4 -0.7 -1.2 -0.6 0.2 -0.9 -0.7 -0.1 -1.3 -0.7 0.3 -0.2 -0.2 0.1 -0.7 -0.6 -0.1 -0.8 -0.2 -0.2 -1.0 -1.5 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 4.0 0.3 2.0 -0.9 -1.3 -1.3 0.5 0.1 0.8 1.3 0.5 0.8 1.1 1.1 1.7 -0.5 1.0 1.3 0.2 0.5 -0.2 0.3 -0.0 0.8 0.1 -0.0 0.5 -0.2 -0.1 0.8
Relative age voice broke 1.1 1.6 5.1 -1.0 -0.0 -0.9 0.1 -1.4 -1.6 -0.7 -0.0 -1.2 -1.1 -0.8 -1.6 -1.5 -0.7 -1.6 -1.5 -0.5 -2.0 -0.8 -0.1 -2.3 -1.2 -0.9 -1.8 -1.5 -1.8 -1.2 -1.5 -1.5
Taking other prescription medications 0.6 0.9 3.9 1.8 1.0 0.9 -1.3 0.9 0.4 0.6 0.3 0.8 -0.1 0.9 1.0 0.4 -0.0 0.3 0.6 1.0 1.6 0.5 0.5 1.2 2.0 0.0 1.3 0.2 -0.1 1.1 1.2 1.3
Age when periods started (menarche) 1.1 2.7 7.6 0.6 1.4 0.8 -1.3 2.8 0.8 1.3 2.3 1.4 1.8 1.6 1.8 2.1 1.5 2.2 1.4 1.6 0.2 2.3 0.4 1.2 2.3 1.6 1.4 1.2 0.6 0.9 2.7 2.5
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 2.6 0.3 0.9 -0.6 -0.5 -0.4 0.2 -0.0 -0.8 0.4 -0.7 0.8 0.2 -0.4 -0.6 -1.0 -0.1 0.4 0.9 0.3 -1.6 0.7 0.5 -0.6 0.0 0.5 -0.4 -0.2 0.2 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.3 24.0 -2.0 0.2 2.5 -0.9 -0.5 -1.5 -3.0 0.4 -1.3 1.0 1.0 0.3 0.9 0.4 0.6 -1.4 -0.8 0.0 0.3 3.3 -3.0 -0.9 -0.3 -4.9 -4.2 -0.9 -1.2 0.9 0.4
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 1.8 1.1 -0.1 0.2 0.6 -0.1 1.1 0.3 0.2 0.6 -0.0 0.1 0.3 0.0 -0.4 0.3 1.0 -0.5 0.7 -0.1 -0.1 1.2 1.3 0.1 -0.4 -0.4 0.7 0.7 0.9 0.2
Qualifications: CSEs or equivalent 0.3 0.3 1.7 -0.1 0.3 -0.9 -0.1 0.7 -0.6 0.2 0.5 0.7 -0.5 -0.5 0.2 0.1 0.6 -0.0 -0.1 0.0 -1.2 -0.3 0.1 -1.2 -0.7 0.1 -0.2 -0.5 -0.8 -1.3 0.1 0.1
Serious illness, injury or assault to yourself 3.2 3.9 10.3 1.9 2.3 -0.1 -2.5 0.9 2.0 2.6 1.8 1.2 0.9 2.0 1.9 1.7 2.0 1.2 2.8 2.1 1.7 3.2 -1.2 2.1 1.9 2.4 1.7 1.5 2.4 2.4 1.9 1.9
High blood pressure 0.4 1.1 3.7 0.7 0.7 1.3 -1.5 -0.7 1.3 1.8 1.0 1.1 -0.3 1.8 0.9 -0.4 0.2 -0.5 1.5 1.7 0.6 0.4 0.4 1.4 0.9 0.2 0.9 1.9 1.1 0.5 -0.2 -0.4
Hayfever, allergic rhinitis or eczema 1.0 2.2 4.5 -1.4 -2.0 -0.6 1.6 -0.5 -1.4 -1.3 -1.1 -1.4 -0.9 -1.1 -1.9 -1.8 -2.1 -0.6 -1.9 -1.8 -0.0 -2.0 0.1 -2.0 -0.9 -2.0 -1.5 -2.0 -2.1 -1.2 -1.2 -1.6
Multivitamins +/- minerals 1.0 1.2 4.6 -0.6 -1.4 -0.7 1.2 -0.1 -0.4 -1.0 -0.4 -0.4 -0.3 -0.6 -1.3 -1.5 -1.9 -0.4 -0.9 -1.7 0.5 -0.0 -0.7 -0.9 -1.0 -1.2 -1.4 -2.1 -1.8 -1.0 -0.9 -1.5
Stomach or abdominal pain in last month 1.2 1.4 3.4 -0.4 -0.8 -1.1 0.8 0.3 -1.4 -0.2 0.0 -1.1 -1.8 -1.1 -1.3 -1.2 -0.5 -1.3 -0.8 -1.1 -1.8 -1.7 -1.7 -1.7 -0.1 -0.9 -1.6 -1.7 -0.6 -1.5 -1.2 -1.4
Supplements: Glucosamine 0.9 1.1 5.3 -0.0 0.3 -0.5 -0.7 0.6 0.8 1.3 1.1 0.5 1.4 0.9 1.4 1.4 1.3 1.3 1.3 0.4 0.2 2.3 -0.0 0.8 0.4 1.5 1.2 0.9 0.9 1.1 1.4 1.1
Diverticular disease/diverticulitis (self-reported) 2.8 3.3 9.7 -3.0 -2.0 -1.1 1.9 -0.5 -1.4 0.3 -0.8 -1.9 -1.9 -2.0 -2.1 -2.0 -0.6 -2.3 -1.4 -1.6 -1.9 -1.8 -0.9 -2.0 -2.0 -1.1 -2.2 -1.1 -0.0 -2.2 -3.1 -2.6
Medication: Atenolol 0.3 0.4 2.0 -0.1 -0.7 -0.2 -0.1 -0.8 -0.3 -1.0 -0.6 0.3 -0.3 -0.4 -0.2 -0.4 0.1 -1.4 -0.5 -0.4 -0.5 -0.4 -1.1 -0.8 -0.5 -0.1 -0.1 -0.3 0.2 -0.8 -1.0 -0.8
Medication: Levothyroxine sodium 0.2 0.3 1.4 -0.1 -0.1 -0.7 0.0 -0.1 -0.7 1.2 0.0 -1.0 -1.1 -0.4 -0.2 -0.3 0.3 -0.3 -0.1 -0.2 -0.8 0.1 -0.7 -1.1 0.3 0.2 0.2 -0.4 0.5 -0.6 -0.3 -0.4
Sitting height 1.6 11.5 31.8 -1.7 -1.4 -1.6 0.8 -2.9 -5.6 -2.9 -4.6 -5.1 -3.9 -2.0 -3.7 -4.0 -3.7 -3.4 -4.7 -2.5 -0.1 -1.9 -2.5 -3.8 -1.1 -3.3 -4.0 -4.7 -5.1 -3.8 -2.0 -2.8
Chronic bronchitis/emphysema (father) 0.7 0.9 3.0 0.3 1.0 1.7 -0.9 1.0 0.5 0.4 1.4 0.4 1.0 0.2 0.8 1.1 1.2 0.8 0.3 1.1 -0.3 1.7 1.3 0.5 0.5 1.2 1.1 0.7 0.8 0.8 -0.1 0.7
High blood pressure (mother) 0.4 0.6 3.1 -1.0 0.4 -0.6 -0.1 -1.4 -0.4 0.6 0.0 -0.5 -0.5 0.7 -0.5 -1.0 -0.5 -0.8 0.1 -0.1 -0.7 -0.7 1.8 -1.2 0.1 -0.2 -1.3 -0.8 0.1 0.6 -1.1 -1.2
Body mass index (BMI) 2.2 9.3 22.8 -3.8 -3.0 -4.3 3.1 -4.8 -1.8 -0.4 -2.2 -1.7 -2.5 -2.5 -2.6 -2.5 -0.9 -4.6 -2.0 -3.2 -1.5 -3.3 -2.4 -3.1 -3.8 -2.0 -4.0 -1.6 -1.0 -4.4 -4.3 -4.2
Impedance of leg (left) 0.3 1.7 9.5 1.5 0.5 2.0 -0.5 3.1 1.0 0.6 -0.3 0.5 0.1 1.3 0.4 0.4 -0.4 2.7 0.8 0.6 0.6 1.1 -0.9 1.9 1.2 0.0 1.2 0.6 0.5 2.3 1.6 1.6
Leg predicted mass (left) 2.4 12.4 28.4 -3.3 -2.4 -3.7 2.2 -4.6 -4.4 -2.3 -3.3 -3.7 -3.5 -3.2 -3.4 -3.6 -2.5 -4.8 -3.9 -3.0 -1.4 -2.8 -2.7 -4.6 -2.5 -2.7 -3.8 -3.2 -3.9 -5.3 -4.1 -4.1
Trunk fat mass 3.8 16.2 30.9 -4.4 -3.7 -4.5 3.8 -4.3 -3.5 -1.4 -4.3 -3.4 -4.6 -3.2 -4.0 -4.4 -3.0 -5.2 -3.4 -4.3 -1.6 -4.0 -4.6 -3.9 -3.8 -3.5 -4.8 -2.8 -3.2 -5.6 -5.0 -5.0
Waist circumference 3.3 11.9 25.4 -4.0 -3.2 -4.7 3.4 -4.4 -2.5 -0.3 -3.2 -2.4 -3.6 -2.8 -3.2 -3.5 -1.8 -5.0 -2.5 -3.6 -1.7 -3.3 -3.8 -3.6 -3.6 -2.7 -4.2 -1.9 -1.9 -4.8 -4.5 -4.7
Number of incorrect matches in round 2.1 3.5 7.5 1.6 2.4 0.6 -1.2 0.3 2.6 0.4 1.7 2.5 2.7 1.9 2.1 2.5 2.4 1.4 2.0 2.2 0.1 2.1 0.0 2.2 -0.4 2.6 2.2 2.1 1.8 1.7 1.4 1.6
Past tobacco smoking 3.5 6.5 18.3 0.7 2.6 1.2 -2.9 1.2 1.9 0.6 2.1 2.4 2.7 2.0 3.2 3.4 2.8 2.1 2.6 2.8 4.3 2.0 2.1 2.4 3.0 3.1 2.7 1.5 2.5 1.6 3.2 3.9
Alcohol usually taken with meals 1.8 3.0 8.5 0.4 2.4 -0.2 -1.5 0.0 1.6 2.1 2.0 1.5 2.2 1.8 2.3 2.4 2.9 -0.0 2.2 1.8 2.1 2.2 -0.6 1.6 -0.3 2.4 0.8 0.5 2.0 1.2 1.3 2.0
Nervous feelings 2.1 3.8 8.4 -1.6 -2.0 -0.3 1.3 -1.3 -2.2 -0.7 -1.8 -2.5 -2.5 -2.4 -2.8 -2.6 -1.9 -2.6 -2.3 -1.9 -0.9 -2.0 -0.7 -2.1 -1.1 -1.6 -2.9 -2.6 -1.5 -1.2 -1.8 -2.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 4.2 -0.5 0.6 0.5 0.1 0.2 1.3 0.8 0.4 1.2 0.2 0.3 0.1 0.2 0.4 -0.1 1.1 0.5 -0.5 -0.0 2.0 0.4 -0.3 0.2 0.1 0.7 0.9 1.0 -0.5 -0.0
Hearing difficulty/problems with background noise 0.6 0.9 3.6 -1.6 0.9 -0.4 -0.2 -1.5 -0.6 1.3 0.5 -0.8 0.7 -0.2 0.0 0.4 1.4 -1.3 0.2 -0.2 -1.2 -0.1 -0.9 -1.3 -1.6 0.2 -1.5 -0.1 0.9 -0.6 -1.9 -0.5
