TWAS hub - ARHGEF26

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1000	0.0350	7.6e-06	0.058	NA	0.070	NA	0.057	1.5e-05	NA	2.2e-06	NA	1.9e-05
2	GTEx	Artery Aorta	0.0910	0.0370	1.1e-03	0.023	NA	0.025	NA	0.043	2.0e-02	NA	1.5e-02	NA	2.0e-03
3	GTEx	Artery Tibial	0.1103	0.0335	2.6e-08	0.118	NA	0.124	NA	0.122	1.5e-09	NA	5.9e-10	NA	9.3e-10
4	GTEx	Cells Transformed fibroblasts	0.0540	0.0240	6.9e-03	0.046	NA	0.057	NA	0.068	2.3e-04	NA	4.2e-05	NA	7.6e-06
5	GTEx	Nerve Tibial	0.2372	0.0553	5.7e-10	0.129	NA	0.161	NA	0.161	2.1e-09	NA	1.8e-11	NA	1.6e-11
6	GTEx	Ovary	0.1390	0.0640	5.3e-03	0.033	NA	0.060	NA	0.045	5.3e-02	NA	1.4e-02	NA	2.9e-02
7	GTEx	Pancreas	0.2560	0.0600	2.8e-09	0.255	NA	0.236	NA	0.279	3.4e-11	NA	2.3e-10	NA	3.1e-12
8	GTEx	Skin Not Sun Exposed Suprapubic	0.1260	0.0420	9.4e-05	0.112	NA	0.069	NA	0.074	1.1e-06	NA	1.3e-04	NA	6.8e-05
9	GTEx	Skin Sun Exposed Lower leg	0.1000	0.0330	7.4e-06	0.078	NA	0.108	NA	0.106	5.4e-07	NA	2.9e-09	NA	4.2e-09
10	GTEx	Testis	0.1890	0.0670	1.6e-04	0.140	NA	0.134	NA	0.131	8.6e-07	NA	1.5e-06	NA	2.0e-06
11	GTEx	Thyroid	0.0870	0.0350	8.7e-05	0.065	NA	0.076	NA	0.066	9.8e-06	NA	2.0e-06	NA	9.1e-06
12	METSIM	Adipose	0.0725	0.0244	1.1e-08	0.076	0.065	0.072	0.066	0.074	1.8e-11	6e-10	6.6e-11	3.4e-10	3.5e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Coronary Artery Disease (CAD)	8.3	10.0	16.9	3.6	2.6	4.1	2.0	-1.7	1.4	4.0	3.7	3.5	2.0	3.8	3.8
Hip circumference	8.3	35.9	56.2	7.0	1.8	6.3	4.6	1.2	7.1	7.4	7.5	6.6	4.3	6.8	6.8
BMI	6.7	39.0	65.6	7.3	2.2	6.6	4.4	1.1	8.1	7.7	7.4	6.6	3.6	7.5	7.3
Leg fat-free mass (left)	5.8	30.5	50.8	6.3	1.7	5.7	4.0	0.6	7.1	7.0	6.7	5.9	4.1	6.3	6.2
Lung FEV1/FVC ratio	5.7	29.1	54.5	6.3	4.4	7.4	1.8	-3.2	5.2	6.2	5.7	5.0	1.7	6.8	7.1
Leg predicted mass (left)	5.6	29.8	48.7	6.2	1.6	5.6	3.9	0.6	7.0	7.0	6.6	5.9	4.1	6.2	6.2
Weight	5.6	27.7	52.3	6.0	1.6	5.5	3.4	1.3	7.2	6.6	6.3	5.4	3.0	6.5	5.8
Arm fat mass (left)	5.3	21.8	44.1	5.3	1.1	4.8	3.2	1.9	6.6	5.7	5.5	4.7	2.6	5.6	5.2
Arm fat mass (right)	5.2	21.4	40.8	5.3	1.2	4.8	3.3	1.8	6.4	5.6	5.5	4.8	2.7	5.6	5.2
Whole body fat mass	5.2	21.9	40.2	5.5	2.0	5.0	2.8	1.7	6.3	5.8	5.5	4.6	2.2	6.0	5.0
Other serious medical condition/disability diagnosed by doctor	5.0	6.5	12.7	2.4	-1.1	1.9	3.3	0.2	3.6	2.6	2.7	3.1	2.8	2.2	2.6
Leg fat-free mass (right)	5.0	26.7	44.7	5.8	1.2	5.2	3.9	0.7	6.7	6.6	6.2	5.7	4.0	5.8	5.9
Leg predicted mass (right)	5.0	26.7	45.3	5.8	1.2	5.2	3.9	0.8	6.7	6.5	6.2	5.6	4.1	5.8	5.8
Trunk fat mass	4.9	21.2	36.5	5.5	2.4	5.0	2.6	1.6	6.0	5.8	5.5	4.6	2.2	5.8	5.0
Leg fat mass (right)	4.9	18.9	38.4	5.0	1.9	4.6	2.6	1.4	6.2	5.4	5.0	4.2	1.9	5.8	4.7
Pulse wave peak to peak time	4.8	5.7	10.4	2.8	1.6	2.7	0.9	-0.1	3.0	3.2	3.0	2.2	1.5	2.8	2.5
Illnesses of siblings: Diabetes	4.7	5.8	10.0	2.9	1.4	2.8	0.4	-1.4	3.1	3.0	3.1	2.0	0.7	3.2	2.5
Basal metabolic rate	4.7	26.2	52.4	5.7	1.1	5.3	3.3	0.5	7.2	6.5	6.1	5.3	3.3	6.1	5.8
Fractured/broken bones in last 5 years	4.5	5.7	9.4	2.6	2.3	2.5	2.5	-0.4	0.8	2.9	2.5	3.1	2.7	2.2	2.6
Leg fat mass (left)	4.5	17.6	37.2	4.7	1.6	4.4	2.6	1.5	6.1	5.2	4.8	4.0	1.7	5.7	4.5
Systolic Blood Pressure	4.4	22.3	39.4	-6.0	-5.0	-6.3	-1.6	2.3	-3.9	-5.8	-5.6	-4.3	-1.7	-5.5	-5.3
Illnesses of father: Heart disease	4.4	6.2	12.2	2.5	3.5	3.5	-1.4	-2.9	2.3	2.0	1.4	0.7	-1.4	3.5	2.8
Heart disease (siblings)	4.3	5.2	7.8	2.8	1.8	2.5	2.3	-1.4	1.6	2.4	2.3	2.7	2.2	2.1	2.8
Waist Hip Ratio (WHR)	4.2	19.1	31.5	-4.8	-0.2	-4.6	-4.6	-0.2	-3.2	-5.3	-5.6	-5.3	-4.3	-4.5	-5.2
Arm predicted mass (right)	4.2	21.6	45.0	5.2	1.5	5.1	2.3	0.1	6.7	5.9	5.4	4.4	2.2	6.2	5.3
Noisy workplace	4.1	5.1	8.4	2.7	1.2	2.4	1.9	0.3	2.5	2.7	2.9	2.5	1.5	2.3	2.7
Pulse wave Arterial Stiffness index	4.1	4.8	8.7	-2.5	-1.4	-2.5	-0.8	-0.2	-2.8	-3.0	-2.8	-2.1	-1.4	-2.5	-2.3
Whole body fat-free mass	4.1	23.4	47.9	5.4	0.9	5.0	3.1	0.2	6.9	6.2	5.8	5.0	3.2	5.7	5.5
Whole body water mass	4.0	22.8	48.1	5.3	0.9	4.9	2.9	0.2	6.9	6.1	5.7	4.8	3.0	5.6	5.4
Body mass index (BMI)	3.7	15.7	37.7	4.3	0.3	3.9	2.7	2.2	6.1	4.7	4.5	3.8	1.9	4.9	4.5
Arm fat-free mass (right)	3.7	18.8	41.6	4.9	1.2	4.7	1.9	-0.0	6.5	5.6	5.0	4.0	1.9	5.7	4.9
Arm fat percentage (left)	3.7	14.7	28.5	4.5	1.0	3.9	2.7	2.1	5.3	4.6	4.6	3.9	2.2	4.6	4.2
Arm fat-free mass (left)	3.7	18.9	42.1	4.8	0.8	4.6	2.2	0.4	6.5	5.6	5.0	4.1	2.2	5.7	4.9
