Best TWAS P=1.25e-09 · Best GWAS P=1.45e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RFTN2 | 0.14 | 0.10 | enet | 11 | 0.13 | 5.3e-11 | -5.5 | -5.2 | 1.9e-07 | 0.84 | 0.14 | 0.86 | FALSE |
| 2 | GTEx | Lung | RFTN2 | 0.06 | 0.08 | lasso | 8 | 0.06 | 2.7e-05 | -5.6 | -5.7 | 1.3e-08 | 0.97 | 0.07 | 0.93 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | MARS2 | 0.04 | 0.05 | enet | 8 | 0.03 | 1.2e-03 | -5.9 | 6.1 | 1.3e-09 | -0.99 | 0.04 | 0.96 | TRUE |
| 4 | GTEx | Spleen | RFTN2 | 0.11 | 0.03 | enet | 26 | 0.05 | 2.4e-02 | -5.9 | -5.6 | 2.4e-08 | 0.97 | 0.06 | 0.55 | FALSE |
| 5 | GTEx | Spleen | MARS2 | 0.12 | 0.04 | lasso | 5 | 0.00 | 3.4e-01 | -5.9 | 5.7 | 9.7e-09 | -0.97 | 0.05 | 0.49 | FALSE |
| 6 | GTEx | Thyroid | PLCL1 | 0.04 | 0.01 | lasso | 4 | 0.00 | 2.6e-01 | -6.0 | -5.3 | 1.3e-07 | 0.92 | 0.11 | 0.72 | FALSE |
| 7 | GTEx | Whole Blood | PLCL1 | 0.08 | 0.08 | enet | 15 | 0.05 | 4.1e-05 | -5.9 | -5.4 | 6.2e-08 | 0.85 | 0.10 | 0.90 | FALSE |