Best TWAS P=4.66e-13 · Best GWAS P=1.28e-11 conditioned to 0.0522
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DHX36 | 0.05 | 0.06 | blup | 357 | 0.05 | 1.3e-06 | -5.8 | -6.5 | 9.4e-11 | 0.66 | 0.65 | 0.35 | FALSE |
2 | GTEx | Adipose Subcutaneous | ARHGEF26 | 0.10 | 0.06 | enet | 8 | 0.07 | 2.2e-06 | -5.8 | 6.0 | 1.5e-09 | -0.61 | 0.61 | 0.38 | FALSE |
3 | GTEx | Artery Tibial | ARHGEF26 | 0.11 | 0.12 | enet | 12 | 0.12 | 5.9e-10 | -5.8 | 5.5 | 4.0e-08 | -0.54 | 0.74 | 0.26 | FALSE |
4 | GTEx | Ovary | ARHGEF26 | 0.14 | 0.03 | enet | 15 | 0.06 | 1.4e-02 | 6.3 | 7.2 | 4.7e-13 | -0.76 | 0.06 | 0.55 | TRUE |
5 | GTEx | Pancreas | ARHGEF26 | 0.26 | 0.26 | lasso | 5 | 0.28 | 3.2e-12 | -5.5 | 6.6 | 4.1e-11 | -0.73 | 0.66 | 0.34 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | ARHGEF26 | 0.13 | 0.11 | lasso | 4 | 0.07 | 6.8e-05 | -5.5 | 6.3 | 2.4e-10 | -0.70 | 0.28 | 0.71 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | ARHGEF26 | 0.10 | 0.08 | enet | 12 | 0.11 | 2.9e-09 | -5.8 | 5.4 | 8.1e-08 | -0.50 | 0.76 | 0.24 | FALSE |
8 | GTEx | Spleen | DHX36 | 0.39 | 0.09 | enet | 21 | 0.34 | 2.1e-09 | -3.5 | -6.0 | 2.2e-09 | 0.66 | 0.41 | 0.55 | FALSE |
9 | GTEx | Thyroid | ARHGEF26 | 0.09 | 0.07 | enet | 17 | 0.08 | 1.9e-06 | -5.7 | 6.5 | 1.1e-10 | -0.62 | 0.34 | 0.63 | FALSE |
10 | METSIM | Adipose | ARHGEF26 | 0.07 | 0.08 | lasso | 6 | 0.07 | 3.5e-11 | -5.8 | 5.8 | 5.2e-09 | -0.55 | 0.70 | 0.30 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SGEF | 0.04 | 0.04 | enet | 12 | 0.04 | 1.1e-05 | -5.6 | 6.7 | 2.4e-11 | -0.77 | 0.09 | 0.88 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DHX36 | 0.11 | 0.09 | enet | 11 | 0.10 | 6.4e-12 | -5.0 | -5.6 | 2.6e-08 | 0.48 | 0.97 | 0.02 | FALSE |
13 | The Cancer Genome Atlas | Soft Tissue Sarcoma | DHX36 | 0.05 | 0.00 | enet | 9 | 0.01 | 1.0e-01 | -3.9 | -5.2 | 1.7e-07 | 0.58 | 0.01 | 0.62 | FALSE |