Hub : Genes

ARHGEF28

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.213 0.0500 2.2e-07 0.082 NA 0.095 NA 0.102 1.0e-06 NA 1.3e-07 NA 4.3e-08
2 GTEx Esophagus Mucosa 0.144 0.0520 2.1e-03 0.031 NA 0.057 NA 0.045 3.8e-03 NA 1.1e-04 NA 5.6e-04
3 GTEx Liver 0.573 0.1010 2.3e-06 0.272 NA 0.086 NA 0.208 3.1e-08 NA 2.1e-03 NA 1.9e-06
4 GTEx Nerve Tibial 0.149 0.0463 3.3e-04 0.033 NA 0.044 NA 0.057 2.1e-03 NA 4.4e-04 NA 6.7e-05
5 GTEx Pancreas 0.232 0.0690 1.1e-03 0.224 NA 0.179 NA 0.201 7.8e-10 NA 5.0e-08 NA 6.3e-09
6 METSIM Adipose 0.081 0.0255 3.0e-05 0.065 0.038 0.068 0.081 0.068 5.0e-10 1.8e-06 2.1e-10 3.8e-12 1.9e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.2 0.3 1.1 -0.1 -0.4 0.7 -0.1 0.4 -1.0
Bipolar Disorder or Schizophrenia 0.4 0.9 1.6 1.2 1.1 1.0 -0.8 0.4 -1.0
Depressed Affect (Nagel 2018) 0.2 0.4 1.1 0.5 0.7 0.7 -0.4 -0.1 1.1
Depression (Nagel 2018) 1.7 2.5 3.7 0.3 -1.9 -1.8 1.3 -1.9 1.7
Intelligence (Savage-Jansen 2018) 0.5 1.5 6.4 2.5 0.7 -0.2 -0.8 -0.8 1.0
Neuroticism (Nagel 2018) 0.7 1.8 7.3 1.5 0.8 0.2 -0.5 -0.3 2.7
Schizophrenia (2018) 0.6 1.2 2.9 1.7 1.7 0.7 -1.0 0.2 -0.4
Schizophrenia vs Biploar Disorder 1.4 1.8 3.9 1.2 1.6 1.4 -2.0 1.1 0.1
Worry (Nagel 2018) 1.2 2.6 11.8 1.4 -0.2 -0.9 -0.2 -1.1 3.4
Alzheimer’s Disease (in mother) 0.9 1.0 1.9 -0.8 -1.1 -0.5 1.4 -1.1 -0.8
Alzheimer’s Disease (in father) 0.6 0.7 2.1 -1.5 -0.5 0.0 0.8 0.5 0.9
Alzheimer’s Disease (including proxy) 0.6 0.9 2.3 -1.3 -0.6 0.3 1.5 0.1 -0.8
Crohns Disease (2017) 0.4 1.0 1.6 0.5 -1.0 -1.3 0.5 -1.0 1.3
Irritable Bowel Disease (IBD) 0.1 0.3 0.7 0.3 -0.5 -0.7 -0.2 -0.8 0.5
Ulcerative Colitis (UC) 0.1 0.1 0.3 -0.0 -0.0 -0.0 -0.5 -0.5 -0.6
Major Depression (MDD) 0.6 0.7 1.5 -0.8 -1.2 0.1 0.8 -0.2 -1.2
Reaction Time 0.1 0.2 0.8 0.4 -0.2 -0.1 -0.5 0.0 0.9
Verbal and Numeric Reasoning (VNR) 0.4 0.9 3.3 1.8 0.5 -0.7 0.2 -1.0 0.2
Breast Cancer 0.4 1.1 2.3 -1.5 -0.9 -0.8 1.3 -0.1 -0.9
Ovarian Cancer 0.2 0.3 0.6 0.7 0.8 0.6 -0.2 0.3 0.6
Prostate Cancer 0.1 0.1 0.2 -0.4 -0.3 0.4 -0.3 0.0 -0.3
Age at First Birth 0.2 0.2 0.7 0.7 -0.2 -0.3 -0.0 -0.2 0.8
Bipolar Disorder (2011) 1.4 1.4 2.6 0.7 1.2 1.5 -1.2 1.6 -0.3
Body Mass Index (BMI) (2010) 0.4 0.6 1.7 1.3 0.6 -0.4 -0.9 -0.3 0.5
Coronary Artery Disease (CAD) 1.4 1.7 4.1 -0.5 1.4 1.2 -1.3 1.0 -2.0
