Hub : Genes

ARHGEF28

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.213	0.0500	2.2e-07	0.082	NA	0.095	NA	0.102	1.0e-06	NA	1.3e-07	NA	4.3e-08
2	GTEx	Esophagus Mucosa	0.144	0.0520	2.1e-03	0.031	NA	0.057	NA	0.045	3.8e-03	NA	1.1e-04	NA	5.6e-04
3	GTEx	Liver	0.573	0.1010	2.3e-06	0.272	NA	0.086	NA	0.208	3.1e-08	NA	2.1e-03	NA	1.9e-06
4	GTEx	Nerve Tibial	0.149	0.0463	3.3e-04	0.033	NA	0.044	NA	0.057	2.1e-03	NA	4.4e-04	NA	6.7e-05
5	GTEx	Pancreas	0.232	0.0690	1.1e-03	0.224	NA	0.179	NA	0.201	7.8e-10	NA	5.0e-08	NA	6.3e-09
6	METSIM	Adipose	0.081	0.0255	3.0e-05	0.065	0.038	0.068	0.081	0.068	5.0e-10	1.8e-06	2.1e-10	3.8e-12	1.9e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.3	1.1	-0.1	-0.4	0.7	-0.1	0.4	-1.0
Bipolar Disorder or Schizophrenia	0.4	0.9	1.6	1.2	1.1	1.0	-0.8	0.4	-1.0
Depressed Affect (Nagel 2018)	0.2	0.4	1.1	0.5	0.7	0.7	-0.4	-0.1	1.1
Depression (Nagel 2018)	1.7	2.5	3.7	0.3	-1.9	-1.8	1.3	-1.9	1.7
Intelligence (Savage-Jansen 2018)	0.5	1.5	6.4	2.5	0.7	-0.2	-0.8	-0.8	1.0
Neuroticism (Nagel 2018)	0.7	1.8	7.3	1.5	0.8	0.2	-0.5	-0.3	2.7
Schizophrenia (2018)	0.6	1.2	2.9	1.7	1.7	0.7	-1.0	0.2	-0.4
Schizophrenia vs Biploar Disorder	1.4	1.8	3.9	1.2	1.6	1.4	-2.0	1.1	0.1
Worry (Nagel 2018)	1.2	2.6	11.8	1.4	-0.2	-0.9	-0.2	-1.1	3.4
Alzheimer’s Disease (in mother)	0.9	1.0	1.9	-0.8	-1.1	-0.5	1.4	-1.1	-0.8
Alzheimer’s Disease (in father)	0.6	0.7	2.1	-1.5	-0.5	0.0	0.8	0.5	0.9
Alzheimer’s Disease (including proxy)	0.6	0.9	2.3	-1.3	-0.6	0.3	1.5	0.1	-0.8
Crohns Disease (2017)	0.4	1.0	1.6	0.5	-1.0	-1.3	0.5	-1.0	1.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	0.3	-0.5	-0.7	-0.2	-0.8	0.5
Ulcerative Colitis (UC)	0.1	0.1	0.3	-0.0	-0.0	-0.0	-0.5	-0.5	-0.6
Major Depression (MDD)	0.6	0.7	1.5	-0.8	-1.2	0.1	0.8	-0.2	-1.2
Reaction Time	0.1	0.2	0.8	0.4	-0.2	-0.1	-0.5	0.0	0.9
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.3	1.8	0.5	-0.7	0.2	-1.0	0.2
Breast Cancer	0.4	1.1	2.3	-1.5	-0.9	-0.8	1.3	-0.1	-0.9
Ovarian Cancer	0.2	0.3	0.6	0.7	0.8	0.6	-0.2	0.3	0.6
Prostate Cancer	0.1	0.1	0.2	-0.4	-0.3	0.4	-0.3	0.0	-0.3
Age at First Birth	0.2	0.2	0.7	0.7	-0.2	-0.3	-0.0	-0.2	0.8
Bipolar Disorder (2011)	1.4	1.4	2.6	0.7	1.2	1.5	-1.2	1.6	-0.3
Body Mass Index (BMI) (2010)	0.4	0.6	1.7	1.3	0.6	-0.4	-0.9	-0.3	0.5
Coronary Artery Disease (CAD)	1.4	1.7	4.1	-0.5	1.4	1.2	-1.3	1.0	-2.0
Crohns Disease (2012)	0.1	0.2	0.3	-0.3	0.2	0.5	-0.5	0.5	0.5
Mean Putamen Volume	0.7	0.8	2.0	-1.4	0.6	0.6	0.3	0.4	-1.4
Fasting Glucose	0.1	0.1	0.2	-0.1	0.0	-0.5	0.5	0.3	-0.2
HbA1C	2.1	2.3	5.1	0.5	0.8	2.3	-1.8	1.1	-1.9
HDL Cholesterol	0.9	1.5	3.1	0.8	-1.1	-1.4	0.9	-1.8	-1.2
LDL Cholesterol	0.2	0.3	0.8	0.9	0.6	0.2	-0.4	0.3	-0.1
Lupus	0.2	0.3	0.8	0.0	-0.5	-0.4	0.1	-0.8	0.9
Neuroticism (2016)	1.7	2.4	5.4	0.4	2.3	1.9	-1.6	1.6	-0.1
Primary Biliary Cirrhosis	2.2	3.2	5.6	-0.0	2.0	2.4	-1.8	2.2	-1.2
Rheumatoid Arthritis	0.9	1.2	2.5	1.6	-0.1	-1.2	0.2	-1.2	1.4
Schizophrenia (2014)	0.9	2.0	3.8	1.6	1.9	1.6	-1.3	1.0	-0.8
Triglycerides	0.1	0.1	0.5	-0.7	-0.2	-0.3	0.3	0.1	0.0
