Best TWAS P=1.26e-15 · Best GWAS P=4.54e-15 conditioned to 0.000176
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | DCAF16 | 0.19 | 0.06 | enet | 10 | 0.11 | 3.9e-06 | 4.0 | 5.1 | 2.8e-07 | 0.59 | 0.18 | 0.67 | FALSE |
| 2 | GTEx | Artery Aorta | DCAF16 | 0.10 | 0.01 | enet | 6 | 0.02 | 4.7e-02 | -7.3 | 8.0 | 1.3e-15 | 0.61 | 0.09 | 0.64 | TRUE |
| 3 | GTEx | Artery Tibial | DCAF16 | 0.16 | 0.16 | lasso | 5 | 0.13 | 1.5e-10 | 4.9 | 5.6 | 2.3e-08 | 0.84 | 0.06 | 0.94 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | DCAF16 | 0.12 | 0.08 | lasso | 4 | 0.10 | 6.4e-06 | 4.0 | 5.7 | 1.5e-08 | 0.71 | 0.13 | 0.68 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Male) | DCAF16 | 0.24 | 0.03 | enet | 18 | -0.01 | 4.4e-01 | -6.7 | 6.0 | 1.7e-09 | 0.50 | 0.06 | 0.40 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | DCAF16 | 0.16 | 0.08 | lasso | 5 | 0.12 | 4.4e-07 | 5.3 | 5.7 | 1.5e-08 | 0.75 | 0.33 | 0.51 | FALSE |
| 7 | GTEx | Spleen | DCAF16 | 0.35 | 0.02 | lasso | 5 | 0.11 | 8.5e-04 | 4.0 | 6.8 | 1.5e-11 | 0.73 | 0.03 | 0.78 | FALSE |
| 8 | GTEx | Stomach | DCAF16 | 0.21 | 0.04 | lasso | 6 | 0.02 | 5.6e-02 | 4.7 | 5.7 | 1.0e-08 | 0.90 | 0.02 | 0.90 | FALSE |
| 9 | GTEx | Thyroid | DCAF16 | 0.11 | 0.02 | lasso | 5 | 0.03 | 2.3e-03 | 4.0 | 6.3 | 2.4e-10 | 0.78 | 0.03 | 0.94 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | DCAF16 | 0.04 | 0.02 | bslmm | 379 | 0.01 | 3.9e-02 | -6.8 | 6.6 | 3.7e-11 | 0.28 | 0.16 | 0.45 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | NCAPG | 0.08 | 0.04 | blup | 34 | 0.09 | 1.1e-05 | -6.9 | -6.2 | 6.0e-10 | 0.02 | 0.01 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NCAPG | 0.14 | 0.07 | lasso | 3 | 0.07 | 5.2e-08 | -6.8 | -6.6 | 3.3e-11 | -0.18 | 0.06 | 0.94 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DCAF16 | 0.09 | 0.02 | lasso | 3 | 0.04 | 5.2e-05 | 4.9 | 7.2 | 6.3e-13 | 0.72 | 0.05 | 0.87 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NCAPG | 0.02 | 0.03 | lasso | 1 | 0.02 | 9.0e-04 | -6.9 | -6.9 | 6.7e-12 | -0.23 | 0.02 | 0.72 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DCAF16 | 0.04 | 0.04 | blup | 31 | 0.04 | 2.2e-05 | 4.0 | 6.1 | 1.0e-09 | 0.72 | 0.27 | 0.24 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NCAPG | 0.02 | 0.02 | blup | 34 | 0.02 | 3.4e-03 | -5.8 | -5.4 | 6.0e-08 | -0.03 | 0.03 | 0.43 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | DCAF16 | 0.07 | 0.04 | blup | 31 | 0.07 | 4.9e-07 | 4.7 | 6.8 | 7.3e-12 | 0.68 | 0.14 | 0.78 | FALSE |