Crohns Disease (2012) 0.1 0.2 0.3 -0.3 0.2 0.5 -0.5 0.5 0.5
Mean Putamen Volume 0.7 0.8 2.0 -1.4 0.6 0.6 0.3 0.4 -1.4
Fasting Glucose 0.1 0.1 0.2 -0.1 0.0 -0.5 0.5 0.3 -0.2
HbA1C 2.1 2.3 5.1 0.5 0.8 2.3 -1.8 1.1 -1.9
HDL Cholesterol 0.9 1.5 3.1 0.8 -1.1 -1.4 0.9 -1.8 -1.2
LDL Cholesterol 0.2 0.3 0.8 0.9 0.6 0.2 -0.4 0.3 -0.1
Lupus 0.2 0.3 0.8 0.0 -0.5 -0.4 0.1 -0.8 0.9
Neuroticism (2016) 1.7 2.4 5.4 0.4 2.3 1.9 -1.6 1.6 -0.1
Primary Biliary Cirrhosis 2.2 3.2 5.6 -0.0 2.0 2.4 -1.8 2.2 -1.2
Rheumatoid Arthritis 0.9 1.2 2.5 1.6 -0.1 -1.2 0.2 -1.2 1.4
Schizophrenia (2014) 0.9 2.0 3.8 1.6 1.9 1.6 -1.3 1.0 -0.8
Triglycerides 0.1 0.1 0.5 -0.7 -0.2 -0.3 0.3 0.1 0.0
Type 2 Diabetes (T2D) (2012) 0.9 1.1 1.8 -1.0 0.8 1.1 -1.3 1.4 -0.0
Ulcerative Colitis 1.7 2.5 4.9 0.5 1.8 1.8 -2.2 1.7 0.6
Blood Eosinophil Count 0.4 3.1 9.4 -3.1 0.7 1.4 0.9 2.1 -1.4
Blood Platelet Count 0.2 2.3 5.5 -0.2 -2.3 -1.9 0.2 -2.1 -0.2
Blood Red Count 0.1 1.1 3.1 -0.6 0.0 -1.2 1.2 -1.8 -0.2
Blood White Count 0.2 1.4 6.2 -2.5 -1.1 -0.2 0.8 -0.3 -0.4
Heel T-Score 1.3 10.0 16.2 -1.4 -3.8 -3.5 3.9 -4.0 -0.2
BMI 1.0 5.5 9.9 -0.2 2.6 3.1 -2.4 3.1 -1.1
Height 0.2 2.9 6.4 -1.5 1.1 1.8 -1.0 2.5 1.9
Waist Hip Ratio (WHR) 0.4 1.6 4.2 1.3 -1.1 -0.9 -0.6 -1.1 -2.0
Systolic Blood Pressure 0.1 0.4 1.0 -0.7 -0.6 -0.4 0.6 -0.5 1.0
Smoking Status 0.2 0.6 2.0 -0.2 -0.3 1.1 -0.3 -0.2 -1.4
Allergy or Eczema 0.1 0.2 0.5 -0.3 0.5 0.5 -0.3 0.6 0.7
Cardiovascular Disease 0.6 2.1 8.3 -2.9 0.1 1.1 0.4 1.6 -0.4
Hypothyroidism (self reported) 0.1 0.2 1.0 0.1 1.0 0.1 -0.3 0.4 0.0
Respiratory disease 1.2 2.6 7.5 -2.7 -1.2 -1.3 2.1 -0.7 0.1
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.1 -0.4 1.0 0.6 -0.3 0.6 -0.1
Lung FEV1/FVC ratio 1.0 5.2 8.9 2.1 3.0 2.7 -2.2 1.5 -1.9
Lung FVC 0.8 3.9 10.8 -3.3 -1.7 -0.7 2.2 0.2 2.1
Neuroticism 0.6 1.5 5.7 1.4 0.7 -0.0 -0.1 -0.8 2.4
Chronotype (morning person) 0.1 0.2 0.5 0.5 -0.1 -0.2 -0.7 -0.3 -0.0
Hair Pigment 0.4 11.2 20.2 -1.0 -3.8 -3.9 4.5 -4.0 1.0
Tanning 0.1 1.6 3.5 -0.9 0.5 1.6 -1.1 1.9 -1.2
Hand grip strength (left) 0.4 1.1 2.5 -0.3 0.5 1.2 -0.7 1.6 -1.4
Number of treatments/medications taken 0.9 1.6 8.6 -2.9 0.1 -0.1 0.9 0.4 0.4
Average weekly spirits intake 1.9 2.3 4.6 -1.3 -2.1 -1.1 2.0 -0.9 -1.3
Sensitivity / hurt feelings 0.2 0.3 1.2 -0.0 0.5 0.6 0.1 -0.0 1.1