Type 2 Diabetes (T2D) (2012)	0.9	1.1	1.8	-1.0	0.8	1.1	-1.3	1.4	-0.0
Ulcerative Colitis	1.7	2.5	4.9	0.5	1.8	1.8	-2.2	1.7	0.6
Blood Eosinophil Count	0.4	3.1	9.4	-3.1	0.7	1.4	0.9	2.1	-1.4
Blood Platelet Count	0.2	2.3	5.5	-0.2	-2.3	-1.9	0.2	-2.1	-0.2
Blood Red Count	0.1	1.1	3.1	-0.6	0.0	-1.2	1.2	-1.8	-0.2
Blood White Count	0.2	1.4	6.2	-2.5	-1.1	-0.2	0.8	-0.3	-0.4
Heel T-Score	1.3	10.0	16.2	-1.4	-3.8	-3.5	3.9	-4.0	-0.2
BMI	1.0	5.5	9.9	-0.2	2.6	3.1	-2.4	3.1	-1.1
Height	0.2	2.9	6.4	-1.5	1.1	1.8	-1.0	2.5	1.9
Waist Hip Ratio (WHR)	0.4	1.6	4.2	1.3	-1.1	-0.9	-0.6	-1.1	-2.0
Systolic Blood Pressure	0.1	0.4	1.0	-0.7	-0.6	-0.4	0.6	-0.5	1.0
Smoking Status	0.2	0.6	2.0	-0.2	-0.3	1.1	-0.3	-0.2	-1.4
Allergy or Eczema	0.1	0.2	0.5	-0.3	0.5	0.5	-0.3	0.6	0.7
Cardiovascular Disease	0.6	2.1	8.3	-2.9	0.1	1.1	0.4	1.6	-0.4
Hypothyroidism (self reported)	0.1	0.2	1.0	0.1	1.0	0.1	-0.3	0.4	0.0
Respiratory disease	1.2	2.6	7.5	-2.7	-1.2	-1.3	2.1	-0.7	0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.1	-0.4	1.0	0.6	-0.3	0.6	-0.1
Lung FEV1/FVC ratio	1.0	5.2	8.9	2.1	3.0	2.7	-2.2	1.5	-1.9
Lung FVC	0.8	3.9	10.8	-3.3	-1.7	-0.7	2.2	0.2	2.1
Neuroticism	0.6	1.5	5.7	1.4	0.7	-0.0	-0.1	-0.8	2.4
Chronotype (morning person)	0.1	0.2	0.5	0.5	-0.1	-0.2	-0.7	-0.3	-0.0
Hair Pigment	0.4	11.2	20.2	-1.0	-3.8	-3.9	4.5	-4.0	1.0
Tanning	0.1	1.6	3.5	-0.9	0.5	1.6	-1.1	1.9	-1.2
Hand grip strength (left)	0.4	1.1	2.5	-0.3	0.5	1.2	-0.7	1.6	-1.4
Number of treatments/medications taken	0.9	1.6	8.6	-2.9	0.1	-0.1	0.9	0.4	0.4
Average weekly spirits intake	1.9	2.3	4.6	-1.3	-2.1	-1.1	2.0	-0.9	-1.3
Sensitivity / hurt feelings	0.2	0.3	1.2	-0.0	0.5	0.6	0.1	-0.0	1.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.8	0.3	-0.7	-0.6	0.3	-0.7	1.3
Hearing difficulty/problems: Yes	22.0	33.5	66.9	4.3	5.7	6.4	-8.2	6.5	0.3
Relative age of first facial hair	0.8	1.6	4.0	2.0	-0.8	-1.1	-0.2	-0.8	1.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.4	0.6	-0.4	0.1	-0.4	-0.6	1.6
Ever used hormone-replacement therapy (HRT)	1.3	1.7	5.1	0.3	-1.1	-1.6	0.3	-1.1	2.3
Ever had hysterectomy (womb removed)	1.0	1.1	2.0	-0.5	-1.4	-1.2	1.4	-0.8	0.7
Systolic blood pressure, automated reading	0.4	1.2	2.7	0.1	-1.0	-1.2	1.4	-1.6	-0.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.0	-0.7	0.3	-0.2	1.0	-0.3	1.0
Angina	0.5	0.6	1.5	0.0	-0.0	-0.7	1.0	-0.8	1.2
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.1	0.4	0.3	-0.2	0.5	-0.2
Vitamin and mineral supplements	1.3	1.8	4.4	1.5	-1.0	-1.7	0.4	-2.1	0.5
Supplements: Zinc	0.5	0.6	1.6	-0.1	-0.3	1.2	-0.8	1.0	0.2
Medication: Co-codamol	0.7	0.8	1.1	-1.0	-0.9	-0.9	1.0	-0.9	0.5
Medication: Metformin	0.6	0.8	1.7	-1.3	-0.3	-1.0	1.2	-0.6	0.6
Diabetes (father)	1.1	1.3	2.8	0.5	1.7	1.0	-1.6	1.1	0.2
Diabetes (mother)	0.2	0.3	0.7	-0.7	0.6	0.3	-0.1	0.3	-0.8
Severe depression (siblings)	0.4	0.4	0.7	0.2	-0.8	-0.4	0.8	-0.7	0.7
Pack years adult smoking proportion	2.2	3.4	4.9	-0.9	2.0	2.0	-1.4	2.2	-2.1
Impedance of leg (right)	0.1	0.3	0.6	-0.2	-0.6	-0.7	0.6	0.1	0.8
Leg fat-free mass (left)	0.3	1.3	2.6	-0.6	1.2	1.4	-1.2	1.6	0.4
