Best TWAS P=1.52e-10 · Best GWAS P=3.12e-09 conditioned to 0.088
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | SLC51A | 0.15 | 0.08 | enet | 9 | 0.13 | 7.8e-08 | 3.4 | -5.1 | 2.7e-07 | -0.75 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Artery Tibial | SLC51A | 0.28 | 0.17 | lasso | 9 | 0.21 | 4.3e-16 | 5.4 | -5.6 | 2.1e-08 | -0.86 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | PCYT1A | 0.11 | 0.03 | lasso | 3 | 0.00 | 3.9e-01 | 5.9 | -6.0 | 2.1e-09 | -0.96 | 0.01 | 0.92 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | SLC51A | 0.28 | 0.06 | lasso | 6 | 0.14 | 1.3e-07 | 3.4 | -5.9 | 4.8e-09 | -0.58 | 0.04 | 0.93 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | UBXN7 | 0.20 | 0.00 | enet | 16 | 0.02 | 3.5e-02 | -4.8 | -6.1 | 1.3e-09 | -0.65 | 0.03 | 0.88 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Male) | PCYT1A | 0.09 | 0.08 | enet | 9 | 0.00 | 2.9e-01 | 5.0 | -5.5 | 3.6e-08 | -0.87 | 0.02 | 0.66 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Male) | UBXN7 | 0.22 | -0.01 | lasso | 4 | 0.01 | 1.6e-01 | -5.5 | -5.1 | 2.9e-07 | -0.52 | 0.03 | 0.52 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | SLC51A | 0.30 | 0.22 | lasso | 4 | 0.24 | 5.0e-18 | 3.4 | -5.2 | 2.5e-07 | -0.66 | 0.69 | 0.30 | FALSE |
| 9 | GTEx | Heart Atrial Appendage | SLC51A | 0.27 | 0.11 | lasso | 4 | 0.15 | 2.9e-07 | 3.4 | -5.5 | 3.8e-08 | -0.70 | 0.07 | 0.92 | FALSE |
| 10 | GTEx | Nerve Tibial | SLC51A | 0.26 | 0.12 | lasso | 7 | 0.22 | 1.9e-15 | 3.4 | -5.3 | 8.6e-08 | -0.73 | 0.05 | 0.95 | FALSE |
| 11 | GTEx | Spleen | PCYT1A | 0.19 | 0.05 | lasso | 4 | 0.09 | 3.1e-03 | -4.3 | -5.5 | 3.8e-08 | -0.82 | 0.04 | 0.66 | FALSE |
| 12 | GTEx | Stomach | SLC51A | 0.13 | 0.06 | enet | 12 | 0.03 | 1.9e-02 | 5.2 | -6.3 | 2.2e-10 | -0.86 | 0.01 | 0.97 | FALSE |
| 13 | GTEx | Thyroid | PCYT1A | 0.09 | 0.01 | enet | 16 | 0.01 | 7.7e-02 | 4.4 | -5.7 | 1.6e-08 | -0.79 | 0.01 | 0.95 | FALSE |
| 14 | GTEx | Thyroid | SLC51A | 0.17 | 0.06 | enet | 17 | 0.06 | 1.9e-05 | 5.2 | -5.5 | 3.2e-08 | -0.78 | 0.03 | 0.97 | FALSE |
| 15 | YFS | Blood | PCYT1A | 0.04 | 0.02 | lasso | 5 | 0.03 | 1.6e-09 | 5.2 | -5.1 | 3.1e-07 | -0.78 | 0.05 | 0.95 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | UBXN7 | 0.02 | 0.01 | blup | 45 | 0.02 | 4.2e-03 | 3.9 | -6.0 | 2.1e-09 | -0.76 | 0.02 | 0.71 | FALSE |
| 17 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PCYT1A | 0.08 | 0.03 | enet | 10 | 0.05 | 2.1e-03 | 5.2 | -5.2 | 1.6e-07 | -0.66 | 0.02 | 0.66 | FALSE |
| 18 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PCYT1A | 0.12 | 0.05 | blup | 68 | 0.06 | 2.0e-04 | 5.4 | -6.4 | 1.5e-10 | -0.75 | 0.01 | 0.92 | TRUE |