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.8 0.3 -0.7 -0.6 0.3 -0.7 1.3
Hearing difficulty/problems: Yes 22.0 33.5 66.9 4.3 5.7 6.4 -8.2 6.5 0.3
Relative age of first facial hair 0.8 1.6 4.0 2.0 -0.8 -1.1 -0.2 -0.8 1.8
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 2.4 0.6 -0.4 0.1 -0.4 -0.6 1.6
Ever used hormone-replacement therapy (HRT) 1.3 1.7 5.1 0.3 -1.1 -1.6 0.3 -1.1 2.3
Ever had hysterectomy (womb removed) 1.0 1.1 2.0 -0.5 -1.4 -1.2 1.4 -0.8 0.7
Systolic blood pressure, automated reading 0.4 1.2 2.7 0.1 -1.0 -1.2 1.4 -1.6 -0.1
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.0 -0.7 0.3 -0.2 1.0 -0.3 1.0
Angina 0.5 0.6 1.5 0.0 -0.0 -0.7 1.0 -0.8 1.2
Medication for hormone replacement therapy 0.1 0.1 0.2 -0.1 0.4 0.3 -0.2 0.5 -0.2
Vitamin and mineral supplements 1.3 1.8 4.4 1.5 -1.0 -1.7 0.4 -2.1 0.5
Supplements: Zinc 0.5 0.6 1.6 -0.1 -0.3 1.2 -0.8 1.0 0.2
Medication: Co-codamol 0.7 0.8 1.1 -1.0 -0.9 -0.9 1.0 -0.9 0.5
Medication: Metformin 0.6 0.8 1.7 -1.3 -0.3 -1.0 1.2 -0.6 0.6
Diabetes (father) 1.1 1.3 2.8 0.5 1.7 1.0 -1.6 1.1 0.2
Diabetes (mother) 0.2 0.3 0.7 -0.7 0.6 0.3 -0.1 0.3 -0.8
Severe depression (siblings) 0.4 0.4 0.7 0.2 -0.8 -0.4 0.8 -0.7 0.7
Pack years adult smoking proportion 2.2 3.4 4.9 -0.9 2.0 2.0 -1.4 2.2 -2.1
Impedance of leg (right) 0.1 0.3 0.6 -0.2 -0.6 -0.7 0.6 0.1 0.8
Leg fat-free mass (left) 0.3 1.3 2.6 -0.6 1.2 1.4 -1.2 1.6 0.4
Trunk fat percentage 0.9 3.6 8.1 -0.3 2.5 2.2 -1.5 2.8 -0.4
Hand grip strength (right) 0.1 0.4 1.5 0.1 -0.2 0.3 -0.5 0.6 -1.2
Townsend deprivation index at recruitment 2.4 3.4 7.1 1.1 2.3 2.0 -2.7 1.6 0.1
Current tobacco smoking 0.5 0.8 2.2 0.7 0.9 0.8 -1.5 0.5 -0.8
Average weekly fortified wine intake 0.2 0.3 0.5 0.3 0.6 0.6 -0.6 0.7 -0.4
Maternal smoking around birth 0.3 0.4 1.3 -0.9 -1.1 -0.1 -0.3 -0.1 0.6
Fed-up feelings 1.2 2.1 3.5 1.3 1.9 1.3 -1.7 1.0 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.3 1.2 -0.1 -0.1 0.5 -0.7 -0.1 1.1
Relative age voice broke 0.2 0.4 1.6 0.0 -0.5 -0.0 -0.3 0.5 1.3
Taking other prescription medications 0.5 0.8 2.6 -1.6 -0.2 -0.5 1.2 -0.1 0.5
Age when periods started (menarche) 0.2 0.4 1.3 0.1 -1.2 -0.2 -0.6 0.6 0.6