Hair/balding pattern: Pattern 2 0.5 0.6 5.0 1.0 1.0 1.2 -0.9 1.1 0.3 0.9 0.1 -0.0 -0.8 0.0 -0.0 -0.7 -0.6 0.2 0.6 1.0 0.2 1.1 -0.5 0.6 2.2 0.7 0.9 0.0 0.1 0.7 0.4 0.1
Had menopause 0.8 1.0 6.2 -0.6 -0.8 -0.5 0.8 0.1 -1.0 0.5 -1.5 -1.6 -1.8 -0.3 -1.1 -1.5 -0.9 -1.3 -0.8 -0.9 -0.2 -0.3 -2.5 -0.6 -0.1 -0.9 -0.9 0.4 -0.0 -0.9 -0.5 -0.9
Had other major operations 1.4 1.7 6.4 -0.4 0.2 -0.9 0.3 -1.6 -2.5 -0.4 -0.6 -1.9 -0.9 -0.1 -1.1 -1.1 -0.9 -1.7 -1.5 -0.1 -0.9 -1.2 -2.4 -2.0 -0.6 -1.0 -1.3 -0.9 -1.7 -2.1 -1.1 -1.0
Forced vital capacity (FVC) 0.4 1.7 8.0 -1.2 -0.2 -1.2 0.4 -1.6 -2.8 -1.6 -1.5 -1.8 -0.1 -1.2 -1.2 -0.4 -0.3 -0.8 -2.0 -0.2 -0.5 -0.5 -1.1 -1.9 -0.4 -0.2 -0.4 -2.2 -1.9 -2.3 -0.5 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.4 37.9 -2.8 -1.1 1.4 0.2 -1.1 -1.6 -3.2 -0.5 -1.6 0.7 0.2 -0.5 0.5 -0.0 -0.0 -2.0 -2.0 -0.3 -0.6 2.4 -3.2 -2.3 -0.8 -6.2 -4.8 -1.0 -2.2 0.2 -0.3
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 5.6 0.1 1.8 0.4 -1.4 0.3 0.8 0.8 2.4 0.9 1.6 1.4 1.2 1.8 1.7 1.9 1.1 1.8 0.5 1.7 1.4 0.7 0.8 1.9 0.9 0.3 1.2 0.6 0.8 1.4
Qualifications: None of the above 0.5 1.1 3.6 -1.1 -0.7 -1.5 0.8 -1.9 -0.5 -1.8 -0.9 -0.2 -1.0 -1.0 -0.7 -0.8 -0.7 -1.3 -0.9 -0.9 0.1 -1.2 -0.5 -0.7 -1.0 -1.1 -1.1 -0.5 -1.2 -1.8 -0.4 -0.9
Financial difficulties in last 2 years 0.5 0.7 2.4 -0.8 -1.4 -0.8 1.4 -0.4 0.4 0.2 -0.8 0.4 -0.5 -1.1 -0.6 -0.6 -0.9 -0.2 0.1 -1.6 1.4 0.2 -1.0 0.2 -0.9 -0.9 -1.0 -1.0 -0.2 -0.6 -0.9 -1.1
Mouth/teeth dental problems 0.2 0.3 1.8 -1.1 -0.5 -0.2 1.0 0.1 0.1 0.1 -0.5 -0.1 -0.3 0.1 -0.4 -0.5 -0.7 0.1 0.2 -0.9 1.1 0.2 -0.2 0.2 -0.3 -0.4 -1.4 -0.3 -0.1 0.3 -0.2 -0.1
Heart attack 0.3 0.3 1.3 -0.5 -0.7 0.1 1.0 0.5 -0.8 -0.7 -0.4 -0.4 -1.1 -0.6 -0.4 -0.3 -0.6 0.1 -0.5 -0.7 0.3 -0.8 0.3 -0.5 0.8 -0.3 -0.1 -0.8 -1.0 -0.4 0.3 0.1
Allergy 1.1 2.5 5.7 1.4 1.4 1.6 -1.4 0.3 1.4 0.7 1.2 1.2 1.5 0.8 1.9 2.1 2.4 1.0 1.7 2.0 -0.2 1.9 0.6 1.5 0.9 2.4 2.3 2.4 2.0 1.1 1.2 1.8
Pain all over the body in last month 0.5 0.5 2.1 0.0 0.3 1.2 0.0 -0.8 -0.0 -1.0 0.9 0.0 1.1 -0.3 0.5 1.4 1.4 0.4 0.0 0.5 -0.9 -0.1 0.1 -0.5 -0.3 0.5 1.1 1.3 0.5 -0.8 -0.3 0.7
Diabetes (self-reported) 1.0 1.6 3.2 -1.7 -1.3 -0.3 1.2 -1.6 -1.7 -1.3 -0.4 -1.8 -0.9 -1.5 -1.2 -1.0 -0.4 -1.3 -1.3 -1.5 0.1 -1.3 -0.8 -1.5 -1.3 -0.7 -1.7 -1.0 -1.4 -1.7 -1.0 -1.3
Hayfever/allergic rhinitis (self-reported) 0.3 0.3 1.6 0.7 -0.7 -0.3 -0.0 0.4 -0.5 -0.7 -0.6 -0.4 0.0 -0.7 -0.4 -0.2 -0.8 -0.0 -0.8 -0.6 1.2 -0.5 -0.0 -0.3 0.4 -0.7 0.3 -0.0 -0.7 0.3 1.3 0.2
Medication: Ramipril 0.3 0.4 2.6 0.1 1.2 0.8 -0.7 0.2 0.3 1.2 0.7 0.8 -0.2 0.3 0.5 0.1 0.2 0.6 0.6 0.8 0.5 1.6 -0.7 0.4 -0.4 0.1 0.4 1.0 0.5 -0.4 -0.4 0.1
Medication: Simvastatin 0.3 0.4 2.4 1.3 -0.4 0.6 -0.8 0.3 0.5 -0.2 -0.8 0.3 -0.1 0.3 0.1 -0.4 -0.5 0.1 0.2 0.5 1.6 -0.5 -0.7 1.1 0.8 -0.0 0.6 0.6 -0.1 0.6 1.0 0.2
Fluid intelligence score 2.7 5.5 10.5 -1.4 -2.7 -0.8 2.3 -1.5 -3.0 -1.0 -3.1 -3.2 -3.2 -2.9 -3.0 -3.1 -2.9 -2.7 -3.0 -2.4 -1.2 -1.8 -1.1 -2.1 -0.5 -2.7 -1.6 -0.9 -2.1 -2.1 -2.9 -2.6
Illnesses of siblings 0.3 0.5 3.2 0.2 -0.5 -1.1 0.8 0.7 -0.1 -1.0 -0.3 0.5 0.7 -1.1 -0.2 0.6 0.1 0.8 -0.4 -0.5 -1.8 -0.8 0.6 -0.4 -0.3 0.3 -0.1 -1.2 -0.5 0.6 0.1 -0.1
Neuroticism score 0.9 1.8 3.9 -1.9 -0.9 -0.5 0.8 -1.5 -1.4 -0.7 -1.0 -1.7 -1.7 -1.3 -2.0 -1.7 -0.8 -1.8 -1.4 -0.9 -0.7 -0.9 0.9 -1.6 -1.1 -0.7 -1.7 -1.4 -0.6 -1.2 -1.9 -1.7
Weight 3.8 18.8 37.7 -4.4 -3.6 -4.7 3.5 -5.5 -4.4 -1.6 -4.3 -4.3 -4.7 -3.4 -4.4 -4.7 -3.1 -6.0 -4.1 -4.2 -1.9 -3.9 -4.5 -4.8 -3.9 -3.7 -5.2 -2.9 -3.6 -6.1 -5.5 -5.5
Impedance of arm (right) 0.2 1.1 10.5 1.4 1.0 1.8 -0.8 3.2 -0.4 0.2 -0.7 -0.5 -0.9 0.1 -0.2 -0.8 -1.3 0.8 -0.1 0.4 -0.5 0.1 -1.6 0.7 1.2 -1.1 0.9 0.3 -1.1 0.8 0.6 0.8
Arm fat percentage (right) 2.5 10.0 21.6 -3.7 -2.7 -3.8 3.0 -3.7 -2.4 -0.6 -2.6 -2.4 -3.2 -2.5 -3.0 -3.2 -1.7 -4.7 -2.3 -3.4 -1.8 -3.6 -3.0 -3.3 -3.8 -2.6 -4.0 -1.7 -2.0 -4.6 -4.2 -4.4
Trunk fat-free mass 1.7 9.9 21.1 -2.6 -2.2 -2.5 1.6 -4.1 -4.6 -2.2 -3.0 -4.1 -3.3 -2.2 -3.3 -3.5 -2.8 -3.8 -4.0 -2.4 -1.0 -2.1 -1.9 -4.3 -1.5 -2.6 -3.2 -2.9 -4.0 -4.3 -3.4 -3.5
Hip circumference 3.4 14.6 32.1 -4.1 -3.0 -5.3 3.2 -5.0 -3.8 -1.6 -3.4 -3.1 -3.6 -3.2 -3.6 -3.5 -2.0 -4.7 -3.5 -3.8 -2.3 -3.3 -4.7 -4.7 -3.9 -3.0 -4.5 -3.1 -3.0 -5.7 -4.3 -4.5
Time employed in main current job 0.6 0.7 2.9 0.1 0.5 0.8 -1.6 -0.2 -1.4 -1.1 0.0 -1.6 0.2 0.5 -0.7 -0.9 -1.0 -0.4 -1.2 0.9 -0.5 0.3 0.7 -1.0 -0.3 -0.7 0.3 0.6 -1.7 -0.3 0.4 -0.3
Alcohol intake versus 10 years previously 1.3 2.0 4.2 -1.7 -0.6 -0.6 0.7 -1.3 -1.7 -0.7 -1.3 -2.1 -1.6 -0.9 -1.6 -1.9 -1.6 -1.7 -1.4 -0.8 -1.0 -1.8 -0.1 -1.4 -0.9 -1.8 -1.6 -1.0 -2.0 -1.2 -1.4 -1.8
Father’s age at death 1.2 1.7 5.2 -0.5 -1.6 0.0 1.6 1.1 -0.7 -0.9 -1.6 -1.5 -1.7 -1.9 -1.9 -1.9 -2.3 0.7 -1.1 -1.8 0.0 -0.8 -0.0 -1.1 -0.5 -1.2 -1.5 -2.0 -0.8 0.4 -0.5 -1.0
Worrier / anxious feelings 0.6 1.1 4.5 -0.9 -0.2 -0.2 -0.2 -0.6 -1.3 -1.3 -0.7 -1.0 -0.9 -0.5 -1.5 -1.4 -0.9 -1.0 -1.4 -0.2 -0.6 -0.9 2.1 -1.4 -1.4 -1.2 -0.8 -0.9 -0.9 -1.0 -1.4 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 3.5 1.2 1.9 0.3 -1.5 -0.4 0.5 0.9 1.2 1.1 0.5 1.1 1.0 1.0 1.2 0.6 0.9 1.4 0.6 1.1 1.1 0.6 1.4 0.9 1.6 0.3 0.7 0.8 -0.3 1.0
Falls in the last year 0.2 0.3 3.3 0.0 -0.1 0.1 -0.6 0.9 -0.1 0.2 -0.2 -0.6 -0.4 0.4 0.1 -0.4 -0.3 -0.1 0.2 -0.0 -0.6 0.2 -1.8 -0.3 0.2 -0.2 -0.2 -0.2 -0.7 -0.6 0.0 -0.3
Hair/balding pattern: Pattern 3 0.3 0.5 2.2 -0.6 0.2 -0.5 0.3 -1.0 0.2 1.2 0.8 0.4 0.7 -0.0 0.8 1.1 1.5 0.3 0.1 -0.2 0.1 0.8 0.2 -0.3 -0.8 0.9 0.2 0.6 1.1 0.4 -0.9 0.3