Trunk fat percentage	0.9	3.6	8.1	-0.3	2.5	2.2	-1.5	2.8	-0.4
Hand grip strength (right)	0.1	0.4	1.5	0.1	-0.2	0.3	-0.5	0.6	-1.2
Townsend deprivation index at recruitment	2.4	3.4	7.1	1.1	2.3	2.0	-2.7	1.6	0.1
Current tobacco smoking	0.5	0.8	2.2	0.7	0.9	0.8	-1.5	0.5	-0.8
Average weekly fortified wine intake	0.2	0.3	0.5	0.3	0.6	0.6	-0.6	0.7	-0.4
Maternal smoking around birth	0.3	0.4	1.3	-0.9	-1.1	-0.1	-0.3	-0.1	0.6
Fed-up feelings	1.2	2.1	3.5	1.3	1.9	1.3	-1.7	1.0	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	1.2	-0.1	-0.1	0.5	-0.7	-0.1	1.1
Relative age voice broke	0.2	0.4	1.6	0.0	-0.5	-0.0	-0.3	0.5	1.3
Taking other prescription medications	0.5	0.8	2.6	-1.6	-0.2	-0.5	1.2	-0.1	0.5
Age when periods started (menarche)	0.2	0.4	1.3	0.1	-1.2	-0.2	-0.6	0.6	0.6
Bilateral oophorectomy (both ovaries removed)	4.7	5.5	12.4	-0.7	-3.5	-2.5	2.1	-2.8	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.5	0.1	-1.1	-1.2	0.2	-1.2	0.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.6	0.6	-0.8	-1.0	0.5	-1.3	0.8
Qualifications: CSEs or equivalent	0.5	0.7	1.4	1.0	0.5	1.0	-1.2	0.4	-0.6
Serious illness, injury or assault to yourself	0.7	0.8	2.5	1.1	0.6	0.5	-0.8	-0.3	1.6
High blood pressure	0.5	1.4	6.0	-2.5	-0.8	-0.2	1.3	0.0	0.0
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	0.0	0.6	0.6	-0.3	0.8	-0.4
Multivitamins +/- minerals	1.8	2.3	5.1	-2.1	1.2	1.5	-0.0	2.3	-0.7
Stomach or abdominal pain in last month	0.9	1.1	1.9	0.5	-1.3	-1.2	0.9	-1.4	-0.8
Supplements: Glucosamine	0.7	1.0	2.3	-0.8	-1.0	-0.7	1.1	0.3	1.5
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	5.9	-1.6	0.1	1.4	-0.5	-0.0	-2.4
Medication: Atenolol	0.3	0.3	0.5	-0.3	-0.4	-0.7	0.7	-0.4	0.7
Medication: Levothyroxine sodium	0.3	0.5	1.3	1.1	0.5	-0.5	-0.4	0.2	1.1
Sitting height	0.5	3.3	10.0	-3.2	0.3	1.3	0.8	1.9	1.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.7	1.0	-0.2	-0.7	0.3	-0.5	1.3
High blood pressure (mother)	0.1	0.1	0.4	-0.6	-0.3	0.0	-0.0	-0.3	-0.0
Body mass index (BMI)	0.3	1.2	2.0	0.1	1.4	1.3	-1.3	1.4	-0.3
Impedance of leg (left)	0.0	0.2	0.4	-0.7	-0.1	-0.0	0.6	0.6	0.3
Leg predicted mass (left)	0.3	1.4	2.8	-0.6	1.2	1.4	-1.2	1.7	0.4
Trunk fat mass	0.8	3.6	8.2	-0.7	2.5	2.2	-1.4	2.9	0.1
Waist circumference	0.2	0.6	1.5	0.6	1.2	0.5	-1.0	0.8	0.5
Number of incorrect matches in round	1.6	2.6	4.7	-0.9	-1.6	-1.8	1.9	-2.2	0.6
Past tobacco smoking	0.2	0.3	1.0	0.3	0.5	-0.7	0.3	0.0	1.0
Alcohol usually taken with meals	0.3	0.5	2.9	1.7	0.1	0.1	-0.3	-0.2	0.1
Nervous feelings	0.8	1.6	7.6	0.8	0.3	-0.8	0.4	-0.5	2.8
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.3	-0.8	-1.4	-0.5	0.9	-0.9	1.5
Hearing difficulty/problems with background noise	11.9	19.1	37.8	3.9	4.3	4.7	-6.1	4.6	0.9
Hair/balding pattern: Pattern 2	0.3	0.4	1.4	-0.3	0.0	1.2	-0.5	0.5	-0.3
Had menopause	0.9	1.2	1.9	0.3	1.4	1.2	-1.3	1.1	0.9
Had other major operations	0.1	0.1	0.2	-0.4	-0.5	0.1	-0.3	-0.0	-0.2