Arm predicted mass (left)	3.7	18.6	43.2	4.7	0.6	4.5	2.2	0.3	6.6	5.5	5.0	4.1	2.1	5.6	4.9
Waist circumference	3.6	13.0	28.7	4.1	1.6	3.7	2.2	1.5	5.4	4.3	4.2	3.5	1.8	4.5	3.9
Trunk fat percentage	3.5	14.0	23.2	4.5	2.1	4.1	2.2	1.9	4.6	4.6	4.5	3.7	1.8	4.8	3.9
Heart attack	3.5	4.5	17.0	1.9	1.0	2.3	1.0	0.5	4.1	2.5	1.8	1.5	0.5	2.8	2.5
Chronic bronchitis/emphysema (mother)	3.5	4.1	7.2	2.1	-0.1	2.0	2.3	-1.7	1.3	2.1	2.1	2.4	1.8	2.3	2.7
Hearing difficulty/problems with background noise	3.4	5.5	9.1	-2.8	-1.8	-2.9	-0.7	0.5	-2.6	-3.0	-2.7	-2.2	-1.4	-2.7	-2.9
Arm fat percentage (right)	3.4	13.3	26.3	4.1	0.7	3.6	2.7	2.2	5.1	4.3	4.4	3.8	2.2	4.2	3.9
Medication: Atorvastatin	3.4	4.2	8.3	2.1	1.3	2.3	0.8	0.7	2.9	2.8	2.4	1.7	0.2	2.7	2.2
Diastolic blood pressure, automated reading	3.4	10.6	19.3	-3.8	-3.0	-4.2	-1.9	1.6	-1.1	-4.2	-4.4	-3.6	-2.1	-3.1	-3.8
Seen a psychiatrist for nerves, anxiety, tension or depression	3.3	4.3	8.5	1.9	0.5	2.0	2.9	-0.6	1.5	2.4	2.3	2.9	2.5	1.0	2.4
Overall health rating	3.3	7.1	13.2	2.7	0.3	2.1	3.6	-0.3	2.7	2.8	2.9	3.6	2.9	2.6	2.8
Heart attack/myocardial infarction (self-reported)	3.3	4.2	15.5	1.9	1.2	2.3	0.8	0.6	3.9	2.4	1.7	1.4	0.3	2.7	2.4
Falls in the last year	3.2	4.4	8.1	2.4	-0.1	1.6	2.8	1.1	1.6	2.3	2.6	2.7	2.7	1.1	2.0
Body fat percentage	3.2	12.6	22.8	4.2	1.8	3.8	2.0	1.8	4.8	4.3	4.2	3.4	1.4	4.8	3.7
Cholesterol lowering medication	3.2	4.7	13.2	2.0	1.7	2.5	0.8	0.3	2.8	2.6	2.5	1.7	0.4	3.6	2.2
Impedance of leg (left)	3.1	14.9	26.3	-3.7	0.9	-3.4	-3.9	-0.9	-5.1	-4.5	-4.5	-4.4	-4.0	-3.6	-4.6
Financial difficulties in last 2 years	3.0	4.0	7.2	2.5	0.3	2.4	2.0	-1.6	0.8	2.3	2.2	2.7	1.7	1.3	2.6
Trunk predicted mass	3.0	17.2	41.1	4.5	0.5	4.2	2.4	-0.1	6.4	5.3	4.9	4.1	2.5	4.9	4.7
Trunk fat-free mass	2.9	16.7	40.3	4.5	0.5	4.2	2.3	-0.1	6.3	5.2	4.8	4.0	2.4	4.9	4.6
Medication: Allopurinol	2.9	3.9	6.5	2.2	1.7	2.5	0.4	-0.8	2.3	2.5	2.4	1.8	0.5	2.5	2.1
Prostate Cancer	2.8	3.9	10.5	1.2	3.2	2.7	-2.1	-2.7	1.6	1.3	1.0	-0.1	-1.9	2.0	1.9
Number of self-reported non-cancer illnesses	2.8	4.9	8.8	2.4	0.5	2.0	2.3	1.4	3.0	2.8	2.8	2.6	1.4	1.7	2.3
Relative age voice broke	2.7	4.1	14.5	-1.2	1.1	-0.2	-3.2	-2.9	-0.7	-1.5	-1.6	-2.6	-3.8	-0.6	-1.1
Basal cell carcinoma (self-reported)	2.7	3.2	6.2	-2.2	-1.1	-2.0	-0.8	-1.4	-2.0	-2.2	-2.5	-1.5	-1.0	-2.2	-1.5
Peak expiratory flow (PEF)	2.5	5.9	11.0	2.5	1.7	3.0	1.6	-2.5	1.1	2.7	2.5	2.8	2.2	2.4	3.3
Relative age of first facial hair	2.4	4.9	11.2	-2.3	0.3	-1.6	-2.9	-0.3	-1.5	-2.2	-2.2	-3.1	-3.4	-1.5	-2.5
Impedance of leg (right)	2.4	11.8	22.2	-3.0	1.6	-2.7	-3.8	-0.9	-4.7	-3.8	-3.7	-4.0	-3.8	-3.1	-4.1
Hair/balding pattern: Pattern 3	2.3	3.5	12.3	-0.6	-3.5	-1.6	3.2	1.5	-0.4	-0.6	-0.1	1.4	3.2	-1.2	-0.2
Illnesses of mother	2.3	2.8	4.5	-1.8	-0.3	-1.7	-2.0	0.6	-1.7	-2.0	-1.8	-2.0	-1.3	-1.5	-2.1
Diabetes diagnosed by doctor	2.3	3.8	8.1	2.1	1.9	2.3	0.4	0.7	2.8	2.2	2.1	1.4	-0.1	2.9	2.2
Crohns Disease (2017)	2.2	4.8	9.0	2.7	1.6	2.5	1.7	0.7	1.5	2.9	3.0	2.6	1.8	1.2	2.5
Ovarian Cancer	2.2	2.9	4.7	-2.0	-1.1	-1.5	-2.2	-1.6	-0.6	-1.5	-2.0	-2.2	-2.0	-1.5	-1.6
Gout (self-reported)	2.2	3.0	5.6	2.1	1.9	2.4	0.2	-1.0	1.2	2.2	2.0	1.5	0.2	2.3	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.7	5.9	-1.3	-0.1	-1.1	-2.2	-1.8	-1.1	-1.7	-1.8	-2.1	-2.4	-1.0	-1.4
Leg pain on walking	2.2	2.7	5.8	1.7	1.0	2.2	0.2	0.2	1.6	2.3	2.0	1.6	0.5	2.4	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	6.0	1.7	0.7	1.7	0.6	1.7	2.5	2.1	2.0	1.1	0.4	1.8	1.5
Rheumatoid Arthritis	2.1	2.9	6.6	-2.1	-1.8	-2.6	-0.1	0.2	-0.6	-2.1	-2.2	-1.5	-0.0	-2.0	-2.2
Systolic blood pressure, automated reading	2.1	6.0	10.7	-3.1	-1.6	-3.3	-0.8	2.1	-1.3	-3.1	-3.1	-2.5	-1.4	-2.5	-2.9
Long-standing illness, disability or infirmity	2.1	3.3	6.4	2.1	0.2	1.7	2.0	-0.4	2.5	1.9	2.1	2.3	1.7	1.0	2.1
Ever taken oral contraceptive pill	2.1	2.3	5.1	-1.0	-0.6	-0.8	-2.0	-2.2	-0.2	-1.6	-1.9	-2.0	-2.3	-1.0	-0.7
Tinnitus: Yes, now most or all of the time	2.1	2.4	4.3	2.0	1.4	2.1	0.8	-2.0	1.3	1.5	1.7	1.4	0.5	1.0	2.0
Number of incorrect matches in round	2.0	3.3	6.6	1.4	-1.7	0.9	2.5	1.1	2.6	1.7	1.5	2.2	2.4	1.0	1.9
Diabetes (self-reported)	2.0	3.1	7.7	1.8	1.6	2.2	0.5	0.3	1.9	2.0	2.0	1.4	0.2	2.8	2.1
Hair/balding pattern: Pattern 4	2.0	4.8	9.7	-2.2	0.1	-2.5	-1.5	-0.5	-2.9	-3.1	-2.7	-2.3	-1.3	-2.6	-2.3