Number of live births 0.4 0.6 4.4 0.2 -0.9 -0.1 2.1 0.0 0.3 -0.1 -1.1 -0.3 -0.5 -0.2 -0.6 -0.8 -1.4 -1.0 -0.2 -1.1 -1.0 -1.1 -0.7 0.1 -0.1 -0.8 -0.6 0.1 -1.1 0.0 -0.4 -1.0
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 6.2 -1.2 0.5 -1.1 -0.3 -1.8 -2.5 -1.1 -0.8 -1.6 0.6 -0.4 -0.8 -0.0 0.1 -0.9 -1.4 0.3 0.1 0.2 -1.2 -1.6 -1.1 -0.2 -0.3 -1.4 -1.4 -2.3 -0.7 -0.3
Pulse rate 1.7 2.9 6.6 0.8 1.6 1.1 -0.7 0.6 0.9 1.4 1.8 1.7 1.2 0.0 2.4 2.4 2.4 1.5 2.2 1.5 2.6 0.8 1.4 1.2 2.3 2.5 2.4 1.1 1.7 0.6 2.2 2.0
Happiness 1.8 2.1 7.5 0.2 2.5 1.3 -2.3 1.2 0.1 1.9 2.0 -0.1 1.2 2.7 1.1 0.6 1.4 -0.4 1.3 2.6 1.2 2.5 0.6 0.4 0.6 1.2 0.7 1.4 2.0 0.9 -0.5 1.1
Noisy workplace 1.1 1.3 4.2 0.3 0.5 -1.0 -0.9 -0.7 2.0 0.4 1.0 2.0 1.7 1.0 1.4 1.7 1.7 0.7 1.9 1.2 0.6 0.9 -0.3 1.2 -0.0 1.2 0.9 0.7 1.5 0.6 0.3 0.7
Qualifications: A levels/AS levels or equivalent 0.3 0.6 2.3 0.2 1.1 1.5 -1.5 0.6 -0.8 0.9 0.8 -1.0 0.2 0.5 0.1 -0.4 0.3 -1.1 0.1 1.1 -0.4 1.5 0.3 -0.8 0.4 0.6 0.4 -0.1 0.5 0.0 -0.9 0.0
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.1 4.8 1.4 1.3 -0.4 -1.2 1.7 1.3 1.7 1.3 1.9 1.8 0.7 1.4 1.8 1.5 1.1 1.6 1.5 1.5 1.1 0.8 1.3 0.2 1.6 2.1 2.2 1.7 0.7 1.9 1.7
Mouth/teeth dental problems: Dentures 0.4 0.6 3.2 -0.4 -1.0 0.0 0.5 -1.1 -0.7 -1.5 -0.8 -0.2 -0.6 -1.4 -0.4 -0.5 -0.6 -0.1 -1.0 -0.2 -1.8 -1.1 -0.5 -1.1 -0.1 -0.3 0.6 0.2 -0.7 -1.1 -0.3 -0.5
Asthma 0.9 1.9 6.9 -0.8 -1.1 -1.5 1.1 0.2 -0.5 0.6 -1.1 -0.9 -2.0 -0.7 -1.7 -2.2 -2.0 -1.7 -1.0 -1.6 0.1 -1.9 -1.1 -0.4 -0.7 -1.7 -2.6 -1.5 -0.8 -0.5 -1.3 -1.9
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 2.4 0.1 -0.1 0.0 -0.3 0.2 0.5 1.0 1.5 0.9 0.9 0.4 0.4 0.6 0.9 -0.0 0.9 0.6 0.9 0.6 -0.2 0.3 0.0 1.2 0.7 1.2 0.8 0.6 0.5 0.6
Medication: Cholesterol lowering 0.6 0.9 3.5 0.4 -0.7 0.8 0.2 -0.1 -1.9 -0.5 -0.7 -1.5 -1.3 -0.6 -1.2 -1.8 -1.1 -1.2 -1.0 -0.4 -0.6 -0.7 -0.4 -1.3 -0.4 -0.7 -0.8 -0.9 -1.1 -0.7 -1.1 -0.9
Depression (self-reported) 0.3 0.3 2.1 -0.5 -0.2 -0.2 0.3 -0.4 -0.2 -0.2 -0.6 -0.0 -1.1 0.3 -0.2 0.2 0.6 0.3 -0.3 -0.1 1.1 -0.1 -0.2 0.2 0.3 1.3 -0.7 -1.5 0.1 -0.5 -0.2 0.4
Medication: Lansoprazole 0.6 0.6 2.3 0.8 0.6 0.5 -0.7 0.2 0.6 1.5 0.4 0.5 0.1 1.0 0.8 0.6 1.1 -0.1 0.8 0.6 0.9 0.8 -0.5 1.1 1.5 1.3 0.6 0.5 0.9 0.9 0.1 0.5
Prospective memory result 0.7 0.8 3.1 0.0 0.4 0.4 -0.3 -1.3 0.8 -1.6 -0.8 0.5 -0.8 1.3 -0.6 -1.3 -1.7 -0.6 -0.3 0.6 0.5 -0.8 1.8 -0.0 0.1 -1.5 -0.4 -0.4 -1.2 0.5 -1.0 -1.1
Lung cancer (father) 0.5 0.6 2.8 0.4 -1.0 -0.1 0.8 0.7 -0.6 -0.3 -1.1 -1.7 -1.3 -0.3 -1.2 -1.3 -1.3 -0.0 -0.5 -0.5 0.5 0.1 -1.1 0.3 0.6 -0.4 0.2 1.3 -0.6 0.4 0.2 -0.4
Illnesses of mother 0.4 0.6 2.4 0.6 0.2 0.1 -0.2 1.5 0.6 1.1 0.8 0.0 0.4 0.3 0.6 1.1 0.8 1.5 0.5 0.2 0.2 0.9 -1.3 0.6 0.8 0.7 0.7 -0.0 0.5 0.1 0.7 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 7.4 -1.8 0.4 -1.5 -0.2 -1.9 -2.7 -1.2 -0.7 -1.7 0.5 -0.4 -0.9 -0.0 0.3 -0.7 -1.6 -0.0 -0.3 0.1 -0.5 -2.2 -1.6 -0.2 -0.6 -1.7 -1.6 -2.3 -0.8 -0.2
Pulse wave Arterial Stiffness index 2.3 2.7 8.7 -1.2 -1.8 -0.7 1.8 -3.0 -0.5 -0.3 -2.1 -2.3 -2.1 -1.4 -1.7 -1.8 -1.2 -2.6 -1.1 -2.2 0.8 -1.5 -1.0 -0.5 -1.4 -0.9 -2.1 -1.1 0.5 -1.3 -2.2 -2.3
Impedance of arm (left) 0.2 0.9 10.4 0.9 1.0 1.3 -0.7 3.2 0.1 0.5 -0.4 -0.2 -0.6 0.0 0.2 -0.4 -0.6 1.0 0.4 0.3 -0.6 0.4 -2.1 0.9 0.8 -0.4 1.1 0.2 -0.6 1.0 0.5 0.9
Arm fat mass (right) 3.3 13.6 29.9 -4.0 -3.2 -4.2 3.2 -4.8 -3.4 -0.9 -3.3 -3.3 -3.8 -2.9 -3.5 -3.7 -2.0 -5.5 -3.0 -3.6 -1.8 -3.7 -3.6 -4.0 -3.8 -2.8 -4.6 -2.2 -2.6 -5.5 -4.8 -4.9
Trunk predicted mass 1.8 10.0 21.5 -2.5 -2.2 -2.6 1.6 -4.1 -4.6 -2.2 -3.1 -4.1 -3.3 -2.3 -3.4 -3.5 -2.8 -3.8 -4.1 -2.4 -1.1 -2.1 -1.9 -4.4 -1.6 -2.6 -3.3 -2.9 -4.0 -4.3 -3.4 -3.5
Standing height 1.4 13.5 36.8 -1.7 -1.6 -1.2 1.0 -1.8 -6.1 -2.4 -4.7 -5.9 -5.0 -2.4 -4.2 -5.0 -4.6 -3.5 -4.9 -2.3 -1.5 -1.7 -4.6 -4.1 -0.3 -3.6 -2.8 -3.3 -5.7 -4.2 -3.1 -3.1
Length of working week for main job 0.5 0.6 3.9 -0.5 -0.6 -0.2 0.1 -0.6 -1.0 0.1 0.3 -1.4 -0.0 0.4 -0.8 -0.2 0.2 -0.0 -1.3 -0.4 -2.0 -1.1 1.3 -1.2 -0.5 0.4 -0.4 0.6 -0.3 -0.2 -0.2 -0.8
Exposure to tobacco smoke at home 0.5 0.6 2.1 -1.4 0.0 0.5 -0.2 -0.6 1.1 0.7 0.5 0.7 0.3 0.2 0.7 0.7 1.4 -0.5 0.8 0.6 -1.0 1.0 0.2 0.3 -0.4 1.2 0.1 1.2 1.3 0.1 -1.1 -0.3
Breastfed as a baby 0.2 0.3 1.7 -0.2 0.4 -0.1 0.0 1.0 -0.1 1.0 0.7 0.3 0.5 0.2 0.1 0.4 0.7 -0.5 0.1 0.3 -0.7 0.5 -1.3 -0.2 -0.4 0.4 0.6 1.0 0.3 -0.5 -0.6 0.0
Tense / ‘highly strung’ 3.1 5.2 12.9 -3.6 -2.7 -1.9 2.7 -2.0 -1.7 -0.6 -1.6 -1.8 -2.1 -2.9 -2.9 -2.1 -1.0 -1.7 -1.8 -2.9 -2.2 -2.3 1.0 -3.0 -3.1 -1.2 -3.2 -2.4 -0.4 -1.4 -2.8 -2.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 4.2 -1.1 -0.3 -1.0 -0.3 -0.0 -0.2 -0.5 0.1 -0.4 -0.5 -0.1 -1.2 -0.5 -0.3 0.1 -0.5 -0.2 -1.4 -0.8 0.5 -1.0 -1.5 -0.2 -1.7 -2.1 -0.4 -0.1 -1.4 -1.3
Hair/balding pattern: Pattern 4 0.4 0.9 3.5 -1.2 -1.3 -0.5 1.0 -0.7 -0.6 -1.9 -0.4 -0.8 0.2 -1.0 -0.7 0.1 0.1 -0.8 -0.7 -1.4 -1.0 -1.3 0.1 -0.8 -1.7 -0.8 -1.8 -1.2 -0.5 -0.9 0.1 -0.6
Birth weight of first child 2.4 4.3 11.0 1.7 0.9 2.6 -1.1 2.4 2.4 3.3 2.9 1.8 1.8 1.7 1.8 1.7 1.8 1.5 2.3 1.7 0.9 1.1 2.8 2.0 2.0 2.4 1.8 1.6 2.7 2.9 1.8 1.7
Peak expiratory flow (PEF) 0.3 0.7 4.7 -1.3 0.4 -1.4 -0.0 -1.3 -1.0 -0.6 -0.1 -0.6 0.4 0.2 -0.3 -0.0 0.4 -1.4 -0.4 0.4 0.1 0.0 -0.7 -0.7 -1.1 -0.0 -0.2 -0.6 -0.5 -2.2 -1.2 -0.6
Pulse wave reflection index 0.4 0.5 2.5 0.1 -0.8 0.3 0.3 -1.6 0.1 -0.2 -0.9 -1.4 -0.7 0.4 -0.7 -0.9 -0.6 -1.5 -0.4 -0.6 0.1 -0.0 -0.2 0.2 -0.3 0.0 -1.0 -0.8 0.7 -0.2 -0.5 -0.7
Ever highly irritable/argumentative for 2 days 1.6 1.9 5.0 -0.3 1.7 0.3 -1.7 0.4 1.3 1.5 2.2 1.3 1.8 1.7 1.4 1.5 1.9 0.9 1.8 1.8 -0.1 1.4 1.6 1.1 0.3 1.7 0.7 0.8 1.8 1.4 0.4 1.1