Forced vital capacity (FVC)	0.7	2.5	8.1	-2.8	-0.3	0.8	1.0	1.4	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.6	-0.3	-1.3	-1.0	0.2	-0.7	1.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	-0.8	0.2	1.1	-0.5	0.2	-1.1
Qualifications: None of the above	0.1	0.3	0.7	-0.8	-0.4	0.1	0.1	-0.0	0.9
Financial difficulties in last 2 years	0.4	0.6	1.5	0.0	0.6	1.1	-1.2	0.3	-0.5
Mouth/teeth dental problems	0.4	0.7	2.6	-1.6	-0.2	0.0	1.1	-0.2	-0.5
Heart attack	0.5	0.6	2.4	-1.0	-0.2	0.5	0.3	0.2	-1.5
Allergy	0.3	0.7	1.7	1.3	0.7	0.4	-1.1	-0.0	0.6
Pain all over the body in last month	1.9	2.1	3.9	-1.6	-1.6	-1.1	2.0	-0.8	1.3
Diabetes (self-reported)	0.1	0.1	0.5	-0.4	0.3	-0.2	0.2	-0.3	0.7
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.6	-0.1	0.3	0.5	-0.3	0.8	-0.1
Medication: Ramipril	1.7	2.2	6.8	-2.6	-1.3	-0.7	1.9	-0.6	-0.1
Medication: Simvastatin	1.0	1.4	3.9	-1.0	1.3	1.2	-0.7	2.0	0.5
Fluid intelligence score	0.4	0.9	3.8	1.9	0.5	-0.9	-0.1	-0.6	0.3
Illnesses of siblings	0.3	0.4	1.4	0.5	-1.2	-0.7	0.5	-0.5	0.0
Neuroticism score	1.2	2.5	6.2	2.1	1.8	0.8	-0.9	-0.1	2.5
Weight	0.4	2.0	3.9	-0.4	1.7	1.6	-1.4	2.0	0.7
Impedance of arm (right)	0.2	0.9	1.8	0.4	1.1	1.1	-0.8	1.3	-0.5
Arm fat percentage (right)	0.7	2.8	5.0	-0.2	2.2	2.0	-1.6	2.2	-0.5
Trunk fat-free mass	0.2	1.0	1.7	-1.1	0.6	0.9	-0.6	1.2	1.3
Hip circumference	0.4	1.8	4.4	-0.1	2.1	1.1	-0.6	1.7	1.4
Time employed in main current job	0.6	0.7	1.2	-0.4	-0.8	-1.1	0.8	-1.1	-0.5
Alcohol intake versus 10 years previously	0.2	0.3	0.9	-0.2	0.9	0.2	-0.2	0.4	0.9
Father’s age at death	0.3	0.4	1.1	-1.1	0.0	0.4	-0.1	0.8	0.6
Worrier / anxious feelings	0.9	1.7	7.8	0.7	0.8	0.5	-0.7	0.4	2.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.7	-1.3	-0.3	1.0	-0.6	0.6	1.1
Falls in the last year	0.6	0.7	2.9	-1.7	-0.7	-0.1	0.7	-0.3	-0.7
Hair/balding pattern: Pattern 3	0.5	0.8	3.6	-0.4	-0.2	0.6	0.6	-0.1	-1.9
Number of live births	0.9	1.3	2.5	-0.0	1.6	1.0	-1.6	1.4	0.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.6	-1.9	0.7	1.3	0.2	1.6	1.5
Pulse rate	1.1	1.9	4.6	0.3	-1.7	-1.4	1.0	-2.1	-1.0
Happiness	0.2	0.2	0.6	0.5	-0.4	0.7	-0.3	-0.5	0.0
Noisy workplace	0.4	0.5	1.4	-1.2	-0.7	-0.3	0.8	-0.1	-0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	0.8	0.0	-0.3	-0.1	-0.6	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.4	-0.3	0.1	-0.8	-0.2	-0.2	1.2
Mouth/teeth dental problems: Dentures	3.5	6.0	10.4	0.9	2.8	2.9	-3.2	2.7	-1.1
Asthma	1.1	2.1	7.2	-2.7	-1.4	-1.1	1.5	-0.4	-0.0
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	6.1	-2.5	-1.6	-0.9	2.0	-1.7	-0.9
Medication: Cholesterol lowering	1.5	2.3	5.5	-1.5	1.3	1.7	-1.1	2.4	-0.7
Depression (self-reported)	2.2	2.7	4.8	0.6	-1.9	-2.0	1.7	-2.2	0.5
Medication: Lansoprazole	1.1	1.3	2.9	0.7	-1.3	-1.7	0.8	-1.4	-0.1
Prospective memory result	0.2	0.3	0.4	0.0	-0.5	-0.7	0.4	-0.5	0.7
Lung cancer (father)	0.3	0.3	1.2	0.4	0.5	0.4	-0.5	0.3	1.1
Illnesses of mother	0.4	0.4	1.0	1.0	0.8	0.2	-0.1	0.2	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.8	-2.2	0.3	0.8	0.8	1.0	1.6
Pulse wave Arterial Stiffness index	0.6	0.7	2.3	-1.5	0.4	0.8	-0.2	1.0	-0.2