Medication: Paracetamol	2.0	3.4	10.3	1.0	-1.2	0.1	3.2	3.2	1.1	0.7	1.8	2.0	2.7	-0.2	0.8
Medication for pain relief, constipation, heartburn	2.0	3.5	10.3	-1.7	-0.5	-1.0	-2.4	-3.2	-2.0	-1.5	-2.4	-1.9	-1.8	-0.8	-1.4
Medication: Paracetamol	2.0	3.1	7.2	1.3	-1.4	0.4	2.7	2.5	1.5	1.2	2.0	2.0	2.5	0.7	0.9
Alcohol usually taken with meals	1.9	3.0	7.6	1.6	2.7	2.3	-0.5	-2.5	1.8	1.3	0.8	0.7	-0.4	2.1	2.0
Leg fat percentage (right)	1.9	7.0	17.6	2.9	1.4	2.7	1.0	1.7	4.2	3.0	2.8	2.0	-0.0	4.1	2.5
Health satisfaction	1.9	2.4	5.2	1.5	0.0	1.3	2.0	-0.1	1.4	1.6	2.1	2.3	2.0	1.0	1.4
Illnesses of father: None of the above (group 1)	1.9	2.4	6.8	-1.8	-2.6	-2.1	0.7	1.2	-1.4	-1.3	-1.2	-0.7	0.5	-1.8	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	6.6	1.3	-0.1	0.9	1.5	2.6	1.2	1.8	1.9	1.6	1.3	1.5	1.1
Fed-up feelings	1.8	3.3	6.0	1.9	0.9	1.8	2.2	-0.4	0.7	2.3	2.2	2.4	2.2	1.2	1.8
Lung cancer (father)	1.8	2.1	5.9	-2.1	-2.4	-1.7	-1.0	1.1	-0.6	-0.9	-1.2	-1.5	-1.0	-0.7	-1.8
Angina (self-reported)	1.8	2.3	7.7	1.2	1.4	2.1	-0.0	-0.7	1.9	1.6	1.2	0.8	-0.5	2.8	1.8
Taking other prescription medications	1.7	2.7	6.4	1.4	-0.0	1.2	1.8	1.0	2.5	1.9	2.1	2.0	1.1	1.2	1.8
Illnesses of siblings	1.7	2.4	4.6	-2.1	-0.5	-1.9	-0.6	0.4	-2.2	-1.9	-1.6	-1.5	-0.3	-1.7	-2.0
Miserableness	1.7	3.0	5.0	2.0	1.4	2.2	0.5	-0.4	2.0	2.1	2.2	1.7	0.8	2.1	1.8
Angina	1.6	2.2	6.6	1.1	1.4	2.0	-0.1	-0.9	1.9	1.5	1.0	0.8	-0.5	2.6	1.8
Commuting to job workplace: Walk	1.6	1.7	3.0	-1.2	0.7	-0.7	-1.6	-1.6	-0.7	-1.4	-1.6	-1.6	-1.7	-1.2	-1.1
Alcohol drinker status: Never	1.6	1.9	7.7	1.1	-0.0	0.4	2.3	-0.2	0.1	1.2	1.4	2.0	2.8	0.1	1.0
Fasting Glucose	1.5	1.8	4.2	-1.4	-0.9	-1.5	-0.5	1.8	-1.6	-2.0	-1.5	-1.2	-0.6	-0.8	-1.2
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	5.0	-1.5	-1.1	-0.8	-1.9	0.4	1.2	-1.1	-1.1	-1.9	-2.2	0.1	-1.1
Time employed in main current job	1.5	1.7	5.1	-1.1	-1.8	-1.5	1.6	0.1	-0.7	-1.3	-1.1	0.1	1.6	-2.3	-0.8
Qualifications: A levels/AS levels or equivalent	1.5	3.3	6.0	-2.2	-0.8	-1.9	-1.5	-1.4	-2.4	-2.2	-2.0	-1.7	-0.5	-2.3	-1.9
Average weekly champagne plus white wine intake	1.5	2.0	5.8	1.5	2.4	2.0	0.2	-1.5	0.7	1.5	1.2	1.2	0.7	1.2	1.6
Leg fat percentage (left)	1.5	5.4	15.2	2.4	0.8	2.3	0.9	1.7	3.8	2.5	2.3	1.7	-0.2	3.9	2.2
Ever depressed for a whole week	1.5	1.8	5.5	1.0	2.4	1.8	-0.8	-0.7	1.4	1.4	0.9	0.3	-0.9	1.7	1.4
Depressed Affect (Nagel 2018)	1.4	2.9	5.2	2.3	1.5	2.0	1.4	-1.1	1.1	2.1	2.0	2.0	1.5	1.3	1.7
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	5.9	-0.8	-0.4	-1.5	0.3	2.3	-1.7	-1.3	-0.6	-0.7	-0.1	-2.4	-1.1
Medication: Lansoprazole	1.4	1.6	4.7	1.5	0.2	1.5	-0.4	1.2	2.2	1.7	1.4	0.5	-0.5	1.4	0.9
Neck or shoulder pain in last month	1.4	2.0	4.8	1.2	0.7	1.2	1.4	1.0	2.2	1.6	1.7	1.4	1.1	1.7	1.3
Medication: Omeprazole	1.4	1.6	9.6	0.4	-1.6	-0.3	1.7	3.1	0.6	0.8	0.9	1.0	1.3	0.1	0.2
Risk taking	1.4	2.0	4.7	1.2	-1.3	0.9	2.2	0.9	1.5	1.3	1.4	1.7	1.8	0.6	1.6
Body Mass Index (BMI) (2010)	1.3	1.8	6.0	1.4	0.7	1.7	0.2	0.1	2.4	1.3	1.0	1.0	0.2	2.0	1.7
Type 2 Diabetes (T2D) (2018)	1.3	2.4	7.8	1.4	2.3	1.9	-0.2	-0.0	1.9	1.3	1.3	0.7	-0.9	2.8	1.6
Hearing difficulty/problems: Yes	1.3	2.0	3.9	-1.2	-0.7	-1.6	-0.6	1.9	-0.9	-1.5	-1.4	-1.5	-1.1	-2.0	-1.8
Medication: Co-codamol	1.3	1.5	2.6	-1.6	-0.9	-1.4	-0.5	1.1	-1.2	-1.5	-1.2	-1.2	-1.1	-1.0	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	6.0	1.7	2.1	1.8	-1.9	-0.9	2.4	1.5	1.0	-0.5	-2.4	2.2	1.0
Medication: Ventolin 100micrograms inhaler	1.3	1.7	4.8	-1.0	-1.5	-1.6	0.6	2.2	-1.4	-0.9	-0.3	-0.2	0.7	-2.0	-1.3
Medication: Aspirin	1.3	1.6	7.9	1.0	0.2	1.3	-0.4	0.6	2.8	1.2	1.1	0.4	-0.6	1.8	1.5
Pain experienced in last month	1.3	2.2	4.7	-1.7	-1.2	-2.0	-1.1	0.2	-1.2	-1.7	-2.2	-1.4	-0.5	-1.4	-1.8
Impedance of whole body	1.3	6.7	21.5	-2.2	1.8	-2.1	-2.1	-0.7	-4.6	-2.9	-2.6	-2.4	-1.7	-3.0	-3.1
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	2.9	1.7	-0.1	1.4	0.3	-1.6	1.0	1.0	1.0	1.1	0.7	0.7	1.6
Qualifications: CSEs or equivalent	1.2	1.6	4.2	1.1	0.0	0.5	1.3	1.9	2.0	1.5	1.8	1.2	1.4	-0.1	0.5
Hair/balding pattern: Pattern 2	1.2	1.6	4.2	0.3	1.9	1.0	-1.9	-1.7	1.1	0.7	0.0	-0.9	-2.1	1.1	0.0
Pain all over the body in last month	1.2	1.3	2.5	1.3	0.4	0.2	1.0	1.5	1.6	1.3	1.2	1.1	1.6	1.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	6.6	2.1	1.2	2.0	2.0	-1.2	0.7	2.4	2.1	2.6	2.4	1.9	2.1