Loud music exposure frequency 0.9 1.0 4.7 -1.2 -1.4 -0.6 1.1 0.1 0.0 0.6 -0.5 0.0 -1.0 -0.4 -1.1 -1.5 -1.3 -0.6 -0.4 -1.1 -2.2 -0.9 -0.2 -0.4 -1.2 -1.3 -1.2 -0.4 -0.6 -0.4 -0.9 -1.7
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 1.4 -0.3 -0.2 0.8 -0.1 1.2 0.5 0.3 0.1 0.1 -0.1 0.4 0.4 0.0 0.5 -0.2 0.2 0.2 -0.7 -0.4 -0.2 0.1 0.6 0.8 -0.0 -1.1 0.5 0.4 -0.3 -0.2
Mouth/teeth dental problems: Bleeding gums 1.8 2.3 5.8 1.9 2.3 1.1 -2.3 0.1 0.2 2.0 2.1 0.8 1.6 1.7 1.6 1.6 2.0 -0.2 1.1 2.4 0.4 1.1 0.1 0.9 1.5 2.1 2.3 1.5 1.4 0.8 0.7 1.2
Blood clot in the leg (DVT) 0.9 1.2 4.8 -0.9 -0.3 -2.2 0.4 -0.6 -0.8 -0.8 -1.2 0.1 -1.7 -1.3 -0.6 -0.7 -0.6 -0.7 -0.7 -1.4 -1.3 0.2 -2.2 -1.0 -1.2 -1.2 -1.2 -0.9 -1.3 -1.3 -0.5 -0.7
Medication: Paracetamol 3.8 6.2 12.7 -2.4 -2.7 -2.9 2.5 -2.4 -2.8 -0.5 -1.9 -2.8 -3.2 -3.0 -3.6 -3.1 -2.4 -2.1 -2.8 -2.8 -1.0 -2.5 -1.0 -3.5 -2.1 -2.0 -2.6 -1.6 -1.8 -2.2 -2.3 -3.0
Headache pain in last month 1.3 2.2 6.3 -1.6 -0.3 -0.8 1.0 -2.1 -1.2 -0.2 -0.1 -1.5 -1.4 -1.4 -1.9 -1.4 -0.7 -1.6 -1.6 -1.1 -1.2 -1.3 1.0 -1.9 -1.9 -1.1 -2.5 -1.3 -0.9 -1.4 -2.5 -1.9
Medication for cholesterol, blood pressure or diabetes 0.3 0.4 3.1 -0.9 -0.1 -1.8 1.0 0.0 0.3 -1.3 -0.5 0.2 0.1 -0.6 -0.3 0.7 -0.2 0.8 -0.6 -0.9 -0.1 -0.4 -0.1 -0.2 -0.5 -0.5 -0.2 -0.4 -0.8 -0.4 0.7 0.3
Glaucoma (self-reported) 1.4 1.7 5.1 0.2 1.7 -0.0 -1.4 -0.1 0.7 0.4 1.4 1.1 2.3 0.8 1.6 1.9 1.6 2.1 1.7 1.3 1.3 1.4 0.6 0.9 0.5 1.0 1.2 0.7 1.1 1.0 2.1 1.7
Gout (self-reported) 0.3 0.4 2.5 -0.2 0.6 1.0 -0.1 -1.0 -0.3 0.6 0.4 -0.3 0.3 0.3 0.7 0.1 0.4 -1.6 0.4 0.6 0.6 -0.5 0.7 -0.5 0.6 0.1 -0.3 -0.5 0.2 -0.5 -1.0 -0.2
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.8 0.7 -0.3 0.2 0.2 1.1 -0.7 0.3 -0.3 -1.1 -1.0 -0.3 -0.3 -0.4 -0.3 0.3 -0.4 -0.2 -0.0 0.6 -1.3 -0.8 0.2 -0.6 0.6 0.4 -0.3 -0.7 -0.1 0.2
Medication: Amlodipine 0.4 0.6 2.3 -1.2 1.0 0.1 -1.1 -1.5 -0.3 0.1 0.3 -0.2 -0.1 1.2 -0.1 -0.6 0.6 -1.1 0.0 1.1 -0.9 -0.7 0.8 -0.8 -0.7 0.4 -0.2 0.0 -0.1 -0.5 -1.4 -0.7
Medication: Ventolin 100micrograms inhaler 1.0 1.2 4.7 1.6 0.9 0.6 -1.0 1.6 1.3 -0.1 0.8 0.7 1.2 0.7 1.3 0.9 0.5 0.4 1.5 1.0 1.4 -0.1 0.6 1.7 1.1 1.3 1.2 0.5 0.6 1.2 2.2 1.2
Birth weight 0.9 2.0 6.5 -2.5 -0.8 -0.5 1.3 -1.7 -1.8 -1.5 -0.5 -1.9 -1.9 -1.2 -1.3 -1.5 -0.9 -1.3 -1.6 -1.0 -0.6 -1.0 -0.1 -2.1 -0.7 -0.6 -1.1 -2.0 -1.2 -2.5 -0.9 -1.5
Chronic bronchitis/emphysema (mother) 0.8 0.9 3.5 0.9 0.7 0.7 -0.9 1.9 0.7 1.4 0.9 0.6 0.7 0.5 0.8 0.8 1.0 -0.3 0.8 1.2 0.3 1.1 -0.3 1.4 0.7 1.6 1.2 1.3 0.5 0.9 1.1 1.0
High blood pressure (siblings) 0.5 0.7 2.9 -0.6 0.7 1.7 -0.7 -0.7 0.6 1.5 0.9 0.1 -0.4 1.4 0.6 -0.2 0.4 -1.0 0.9 0.8 0.5 0.3 -0.3 0.6 0.3 -0.2 -0.2 1.7 1.0 -0.3 -0.7 -0.1
Forced vital capacity (FVC), Best measure 0.4 1.5 7.7 -1.2 -0.2 -1.2 0.3 -1.3 -2.8 -1.5 -1.4 -1.6 -0.1 -1.0 -1.2 -0.4 -0.3 -0.5 -1.8 -0.3 -0.4 -0.3 -0.7 -2.0 -0.6 -0.5 -0.6 -2.3 -1.9 -2.0 -0.2 -0.1
Body fat percentage 2.7 10.6 20.2 -3.8 -3.1 -4.0 3.4 -3.3 -2.2 -0.6 -3.3 -2.3 -3.6 -2.4 -3.1 -3.4 -2.1 -4.3 -2.4 -3.7 -1.4 -3.6 -4.0 -2.9 -3.7 -2.9 -4.1 -1.7 -2.1 -4.5 -4.2 -4.3
Leg fat percentage (right) 2.3 8.2 16.1 -3.4 -3.1 -3.6 3.4 -3.2 -1.5 0.1 -2.8 -1.7 -3.0 -1.7 -2.6 -2.8 -1.7 -3.7 -1.6 -3.4 -1.5 -3.3 -3.4 -2.5 -3.5 -2.6 -3.8 -1.0 -1.0 -3.6 -4.0 -3.9
Arm fat-free mass (right) 1.7 8.8 19.5 -2.7 -2.1 -3.2 1.8 -4.2 -3.9 -1.7 -3.0 -3.5 -3.1 -2.0 -2.9 -3.0 -2.1 -3.9 -3.4 -2.4 -0.9 -1.9 -2.9 -3.9 -2.0 -2.2 -3.3 -2.7 -3.2 -4.4 -3.2 -3.4
Exposure to tobacco smoke outside home 2.8 3.7 11.3 -2.1 -2.1 -1.9 1.5 -1.6 -1.0 -1.4 -1.4 -1.6 -2.3 -1.4 -2.3 -2.2 -1.3 -2.4 -1.5 -1.8 -2.2 -3.4 -1.4 -1.7 -2.6 -1.3 -1.9 -0.7 -1.0 -1.7 -2.5 -2.9
Comparative body size at age 10 0.9 2.4 10.0 -1.9 -1.4 -1.7 1.6 -2.3 -0.1 -0.8 -0.9 0.4 -0.2 -0.2 -0.5 -0.4 -0.3 -1.9 -0.7 -2.0 -1.5 -2.5 -1.4 -1.5 -3.2 -1.4 -1.7 0.1 -0.5 -2.8 -2.0 -1.9
Number of full brothers 2.6 3.2 7.6 -0.9 -1.6 -1.8 1.6 -1.2 -1.4 -1.2 -2.3 -1.7 -2.5 -1.1 -2.4 -2.2 -2.4 -1.5 -1.8 -2.2 0.1 -1.3 -1.5 -1.3 -1.9 -2.8 -2.5 -1.2 -1.8 -1.4 -1.7 -2.2
Worry too long after embarrassment 0.7 1.2 3.3 -0.1 1.0 1.1 -0.6 0.4 1.7 1.8 0.9 1.2 0.4 0.7 1.2 0.7 1.4 -0.8 1.4 1.3 1.2 0.9 0.7 1.4 0.9 1.8 1.0 1.4 1.8 0.7 -0.2 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 3.4 -0.7 -0.3 -0.1 -0.1 -0.0 -0.0 -0.8 -0.4 -1.3 -1.2 -0.3 -1.2 -1.0 -0.9 0.1 -0.3 -0.2 -0.7 -0.6 0.5 -0.4 -0.3 -0.7 -1.3 -1.9 -0.1 0.8 -1.1 -0.7
Wheeze or whistling in the chest in last year 1.0 1.7 5.8 -0.8 -1.1 -1.0 0.1 -0.4 -1.0 -1.6 -1.2 -0.7 -1.4 0.3 -1.4 -2.0 -2.1 -1.8 -1.5 -0.8 0.3 -1.0 -1.7 -0.7 -1.1 -2.4 -0.9 0.4 -2.1 -1.8 -1.2 -1.5
Number of children fathered 0.3 0.4 1.8 0.3 -0.2 0.6 0.7 1.3 0.2 -0.7 0.2 0.7 0.3 0.7 0.1 0.5 -0.4 0.9 -0.2 -0.0 -0.7 -0.6 0.5 -0.0 0.5 -0.9 0.3 1.1 -1.0 -0.2 -0.3 0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.9 6.6 1.2 2.5 1.3 -2.6 0.8 1.2 0.7 1.2 1.1 2.4 1.8 1.7 1.3 1.2 0.3 1.1 2.3 0.1 1.4 0.3 1.7 0.8 0.7 1.2 0.8 0.8 0.7 0.7 1.4
Age at first live birth 0.2 0.3 1.7 -0.2 -0.4 -0.0 0.6 0.4 -0.4 0.0 -0.5 -0.4 0.7 -0.5 -0.3 0.3 -0.0 1.3 -0.5 -0.7 0.4 0.8 0.9 -0.1 -0.4 0.1 -0.6 -0.7 0.1 0.2 0.6 0.3
Pulse wave peak to peak time 2.0 2.4 8.9 1.3 1.8 0.7 -1.8 3.0 0.2 0.3 1.8 1.9 1.8 1.4 1.5 1.5 0.9 2.5 0.9 2.1 -0.6 1.6 0.7 0.5 1.4 0.7 2.0 1.1 -0.8 1.3 2.1 2.2
Health satisfaction 2.8 3.6 11.8 1.7 2.2 1.2 -3.0 0.4 1.1 2.1 2.1 0.8 2.3 3.4 1.9 1.9 2.4 0.1 2.2 2.4 2.3 2.3 0.3 1.2 1.1 2.1 1.3 1.9 2.5 1.5 0.9 1.8
Shortness of breath walking on level ground 0.2 0.3 3.4 0.4 0.8 0.3 -0.6 0.4 -0.2 -0.1 0.6 0.3 0.2 0.0 0.6 0.4 0.2 -0.3 0.1 0.1 1.9 1.0 0.5 0.0 -0.0 -0.4 -0.0 0.2 0.2 0.1 0.3 0.3