Impedance of arm (left)	0.2	0.8	1.7	0.4	1.2	1.0	-0.8	1.3	-0.1
Arm fat mass (right)	0.5	2.2	4.1	0.1	1.9	1.8	-1.6	2.0	0.0
Trunk predicted mass	0.2	1.0	1.9	-1.1	0.6	0.9	-0.5	1.1	1.4
Standing height	0.2	1.5	3.4	-1.1	0.7	1.0	-0.3	1.7	1.9
Length of working week for main job	1.9	2.1	5.3	-0.4	-1.9	-0.3	1.0	-1.6	-2.3
Exposure to tobacco smoke at home	2.6	2.9	11.1	2.0	0.2	-0.8	-0.7	-0.9	3.3
Breastfed as a baby	0.6	0.7	1.7	-1.1	-0.4	0.7	0.6	0.5	-1.3
Tense / ‘highly strung’	0.3	0.5	2.1	0.4	0.9	0.1	-0.4	-0.2	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.0	-0.4	0.9	0.9	-0.8	1.0	0.8
Hair/balding pattern: Pattern 4	0.8	2.0	7.7	1.5	0.7	-0.8	-0.9	0.0	2.8
Birth weight of first child	1.2	2.2	7.6	1.1	0.8	1.5	-2.8	1.2	-0.1
Peak expiratory flow (PEF)	0.9	2.1	3.8	-1.7	2.0	1.4	-0.4	1.5	1.1
Pulse wave reflection index	3.6	4.5	9.6	-3.1	1.9	2.0	-0.3	3.0	-0.8
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.5	-0.1	0.5	0.0	0.1	0.1
Loud music exposure frequency	0.3	0.3	0.6	-0.6	0.2	0.8	-0.4	0.5	-0.6
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	4.5	2.1	1.1	0.7	-2.0	0.4	1.3
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	4.6	1.6	-0.8	-2.0	0.6	-1.6	2.2
Blood clot in the leg (DVT)	1.8	2.4	4.7	-1.7	-1.5	-1.0	2.2	-1.4	-1.3
Medication: Paracetamol	0.2	0.4	1.1	-0.1	-0.9	-0.1	-0.1	-0.5	-1.1
Headache pain in last month	0.5	0.8	2.2	-1.3	0.0	0.9	0.3	-0.0	-1.5
Medication for cholesterol, blood pressure or diabetes	1.5	2.6	7.9	2.8	-0.7	-1.5	0.3	-2.0	0.8
Glaucoma (self-reported)	2.2	2.6	6.3	-0.4	2.5	2.0	-0.9	2.0	-0.7
Gout (self-reported)	1.7	2.4	4.0	2.0	-1.1	-2.0	0.7	-1.6	1.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.5	0.5	0.7	-0.3	0.1	0.2	0.1
Medication: Amlodipine	0.3	0.4	1.8	-1.4	-0.3	-0.1	0.4	0.1	-0.1
Medication: Ventolin 100micrograms inhaler	2.0	2.6	12.6	-3.5	0.2	0.7	0.8	1.2	-0.8
Birth weight	0.6	1.3	4.5	2.1	0.6	0.5	-1.5	0.3	-0.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	-0.1	-0.6	-0.6	0.1	-0.6	1.0
High blood pressure (siblings)	0.1	0.2	0.7	-0.8	0.2	0.5	-0.2	0.4	0.2
Forced vital capacity (FVC), Best measure	0.7	2.7	9.4	-3.1	-0.7	0.1	1.5	0.7	1.9
Body fat percentage	0.7	2.9	6.4	-0.4	2.3	1.9	-1.3	2.5	-0.2
Leg fat percentage (right)	0.5	1.7	4.2	-0.6	1.8	1.2	-1.0	2.0	0.1
Arm fat-free mass (right)	0.1	0.5	1.1	-1.1	0.4	0.5	-0.1	0.8	1.1
Exposure to tobacco smoke outside home	2.0	2.6	6.1	1.4	1.3	1.3	-2.5	1.6	1.4
Comparative body size at age 10	3.6	9.9	17.2	-1.0	3.7	4.1	-2.4	3.7	-2.9
Number of full brothers	0.2	0.3	0.7	0.8	-0.2	0.0	-0.3	-0.5	-0.7
Worry too long after embarrassment	1.1	1.9	8.4	1.3	0.7	-0.4	0.5	-0.7	2.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.7	-1.6	0.4	0.3	0.7	0.1	0.6
Wheeze or whistling in the chest in last year	1.0	1.8	7.1	-2.7	-0.8	-0.2	1.6	-0.5	-0.6
Number of children fathered	0.6	0.6	1.4	0.5	-0.6	-1.2	0.8	-1.1	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.0	1.0	-0.2	-1.4	1.0	-1.7	0.8
Age at first live birth	1.0	1.7	3.0	-0.3	0.9	1.7	-1.4	1.6	-1.4
Pulse wave peak to peak time	0.4	0.5	1.6	1.3	-0.3	-0.7	0.3	-0.8	0.5