Bilateral oophorectomy (both ovaries removed) 4.7 5.5 12.4 -0.7 -3.5 -2.5 2.1 -2.8 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.5 0.1 -1.1 -1.2 0.2 -1.2 0.3
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.6 0.6 -0.8 -1.0 0.5 -1.3 0.8
Qualifications: CSEs or equivalent 0.5 0.7 1.4 1.0 0.5 1.0 -1.2 0.4 -0.6
Serious illness, injury or assault to yourself 0.7 0.8 2.5 1.1 0.6 0.5 -0.8 -0.3 1.6
High blood pressure 0.5 1.4 6.0 -2.5 -0.8 -0.2 1.3 0.0 0.0
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.6 0.0 0.6 0.6 -0.3 0.8 -0.4
Multivitamins +/- minerals 1.8 2.3 5.1 -2.1 1.2 1.5 -0.0 2.3 -0.7
Stomach or abdominal pain in last month 0.9 1.1 1.9 0.5 -1.3 -1.2 0.9 -1.4 -0.8
Supplements: Glucosamine 0.7 1.0 2.3 -0.8 -1.0 -0.7 1.1 0.3 1.5
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 5.9 -1.6 0.1 1.4 -0.5 -0.0 -2.4
Medication: Atenolol 0.3 0.3 0.5 -0.3 -0.4 -0.7 0.7 -0.4 0.7
Medication: Levothyroxine sodium 0.3 0.5 1.3 1.1 0.5 -0.5 -0.4 0.2 1.1
Sitting height 0.5 3.3 10.0 -3.2 0.3 1.3 0.8 1.9 1.8
Chronic bronchitis/emphysema (father) 0.5 0.6 1.7 1.0 -0.2 -0.7 0.3 -0.5 1.3
High blood pressure (mother) 0.1 0.1 0.4 -0.6 -0.3 0.0 -0.0 -0.3 -0.0
Body mass index (BMI) 0.3 1.2 2.0 0.1 1.4 1.3 -1.3 1.4 -0.3
Impedance of leg (left) 0.0 0.2 0.4 -0.7 -0.1 -0.0 0.6 0.6 0.3
Leg predicted mass (left) 0.3 1.4 2.8 -0.6 1.2 1.4 -1.2 1.7 0.4
Trunk fat mass 0.8 3.6 8.2 -0.7 2.5 2.2 -1.4 2.9 0.1
Waist circumference 0.2 0.6 1.5 0.6 1.2 0.5 -1.0 0.8 0.5
Number of incorrect matches in round 1.6 2.6 4.7 -0.9 -1.6 -1.8 1.9 -2.2 0.6
Past tobacco smoking 0.2 0.3 1.0 0.3 0.5 -0.7 0.3 0.0 1.0
Alcohol usually taken with meals 0.3 0.5 2.9 1.7 0.1 0.1 -0.3 -0.2 0.1
Nervous feelings 0.8 1.6 7.6 0.8 0.3 -0.8 0.4 -0.5 2.8
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.3 -0.8 -1.4 -0.5 0.9 -0.9 1.5
Hearing difficulty/problems with background noise 11.9 19.1 37.8 3.9 4.3 4.7 -6.1 4.6 0.9
Hair/balding pattern: Pattern 2 0.3 0.4 1.4 -0.3 0.0 1.2 -0.5 0.5 -0.3
Had menopause 0.9 1.2 1.9 0.3 1.4 1.2 -1.3 1.1 0.9
Had other major operations 0.1 0.1 0.2 -0.4 -0.5 0.1 -0.3 -0.0 -0.2
Forced vital capacity (FVC) 0.7 2.5 8.1 -2.8 -0.3 0.8 1.0 1.4 1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 1.6 -0.3 -1.3 -1.0 0.2 -0.7 1.1
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.3 -0.8 0.2 1.1 -0.5 0.2 -1.1