Standing height	1.2	12.2	21.7	4.3	3.0	4.0	1.8	-1.7	3.0	4.7	4.3	3.7	2.7	3.8	3.5
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.9	1.3	0.3	0.8	1.7	1.0	1.3	1.6	1.6	1.5	1.2	0.8	0.8
Alcohol drinker status: Previous	1.2	1.3	8.9	0.1	-1.5	-0.4	1.1	3.0	1.3	0.3	0.6	0.3	0.6	-0.7	-0.2
Irritable Bowel Disease (IBD)	1.1	2.7	5.0	2.1	1.1	2.1	1.2	0.1	0.6	2.1	2.2	2.2	1.6	0.1	2.1
Lupus	1.1	1.6	8.3	-0.5	0.8	0.1	-2.3	-0.3	0.8	-0.6	-1.0	-1.7	-2.9	0.6	-0.2
Average weekly spirits intake	1.1	1.3	2.2	1.5	1.0	1.3	1.4	0.3	1.0	1.1	1.2	1.4	1.2	0.3	1.3
Ever used hormone-replacement therapy (HRT)	1.1	1.3	5.0	0.2	1.3	0.7	-2.2	0.0	1.1	0.1	-0.2	-1.2	-2.2	1.0	-0.1
Medication: Metformin	1.1	1.6	5.7	0.9	1.9	1.4	-0.8	0.2	1.6	0.9	0.8	0.1	-1.2	2.4	1.1
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	4.2	0.9	-0.8	0.2	1.3	2.1	1.8	1.0	0.9	0.9	1.1	0.5	0.5
Medication: Ramipril	1.1	1.5	5.1	0.4	0.8	1.0	-1.9	-0.1	2.3	0.2	0.3	-0.6	-1.8	1.7	0.6
Alcohol intake versus 10 years previously	1.1	1.7	5.5	1.5	0.7	1.7	-0.2	0.3	1.7	1.4	1.5	0.7	-0.5	2.3	1.2
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	5.9	2.1	1.2	1.9	1.7	-1.2	0.6	2.4	2.1	2.4	2.2	1.7	2.1
Pulse wave reflection index	1.1	1.4	2.6	-1.6	-1.6	-1.4	0.3	1.0	-1.0	-1.4	-1.3	-0.8	0.1	-1.3	-1.3
Comparative body size at age 10	1.1	3.1	14.4	1.2	-2.3	1.0	0.4	1.0	3.8	1.6	1.7	0.9	0.3	2.3	1.5
Age at last live birth	1.1	1.6	5.7	-1.4	-0.3	-1.1	-0.9	0.3	-2.0	-1.1	-1.0	-1.0	-0.2	-2.4	-1.5
Knee pain experienced in last month	1.1	1.8	3.4	1.2	0.7	1.7	1.2	-0.3	0.6	1.7	1.8	1.6	0.6	1.4	1.8
Neuroticism (Nagel 2018)	1.0	2.4	5.0	2.0	2.2	1.5	1.4	-1.7	1.0	1.5	1.2	1.9	1.5	0.3	1.2
Schizophrenia (2018)	1.0	2.1	6.7	1.7	-0.1	1.6	0.9	-0.7	2.6	1.6	1.1	1.4	0.6	1.5	2.0
Crohns Disease (2012)	1.0	1.7	3.7	1.5	0.6	1.2	1.6	0.4	0.3	1.3	1.4	1.9	1.6	0.5	1.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	5.2	-0.9	0.7	-0.1	-1.7	0.3	0.2	-0.6	-0.9	-1.4	-2.3	0.7	-0.4
Serious illness, injury or assault to yourself	1.0	1.2	5.0	0.9	-0.4	0.8	1.0	-1.1	2.2	0.7	0.7	1.0	1.0	0.8	1.3
Sitting height	1.0	7.3	13.5	3.0	1.3	2.7	2.0	-1.3	2.7	3.7	3.1	3.2	2.6	3.1	2.7
Loud music exposure frequency	1.0	1.1	3.8	0.1	-1.7	-0.1	1.9	0.3	0.5	0.8	0.9	1.1	1.9	-0.4	0.3
Qualifications: College or University degree	1.0	3.1	9.3	-1.6	1.0	-0.7	-1.8	-3.0	-2.5	-1.8	-2.1	-1.4	-0.5	-1.9	-1.3
Average weekly red wine intake	1.0	1.4	2.9	1.2	0.5	1.4	1.0	-0.2	1.4	1.3	1.3	1.4	0.9	1.1	1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	3.0	-0.9	0.0	-1.1	-0.1	-0.4	-1.7	-1.4	-1.1	-0.9	-0.9	-1.1	-1.2
Ulcerative Colitis	0.9	1.4	3.1	-1.5	-1.4	-1.3	-0.6	0.2	-1.1	-1.4	-1.5	-0.9	-0.3	-1.8	-1.0
Blood Eosinophil Count	0.9	6.6	11.9	2.6	1.4	3.0	2.4	-2.7	1.2	2.6	2.5	3.4	2.9	1.8	3.5
Height	0.9	17.2	31.2	5.3	3.7	4.5	2.7	-0.6	3.1	5.6	5.3	4.7	3.4	4.1	4.1
Respiratory disease	0.9	2.1	5.6	1.2	-1.0	0.8	2.1	-0.1	0.3	1.6	1.6	2.1	2.4	0.9	1.3
Medication for hormone replacement therapy	0.9	1.0	3.6	-0.5	0.4	0.0	-1.9	-0.2	-1.1	-0.6	-0.7	-1.2	-1.5	-1.1	-0.6
Diabetes (mother)	0.9	1.2	4.4	1.4	2.1	1.4	0.4	0.1	0.2	1.0	1.1	0.7	-0.3	1.5	0.9
Chronic bronchitis/emphysema (father)	0.9	1.1	2.5	1.4	0.3	1.0	1.1	0.0	0.7	1.1	1.3	1.6	1.2	0.1	1.3
Neuroticism score	0.9	1.9	3.0	1.7	1.4	1.3	1.1	-1.3	1.5	1.5	1.2	1.7	1.6	0.5	1.0
Number of live births	0.9	1.2	5.6	-1.8	-2.4	-1.2	0.5	-0.8	-1.0	-1.0	-0.9	-0.5	-0.4	-0.6	-0.4
Depression (self-reported)	0.9	1.1	3.9	0.9	0.2	0.8	0.7	0.2	2.0	1.5	1.1	1.0	0.8	1.4	0.6
Length of working week for main job	0.9	1.0	2.6	1.4	1.6	1.0	-0.8	0.5	1.6	0.8	1.0	0.1	-0.5	1.0	0.5
Breastfed as a baby	0.9	1.1	2.4	-1.5	-0.9	-1.2	-0.2	-0.9	0.6	-1.5	-1.5	-1.0	-0.5	-1.1	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.6	1.2	1.1	1.6	0.7	-0.9	1.0	1.6	1.3	1.2	0.3	1.1	1.2
Medication: Ibuprofen	0.9	1.1	4.2	-0.5	-0.0	-1.1	0.2	1.3	-1.5	-1.2	-0.6	-0.6	-0.0	-2.0	-0.9
Comparative height size at age 10	0.9	5.1	11.8	2.1	0.9	1.4	3.1	1.3	1.4	2.9	2.9	3.0	3.4	1.0	1.5
Suffer from ‘nerves’	0.9	1.4	3.0	1.1	-0.4	0.7	1.7	0.2	1.6	1.2	1.1	1.7	1.7	0.3	1.1
Had major operations	0.9	1.1	2.0	-1.1	0.4	-0.9	-1.4	-0.7	0.2	-1.1	-1.2	-1.4	-1.4	-0.9	-1.1
Supplements: Vitamin C	0.9	1.1	3.2	1.2	1.8	1.2	-0.1	-0.2	-0.1	1.4	1.2	0.7	0.0	1.7	0.8