Health satisfaction	0.9	1.1	2.5	-0.9	0.3	1.3	-0.5	1.1	-1.6
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.5	-0.7	0.4	-0.1	0.6	-0.2
Qualifications: College or University degree	0.2	0.7	1.5	0.4	0.7	1.2	-0.7	1.0	-0.9
Eye problems/disorders: None of the above	0.5	0.5	1.0	0.9	-0.8	-1.0	0.2	-1.0	0.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.2	0.7	0.4	0.8	-1.1	0.4	-0.6
Emphysema/chronic bronchitis	1.9	2.1	5.7	-2.4	-1.6	-0.5	1.3	-0.1	-1.7
Medication for pain relief, constipation, heartburn	0.7	1.2	2.6	1.6	0.5	1.0	-1.4	1.2	0.4
Neck or shoulder pain in last month	0.2	0.3	0.6	0.0	-0.8	0.2	-0.6	-0.4	-0.6
Medication: Blood pressure	0.9	1.6	6.5	-2.5	-1.1	-0.3	1.3	0.1	-0.6
Angina (self-reported)	0.3	0.4	1.1	-0.0	0.0	-0.5	0.8	-0.8	1.0
Migraine (self-reported)	0.9	1.1	2.3	-1.1	-1.5	-0.7	0.7	-1.4	-0.1
Medication: Ibuprofen	1.8	2.1	3.6	-1.7	-1.2	-1.0	1.8	-1.9	-0.8
Medication: Allopurinol	1.2	1.6	3.7	1.2	-0.9	-1.9	1.3	-1.4	0.2
Medication: Omeprazole	0.2	0.2	0.6	-0.3	-0.7	-0.0	0.1	-0.1	-0.8
Medication: Seretide 50 evohaler	4.6	5.3	13.9	-3.6	-1.6	0.8	1.2	0.4	-3.7
Mean time to correctly identify matches	0.3	0.5	0.8	0.5	0.7	0.4	-0.9	0.7	0.8
Heart disease (mother)	4.2	5.1	9.7	-0.3	3.1	2.6	-1.8	3.0	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	-0.6	-0.4	0.2	-0.3	0.5	-0.1
Whole body fat mass	0.8	3.2	7.0	-0.6	2.3	2.0	-1.4	2.6	0.1
Leg fat mass (right)	0.6	2.3	5.6	-0.7	1.9	1.6	-1.3	2.4	0.3
Arm predicted mass (right)	0.2	0.8	2.2	-1.5	0.4	0.7	-0.1	1.0	1.0
Pulse rate, automated reading	1.0	3.3	8.9	-3.0	-2.0	-0.7	2.1	-1.0	-1.2
Alcohol intake frequency.	0.4	0.9	4.2	-0.1	0.4	-0.6	0.2	-0.9	2.1
Comparative height size at age 10	0.3	1.8	3.2	0.4	1.8	1.1	-1.2	1.3	1.7
Number of full sisters	0.3	0.4	1.1	0.9	-0.2	0.6	-1.0	0.3	-0.1
Suffer from ‘nerves’	1.3	2.1	6.8	1.5	1.4	-0.2	-1.1	-0.1	2.6
Overall health rating	0.3	0.7	3.5	-1.9	-0.6	0.1	0.5	-0.2	0.2
Chest pain or discomfort	0.3	0.4	1.0	1.0	-0.4	-0.6	0.1	-0.7	0.5
Had major operations	0.1	0.2	0.7	-0.3	-0.2	-0.0	-0.4	0.1	0.8
Age at last live birth	2.0	2.9	4.9	-0.7	1.6	2.2	-1.8	2.2	-1.3
Family relationship satisfaction	0.2	0.2	0.9	-0.4	-0.5	0.9	-0.3	-0.1	-0.2
Leg pain on walking	0.9	1.1	2.8	0.6	-1.7	-1.0	0.1	-1.6	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.6	0.0	-0.3	-0.3	0.0	0.1
Commuting to job workplace: Car/motor vehicle	2.3	2.6	4.5	-0.9	-2.1	-1.9	2.0	-1.6	0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.8	1.4	0.3	0.4	-0.8	0.2	-0.3
Medication: Aspirin	0.8	1.1	2.2	-0.9	-0.3	-1.5	1.4	-0.9	0.9
Supplements: Vitamin C	0.1	0.2	0.4	-0.5	-0.7	0.3	-0.3	0.2	-0.3
Knee pain experienced in last month	0.6	0.9	2.1	-0.3	-1.4	-0.9	0.6	-1.4	-0.3
Hypertension (Self-reported)	0.5	1.5	6.4	-2.5	-0.6	-0.2	1.5	-0.0	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.0	0.7	-0.2	-0.1	-1.7	0.4	1.4
Illnesses of father: Heart disease	1.5	2.1	4.4	-1.0	0.7	1.8	-1.1	1.4	-2.1
Illnesses of siblings: Diabetes	0.4	0.5	1.6	-0.3	-0.1	-0.6	0.5	-1.0	-1.2
