Best TWAS P=2.92e-16 · Best GWAS P=1.37e-19 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | UTP15 | 0.11 | 0.05 | lasso | 3 | 0.05 | 8.8e-05 | -6.3 | -5.9 | 4.5e-09 | -0.27 | 0.92 | 0.00 | FALSE |
| 2 | GTEx | Artery Tibial | UTP15 | 0.15 | 0.06 | lasso | 5 | 0.06 | 1.0e-05 | -6.5 | -6.3 | 3.6e-10 | -0.30 | 0.91 | 0.01 | FALSE |
| 3 | GTEx | Brain Cortex | UTP15 | 0.19 | 0.01 | lasso | 4 | 0.01 | 1.8e-01 | 2.1 | -5.3 | 1.2e-07 | -0.38 | 0.15 | 0.16 | TRUE |
| 4 | GTEx | Breast Mammary Tissue | UTP15 | 0.13 | 0.08 | enet | 15 | 0.00 | 2.4e-01 | -7.5 | -5.3 | 1.2e-07 | -0.29 | 0.18 | 0.05 | TRUE |
| 5 | GTEx | Esophagus Mucosa | ARHGEF28 | 0.14 | 0.03 | enet | 17 | 0.06 | 1.1e-04 | 6.3 | 5.7 | 1.0e-08 | 0.17 | 0.80 | 0.02 | FALSE |
| 6 | GTEx | Liver | ARHGEF28 | 0.57 | 0.27 | lasso | 16 | 0.21 | 1.9e-06 | 6.3 | 6.4 | 1.7e-10 | 0.06 | 0.90 | 0.01 | FALSE |
| 7 | GTEx | Nerve Tibial | ARHGEF28 | 0.15 | 0.03 | lasso | 5 | 0.06 | 6.7e-05 | -7.5 | -8.2 | 2.9e-16 | -0.29 | 0.62 | 0.05 | TRUE |
| 8 | GTEx | Pancreas | ARHGEF28 | 0.23 | 0.22 | lasso | 3 | 0.20 | 6.3e-09 | 6.5 | 6.5 | 7.8e-11 | 0.05 | 0.98 | 0.00 | TRUE |
| 9 | METSIM | Adipose | UTP15 | 0.09 | 0.05 | lasso | 14 | 0.06 | 2.7e-09 | -7.4 | -6.0 | 1.7e-09 | -0.30 | 1.00 | 0.00 | TRUE |
| 10 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RGNEF | 0.16 | 0.04 | lasso | 4 | 0.06 | 1.0e-03 | -6.4 | 7.2 | 4.4e-13 | 0.23 | 0.28 | 0.03 | FALSE |
| 11 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ANKRA2 | 0.06 | 0.04 | blup | 74 | 0.03 | 5.6e-03 | 4.2 | -5.6 | 2.2e-08 | -0.29 | 0.03 | 0.72 | TRUE |
| 12 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RGNEF | 0.15 | 0.09 | lasso | 7 | 0.07 | 7.8e-04 | -7.9 | 8.0 | 1.7e-15 | 0.34 | 0.24 | 0.06 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ANKRA2 | 0.09 | 0.05 | blup | 74 | 0.06 | 5.9e-07 | -6.3 | -5.9 | 4.5e-09 | -0.20 | 0.11 | 0.88 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RGNEF | 0.20 | 0.14 | lasso | 4 | 0.20 | 1.3e-20 | -7.5 | -7.7 | 1.1e-14 | -0.23 | 1.00 | 0.00 | FALSE |
| 15 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ANKRA2 | 0.23 | 0.14 | lasso | 4 | 0.10 | 2.3e-03 | 4.8 | -5.5 | 4.5e-08 | -0.32 | 0.02 | 0.72 | FALSE |
| 16 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RGNEF | 0.18 | 0.00 | blup | 254 | 0.08 | 3.7e-03 | 4.2 | 6.1 | 1.3e-09 | 0.63 | 0.07 | 0.30 | TRUE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | UTP15 | 0.04 | 0.05 | enet | 4 | 0.05 | 1.4e-05 | -6.5 | -6.5 | 9.4e-11 | -0.25 | 0.06 | 0.89 | FALSE |