Osteoarthritis (self-reported)	0.9	1.1	6.9	-0.3	-0.5	-0.9	1.2	2.6	0.8	0.5	0.7	0.5	1.6	-0.1	-0.5
Medication: Aspirin	0.9	1.1	6.3	0.7	-0.0	1.0	-0.7	0.3	2.5	0.9	0.8	0.0	-0.8	1.4	1.0
Unable to work because of sickness or disability	0.9	1.2	3.9	0.7	-0.7	0.3	1.9	0.0	-0.3	1.0	1.0	1.7	2.0	0.0	0.6
HDL Cholesterol	0.8	1.3	4.8	0.4	-0.1	0.2	2.1	0.3	-1.0	0.6	0.9	1.7	2.2	-0.0	0.8
Supplements: Zinc	0.8	0.8	3.3	0.2	-0.2	-0.0	1.8	1.0	-0.5	0.6	1.0	1.1	1.6	0.0	0.1
Current tobacco smoking	0.8	1.2	7.0	-0.6	-2.0	-0.6	0.9	2.6	1.0	0.2	0.7	0.2	0.5	-0.4	0.1
Past tobacco smoking	0.8	1.4	8.1	0.5	0.9	0.3	1.1	-2.8	-1.4	0.0	-0.1	1.0	1.7	-0.4	0.5
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.9	1.0	-0.6	0.7	0.9	0.8	-0.4	1.2	1.4	1.4	1.3	-0.7	0.9
Worrier / anxious feelings	0.8	1.5	2.5	1.2	1.2	1.3	0.7	-1.4	1.2	1.6	1.0	1.4	0.8	1.6	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	4.1	-1.0	-0.6	-1.2	-0.1	-0.2	-1.0	-1.0	-1.2	-0.7	-0.2	-2.0	-1.0
Mood swings	0.8	1.5	5.5	1.2	0.8	1.0	0.6	0.6	2.3	1.5	1.5	1.0	0.6	1.6	0.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.6	1.2	1.1	1.3	-1.6	-0.1	1.2	0.8	0.8	-0.4	-1.6	1.5	0.7
Commuting to job workplace: Public transport	0.8	0.9	2.6	-0.5	1.0	0.3	-1.6	-1.0	-0.9	-0.8	-1.0	-1.1	-1.6	-0.2	-0.3
Ever smoked	0.8	1.4	10.6	-0.6	-1.5	-0.4	-0.5	3.3	1.4	0.2	0.3	-0.6	-0.9	0.1	-0.4
Number of operations (self-reported)	0.8	1.2	3.4	-0.9	-0.6	-1.3	-0.7	1.7	0.4	-1.1	-1.0	-1.0	-0.7	-1.8	-1.1
Commuting to job workplace: Cycle	0.8	0.9	3.6	0.7	0.3	0.2	1.6	0.3	0.1	0.9	1.3	1.3	1.9	-0.3	0.4
Bipolar Disorder or Schizophrenia	0.7	1.6	3.9	1.0	-0.9	1.2	1.2	-1.2	1.9	1.0	0.8	1.5	1.1	0.6	2.0
Verbal and Numeric Reasoning (VNR)	0.7	1.6	13.5	0.1	3.7	0.4	-1.1	-1.0	-0.6	-0.5	-0.3	-0.9	-1.1	0.6	-0.3
Blood Platelet Count	0.7	7.7	12.9	-3.4	-2.5	-3.2	-2.3	2.1	-1.5	-3.0	-3.0	-3.3	-2.4	-2.2	-3.6
Smoking Status	0.7	1.7	7.9	-0.1	-0.9	0.2	-0.9	2.8	2.6	0.5	0.8	-0.7	-1.6	0.9	0.2
Medication: Simvastatin	0.7	1.0	3.1	0.5	1.7	0.9	-0.9	0.4	1.6	0.5	0.5	-0.2	-1.0	1.8	0.6
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.7	-0.6	-0.5	-1.1	0.8	0.5	-2.2	-0.3	-0.1	0.1	1.1	-1.8	-0.9
Exposure to tobacco smoke outside home	0.7	0.9	2.1	1.2	-0.3	0.7	0.4	1.4	1.2	1.2	1.2	1.0	0.7	0.8	0.6
Medication: Gliclazide	0.7	0.8	2.6	1.2	1.2	1.1	-0.2	0.2	1.6	0.6	0.5	0.3	-0.5	1.1	1.0
Guilty feelings	0.7	1.0	2.8	0.8	1.4	1.0	1.1	-1.7	1.0	0.5	0.7	1.1	0.9	0.1	0.7
Hearing aid user	0.7	0.8	2.0	-1.2	-1.2	-0.9	-0.7	0.6	-0.4	-0.8	-0.8	-0.8	-0.5	-1.4	-1.1
High cholesterol (Self-reported)	0.7	1.3	3.6	0.1	1.7	1.0	-1.3	0.2	1.5	0.6	0.2	-0.6	-1.9	1.6	0.5
Worry (Nagel 2018)	0.6	1.3	2.3	1.4	1.1	0.9	1.0	-0.9	1.3	1.4	1.0	1.5	1.3	0.2	0.8
Breast Cancer	0.6	1.4	3.2	-1.6	-1.3	-1.8	0.1	1.8	0.0	-1.2	-0.9	-1.0	0.2	-1.2	-1.4
HbA1C	0.6	0.7	2.0	0.3	0.8	0.5	0.8	1.4	0.6	0.8	1.1	0.8	1.0	0.9	0.3
Sensitivity / hurt feelings	0.6	0.9	1.9	1.2	1.2	0.8	1.4	-1.2	-0.1	0.7	0.4	1.3	1.1	0.2	0.9
Severe depression (siblings)	0.6	0.7	1.6	1.1	1.3	0.8	0.1	0.4	1.2	1.0	1.0	0.5	0.2	0.6	0.5
Maternal smoking around birth	0.6	0.8	3.3	0.8	-0.1	0.7	0.2	0.9	1.6	0.6	0.8	0.5	-0.1	1.8	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.1	-1.0	0.9	-0.8	-0.4	0.3	-0.4	-0.9	-0.8	-0.9	-0.7	-1.4	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	4.9	0.8	0.8	0.7	-1.6	-1.1	2.0	0.5	-0.2	-1.0	-2.2	1.3	0.4
Supplements: Glucosamine	0.6	0.8	3.8	0.6	0.8	0.8	0.0	1.6	0.1	0.8	0.4	0.0	-0.6	1.9	0.6
Allergy	0.6	1.3	4.0	-1.0	0.2	-0.4	-1.3	0.1	1.1	-1.2	-1.5	-1.7	-2.0	0.5	-0.6
Fluid intelligence score	0.6	1.3	9.1	0.0	3.0	0.3	-1.2	-1.0	-0.7	-0.4	-0.4	-0.9	-1.1	0.9	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.2	0.8	0.2	0.6	0.7	0.6	1.8	1.3	1.4	0.9	0.7	0.8	0.7
Pulse rate	0.6	1.1	2.1	-0.9	-0.3	-1.0	-0.6	-0.9	-1.2	-1.4	-1.5	-1.0	-0.8	-1.2	-1.2
Medication: Cholesterol lowering	0.6	1.0	3.1	0.4	1.6	1.0	-1.0	0.8	1.8	0.5	0.3	-0.4	-1.3	0.9	0.6
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.2	0.5	-0.2	-0.0	0.8	1.3	1.5	0.6	1.1	0.9	1.3	-0.5	0.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.7	0.2	1.3	0.2	-1.1	-1.2	-0.9	-0.6	-0.6	-0.8	-1.2	0.0	-0.5
Number of full brothers	0.6	0.7	1.5	0.6	-0.5	0.6	1.2	0.3	1.2	1.1	1.2	0.8	0.7	0.3	0.9
Age at first live birth	0.6	1.0	4.1	-0.7	-0.2	-1.0	-0.4	0.6	-1.8	-0.9	-0.7	-0.4	0.5	-2.0	-1.3