Smoking status: Previous	0.3	0.5	1.1	-0.6	-0.4	1.0	-0.2	0.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.3	-0.0	-0.5	-0.4	0.4	-0.2	0.1
Whole body fat-free mass	0.2	0.9	1.7	-1.1	0.8	1.1	-0.7	1.3	0.8
Leg fat-free mass (right)	0.3	1.5	2.8	-0.7	1.3	1.6	-1.1	1.7	0.2
Arm fat percentage (left)	0.7	3.0	5.8	-0.2	2.4	2.0	-1.6	2.3	-0.3
Average weekly red wine intake	1.5	2.3	4.0	0.1	-2.0	-1.8	1.6	-1.9	0.7
Handedness (chirality/laterality): Left-handed	0.5	0.7	2.6	-0.2	0.9	-0.0	-0.2	0.7	1.6
Mood swings	1.9	3.4	7.9	1.4	2.8	1.7	-2.3	1.3	0.7
Loneliness, isolation	0.9	1.2	2.2	0.9	1.5	1.5	-1.4	0.4	0.2
Long-standing illness, disability or infirmity	0.6	1.0	5.0	-0.5	-0.6	-0.3	-0.0	-0.3	2.2
Ever had bowel cancer screening	0.6	0.7	1.0	0.7	-1.0	-1.0	0.6	-0.9	0.6
Diabetes diagnosed by doctor	0.1	0.1	0.3	-0.6	0.5	0.0	0.1	-0.1	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.8	-0.8	0.7	0.4	-0.3	0.9	-0.2
Friendships satisfaction	0.7	0.9	2.5	0.2	0.6	1.6	-1.0	0.8	0.8
Qualifications: nursing, teaching	1.7	2.6	5.1	2.3	-1.0	-2.2	0.5	-1.9	1.0
Commuting to job workplace: Walk	0.1	0.2	0.6	0.3	-0.0	0.4	-0.2	-0.1	-0.8
Eye problems/disorders: Cataract	1.0	1.2	4.7	-2.2	-0.8	0.2	0.8	0.4	-1.0
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.1	0.4	-1.8	-1.4	1.3	-1.6	-0.3
Medication for cholesterol	0.3	0.5	0.9	1.0	-0.9	0.1	-0.9	-0.5	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.8	-0.9	0.9	0.7	0.8	0.5	-0.1
Back pain experienced in last month	0.2	0.3	0.7	0.4	-0.4	-0.8	-0.2	-0.5	0.7
Mineral and other dietary supplements	0.8	1.1	2.3	0.9	1.5	0.8	-1.1	0.5	-1.1
Breast cancer (self-reported)	1.4	1.6	3.3	1.8	-1.4	-1.3	0.4	-1.4	0.7
Asthma (self-reported)	1.0	2.0	6.8	-2.6	-1.2	-1.1	1.5	-0.3	-0.0
Osteoporosis (self-reported)	0.3	0.3	0.7	0.5	0.4	0.4	-0.9	0.4	-0.8
Osteoarthritis (self-reported)	1.0	1.3	3.1	1.2	-0.7	-1.3	0.5	-1.8	1.0
Medication: Aspirin	0.5	0.6	1.3	-0.5	0.2	-1.1	1.0	-0.6	0.9
Medication: Gliclazide	0.7	0.8	1.6	-0.8	1.0	1.1	-0.5	1.2	0.2
Illnesses of father: None of the above (group 1)	0.7	0.9	1.6	0.2	0.9	1.2	-1.0	1.3	-0.7
Smoking status: Current	0.3	0.5	1.5	1.1	0.5	0.3	-1.2	0.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.8	-1.9	0.4	0.1	1.2	0.5	0.9
Whole body water mass	0.2	0.9	1.6	-0.9	0.8	1.1	-0.7	1.3	0.8
Leg predicted mass (right)	0.3	1.6	3.1	-0.9	1.3	1.7	-1.1	1.8	0.2
Arm fat mass (left)	0.5	2.3	4.4	-0.4	1.9	1.8	-1.3	2.1	-0.2
Number of self-reported non-cancer illnesses	0.6	1.0	4.2	-2.1	0.1	0.7	-0.1	1.2	-0.3
Average weekly champagne plus white wine intake	0.5	0.7	1.8	0.6	0.5	1.3	-1.1	0.4	-0.8
Miserableness	0.9	1.5	3.3	1.4	1.3	1.8	-1.3	0.6	-0.2
Guilty feelings	0.5	0.8	3.0	1.7	0.3	0.1	-0.5	-0.3	1.0
Wears glasses or contact lenses	0.9	1.0	1.8	0.9	-1.3	-1.3	0.7	-0.7	1.0
Ever taken oral contraceptive pill	1.7	1.9	5.4	-2.1	0.4	0.9	-0.0	0.5	-2.3
Hearing aid user	7.3	8.3	21.8	4.2	2.3	1.5	-4.7	1.2	1.0
Mother’s age at death	1.4	1.8	2.9	1.5	-1.2	-1.7	0.6	-1.6	1.0
Financial situation satisfaction	0.4	0.4	1.2	-0.1	-1.1	-0.3	0.5	-0.9	-0.6
Tinnitus: Yes, now most or all of the time	1.8	2.1	5.0	0.5	1.2	2.2	-1.6	1.6	-0.7