Qualifications: None of the above 0.1 0.3 0.7 -0.8 -0.4 0.1 0.1 -0.0 0.9
Financial difficulties in last 2 years 0.4 0.6 1.5 0.0 0.6 1.1 -1.2 0.3 -0.5
Mouth/teeth dental problems 0.4 0.7 2.6 -1.6 -0.2 0.0 1.1 -0.2 -0.5
Heart attack 0.5 0.6 2.4 -1.0 -0.2 0.5 0.3 0.2 -1.5
Allergy 0.3 0.7 1.7 1.3 0.7 0.4 -1.1 -0.0 0.6
Pain all over the body in last month 1.9 2.1 3.9 -1.6 -1.6 -1.1 2.0 -0.8 1.3
Diabetes (self-reported) 0.1 0.1 0.5 -0.4 0.3 -0.2 0.2 -0.3 0.7
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.6 -0.1 0.3 0.5 -0.3 0.8 -0.1
Medication: Ramipril 1.7 2.2 6.8 -2.6 -1.3 -0.7 1.9 -0.6 -0.1
Medication: Simvastatin 1.0 1.4 3.9 -1.0 1.3 1.2 -0.7 2.0 0.5
Fluid intelligence score 0.4 0.9 3.8 1.9 0.5 -0.9 -0.1 -0.6 0.3
Illnesses of siblings 0.3 0.4 1.4 0.5 -1.2 -0.7 0.5 -0.5 0.0
Neuroticism score 1.2 2.5 6.2 2.1 1.8 0.8 -0.9 -0.1 2.5
Weight 0.4 2.0 3.9 -0.4 1.7 1.6 -1.4 2.0 0.7
Impedance of arm (right) 0.2 0.9 1.8 0.4 1.1 1.1 -0.8 1.3 -0.5
Arm fat percentage (right) 0.7 2.8 5.0 -0.2 2.2 2.0 -1.6 2.2 -0.5
Trunk fat-free mass 0.2 1.0 1.7 -1.1 0.6 0.9 -0.6 1.2 1.3
Hip circumference 0.4 1.8 4.4 -0.1 2.1 1.1 -0.6 1.7 1.4
Time employed in main current job 0.6 0.7 1.2 -0.4 -0.8 -1.1 0.8 -1.1 -0.5
Alcohol intake versus 10 years previously 0.2 0.3 0.9 -0.2 0.9 0.2 -0.2 0.4 0.9
Father’s age at death 0.3 0.4 1.1 -1.1 0.0 0.4 -0.1 0.8 0.6
Worrier / anxious feelings 0.9 1.7 7.8 0.7 0.8 0.5 -0.7 0.4 2.8
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.7 -1.3 -0.3 1.0 -0.6 0.6 1.1
Falls in the last year 0.6 0.7 2.9 -1.7 -0.7 -0.1 0.7 -0.3 -0.7
Hair/balding pattern: Pattern 3 0.5 0.8 3.6 -0.4 -0.2 0.6 0.6 -0.1 -1.9
Number of live births 0.9 1.3 2.5 -0.0 1.6 1.0 -1.6 1.4 0.2
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 3.6 -1.9 0.7 1.3 0.2 1.6 1.5
Pulse rate 1.1 1.9 4.6 0.3 -1.7 -1.4 1.0 -2.1 -1.0
Happiness 0.2 0.2 0.6 0.5 -0.4 0.7 -0.3 -0.5 0.0
Noisy workplace 0.4 0.5 1.4 -1.2 -0.7 -0.3 0.8 -0.1 -0.7
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.7 0.8 0.0 -0.3 -0.1 -0.6 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.4 -0.3 0.1 -0.8 -0.2 -0.2 1.2
Mouth/teeth dental problems: Dentures 3.5 6.0 10.4 0.9 2.8 2.9 -3.2 2.7 -1.1
Asthma 1.1 2.1 7.2 -2.7 -1.4 -1.1 1.5 -0.4 -0.0
Medication: Ibuprofen (e.g. Nurofen) 2.3 2.9 6.1 -2.5 -1.6 -0.9 2.0 -1.7 -0.9