Qualifications: College or University degree 0.3 0.9 5.1 1.3 1.3 0.8 -0.9 1.0 0.2 1.5 0.9 -0.9 1.0 0.9 0.2 0.4 -0.0 1.3 0.6 1.0 0.6 2.3 0.6 0.6 -0.0 -0.2 0.5 1.3 1.0 1.6 -0.2 0.7
Eye problems/disorders: None of the above 2.8 3.2 6.2 -1.2 -1.7 -1.0 1.5 -0.4 -2.0 -1.6 -2.0 -2.0 -2.2 -2.5 -2.3 -2.4 -2.3 -1.0 -2.4 -1.8 -0.2 -1.7 -0.9 -1.8 -0.7 -2.0 -1.9 -1.8 -1.8 -1.9 -2.2 -2.0
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.9 1.3 1.4 0.1 -1.3 -0.8 -0.0 0.8 -0.3 0.4 -0.3 1.4 0.5 -0.0 0.3 -0.5 0.4 1.1 -0.1 0.8 -0.7 0.2 0.7 0.6 0.1 -0.5 0.1 0.7 -0.0 -0.0
Emphysema/chronic bronchitis 0.3 0.4 1.6 0.3 -0.8 0.3 0.3 0.1 0.5 0.2 -0.4 0.4 -0.5 0.2 -0.2 -0.4 -0.6 -1.3 0.3 -0.1 1.2 -1.2 0.8 0.7 0.6 -0.5 -0.2 1.0 0.5 0.7 -0.6 -0.5
Medication for pain relief, constipation, heartburn 0.9 1.6 4.2 0.8 1.7 1.4 -1.4 0.9 1.3 -1.0 0.7 1.7 2.0 1.4 1.9 1.8 1.4 1.0 1.0 1.3 0.1 1.4 1.3 1.5 0.9 1.1 1.2 -0.7 0.4 0.7 1.0 1.3
Neck or shoulder pain in last month 0.6 0.8 3.2 1.8 0.8 1.0 -1.3 1.4 0.2 -0.2 1.0 0.7 0.5 1.0 0.5 0.3 -0.2 1.7 0.2 0.7 0.5 0.7 1.1 0.7 1.4 -0.3 0.6 -0.1 -0.3 0.8 1.3 1.1
Medication: Blood pressure 1.3 2.3 6.6 1.2 1.4 2.4 -2.1 0.3 1.1 2.6 1.5 0.9 1.1 2.1 1.6 0.5 1.3 0.5 2.0 2.1 1.3 1.7 1.1 1.6 0.9 1.5 1.1 1.8 2.2 1.8 0.1 0.8
Angina (self-reported) 0.2 0.2 1.0 0.8 0.6 0.4 -0.9 0.1 0.2 -0.2 0.1 0.1 -0.5 1.0 0.2 -0.7 -0.2 -0.7 0.1 0.4 0.7 -0.3 0.2 0.1 0.3 -0.4 0.0 -0.2 -0.1 0.7 -0.3 -0.3
Migraine (self-reported) 0.7 0.9 3.2 -0.1 -0.4 -0.2 0.6 -1.2 -0.4 -0.8 -1.0 -0.8 0.1 0.4 -0.7 -0.7 -1.6 -1.1 -0.7 -1.1 1.6 -1.2 0.6 0.0 -1.1 -1.6 -1.8 -0.1 -1.6 -0.4 -0.0 -0.6
Medication: Ibuprofen 0.4 0.5 2.2 0.5 -0.0 -0.1 -0.5 0.1 0.4 0.7 1.5 1.0 1.0 0.7 0.4 0.7 1.0 -0.1 0.8 0.7 0.5 0.1 -0.4 0.3 -0.1 1.1 0.6 0.9 0.7 0.7 0.8 0.8
Medication: Allopurinol 0.4 0.6 3.3 -0.8 0.0 0.3 -0.0 -1.3 -0.7 0.2 -0.1 -0.5 -0.5 -0.2 -0.1 -0.8 -0.2 -1.8 -0.2 -0.0 -0.4 -1.1 0.5 -1.3 0.1 -0.3 -0.8 -0.9 -0.3 -0.9 -1.8 -0.9
Medication: Omeprazole 2.2 2.6 9.0 1.0 2.2 -0.3 -1.7 -0.1 1.0 2.2 1.2 1.2 0.6 2.4 2.1 1.3 1.3 -0.1 2.2 2.0 3.0 2.2 -1.3 1.3 2.0 1.0 1.2 1.3 2.2 0.9 1.4 1.8
Medication: Seretide 50 evohaler 0.9 1.0 3.7 0.2 -0.8 -1.2 0.6 -1.2 -0.6 -1.2 -1.2 -0.9 -1.0 -0.9 -1.3 -1.0 -0.9 -1.9 -0.9 -0.9 -0.3 -1.1 -1.1 -0.7 -1.0 -0.7 -1.2 -1.6 -0.9 -0.5 0.0 -0.8
Mean time to correctly identify matches 0.3 0.6 2.5 -1.5 -0.3 -0.1 0.5 -1.6 0.9 -0.0 0.2 0.1 0.1 -0.1 -0.2 -0.1 0.3 -1.2 0.2 -0.6 -0.8 0.3 0.7 0.1 -1.6 -0.4 -1.4 -0.1 0.5 -0.0 -1.5 -1.2
Heart disease (mother) 1.4 1.7 4.7 -1.2 -0.7 -0.8 0.6 -1.6 -1.5 -1.4 -1.7 -0.8 -1.8 -1.3 -1.3 -1.8 -1.8 -0.7 -1.5 -1.0 0.0 -0.2 -0.2 -1.3 -0.9 -2.0 -0.7 -0.3 -1.6 -1.6 -2.2 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 2.0 0.8 0.7 1.4 -0.1 -0.6 0.3 -0.7 -0.3 -0.0 0.5 0.6 0.1 0.0 -0.8 0.4 -0.2 0.9 0.6 0.1 0.7 1.0 0.7 -0.6 1.4 0.9 -0.7 0.5 -0.8 -0.1
Whole body fat mass 3.6 15.0 29.9 -4.3 -3.6 -4.5 3.6 -4.1 -3.4 -1.2 -3.9 -3.4 -4.3 -3.1 -3.8 -4.1 -2.6 -5.0 -3.3 -4.2 -1.8 -3.8 -4.3 -3.9 -4.0 -3.2 -4.8 -2.6 -2.9 -5.5 -4.9 -4.9
Leg fat mass (right) 3.1 12.0 22.8 -3.9 -3.2 -4.1 3.3 -4.2 -2.8 -0.9 -3.4 -2.8 -3.6 -2.4 -3.3 -3.5 -2.1 -4.5 -2.7 -3.8 -1.6 -3.4 -3.8 -3.6 -3.9 -2.9 -4.6 -2.2 -2.2 -4.8 -4.7 -4.5
Arm predicted mass (right) 1.8 9.4 20.5 -2.9 -2.4 -3.5 2.0 -4.5 -3.9 -1.8 -3.1 -3.5 -3.0 -2.2 -3.1 -3.1 -2.1 -3.9 -3.5 -2.6 -0.9 -2.1 -2.9 -3.9 -2.2 -2.3 -3.4 -2.8 -3.2 -4.3 -3.3 -3.6
Pulse rate, automated reading 3.5 11.4 27.5 1.3 2.9 0.4 -2.2 1.8 3.3 3.5 3.4 3.8 4.3 2.2 4.5 5.0 5.2 1.8 4.6 3.0 4.1 1.9 1.6 2.9 1.3 5.0 3.9 3.0 4.6 2.4 3.8 3.5
Alcohol intake frequency. 0.3 0.7 2.3 -0.2 1.0 -0.0 -0.6 0.5 0.5 -0.4 1.1 0.9 1.4 1.3 1.3 1.5 0.8 1.1 0.6 0.9 -0.0 0.1 -0.0 0.3 0.6 0.2 0.9 1.2 0.1 0.3 1.0 1.0
Comparative height size at age 10 1.6 8.6 19.4 -1.0 -1.4 -0.6 1.4 -1.9 -3.6 -2.0 -4.2 -3.6 -4.0 -2.3 -3.1 -4.2 -4.2 -3.2 -3.4 -1.9 -0.9 -2.2 -4.4 -2.3 -0.6 -3.4 -2.3 -2.5 -4.1 -3.1 -3.0 -3.2
Number of full sisters 1.5 1.8 8.0 0.7 -2.1 -0.7 1.6 0.9 -0.2 -2.6 -1.5 0.1 -0.9 -0.5 -1.3 -1.0 -2.6 0.5 -1.4 -1.7 0.8 -1.7 0.2 0.1 0.2 -2.4 -0.4 -0.7 -2.8 0.1 1.0 -0.3
Suffer from ‘nerves’ 4.3 6.7 15.0 -2.4 -2.0 -1.9 1.6 -2.3 -3.0 -1.4 -3.1 -3.1 -3.9 -3.0 -3.4 -3.2 -2.4 -2.3 -3.0 -2.4 -1.4 -2.2 -1.8 -3.1 -2.3 -2.1 -3.0 -2.6 -2.1 -2.8 -2.4 -2.8
Overall health rating 1.2 2.6 7.3 2.4 2.5 1.3 -2.7 1.1 0.5 2.0 2.0 0.7 0.6 2.7 1.5 1.1 1.4 1.1 1.5 2.2 1.8 2.3 1.2 1.0 1.9 1.1 1.5 1.1 0.8 1.3 0.7 1.8
Chest pain or discomfort 0.9 1.3 3.2 1.5 1.4 1.2 -1.7 0.9 1.0 1.8 1.5 0.0 0.2 0.9 1.1 0.6 0.9 0.6 1.2 1.6 0.1 1.6 0.4 1.3 1.6 1.1 0.9 1.4 1.5 1.4 0.6 0.9
Had major operations 0.4 0.5 2.8 -0.6 0.5 -1.6 -0.0 -1.7 -0.4 -0.9 -0.7 0.8 0.6 0.5 -0.2 -0.3 -0.5 -0.5 -0.4 0.5 -0.2 -0.6 1.0 -0.8 -0.7 -0.4 -0.2 -1.0 -0.5 0.1 -0.6 -0.9
Age at last live birth 0.3 0.4 2.4 0.4 -0.2 1.1 0.6 1.3 -0.0 -0.1 -0.5 0.0 0.4 -0.2 -0.0 0.1 -0.7 0.7 -0.3 -0.2 1.1 0.2 1.6 0.4 0.8 -0.2 -0.2 -0.1 -0.3 0.7 1.3 0.6
Family relationship satisfaction 2.7 3.4 9.6 1.1 2.4 2.6 -2.3 1.9 1.2 2.8 2.1 0.0 0.6 2.6 1.8 0.9 1.4 0.2 2.1 2.2 1.3 3.1 -0.3 1.6 2.2 1.6 1.5 2.0 2.3 1.6 -0.0 1.7
Leg pain on walking 0.8 1.0 3.0 -1.3 -0.9 -1.1 0.8 -1.7 -0.7 -1.4 -0.1 -1.0 -0.2 -1.2 -1.3 -0.2 0.1 -0.4 -0.9 -0.8 -1.4 -0.8 0.4 -1.6 -1.6 -0.1 -0.8 -0.2 -0.4 -1.7 -0.3 -0.9
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 6.1 0.9 0.9 0.5 -1.4 2.5 1.6 1.3 0.9 1.3 0.7 1.9 1.4 0.8 0.9 1.1 1.5 1.2 1.9 0.5 -0.1 1.6 1.2 1.4 0.7 -0.4 0.7 1.1 1.8 1.4
Commuting to job workplace: Car/motor vehicle 0.3 0.4 2.1 -0.6 0.1 1.4 0.2 0.1 0.3 1.1 -0.2 -0.5 -0.6 -0.1 0.1 -0.5 0.1 -0.4 0.4 -0.5 -1.3 -1.0 0.1 -0.0 -1.1 0.2 -0.7 0.3 0.8 0.1 -0.7 -0.7