Heart disease (mother)	0.6	0.7	2.0	-0.4	0.3	-0.2	-1.4	0.2	0.4	-0.4	-0.9	-1.1	-1.4	-0.9	-0.9
Smoking status: Previous	0.6	0.8	6.1	-0.2	-0.5	-0.2	-0.8	2.5	0.9	0.1	0.2	-0.6	-1.0	0.6	-0.5
Wears glasses or contact lenses	0.6	0.7	2.2	-0.7	0.6	-0.2	-1.5	-0.7	0.2	-0.9	-0.9	-1.2	-1.4	0.0	-0.6
Average weekly beer plus cider intake	0.6	0.8	6.5	-0.4	-1.5	-0.6	0.1	2.5	0.4	0.2	0.3	-0.1	0.2	-0.0	-0.5
Depression (Nagel 2018)	0.5	0.7	3.8	0.7	1.9	0.8	0.8	-0.6	-0.3	0.5	0.6	0.9	0.9	-0.6	0.4
Reaction Time	0.5	1.0	1.9	1.4	0.8	1.0	0.8	0.9	-0.0	1.1	1.4	1.1	1.2	0.6	0.6
Mean Putamen Volume	0.5	0.6	2.5	0.6	1.6	0.9	-0.2	-1.1	0.2	0.7	0.6	0.4	-0.0	0.7	0.6
LDL Cholesterol	0.5	0.9	4.9	0.5	2.2	0.6	-1.2	-1.4	-0.7	-0.1	0.0	-0.4	-0.8	-0.3	0.2
Schizophrenia (2014)	0.5	1.2	3.4	1.0	-0.8	1.1	1.1	-0.9	1.9	1.0	0.4	1.2	0.7	0.6	1.6
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.8	0.4	0.5	1.1	-0.4	-0.4	1.3	0.3	0.4	0.1	-0.5	1.0	1.1
Tanning	0.5	5.5	13.2	2.5	1.6	3.2	-0.3	-0.1	3.6	2.8	2.3	1.5	-0.5	3.1	2.9
Ever had hysterectomy (womb removed)	0.5	0.6	1.0	0.7	0.2	0.6	0.8	0.2	0.4	1.0	1.0	0.8	0.7	1.0	0.9
Townsend deprivation index at recruitment	0.5	0.7	2.0	0.8	-0.0	0.6	0.7	0.8	1.4	0.9	1.2	0.7	0.4	0.6	0.8
Medication: Levothyroxine sodium	0.5	0.9	2.6	-0.7	-0.3	-1.4	1.1	0.9	-0.8	-0.8	-0.8	0.0	1.1	-1.6	-0.7
Nervous feelings	0.5	0.9	2.1	1.2	1.5	1.2	0.4	-1.3	0.4	1.1	0.7	1.2	0.3	0.4	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.8	1.2	0.4	0.9	1.2	-0.1	0.7	0.9	1.1	1.3	1.0	0.5	0.8
Mouth/teeth dental problems	0.5	0.7	2.4	0.4	-0.5	0.5	1.2	0.1	0.7	0.9	0.6	1.1	1.5	0.5	1.0
Impedance of arm (right)	0.5	2.5	12.2	-0.9	1.8	-1.0	-0.6	-0.3	-3.5	-1.4	-0.9	-0.8	-0.0	-2.3	-1.7
Father’s age at death	0.5	0.7	2.8	-0.5	-1.7	-0.8	1.3	-0.3	-0.0	0.0	0.3	0.6	1.6	0.0	-0.0
Mouth/teeth dental problems: Dentures	0.5	0.9	1.8	-1.1	-1.0	-1.3	0.7	1.3	-0.9	-0.9	-0.3	-0.1	0.4	-1.3	-1.1
Asthma	0.5	1.0	2.9	1.0	-0.1	0.6	1.4	0.1	0.1	1.2	1.3	1.5	1.7	-0.1	0.9
Prospective memory result	0.5	0.6	2.6	0.7	0.4	0.7	0.1	0.3	1.6	0.9	0.9	0.7	0.4	0.4	1.0
Worry too long after embarrassment	0.5	0.9	7.0	0.0	1.2	0.0	-0.4	-2.6	-0.0	-0.4	-1.0	-0.2	-0.2	-0.7	-0.3
Migraine (self-reported)	0.5	0.7	2.0	-0.8	-0.7	-1.0	0.4	-0.4	-0.4	-1.4	-0.9	-0.4	0.5	-1.2	-0.8
Pulse rate, automated reading	0.5	1.6	4.0	-1.1	-0.7	-1.3	-1.0	-0.9	-0.9	-2.0	-1.9	-1.3	-1.1	-1.0	-0.9
Alcohol intake frequency.	0.5	1.3	4.3	0.6	-0.7	0.3	2.1	0.3	0.4	1.1	1.3	1.5	2.0	0.1	0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.8	-0.8	1.0	-0.1	-0.8	1.3	-1.1	-0.4	-0.2	-0.7	-0.8	0.7	-0.5
Ever had bowel cancer screening	0.5	0.6	2.4	0.7	1.5	1.0	-0.1	-1.3	0.6	0.6	0.3	0.4	-0.3	0.3	0.9
Asthma (self-reported)	0.5	0.9	3.0	0.9	-0.3	0.4	1.4	0.2	0.0	1.1	1.2	1.4	1.7	-0.1	0.7
Smoking status: Current	0.5	0.7	3.9	-0.6	-1.6	-0.5	0.2	2.0	1.1	-0.0	0.4	-0.3	-0.4	-0.3	-0.0
Mother’s age at death	0.5	0.7	1.5	-0.9	-1.2	-1.1	-0.2	0.7	-1.0	-0.6	-0.6	-0.5	0.0	-1.0	-0.8
Medication: Blood pressure	0.5	1.0	5.2	-0.4	-2.3	-0.6	1.5	0.8	0.8	0.3	0.4	0.6	1.1	0.6	0.2
Irritability	0.5	0.9	1.9	1.2	1.4	0.6	0.6	1.0	1.4	1.0	1.1	0.9	0.8	-0.2	0.3
Bipolar Disorder (2018)	0.4	0.6	1.8	-0.4	-1.4	-0.1	0.8	-1.1	-0.1	-0.4	-0.0	0.7	1.0	-1.1	0.7
Alzheimer’s Disease (in mother)	0.4	0.5	1.7	0.5	-0.5	0.4	1.0	-0.6	1.3	0.3	0.3	0.7	0.6	0.8	0.9
Alzheimer’s Disease (in father)	0.4	0.4	2.6	-0.0	1.6	0.4	0.0	-0.5	-0.5	0.1	0.4	0.3	0.6	-0.9	0.1
Ulcerative Colitis (UC)	0.4	0.8	1.7	0.9	0.3	1.2	0.7	-0.5	0.0	0.9	1.0	1.3	1.0	-0.5	1.2
Bipolar Disorder (2011)	0.4	0.4	1.6	0.3	0.5	0.6	1.2	-0.4	-0.1	0.3	0.3	0.8	1.0	-0.5	0.7
Allergy or Eczema	0.4	1.1	5.9	-0.3	-0.3	-0.7	0.9	-0.9	-2.4	-0.2	0.0	0.7	1.6	-1.2	-0.5
Hand grip strength (left)	0.4	1.1	6.7	-1.5	-2.6	-1.1	-0.3	-0.4	0.4	-0.8	-0.9	-0.8	-0.3	-0.3	-0.5
Number of treatments/medications taken	0.4	0.8	3.5	0.6	0.0	0.4	0.5	1.6	1.9	0.8	1.0	0.5	-0.1	0.5	0.4
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.2	0.7	1.5	0.6	0.8	-0.9	0.1	0.4	0.2	0.8	0.7	-0.5	0.3
Pack years adult smoking proportion	0.4	0.5	1.1	0.6	-0.5	0.5	0.5	0.6	1.1	0.8	1.1	0.9	0.6	0.2	1.0
Hayfever, allergic rhinitis or eczema	0.4	0.9	4.6	-0.4	-0.7	-0.7	0.3	-0.8	-2.1	-0.1	0.1	0.5	1.2	-1.5	-0.7
Happiness	0.4	0.5	1.5	0.2	1.0	-0.0	-0.8	-1.0	-0.5	-0.4	-0.4	-0.6	-0.6	-1.2	-0.5