Medication: Cholesterol lowering 1.5 2.3 5.5 -1.5 1.3 1.7 -1.1 2.4 -0.7
Depression (self-reported) 2.2 2.7 4.8 0.6 -1.9 -2.0 1.7 -2.2 0.5
Medication: Lansoprazole 1.1 1.3 2.9 0.7 -1.3 -1.7 0.8 -1.4 -0.1
Prospective memory result 0.2 0.3 0.4 0.0 -0.5 -0.7 0.4 -0.5 0.7
Lung cancer (father) 0.3 0.3 1.2 0.4 0.5 0.4 -0.5 0.3 1.1
Illnesses of mother 0.4 0.4 1.0 1.0 0.8 0.2 -0.1 0.2 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 4.8 -2.2 0.3 0.8 0.8 1.0 1.6
Pulse wave Arterial Stiffness index 0.6 0.7 2.3 -1.5 0.4 0.8 -0.2 1.0 -0.2
Impedance of arm (left) 0.2 0.8 1.7 0.4 1.2 1.0 -0.8 1.3 -0.1
Arm fat mass (right) 0.5 2.2 4.1 0.1 1.9 1.8 -1.6 2.0 0.0
Trunk predicted mass 0.2 1.0 1.9 -1.1 0.6 0.9 -0.5 1.1 1.4
Standing height 0.2 1.5 3.4 -1.1 0.7 1.0 -0.3 1.7 1.9
Length of working week for main job 1.9 2.1 5.3 -0.4 -1.9 -0.3 1.0 -1.6 -2.3
Exposure to tobacco smoke at home 2.6 2.9 11.1 2.0 0.2 -0.8 -0.7 -0.9 3.3
Breastfed as a baby 0.6 0.7 1.7 -1.1 -0.4 0.7 0.6 0.5 -1.3
Tense / ‘highly strung’ 0.3 0.5 2.1 0.4 0.9 0.1 -0.4 -0.2 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.0 -0.4 0.9 0.9 -0.8 1.0 0.8
Hair/balding pattern: Pattern 4 0.8 2.0 7.7 1.5 0.7 -0.8 -0.9 0.0 2.8
Birth weight of first child 1.2 2.2 7.6 1.1 0.8 1.5 -2.8 1.2 -0.1
Peak expiratory flow (PEF) 0.9 2.1 3.8 -1.7 2.0 1.4 -0.4 1.5 1.1
Pulse wave reflection index 3.6 4.5 9.6 -3.1 1.9 2.0 -0.3 3.0 -0.8
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.3 -0.5 -0.1 0.5 0.0 0.1 0.1
Loud music exposure frequency 0.3 0.3 0.6 -0.6 0.2 0.8 -0.4 0.5 -0.6
Qualifications: O levels/GCSEs or equivalent 1.3 2.0 4.5 2.1 1.1 0.7 -2.0 0.4 1.3
Mouth/teeth dental problems: Bleeding gums 1.9 2.5 4.6 1.6 -0.8 -2.0 0.6 -1.6 2.2
Blood clot in the leg (DVT) 1.8 2.4 4.7 -1.7 -1.5 -1.0 2.2 -1.4 -1.3
Medication: Paracetamol 0.2 0.4 1.1 -0.1 -0.9 -0.1 -0.1 -0.5 -1.1
Headache pain in last month 0.5 0.8 2.2 -1.3 0.0 0.9 0.3 -0.0 -1.5
Medication for cholesterol, blood pressure or diabetes 1.5 2.6 7.9 2.8 -0.7 -1.5 0.3 -2.0 0.8
Glaucoma (self-reported) 2.2 2.6 6.3 -0.4 2.5 2.0 -0.9 2.0 -0.7
Gout (self-reported) 1.7 2.4 4.0 2.0 -1.1 -2.0 0.7 -1.6 1.4
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.5 0.5 0.7 -0.3 0.1 0.2 0.1
Medication: Amlodipine 0.3 0.4 1.8 -1.4 -0.3 -0.1 0.4 0.1 -0.1