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 5.8 -0.3 -0.6 0.7 0.4 -0.1 -0.5 -0.7 -0.4 -0.3 0.1 -0.7 -0.1 -0.3 -0.1 -1.1 -0.8 -0.4 -1.6 -2.4 -0.9 -0.7 -0.5 -0.4 -0.2 0.0 -0.2 -0.9 -0.6 -0.5
Medication: Aspirin 0.4 0.6 1.5 -0.4 -1.2 0.7 0.2 -0.1 -0.3 0.3 -1.1 -1.2 -1.1 -1.0 -0.6 -1.0 -0.7 -1.1 -0.2 -0.6 0.5 -0.9 -1.2 0.1 -0.4 -0.8 -0.5 1.2 0.0 -0.2 -0.2 -0.6
Supplements: Vitamin C 1.9 2.2 4.5 -0.6 -1.1 -1.6 1.3 -2.1 -2.0 -0.9 -2.1 -1.6 -0.7 -1.1 -1.5 -1.4 -1.2 -1.8 -1.8 -1.4 -1.7 -1.5 0.0 -1.6 -1.6 -1.4 -1.8 -1.0 -1.1 -1.6 -1.7 -1.8
Knee pain experienced in last month 1.6 2.5 6.9 -2.4 -2.0 -2.1 2.4 -0.7 -0.6 0.2 -0.7 -0.3 -1.5 -1.1 -1.2 -0.8 0.2 -2.5 -0.7 -2.2 -2.1 -2.6 -0.6 -1.7 -1.9 -1.0 -2.0 -0.3 -0.6 -2.2 -1.7 -2.0
Hypertension (Self-reported) 0.5 1.3 5.1 1.1 0.9 1.4 -1.9 -0.6 1.1 1.8 0.9 0.8 -0.2 2.3 0.9 -0.4 0.1 -0.4 1.3 1.8 1.3 0.7 0.5 1.4 0.9 0.1 0.9 2.1 0.9 0.6 -0.1 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 2.6 0.9 0.9 0.3 -0.5 1.4 0.5 1.5 0.2 -0.0 0.2 1.4 0.9 0.3 0.4 0.6 1.0 0.9 0.7 1.6 -0.6 1.1 1.3 0.7 0.9 1.0 1.2 1.2 0.2 0.9
Illnesses of father: Heart disease 1.5 2.1 5.0 0.3 0.1 0.5 -0.6 1.1 2.2 1.3 1.5 2.2 1.9 0.7 2.0 1.8 1.7 0.8 2.2 1.3 0.8 0.8 -1.0 2.0 0.8 1.2 1.8 1.7 2.2 0.9 1.3 1.1
Illnesses of siblings: Diabetes 0.4 0.4 3.8 -0.4 -0.1 0.0 0.1 0.6 -0.4 -0.5 -0.5 -1.0 -0.4 0.1 -0.3 -0.3 -0.6 0.4 -0.5 -0.2 1.4 0.3 -1.9 0.2 0.3 0.1 0.1 -0.0 -0.6 -0.7 1.4 0.3
Smoking status: Previous 4.9 7.3 22.5 -1.4 -2.7 -1.8 3.4 -1.7 -2.2 -0.3 -2.3 -2.6 -2.8 -2.6 -3.3 -3.3 -2.7 -1.9 -2.6 -3.4 -4.7 -1.9 -1.4 -2.9 -3.3 -3.2 -3.2 -2.1 -2.4 -1.3 -3.2 -3.6
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 6.5 -1.9 0.5 -0.8 -0.5 -1.1 -2.3 -1.9 -1.4 -0.9 -0.6 0.1 -0.9 -0.9 -1.2 -1.7 -1.7 -0.1 -0.1 -1.0 0.1 -1.6 -0.0 -1.6 -1.3 -1.5 -2.5 -2.1 -1.2 -0.6
Whole body fat-free mass 1.9 11.0 23.7 -2.9 -2.2 -3.1 1.8 -4.6 -4.6 -2.2 -3.2 -4.0 -3.4 -2.6 -3.4 -3.5 -2.6 -4.3 -4.0 -2.6 -1.1 -2.4 -2.3 -4.5 -2.0 -2.6 -3.5 -3.0 -3.9 -4.9 -3.7 -3.8
Leg fat-free mass (right) 2.3 12.2 28.8 -3.3 -2.3 -3.7 2.0 -4.7 -4.5 -2.4 -3.2 -3.7 -3.4 -3.2 -3.4 -3.5 -2.4 -4.5 -4.1 -2.9 -1.3 -2.7 -2.5 -4.6 -2.6 -2.6 -3.7 -3.3 -4.0 -5.4 -3.9 -4.0
Arm fat percentage (left) 2.4 9.8 20.1 -3.9 -2.7 -4.1 3.0 -3.7 -2.1 -0.5 -2.6 -2.2 -3.1 -2.5 -2.8 -3.0 -1.5 -4.5 -2.1 -3.4 -1.8 -3.5 -3.3 -3.1 -4.0 -2.5 -3.9 -1.7 -1.8 -4.5 -4.2 -4.2
Average weekly red wine intake 0.7 1.0 2.7 0.9 0.5 -0.7 -0.2 0.2 1.4 -0.2 1.3 1.6 1.5 1.4 1.5 1.6 1.2 0.8 0.9 0.9 1.2 -0.1 0.6 1.0 0.4 0.8 1.3 0.1 0.7 -0.0 0.8 0.9
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.1 0.2 0.5 0.8 -1.0 0.6 0.6 1.0 1.1 0.4 0.0 1.0 0.4 -0.0 0.2 -0.3 0.7 0.1 -0.5 0.7 0.7 -0.1 -0.9 -0.3 -0.2 -0.1 0.6 0.4 -0.9 -0.4
Mood swings 1.0 1.8 5.0 -2.2 -0.9 -0.9 1.2 -1.4 -1.7 -0.4 -0.9 -2.0 -1.2 -0.5 -1.9 -1.5 -1.1 -0.6 -1.4 -0.9 0.0 -0.4 0.3 -1.8 -1.2 -0.8 -2.1 -1.4 -1.1 -1.9 -1.5 -1.6
Loneliness, isolation 0.4 0.6 1.5 0.4 1.0 0.3 -0.8 -0.1 1.2 0.6 1.1 0.8 0.7 1.0 0.9 0.9 0.9 -0.0 1.2 0.7 0.5 0.9 0.9 0.8 0.5 0.4 0.2 0.2 0.4 1.1 -0.0 0.3
Long-standing illness, disability or infirmity 1.5 2.3 5.8 1.9 2.3 1.0 -2.1 1.5 1.0 2.4 2.0 0.8 0.8 2.2 1.6 1.0 1.3 -0.2 2.0 2.0 1.6 1.6 -0.0 1.4 1.8 1.1 0.8 1.0 1.5 1.5 0.7 1.6
Ever had bowel cancer screening 2.4 2.8 6.7 -1.0 -1.4 -1.8 1.6 -0.4 -1.8 -1.4 -2.2 -1.5 -1.7 -1.9 -1.7 -1.8 -1.9 -1.2 -2.1 -1.6 -1.3 -1.4 -2.6 -1.5 -1.2 -2.3 -1.7 -1.4 -2.0 -1.9 -1.4 -1.2
Diabetes diagnosed by doctor 0.4 0.7 1.9 -1.0 -0.8 0.1 0.6 -1.1 -1.2 -0.4 0.3 -1.3 -0.8 -1.1 -0.7 -0.8 0.1 -1.4 -0.5 -1.0 0.1 -1.0 -0.1 -1.0 -1.1 -0.1 -1.3 -0.2 -0.6 -0.9 -0.7 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 2.7 2.9 7.4 1.7 1.4 2.2 -1.2 2.1 1.7 0.7 1.4 1.2 1.0 1.4 1.9 1.7 0.8 1.7 1.5 1.5 2.3 2.1 1.3 2.0 2.7 1.5 2.0 0.6 0.8 1.8 1.9 2.5
Friendships satisfaction 0.9 1.1 4.7 1.2 1.4 1.3 -0.8 1.4 -0.3 1.7 0.5 -1.1 0.1 1.2 0.2 -0.5 0.2 -1.4 0.4 0.9 1.1 2.0 -1.2 0.2 0.5 -0.6 0.5 2.2 0.9 0.5 -1.1 0.3
Qualifications: nursing, teaching 0.4 0.6 3.1 0.7 0.4 0.8 -0.2 1.8 1.0 1.4 0.9 1.1 0.4 0.6 0.7 0.4 0.6 0.0 0.8 0.5 -0.7 1.2 -0.2 0.5 0.2 0.5 0.4 0.8 0.8 1.2 0.1 0.4
Commuting to job workplace: Walk 0.2 0.2 1.2 -0.4 -0.0 -0.0 0.3 0.3 -0.2 -0.7 -0.2 0.1 0.3 -0.2 -0.1 0.1 -0.1 1.1 -0.4 0.1 0.0 0.4 0.5 0.3 0.8 0.5 1.1 -0.4 -0.1 0.0 -0.1 0.4
Eye problems/disorders: Cataract 1.0 1.1 3.0 1.2 1.2 0.7 -1.5 0.1 0.9 0.9 1.7 1.1 1.4 1.5 1.4 1.1 1.5 0.1 1.3 1.2 -1.6 0.5 -0.0 0.5 -0.2 1.1 1.0 0.5 0.6 0.8 1.3 0.9
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 6.6 1.9 0.7 1.8 -0.9 2.6 1.5 0.8 1.3 1.1 1.2 0.6 1.0 1.5 1.3 1.6 0.7 0.6 -0.7 0.5 2.1 1.0 0.1 0.3 1.2 0.7 0.7 1.2 0.7 1.2
Medication for cholesterol 0.2 0.3 1.3 -0.2 0.6 0.3 0.2 0.6 -0.5 0.5 0.7 -0.5 0.6 -0.1 -0.2 0.3 0.6 0.3 -0.1 -0.0 -0.5 0.9 0.4 -0.6 -0.3 1.1 -0.8 -1.0 0.4 0.1 -0.1 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 2.1 -0.9 0.1 0.9 -0.3 0.8 -0.9 -0.1 0.4 -1.1 -0.2 0.5 0.3 -0.1 -0.3 0.4 0.1 0.2 1.0 0.5 1.4 -1.0 1.4 0.5 -0.1 -1.2 -0.4 0.2 0.2 0.4
Back pain experienced in last month 0.4 0.6 2.1 -0.9 0.1 -0.6 -0.2 0.2 -0.8 -0.8 -0.6 -0.0 -0.5 1.3 -0.2 -0.5 -0.6 -0.7 -0.6 0.0 0.9 -0.9 -1.2 -0.3 1.1 -0.7 -0.9 -0.9 -1.5 -1.2 0.3 -0.2
Mineral and other dietary supplements 1.4 1.9 5.1 0.6 1.8 1.5 -1.5 1.5 0.7 1.6 1.6 1.2 1.7 1.2 1.4 1.5 2.0 1.5 1.3 1.9 -0.1 1.0 0.5 0.8 0.5 1.5 1.8 2.3 1.8 1.1 -0.1 1.2
Breast cancer (self-reported) 1.5 1.8 8.0 2.8 2.1 0.5 -2.2 0.3 -0.6 0.4 1.9 0.1 2.0 0.8 0.9 1.7 1.6 1.3 0.5 1.7 -0.8 1.5 0.8 0.1 0.5 1.6 1.3 0.6 -0.2 0.4 1.8 1.9
Asthma (self-reported) 1.2 2.4 7.6 -0.8 -1.3 -1.7 1.3 -0.0 -0.7 0.3 -1.2 -1.1 -2.2 -1.0 -1.9 -2.4 -2.3 -1.8 -1.1 -2.0 -0.3 -2.1 -1.1 -0.6 -1.1 -2.0 -2.8 -1.6 -1.1 -0.6 -1.3 -2.1