Commuting to job workplace: Public transport	1.3	1.6	3.3	-0.6	1.0	1.8	-0.8	1.7	-1.1
Eye problems/disorders: Glaucoma	1.9	2.2	5.1	0.3	2.2	1.6	-1.4	1.8	-0.6
Medication: Blood pressure	0.3	0.6	1.9	-0.6	0.2	-0.5	0.9	-0.3	1.4
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.6	-0.8	-1.1	-1.4	1.6	-1.0	0.4
Supplements: Fish oil (including cod liver oil)	2.7	3.6	5.3	-1.4	-2.3	-2.3	2.0	-1.7	1.3
High cholesterol (Self-reported)	1.2	2.1	5.0	-0.1	1.9	1.2	-1.6	2.2	0.4
Medication: Bendroflumethiazide	0.3	0.5	1.8	-0.3	-0.5	-0.7	0.5	-0.1	1.3
Medication: Paracetamol	0.3	0.4	0.8	0.9	-0.7	-0.2	-0.4	-0.7	-0.8
Medication: Lisinopril	0.6	0.8	1.7	-1.1	-0.9	-0.6	1.3	-0.3	0.7
Medication: Atorvastatin	1.0	1.3	4.7	-2.2	0.4	-0.0	1.5	0.6	-0.5
Illnesses of father: High blood pressure	1.2	1.5	2.7	0.7	-1.6	-1.4	1.1	-1.6	0.0
Alcohol drinker status: Never	0.4	0.5	1.0	0.1	-0.6	-0.8	0.1	-0.9	1.0
Ever smoked	0.3	0.5	1.0	0.5	0.2	1.0	-0.8	0.3	-1.0
Basal metabolic rate	0.2	1.3	2.5	-0.9	1.1	1.4	-0.9	1.6	0.7
Leg fat percentage (left)	0.6	2.2	5.2	-1.0	2.0	1.6	-0.9	2.3	-0.1
Arm fat-free mass (left)	0.1	0.6	1.0	-0.7	0.6	0.9	-0.6	1.0	0.8
Number of operations (self-reported)	0.2	0.3	0.8	-0.9	-0.6	-0.4	0.4	-0.5	-0.2
Average weekly beer plus cider intake	0.4	0.6	1.5	-1.2	-0.9	0.0	0.7	0.7	-0.4
Irritability	0.8	1.4	3.5	1.2	1.9	1.0	-0.9	1.0	0.7
Risk taking	1.4	2.0	7.2	-2.7	-1.5	0.9	0.9	0.6	-1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.4	0.6	-1.1	-1.0	0.4	-1.2	-0.7
Fractured/broken bones in last 5 years	0.7	0.9	2.2	0.1	1.4	1.0	0.0	0.4	-1.5
Age started oral contraceptive pill	1.4	1.8	5.1	2.2	1.2	0.6	-1.8	0.2	0.9
Diastolic blood pressure, automated reading	1.1	3.4	6.0	-2.5	-2.2	-1.3	2.3	-1.3	-0.8
Ever depressed for a whole week	0.4	0.5	0.7	-0.7	-0.8	-0.8	0.5	-0.7	0.5
Unable to work because of sickness or disability	0.3	0.4	0.9	-0.4	-0.7	-0.6	0.5	-0.4	0.9
Commuting to job workplace: Cycle	1.9	2.3	8.3	2.9	1.0	-0.3	-1.8	-0.3	0.9
Myopia	0.1	0.1	0.4	-0.6	-0.0	0.1	-0.2	0.5	-0.1
Vascular/heart problems diagnosed by doctor	0.6	1.5	7.4	2.7	0.5	0.1	-1.2	-0.3	0.4
Cholesterol lowering medication	0.9	1.3	3.4	-0.2	1.8	0.8	-0.6	1.6	1.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.4	-0.5	-0.1	-0.0	0.0	-0.5
Pain experienced in last month	2.1	3.5	6.6	0.8	2.3	1.9	-1.8	2.6	1.1
Supplements: Calcium	0.5	0.5	1.7	-1.3	-0.4	0.3	0.3	1.0	-0.1
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.1	0.5	0.4	-0.3	0.3	-0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.5	-1.0	-0.0	0.7	0.3	0.3	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	4.4	-1.4	-1.4	-1.1	2.1	-1.5	-1.0
Heart disease (siblings)	1.5	1.8	2.9	-1.5	1.1	1.7	-0.8	1.5	-1.3
Alcohol drinker status: Previous	0.3	0.4	1.5	-1.2	0.3	0.5	0.5	0.3	-0.4
Pack years of smoking	1.6	2.3	4.2	-0.7	1.5	1.5	-1.2	1.8	-2.1
Impedance of whole body	0.1	0.3	1.0	-0.0	0.7	0.5	-0.2	1.0	0.0
Leg fat mass (left)	0.6	2.2	5.0	-1.0	1.9	1.6	-1.1	2.2	0.3
Arm predicted mass (left)	0.1	0.6	1.3	-1.1	0.5	0.9	-0.3	1.0	0.6