Medication: Ventolin 100micrograms inhaler 2.0 2.6 12.6 -3.5 0.2 0.7 0.8 1.2 -0.8
Birth weight 0.6 1.3 4.5 2.1 0.6 0.5 -1.5 0.3 -0.4
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.9 -0.1 -0.6 -0.6 0.1 -0.6 1.0
High blood pressure (siblings) 0.1 0.2 0.7 -0.8 0.2 0.5 -0.2 0.4 0.2
Forced vital capacity (FVC), Best measure 0.7 2.7 9.4 -3.1 -0.7 0.1 1.5 0.7 1.9
Body fat percentage 0.7 2.9 6.4 -0.4 2.3 1.9 -1.3 2.5 -0.2
Leg fat percentage (right) 0.5 1.7 4.2 -0.6 1.8 1.2 -1.0 2.0 0.1
Arm fat-free mass (right) 0.1 0.5 1.1 -1.1 0.4 0.5 -0.1 0.8 1.1
Exposure to tobacco smoke outside home 2.0 2.6 6.1 1.4 1.3 1.3 -2.5 1.6 1.4
Comparative body size at age 10 3.6 9.9 17.2 -1.0 3.7 4.1 -2.4 3.7 -2.9
Number of full brothers 0.2 0.3 0.7 0.8 -0.2 0.0 -0.3 -0.5 -0.7
Worry too long after embarrassment 1.1 1.9 8.4 1.3 0.7 -0.4 0.5 -0.7 2.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 2.7 -1.6 0.4 0.3 0.7 0.1 0.6
Wheeze or whistling in the chest in last year 1.0 1.8 7.1 -2.7 -0.8 -0.2 1.6 -0.5 -0.6
Number of children fathered 0.6 0.6 1.4 0.5 -0.6 -1.2 0.8 -1.1 0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 3.0 1.0 -0.2 -1.4 1.0 -1.7 0.8
Age at first live birth 1.0 1.7 3.0 -0.3 0.9 1.7 -1.4 1.6 -1.4
Pulse wave peak to peak time 0.4 0.5 1.6 1.3 -0.3 -0.7 0.3 -0.8 0.5
Health satisfaction 0.9 1.1 2.5 -0.9 0.3 1.3 -0.5 1.1 -1.6
Shortness of breath walking on level ground 0.2 0.2 0.5 -0.5 -0.7 0.4 -0.1 0.6 -0.2
Qualifications: College or University degree 0.2 0.7 1.5 0.4 0.7 1.2 -0.7 1.0 -0.9
Eye problems/disorders: None of the above 0.5 0.5 1.0 0.9 -0.8 -1.0 0.2 -1.0 0.0
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.2 0.7 0.4 0.8 -1.1 0.4 -0.6
Emphysema/chronic bronchitis 1.9 2.1 5.7 -2.4 -1.6 -0.5 1.3 -0.1 -1.7
Medication for pain relief, constipation, heartburn 0.7 1.2 2.6 1.6 0.5 1.0 -1.4 1.2 0.4
Neck or shoulder pain in last month 0.2 0.3 0.6 0.0 -0.8 0.2 -0.6 -0.4 -0.6
Medication: Blood pressure 0.9 1.6 6.5 -2.5 -1.1 -0.3 1.3 0.1 -0.6
Angina (self-reported) 0.3 0.4 1.1 -0.0 0.0 -0.5 0.8 -0.8 1.0
Migraine (self-reported) 0.9 1.1 2.3 -1.1 -1.5 -0.7 0.7 -1.4 -0.1
Medication: Ibuprofen 1.8 2.1 3.6 -1.7 -1.2 -1.0 1.8 -1.9 -0.8
Medication: Allopurinol 1.2 1.6 3.7 1.2 -0.9 -1.9 1.3 -1.4 0.2