Osteoporosis (self-reported) 0.9 1.2 4.8 1.1 0.5 -0.3 -0.6 0.2 1.2 1.4 1.0 1.6 0.9 1.0 1.0 0.9 0.4 0.7 1.1 0.9 1.7 0.3 -0.2 1.4 1.5 0.4 2.0 2.2 0.4 0.3 0.6 1.1
Osteoarthritis (self-reported) 0.4 0.5 4.6 -0.6 -0.4 -0.6 0.6 -0.2 -0.7 0.5 -0.5 -0.7 -1.0 0.2 -0.6 -0.6 -0.2 -0.1 -0.2 -0.5 -1.3 -0.3 -2.1 -0.9 -0.5 -0.4 -0.7 -0.5 -0.6 -0.6 0.1 -0.6
Medication: Aspirin 0.5 0.6 2.0 -0.4 -1.1 0.6 0.1 0.1 -0.6 0.2 -1.3 -1.4 -1.1 -1.0 -0.8 -1.1 -0.8 -0.9 -0.4 -0.8 0.3 -0.7 -1.2 -0.0 -0.8 -0.9 -0.9 0.8 -0.1 -0.4 -0.3 -0.6
Medication: Gliclazide 1.8 2.0 5.6 -0.3 -1.4 -0.2 1.0 -1.2 -2.1 -1.0 -1.3 -2.4 -1.7 -0.8 -1.8 -1.6 -1.1 -1.2 -1.7 -1.4 -1.1 -1.1 -0.6 -1.6 -2.2 -1.4 -1.8 -0.3 -1.9 -1.7 -1.1 -1.2
Illnesses of father: None of the above (group 1) 1.1 1.3 4.3 -0.4 -0.4 -1.8 0.6 -1.4 -1.7 -0.9 -1.2 -1.6 -1.2 -0.3 -1.4 -1.0 -0.6 -1.2 -1.4 -0.8 -2.1 -1.7 -0.1 -1.4 -1.1 -0.5 -1.0 -0.2 -1.2 -1.2 -0.9 -1.0
Smoking status: Current 0.2 0.4 1.5 0.5 -0.8 0.4 -0.3 -0.3 0.5 -0.5 -0.6 0.0 -0.6 0.9 -0.4 -0.8 -0.5 -1.0 -0.4 0.5 1.2 -0.8 -0.4 0.9 -0.0 0.3 -0.1 0.8 0.3 -0.2 -0.2 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 3.1 11.1 -3.3 -1.5 -2.6 1.7 -2.3 -2.3 -1.9 -1.1 -1.1 -0.3 -1.7 -1.6 -0.2 0.2 0.2 -2.0 -1.5 -1.5 -0.6 -0.4 -2.6 -2.4 -0.5 -1.2 -2.4 -1.1 -2.7 -2.0 -1.1
Whole body water mass 2.0 11.5 24.7 -2.9 -2.3 -3.2 1.9 -4.6 -4.7 -2.3 -3.2 -4.1 -3.4 -2.7 -3.5 -3.6 -2.7 -4.3 -4.2 -2.6 -1.2 -2.5 -2.5 -4.5 -2.1 -2.7 -3.5 -3.0 -4.1 -5.0 -3.7 -3.8
Leg predicted mass (right) 2.4 12.7 30.1 -3.4 -2.4 -3.7 2.1 -4.7 -4.5 -2.5 -3.3 -3.8 -3.5 -3.3 -3.5 -3.6 -2.5 -4.6 -4.2 -3.0 -1.4 -2.7 -2.6 -4.7 -2.6 -2.7 -3.7 -3.4 -4.1 -5.5 -4.0 -4.1
Arm fat mass (left) 3.4 13.9 30.7 -4.2 -3.1 -4.3 3.3 -4.5 -3.4 -1.0 -3.3 -3.3 -3.9 -2.8 -3.6 -3.8 -2.1 -5.3 -3.1 -3.8 -2.0 -3.7 -3.8 -4.1 -4.0 -2.9 -4.7 -2.4 -2.7 -5.5 -4.9 -4.9
Number of self-reported non-cancer illnesses 0.3 0.4 2.0 0.8 0.2 -0.6 -0.3 -0.3 -1.1 0.9 -0.1 -0.8 -1.0 0.9 -0.5 -0.8 -0.7 -0.6 -0.6 0.0 1.4 -0.3 -0.7 -0.2 0.6 -1.1 -0.6 -0.2 -0.5 -0.5 0.0 -0.2
Average weekly champagne plus white wine intake 1.1 1.6 9.7 0.3 2.3 -0.8 -1.8 -0.5 0.2 1.9 1.2 -0.0 1.3 1.8 0.8 0.9 1.6 -0.2 1.2 1.6 -0.1 3.1 -0.9 -0.0 -1.0 1.1 0.9 1.8 0.9 0.2 -0.2 0.8
Miserableness 0.4 0.7 2.6 -1.2 0.5 0.1 -0.8 -0.8 -1.0 1.0 1.0 -1.1 -0.0 0.6 -0.5 -0.2 0.7 -0.9 -0.3 0.6 -1.1 0.1 1.6 -1.1 -1.1 0.6 -0.7 0.0 0.4 -0.9 -0.9 -0.8
Guilty feelings 3.1 4.6 10.0 -0.4 -1.8 0.1 1.3 -1.1 -2.6 -2.2 -2.3 -2.5 -3.1 -2.5 -2.8 -3.1 -3.2 -2.0 -2.4 -1.8 -2.3 -1.7 -0.3 -1.9 -0.2 -2.9 -1.9 -1.4 -2.7 -1.4 -3.0 -1.9
Wears glasses or contact lenses 1.1 1.2 4.7 1.2 1.5 0.6 -1.7 1.4 0.3 0.8 1.1 0.7 1.4 2.2 1.2 0.4 -0.0 1.0 0.4 1.5 0.0 0.8 0.7 0.2 0.7 -0.8 1.8 1.3 -0.1 1.9 0.8 1.0
Ever taken oral contraceptive pill 1.3 1.4 4.6 -0.9 -0.4 -0.7 0.3 -1.1 -1.2 -1.7 -0.8 -1.6 -1.1 -0.7 -1.3 -1.4 -1.1 -0.9 -1.6 -0.3 -2.1 -1.2 0.3 -1.3 -0.9 -1.1 -0.2 -1.1 -1.7 -0.9 -1.7 -1.5
Hearing aid user 1.0 1.1 4.6 0.3 1.7 0.5 -1.8 0.1 0.3 1.2 0.3 -0.3 0.9 2.1 1.6 1.0 1.8 -0.5 1.5 1.2 0.9 1.2 -1.6 0.3 -0.5 0.7 0.1 0.5 1.2 0.4 0.3 1.0
Mother’s age at death 0.5 0.7 4.7 -0.6 -0.4 -0.6 0.3 1.2 1.3 1.0 0.3 1.5 0.4 0.1 0.4 0.0 0.6 -0.6 0.7 -0.2 -2.2 -0.1 -0.8 0.5 -0.8 0.1 0.4 1.3 1.3 0.5 0.2 -0.4
Financial situation satisfaction 0.5 0.6 3.8 -0.9 0.0 -0.2 -0.3 -0.6 -0.5 0.8 0.1 -0.7 -0.2 0.3 -0.4 -0.4 0.1 -1.9 -0.2 -0.2 0.7 0.5 -1.9 -0.4 -1.0 -0.4 -1.0 0.5 0.2 -0.9 -1.2 -0.8
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.6 -0.7 0.4 -1.1 -0.2 0.7 0.3 -0.7 -0.6 1.2 0.4 0.5 0.3 -0.2 -0.6 0.6 0.1 -0.1 -0.3 0.8 -1.4 0.0 -1.6 -0.9 -0.2 0.1 -0.9 -0.1 -0.3 -0.3
Commuting to job workplace: Public transport 1.7 2.0 4.9 0.6 1.0 0.9 -1.1 -0.1 0.7 1.0 1.8 0.4 1.3 0.7 1.3 2.0 2.2 1.4 1.3 1.8 1.9 1.7 -0.1 1.1 1.7 2.1 1.5 1.5 2.0 1.3 1.2 1.7
Eye problems/disorders: Glaucoma 0.7 0.8 2.5 -0.2 1.2 0.7 -1.0 -0.9 0.4 0.8 1.1 0.8 1.6 1.3 0.9 1.3 1.6 0.7 1.2 1.0 0.6 0.5 0.5 0.3 -0.2 1.0 0.2 0.7 1.1 0.5 1.1 0.8
Medication: Blood pressure 0.7 1.3 5.3 0.2 -1.1 -0.1 0.2 -1.6 -0.3 -0.9 -1.0 -0.3 -1.6 -0.2 -1.1 -1.8 -2.0 -1.6 -0.8 -0.5 -0.5 -2.0 -0.7 -0.2 0.2 -2.3 -0.1 0.5 -1.4 -0.8 -1.0 -1.5
Pain type(s) experienced in last month: Hip pain 0.4 0.6 2.6 -0.4 0.9 -1.3 -1.0 -1.6 -0.9 -0.4 0.4 -0.4 0.5 1.0 0.1 0.2 0.9 -1.3 -0.2 0.6 -0.3 -0.3 -0.7 -1.0 -1.0 -0.1 -0.6 -0.4 0.2 -1.1 -0.5 -0.3
Supplements: Fish oil (including cod liver oil) 2.7 3.5 8.7 -0.7 -2.3 -1.0 1.9 -1.8 -1.1 -2.0 -2.2 -1.6 -2.5 -1.7 -2.0 -2.3 -3.0 -2.0 -1.9 -2.4 -0.4 -1.9 -0.1 -1.2 -0.3 -2.3 -2.5 -2.8 -2.1 -1.2 -0.8 -1.8
High cholesterol (Self-reported) 0.6 1.0 3.1 -0.5 -0.6 -0.4 -0.2 -1.0 -1.6 0.2 -1.0 -1.5 -1.3 -0.6 -1.4 -1.6 -0.8 -1.8 -1.2 -0.2 -0.6 -1.1 -0.1 -1.2 -1.0 -0.7 -0.4 0.5 -0.8 -1.1 -1.0 -1.1
Medication: Bendroflumethiazide 0.1 0.2 1.5 0.6 -0.8 -0.0 -0.8 -0.7 0.1 0.2 0.1 0.1 -0.6 -0.2 -0.3 -0.8 -0.6 -0.3 0.1 0.2 1.2 0.1 0.4 0.5 0.7 -0.2 0.2 0.1 0.0 -0.2 -0.1 -0.1
Medication: Paracetamol 1.0 1.5 3.9 -0.8 -1.1 -1.3 0.9 -1.2 -1.7 0.1 -0.4 -1.6 -1.7 -1.8 -2.0 -1.8 -1.5 -0.9 -1.3 -1.2 0.3 -1.1 -0.3 -2.0 -1.0 -0.8 -1.1 -0.6 -1.2 -0.8 -0.3 -1.2
Medication: Lisinopril 1.0 1.3 3.6 1.4 0.8 -0.2 -1.4 -0.5 1.4 1.3 0.2 1.8 0.9 0.9 1.4 0.5 0.2 0.3 1.4 1.1 1.6 1.3 -0.8 1.9 1.0 0.6 1.2 1.6 0.9 1.9 0.5 0.7
Medication: Atorvastatin 3.5 4.3 11.8 -2.0 -1.0 -1.9 0.7 -2.4 -3.4 -2.5 -1.3 -2.3 -2.1 -0.9 -2.4 -2.2 -1.6 -2.0 -3.2 -1.0 -2.3 -0.7 -0.0 -3.4 -1.8 -1.8 -1.6 -1.7 -2.9 -2.8 -1.9 -2.0
Illnesses of father: High blood pressure 0.6 0.7 3.4 0.0 0.8 1.8 -0.4 -0.1 -0.5 -0.8 0.0 -0.6 -1.1 0.3 -0.6 -1.3 -1.5 0.1 -0.7 0.5 0.4 0.6 0.4 -0.4 1.1 -1.2 -0.0 -1.2 -1.2 0.1 -1.1 -0.5
