Best TWAS P=1.85e-14 · Best GWAS P=2.66e-11 conditioned to 0.025
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-723O4.9 | 0.12 | 0.04 | lasso | 5 | 0.06 | 3.4e-05 | 2.2 | 5.3 | 1.1e-07 | -0.52 | 0.09 | 0.84 | FALSE |
| 2 | GTEx | Testis | HMCES | 0.75 | 0.56 | lasso | 8 | 0.55 | 8.4e-29 | 5.6 | 5.7 | 1.2e-08 | -0.15 | 0.48 | 0.52 | FALSE |
| 3 | YFS | Blood | H1FX | 0.02 | 0.01 | lasso | 3 | 0.01 | 1.4e-03 | -6.2 | 6.2 | 5.8e-10 | -0.84 | 0.03 | 0.83 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | H1FX | 0.02 | 0.02 | lasso | 5 | 0.03 | 6.5e-07 | 5.7 | 7.6 | 3.4e-14 | -0.62 | 0.09 | 0.89 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | H1FX | 0.02 | 0.00 | blup | 36 | 0.00 | 5.1e-01 | -6.7 | 7.7 | 1.9e-14 | -0.65 | 0.01 | 0.67 | TRUE |