Impedance of arm (left)	0.4	2.0	10.5	-0.6	2.1	-0.8	-0.4	-0.4	-3.2	-1.2	-0.7	-0.5	0.1	-2.0	-1.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.5	0.3	-0.1	-0.0	1.7	-0.1	-0.8	0.3	0.6	1.2	1.9	-0.8	0.4
High blood pressure (siblings)	0.4	0.6	1.7	-0.6	-1.3	-0.6	-0.4	0.9	1.1	-0.6	-0.6	-0.6	-0.5	-1.0	-0.0
Eye problems/disorders: None of the above	0.4	0.5	3.5	0.6	0.1	0.4	0.2	-1.9	-0.8	-0.2	-0.3	0.2	0.4	-0.4	0.4
Medication: Seretide 50 evohaler	0.4	0.5	1.7	-0.7	0.0	-0.8	0.2	1.1	-0.3	-0.4	-0.4	-0.4	0.1	-1.3	-1.1
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.6	-0.3	-1.3	-1.0	0.3	-0.0	-0.8	-0.3	-0.4	-0.3	0.5	-0.9	-0.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.9	-0.2	-1.1	-0.2	1.4	0.4	-0.6	0.1	0.1	0.8	1.4	-0.3	0.1
Loneliness, isolation	0.4	0.5	3.5	0.7	0.6	0.6	0.5	-1.9	-0.6	0.3	0.1	0.7	0.4	-0.1	0.6
Friendships satisfaction	0.4	0.5	1.8	-0.1	-0.7	-0.8	1.3	0.5	0.3	-0.2	-0.0	0.2	1.2	-0.7	-0.4
Eye problems/disorders: Cataract	0.4	0.5	2.6	-1.1	-0.8	-0.7	-0.3	1.6	-0.2	-0.3	-0.2	-0.5	-0.2	-0.4	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.6	1.0	1.6	0.7	-0.3	-1.1	0.6	0.1	0.3	-0.0	-0.7	0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.8	1.1	1.0	1.1	0.7	-1.3	-0.1	1.1	0.5	1.0	0.6	1.1	1.0
Eye problems/disorders: Glaucoma	0.4	0.4	2.1	0.7	0.8	0.4	0.4	0.3	1.4	0.6	0.5	0.4	0.3	0.6	0.4
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.4	-0.0	0.5	-0.3	-0.6	1.0	1.2	-0.5	-0.2	-0.8	-0.9	0.2	-0.5
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.0	-0.9	1.7	-0.2	-0.7	-1.3	-1.2	-1.2	-0.8	-0.9	-0.9	-0.2	-0.2
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	0.3	0.9	0.4	0.7	-1.2	0.8	0.0	0.0	0.7	0.9	-0.1	0.7
Triglycerides	0.3	0.4	1.7	-0.1	-0.4	-0.1	-1.3	-1.0	-0.3	-0.4	-0.4	-0.8	-1.0	0.2	-0.6
Blood Red Count	0.3	2.5	9.3	-1.4	-1.4	-1.0	-1.1	-3.0	-0.7	-1.6	-2.4	-1.4	-1.7	-0.8	-0.6
Heel T-Score	0.3	2.8	9.2	0.9	2.7	1.5	-2.3	0.5	2.0	0.6	-0.0	-1.2	-3.0	1.5	0.5
Lung FVC	0.3	1.7	4.1	-0.7	-1.1	-1.2	2.0	0.8	-2.0	-0.5	-0.3	0.7	2.0	-1.8	-0.3
Neuroticism	0.3	0.7	2.4	1.0	1.1	0.6	0.5	-1.5	0.9	0.7	0.3	0.8	0.9	-0.7	0.2
Chronotype (morning person)	0.3	0.7	2.9	-0.4	-0.2	-0.0	-1.7	-0.2	0.6	-0.0	-0.5	-1.1	-1.7	0.4	-0.6
Hair Pigment	0.3	8.1	22.0	-2.6	-4.7	-3.8	2.2	1.4	-2.7	-2.4	-1.9	-0.3	2.7	-4.0	-2.5
Hand grip strength (right)	0.3	0.7	2.2	-1.1	-1.5	-0.8	-0.9	-0.6	1.1	-0.6	-0.8	-0.9	-0.6	-0.0	-0.3
Had other major operations	0.3	0.3	1.2	0.7	-0.5	0.1	0.5	0.1	1.1	0.2	0.1	0.7	0.8	-0.3	0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	2.0	0.2	-0.6	-0.4	0.8	-0.2	-1.4	0.2	0.2	0.4	1.2	-0.2	-0.4
Glaucoma (self-reported)	0.3	0.3	1.7	0.3	-0.0	-0.4	0.9	1.3	1.0	0.1	0.1	0.2	0.4	-0.0	-0.1
Birth weight	0.3	0.5	0.8	-0.9	-0.8	-0.8	-0.6	0.7	-0.6	-0.4	-0.5	-0.8	-0.8	-0.7	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.1	3.6	0.8	0.7	0.5	1.7	-0.3	-0.5	1.1	1.0	1.5	1.9	0.3	0.5
Emphysema/chronic bronchitis	0.3	0.4	2.4	0.6	-0.1	-0.5	0.1	1.5	0.8	0.2	0.4	0.2	0.6	-0.4	-0.4
Mean time to correctly identify matches	0.3	0.5	1.1	1.0	0.7	1.0	0.5	0.2	0.3	0.9	1.0	0.7	0.5	0.6	0.8
Number of full sisters	0.3	0.3	1.3	0.2	0.0	-0.1	-1.0	0.4	0.5	-0.4	-0.2	-0.8	-1.1	-0.6	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.0	-0.4	-1.0	-0.5	-0.7	1.0	0.2	-0.4	-0.3	-0.8	-0.8	-0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.0	0.9	0.1	0.2	0.9	-0.4	-0.3	0.9	1.0	1.0	1.4	0.4	0.2
Qualifications: nursing, teaching	0.3	0.5	1.6	0.3	1.3	0.4	0.9	-0.8	-0.3	0.2	0.5	0.7	1.2	0.5	0.3
Back pain experienced in last month	0.3	0.5	1.4	1.2	0.3	0.8	0.6	0.2	0.4	0.7	1.1	0.8	0.2	0.5	0.9
Breast cancer (self-reported)	0.3	0.3	0.9	-0.3	-0.7	-0.6	-0.1	-0.9	-0.1	-0.8	-0.9	-0.4	0.1	-0.2	-0.5
Osteoporosis (self-reported)	0.3	0.3	2.5	0.1	0.6	0.1	0.6	-0.6	-1.6	-0.3	-0.1	0.4	0.2	-0.3	0.2
Financial situation satisfaction	0.3	0.3	1.4	0.1	-0.4	-0.3	1.2	0.8	-0.5	-0.0	0.3	0.7	0.9	-0.4	-0.2
Medication: Bendroflumethiazide	0.3	0.4	1.5	-0.7	-1.2	-0.8	0.8	0.4	0.7	-0.4	-0.4	0.0	0.2	0.5	-0.2
Medication: Lisinopril	0.3	0.4	0.8	-0.8	-0.6	-0.7	-0.8	0.0	0.8	-0.3	-0.3	-0.7	-0.4	0.1	-0.9
Illnesses of father: High blood pressure	0.3	0.3	2.1	-0.2	0.1	-0.2	-0.2	1.2	1.4	-0.5	-0.4	-0.2	0.1	0.1	0.1
Age started oral contraceptive pill	0.3	0.3	1.0	0.5	0.1	0.7	0.2	-0.7	0.3	0.8	0.6	0.5	0.2	1.0	0.7
