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chr3:182,655,858-186,072,370

Best TWAS P=1.78e-14 · Best GWAS P=4.77e-14 conditioned to 0.00692

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ECE2	0.24	0.20	bslmm	542	0.19	1.6e-22	6.5	6.3	3.5e-10	-0.02	0.32	0.68	FALSE
2	CommonMind	Brain Pre-frontal Cortex	KLHL24	0.42	0.60	bslmm	493	0.66	4.5e-107	-5.7	-5.7	1.1e-08	-0.07	0.02	0.98	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SENP2	0.21	0.18	enet	33	0.19	4.2e-22	-5.2	5.8	6.8e-09	-0.11	1.00	0.00	TRUE
4	GTEx	Adipose Subcutaneous	KLHL24	0.15	0.10	lasso	6	0.10	1.4e-08	-5.7	6.0	1.6e-09	0.08	0.02	0.98	TRUE
5	GTEx	Brain Caudate basal ganglia	KLHL24	0.22	0.21	lasso	3	0.19	3.5e-06	-5.8	5.8	7.9e-09	0.09	0.02	0.96	FALSE
6	GTEx	Brain Cerebellum	KLHL24	0.52	0.14	enet	26	0.16	1.9e-05	-5.8	6.0	1.9e-09	0.03	0.02	0.97	FALSE
7	GTEx	Brain Cortex	KLHL24	0.21	0.15	lasso	3	0.07	6.1e-03	-5.7	6.0	1.9e-09	0.08	0.02	0.93	FALSE
8	GTEx	Brain Frontal Cortex BA9	KLHL24	0.36	0.23	lasso	6	0.15	9.3e-05	-5.7	5.4	7.4e-08	0.08	0.02	0.96	FALSE
9	GTEx	Breast Mammary Tissue	KLHL24	0.25	0.13	lasso	5	0.11	3.4e-06	-5.8	5.9	3.4e-09	0.07	0.02	0.98	FALSE
10	GTEx	Esophagus Muscularis	KLHL24	0.10	0.12	lasso	1	0.09	4.4e-06	-5.8	5.8	7.1e-09	0.09	0.02	0.98	FALSE
11	GTEx	Nerve Tibial	KLHL24	0.08	0.06	lasso	3	0.05	1.5e-04	-5.7	5.7	1.4e-08	0.10	0.02	0.96	FALSE
12	GTEx	Pituitary	ECE2	0.52	0.30	lasso	7	0.23	1.5e-06	6.5	6.2	7.6e-10	0.00	0.22	0.56	FALSE
13	GTEx	Skin Sun Exposed Lower leg	KLHL24	0.09	0.06	lasso	10	0.05	9.5e-05	-5.7	5.8	9.1e-09	0.09	0.02	0.98	FALSE
14	GTEx	Testis	KLHL24	0.17	0.10	lasso	4	0.10	4.0e-05	-5.8	5.8	7.4e-09	0.09	0.02	0.98	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ETV5	0.03	0.01	blup	55	0.02	1.3e-03	-7.5	-7.2	4.0e-13	0.82	0.01	0.86	TRUE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	ECE2	0.04	0.02	blup	61	0.03	3.5e-04	6.5	6.8	7.2e-12	0.00	0.26	0.52	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	KLHL24	0.05	0.05	blup	53	0.05	1.1e-06	-5.7	5.8	5.8e-09	0.08	0.02	0.98	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	PSMD2	0.09	0.02	blup	50	0.05	1.2e-06	-5.7	7.7	1.8e-14	0.01	0.03	0.83	TRUE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PSMD2	0.05	0.00	enet	10	0.01	3.6e-02	6.5	5.8	6.6e-09	0.01	0.01	0.11	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	KLHL24	0.03	0.04	enet	5	0.04	5.1e-05	-5.6	5.3	1.5e-07	0.09	0.02	0.97	FALSE
21	The Cancer Genome Atlas	Testicular Germ Cell Tumors	KLHL24	0.16	0.16	blup	53	0.21	4.3e-08	-5.7	5.6	2.1e-08	0.08	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Testicular Germ Cell Tumors	VWA5B2	0.10	0.04	blup	51	0.04	1.8e-02	2.7	-5.7	1.5e-08	0.02	0.03	0.33	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	KLHL24	0.10	0.09	blup	53	0.09	1.7e-09	-5.4	5.4	7.7e-08	0.09	0.02	0.98	FALSE