Alcohol drinker status: Never 0.5 0.6 3.2 0.3 -0.5 0.4 0.7 1.2 0.9 -0.5 -0.5 1.8 0.2 0.9 0.5 -0.0 -0.6 -0.1 0.4 -0.5 -0.9 -1.7 1.3 0.4 -0.8 -1.5 -0.3 0.5 -0.7 0.7 0.8 -0.2
Ever smoked 2.9 5.0 11.6 -0.4 -2.6 -1.1 2.5 -0.8 -1.9 -0.4 -2.3 -2.5 -2.2 -1.7 -2.8 -3.1 -2.6 -2.1 -2.5 -2.4 -2.8 -1.8 -2.7 -2.0 -2.4 -2.5 -2.3 -1.2 -2.2 -1.9 -2.5 -3.4
Basal metabolic rate 2.5 13.6 28.9 -3.4 -2.7 -3.6 2.4 -4.9 -4.7 -2.2 -3.6 -4.2 -3.8 -3.0 -3.8 -3.9 -2.8 -4.8 -4.2 -3.1 -1.4 -2.9 -2.9 -4.7 -2.6 -3.0 -4.0 -3.1 -4.1 -5.4 -4.2 -4.3
Leg fat percentage (left) 2.5 9.1 16.8 -3.7 -3.3 -4.1 3.5 -3.7 -1.6 -0.4 -2.9 -1.6 -3.1 -2.0 -2.8 -2.9 -1.7 -3.7 -1.9 -3.5 -1.3 -3.4 -3.3 -2.7 -3.8 -2.6 -4.0 -1.4 -1.2 -4.0 -4.1 -4.0
Arm fat-free mass (left) 2.4 12.1 25.8 -2.7 -2.5 -3.1 2.2 -4.9 -4.7 -2.1 -3.4 -4.2 -3.6 -2.5 -3.7 -3.7 -2.8 -4.4 -4.2 -2.7 -1.1 -2.5 -2.9 -4.5 -2.2 -2.9 -3.9 -2.8 -3.9 -5.1 -3.9 -4.1
Number of operations (self-reported) 1.9 2.9 8.4 -1.4 -1.2 -1.9 1.7 -2.9 -2.0 -1.1 -1.9 -1.9 -1.9 -0.7 -1.7 -2.1 -1.9 -2.3 -1.4 -1.1 -0.1 -1.5 -2.1 -1.6 -0.4 -1.5 -1.7 -1.7 -1.6 -1.3 -1.6 -2.0
Average weekly beer plus cider intake 0.4 0.6 2.7 0.2 -1.6 0.5 1.1 0.7 -0.3 -0.3 -0.9 -0.3 -1.1 -0.1 -0.8 -0.8 -1.0 -0.2 -0.5 -1.0 -1.3 -0.4 0.9 -0.3 -0.0 -1.3 -0.9 -0.3 -0.6 -0.1 -0.4 -0.6
Irritability 2.4 4.0 11.6 -3.4 -1.0 -1.6 1.5 -2.6 -2.2 -1.1 -1.4 -1.7 -1.3 -1.0 -2.3 -1.8 -0.9 -1.2 -2.1 -1.5 -2.3 -1.2 2.0 -3.0 -2.4 -0.6 -3.1 -2.6 -0.9 -2.0 -2.6 -2.5
Risk taking 0.6 0.9 2.8 -0.2 -0.9 0.4 1.0 -0.6 -1.3 -0.2 -0.6 -1.7 -1.6 -1.1 -1.1 -1.1 -1.2 0.1 -0.8 -1.1 0.6 0.3 0.7 -0.7 1.2 -0.7 -1.2 -1.5 -0.8 -0.6 -1.2 -0.8
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.4 -0.7 -1.2 -0.9 1.2 -0.7 0.6 -0.2 -0.4 0.2 0.1 -0.6 -0.3 -0.3 -0.6 0.0 0.1 -0.9 -0.3 -0.6 1.1 0.1 -0.1 0.2 -0.3 -0.5 0.2 0.5 0.0 -0.9
Fractured/broken bones in last 5 years 0.9 1.1 4.0 -0.5 -1.3 -0.8 0.6 1.2 0.9 1.4 -1.5 -0.4 -1.3 0.6 -0.7 -1.9 -1.6 -1.7 0.5 -0.7 1.6 0.3 -2.0 0.8 -0.3 -0.9 -0.1 0.9 0.0 0.8 -0.5 -1.3
Age started oral contraceptive pill 0.6 0.7 4.8 0.1 -0.4 -0.3 1.0 0.7 -0.7 0.1 -0.9 -0.7 -1.3 -1.8 -0.8 -1.2 -1.0 -0.5 -0.8 -0.5 -0.0 -0.4 -2.2 -0.3 -0.2 -1.2 -0.1 0.6 -0.6 -1.1 0.3 -0.4
Diastolic blood pressure, automated reading 1.4 4.3 10.9 0.8 2.1 0.5 -1.5 -0.3 1.7 1.3 1.6 2.4 2.3 1.3 2.8 3.1 3.0 1.0 2.5 2.7 2.2 1.5 0.1 1.8 1.9 2.6 3.3 3.3 2.3 0.3 1.9 2.5
Ever depressed for a whole week 0.9 1.1 4.2 -1.0 1.2 0.1 -1.2 -0.0 0.3 0.7 1.8 0.8 1.1 2.1 0.8 1.2 1.4 0.8 0.9 1.5 -0.1 1.2 2.0 -0.1 -0.0 1.6 0.4 0.3 1.0 0.6 0.2 0.4
Unable to work because of sickness or disability 0.3 0.5 2.0 0.6 -0.0 0.3 -0.3 1.4 0.6 0.6 -0.7 0.3 -1.3 0.3 -0.2 -1.1 -1.1 -0.6 0.6 -0.1 0.5 0.4 -0.5 0.4 1.1 -1.0 0.3 0.4 -0.1 0.9 -0.5 -0.3
Commuting to job workplace: Cycle 2.2 2.6 7.8 -1.0 -1.2 -1.0 1.5 -0.2 -1.4 -0.5 -1.0 -1.6 -1.8 -1.6 -2.0 -2.2 -1.5 -2.0 -1.0 -1.8 -2.0 -1.1 -1.9 -1.8 -1.5 -1.6 -2.3 -1.1 -0.9 -1.8 -2.8 -2.0
Myopia 0.9 1.3 5.1 0.4 1.5 1.6 -1.8 2.0 -1.2 0.7 1.8 -0.5 0.8 1.3 0.7 0.5 0.2 1.2 -0.1 1.6 -0.6 1.3 1.1 -0.7 0.5 -0.4 1.5 2.3 -0.8 -0.1 0.5 1.4
Vascular/heart problems diagnosed by doctor 0.3 0.7 2.0 -0.7 -0.4 -0.9 1.3 0.9 -0.9 -1.4 -0.7 -0.6 0.6 -1.4 -0.6 0.6 0.0 0.7 -1.0 -1.3 -0.6 -0.1 -0.4 -1.1 -0.9 -0.1 -0.6 -1.4 -0.8 -0.4 0.4 0.6
Cholesterol lowering medication 0.3 0.4 2.5 0.6 -0.3 -1.0 -0.7 -0.7 -0.1 -0.5 -0.8 -0.6 -0.9 0.4 -0.6 -0.7 -0.7 -0.6 -0.6 -0.0 0.3 -0.4 -1.6 0.2 -0.4 -1.0 0.3 1.0 -0.8 -0.5 -0.0 -0.3
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 4.4 0.2 1.5 -0.9 -1.0 -0.6 0.4 1.9 0.6 0.6 -0.1 2.1 1.4 0.8 1.1 -0.3 1.5 1.4 1.9 1.8 -1.6 0.6 1.3 0.5 0.4 0.7 1.8 0.2 0.5 1.0
Pain experienced in last month 0.3 0.6 2.5 0.7 0.6 0.9 -0.3 0.6 0.4 -0.1 0.3 0.3 0.8 -0.4 1.0 0.8 0.4 0.8 0.8 0.6 0.4 1.6 -0.3 0.4 0.7 1.0 1.5 0.1 0.4 0.8 1.2 1.1
Supplements: Calcium 1.4 1.5 5.4 0.3 -0.4 -1.2 -0.5 -1.7 -0.9 -0.7 -1.4 -0.9 -0.9 -0.2 -1.2 -1.9 -2.0 -2.3 -1.5 -0.5 0.4 0.2 -1.9 -0.2 -1.3 -2.2 -0.3 0.6 -1.8 -1.0 -1.0 -1.4
Basal cell carcinoma (self-reported) 0.6 0.7 2.4 0.1 1.3 0.3 -1.0 -0.4 0.4 1.6 1.3 0.3 0.8 0.7 0.8 0.6 0.9 0.3 1.2 0.9 0.2 1.5 -0.1 0.4 0.6 1.3 -0.3 -0.1 1.1 0.6 0.5 0.5
Heart attack/myocardial infarction (self-reported) 0.3 0.3 1.4 -0.3 -0.5 0.3 0.8 0.7 -1.0 -0.6 -0.2 -0.5 -1.1 -0.5 -0.4 -0.3 -0.6 0.3 -0.7 -0.5 0.2 -0.5 0.5 -0.5 0.9 -0.3 -0.0 -0.9 -1.2 -0.3 0.4 0.2
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 4.8 -0.8 -0.6 -2.0 0.7 -0.5 -0.7 -0.8 -1.2 0.1 -1.8 -1.5 -0.7 -0.9 -0.8 -0.8 -0.7 -1.6 -1.5 -0.2 -2.2 -1.0 -1.0 -1.4 -1.2 -0.8 -1.3 -1.3 -0.6 -0.9
Heart disease (siblings) 0.3 0.4 4.2 1.0 -0.1 0.2 -0.4 0.3 -0.0 0.3 -0.1 -1.2 -0.5 -0.2 -0.1 -0.3 -0.4 -0.6 -0.0 -0.3 2.1 0.4 -0.9 0.5 0.6 -0.2 0.7 0.2 0.2 0.6 0.8 0.5
Alcohol drinker status: Previous 0.6 0.7 1.4 1.2 0.3 1.1 -0.5 1.0 0.9 0.8 0.6 0.8 0.6 0.8 0.6 0.2 -0.4 1.1 0.7 0.4 1.1 0.7 -0.9 0.8 1.1 -0.4 1.0 1.0 0.7 1.1 0.6 0.6
Pack years of smoking 0.4 0.6 3.2 0.4 0.9 0.4 -1.4 0.0 1.2 -0.0 0.2 1.8 0.8 1.3 0.9 0.6 0.8 -0.4 0.9 1.0 0.4 0.2 0.3 1.2 -0.1 0.4 -0.0 0.3 0.8 0.9 -0.1 0.3
Impedance of whole body 0.3 1.7 13.8 1.5 1.0 2.1 -0.8 3.7 0.9 0.9 -0.2 0.4 -0.1 0.9 0.5 0.1 -0.5 2.2 1.0 0.7 0.1 0.9 -1.3 1.8 1.3 -0.1 1.5 0.8 0.2 2.1 1.3 1.5
Leg fat mass (left) 3.4 13.3 25.9 -4.1 -3.5 -4.5 3.5 -4.5 -3.0 -1.3 -3.6 -2.7 -3.7 -2.6 -3.5 -3.6 -2.3 -4.7 -3.0 -4.0 -1.6 -3.6 -3.7 -3.8 -4.1 -3.0 -4.8 -2.5 -2.4 -5.1 -4.8 -4.7
Arm predicted mass (left) 2.6 13.1 29.1 -3.1 -2.5 -3.5 2.3 -5.1 -4.9 -2.3 -3.5 -4.3 -3.8 -2.7 -3.8 -3.7 -2.7 -4.5 -4.4 -2.8 -1.4 -2.6 -3.0 -4.8 -2.4 -2.8 -4.0 -3.1 -4.1 -5.4 -3.8 -4.1