Vascular/heart problems diagnosed by doctor	0.3	0.9	6.4	-0.1	1.2	-0.1	-0.4	-0.4	-2.5	-0.4	-0.3	-0.4	0.1	-1.1	-1.0
Pack years of smoking	0.3	0.5	1.3	0.4	-0.7	0.4	0.6	0.6	1.1	0.6	0.9	0.7	0.6	0.3	1.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	-0.6	-0.6	-0.4	-0.5	-0.2	0.2	-0.4	-0.8	-0.5	-0.7	-0.0	-0.3
Major Depression (MDD)	0.2	0.2	0.8	-0.7	-0.9	-0.1	-0.2	0.8	-0.2	0.0	0.4	-0.1	0.3	0.4	-0.2
Age at First Birth	0.2	0.3	1.3	-0.1	0.5	0.1	0.3	-0.4	-1.1	0.1	0.0	0.4	0.8	-0.9	-0.0
Neuroticism (2016)	0.2	0.3	0.8	-0.1	0.9	0.1	-0.3	0.7	0.6	-0.4	-0.4	-0.6	-0.8	-0.2	-0.5
Blood White Count	0.2	1.4	2.6	1.2	-0.1	1.2	1.0	-1.5	1.3	1.2	0.9	1.4	0.8	1.0	1.6
Cardiovascular Disease	0.2	0.5	2.3	-0.2	-1.0	-0.4	0.7	1.1	1.5	0.1	0.1	0.2	-0.1	0.7	0.2
Hypothyroidism (self reported)	0.2	0.5	1.5	0.3	0.6	0.2	1.2	-0.3	-1.1	0.2	0.3	0.8	1.2	-0.2	0.3
Vitamin and mineral supplements	0.2	0.3	0.9	-0.8	-0.6	-0.4	0.2	-0.1	0.2	-0.6	-0.7	-0.4	-0.6	-1.0	-0.4
Diabetes (father)	0.2	0.2	0.9	0.3	-0.9	-0.1	0.6	-0.3	-0.0	0.3	0.2	0.4	0.5	-0.4	0.3
Average weekly fortified wine intake	0.2	0.2	0.7	0.3	-0.8	0.1	-0.2	-0.4	0.8	-0.3	-0.4	-0.1	-0.4	-0.1	0.7
Age when periods started (menarche)	0.2	0.5	1.3	-1.0	-0.8	-0.8	0.3	0.8	-0.3	-0.7	-0.5	-0.5	-0.2	-1.2	-0.6
High blood pressure	0.2	0.5	2.6	-0.6	-1.5	-0.6	0.2	0.9	1.6	-0.3	-0.1	-0.0	-0.1	0.2	0.2
Medication: Atenolol	0.2	0.3	2.5	-0.0	-0.2	0.2	0.2	-0.0	1.6	0.7	0.3	0.3	0.2	0.1	0.4
Had menopause	0.2	0.3	1.4	-0.4	-0.1	-0.5	0.5	0.4	-1.2	-0.3	-0.4	-0.1	0.1	-0.9	-0.4
Forced vital capacity (FVC)	0.2	0.7	2.9	0.6	0.4	-0.0	1.2	0.3	-0.8	0.9	0.8	1.0	1.7	-0.1	0.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.3	0.3	0.6	0.5	-0.0	-0.0	1.1	0.6	0.7	0.3	0.2	-0.2	0.6
Qualifications: None of the above	0.2	0.5	3.3	-0.4	-0.7	-0.4	-0.0	1.8	0.3	-0.0	0.0	-0.4	-1.1	0.7	-0.5
Exposure to tobacco smoke at home	0.2	0.2	0.7	0.4	-0.5	0.1	0.3	-0.8	0.1	0.3	0.2	0.5	0.7	0.7	-0.0
Medication: Amlodipine	0.2	0.3	0.9	0.5	0.1	0.0	1.0	0.9	0.2	0.4	0.5	0.7	0.5	0.5	0.2
Wheeze or whistling in the chest in last year	0.2	0.4	2.1	0.6	-0.5	0.2	0.3	0.4	1.4	0.8	0.8	0.6	0.4	0.3	0.5
Number of children fathered	0.2	0.2	0.9	-0.1	-0.9	-0.1	-0.1	0.1	0.8	-0.0	0.0	-0.2	-0.3	0.7	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.6	0.0	0.5	0.4	-0.2	-0.1	0.5	-0.1	0.6	0.3	0.5	0.6
Shortness of breath walking on level ground	0.2	0.3	0.8	0.6	0.2	0.4	0.2	-0.9	0.9	0.5	0.3	0.5	0.4	0.2	0.4
Medication: Blood pressure	0.2	0.3	2.8	-0.0	0.2	0.5	-0.1	0.1	1.7	0.2	0.1	0.2	-0.3	0.2	0.7
Hypertension (Self-reported)	0.2	0.5	2.1	-0.7	-1.4	-0.8	0.2	0.8	1.4	-0.5	-0.5	-0.2	-0.1	-0.0	-0.0
Medication for cholesterol	0.2	0.3	1.6	-0.0	0.5	-0.2	-0.1	-0.8	-1.3	-0.4	-0.4	-0.0	0.3	-0.9	-0.3
Mineral and other dietary supplements	0.2	0.2	1.2	-0.2	-0.2	-0.4	0.4	-0.5	0.2	-0.5	-0.4	-0.0	0.5	-1.1	-0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.1	-0.2	0.3	0.1	-0.8	-0.4	-0.4	0.1	0.2	-0.4	-0.8	1.1	-0.4
Supplements: Calcium	0.2	0.2	0.8	0.4	-0.0	0.3	0.2	-0.2	-0.2	0.4	0.1	0.4	0.1	0.9	0.6
Primary Biliary Cirrhosis	0.1	0.2	0.5	0.2	0.2	0.2	0.5	-0.7	-0.7	-0.1	0.0	0.2	0.2	-0.7	0.0
Multivitamins +/- minerals	0.1	0.1	0.8	-0.2	0.1	-0.1	-0.9	-0.1	0.2	-0.2	-0.1	-0.5	-0.1	0.4	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.6	0.2	-0.3	0.5	-0.0	-0.8	-0.3	0.1	0.4	0.2	-0.4	0.1	0.5
High blood pressure (mother)	0.1	0.1	0.6	0.3	0.2	0.3	0.2	-0.8	0.1	0.3	-0.0	0.2	0.0	-0.3	0.6
Tense / ‘highly strung’	0.1	0.2	1.4	0.2	0.9	-0.0	0.3	-1.2	0.1	-0.2	0.0	0.2	0.3	-0.3	-0.1
Birth weight of first child	0.1	0.2	1.8	0.1	-0.0	0.2	-0.5	-1.4	0.4	0.3	-0.6	-0.0	0.2	-0.4	0.1
Blood clot in the leg (DVT)	0.1	0.1	0.4	-0.0	0.1	0.2	-0.1	0.1	-0.4	0.2	0.1	-0.2	-0.7	0.2	-0.1
Headache pain in last month	0.1	0.1	0.4	-0.2	-0.5	0.2	0.1	-0.7	0.2	-0.2	0.4	0.0	0.1	0.3	0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.7	-0.3	0.3	-0.0	-0.3	0.4	0.5	-0.2	0.3	-0.2	-0.9	-0.2	0.1
Chest pain or discomfort	0.1	0.1	0.5	0.7	0.5	0.4	-0.1	-0.0	0.2	0.3	0.3	0.2	-0.3	-0.1	-0.1
Family relationship satisfaction	0.1	0.2	0.9	0.1	0.6	0.1	0.2	0.0	1.0	0.4	0.5	0.1	0.5	0.3	0.0
Myopia	0.1	0.2	0.5	0.5	-0.3	-0.1	0.5	0.7	0.3	0.2	0.5	0.4	0.5	0.1	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.2	0.2	0.4	0.0	-0.1	-0.2	0.5	0.3	0.1	-0.5	0.3	0.2

Hub : Genes

ARHGEF26

Models

Trait associations