Medication: Omeprazole 0.2 0.2 0.6 -0.3 -0.7 -0.0 0.1 -0.1 -0.8
Medication: Seretide 50 evohaler 4.6 5.3 13.9 -3.6 -1.6 0.8 1.2 0.4 -3.7
Mean time to correctly identify matches 0.3 0.5 0.8 0.5 0.7 0.4 -0.9 0.7 0.8
Heart disease (mother) 4.2 5.1 9.7 -0.3 3.1 2.6 -1.8 3.0 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.4 -0.6 -0.4 0.2 -0.3 0.5 -0.1
Whole body fat mass 0.8 3.2 7.0 -0.6 2.3 2.0 -1.4 2.6 0.1
Leg fat mass (right) 0.6 2.3 5.6 -0.7 1.9 1.6 -1.3 2.4 0.3
Arm predicted mass (right) 0.2 0.8 2.2 -1.5 0.4 0.7 -0.1 1.0 1.0
Pulse rate, automated reading 1.0 3.3 8.9 -3.0 -2.0 -0.7 2.1 -1.0 -1.2
Alcohol intake frequency. 0.4 0.9 4.2 -0.1 0.4 -0.6 0.2 -0.9 2.1
Comparative height size at age 10 0.3 1.8 3.2 0.4 1.8 1.1 -1.2 1.3 1.7
Number of full sisters 0.3 0.4 1.1 0.9 -0.2 0.6 -1.0 0.3 -0.1
Suffer from ‘nerves’ 1.3 2.1 6.8 1.5 1.4 -0.2 -1.1 -0.1 2.6
Overall health rating 0.3 0.7 3.5 -1.9 -0.6 0.1 0.5 -0.2 0.2
Chest pain or discomfort 0.3 0.4 1.0 1.0 -0.4 -0.6 0.1 -0.7 0.5
Had major operations 0.1 0.2 0.7 -0.3 -0.2 -0.0 -0.4 0.1 0.8
Age at last live birth 2.0 2.9 4.9 -0.7 1.6 2.2 -1.8 2.2 -1.3
Family relationship satisfaction 0.2 0.2 0.9 -0.4 -0.5 0.9 -0.3 -0.1 -0.2
Leg pain on walking 0.9 1.1 2.8 0.6 -1.7 -1.0 0.1 -1.6 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 0.6 0.0 -0.3 -0.3 0.0 0.1
Commuting to job workplace: Car/motor vehicle 2.3 2.6 4.5 -0.9 -2.1 -1.9 2.0 -1.6 0.7
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.8 1.4 0.3 0.4 -0.8 0.2 -0.3
Medication: Aspirin 0.8 1.1 2.2 -0.9 -0.3 -1.5 1.4 -0.9 0.9
Supplements: Vitamin C 0.1 0.2 0.4 -0.5 -0.7 0.3 -0.3 0.2 -0.3
Knee pain experienced in last month 0.6 0.9 2.1 -0.3 -1.4 -0.9 0.6 -1.4 -0.3
Hypertension (Self-reported) 0.5 1.5 6.4 -2.5 -0.6 -0.2 1.5 -0.0 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 3.0 0.7 -0.2 -0.1 -1.7 0.4 1.4
Illnesses of father: Heart disease 1.5 2.1 4.4 -1.0 0.7 1.8 -1.1 1.4 -2.1
Illnesses of siblings: Diabetes 0.4 0.5 1.6 -0.3 -0.1 -0.6 0.5 -1.0 -1.2
Smoking status: Previous 0.3 0.5 1.1 -0.6 -0.4 1.0 -0.2 0.3 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.3 -0.0 -0.5 -0.4 0.4 -0.2 0.1
Whole body fat-free mass 0.2 0.9 1.7 -1.1 0.8 1.1 -0.7 1.3 0.8
Leg fat-free mass (right) 0.3 1.5 2.8 -0.7 1.3 1.6 -1.1 1.7 0.2
Arm fat percentage (left) 0.7 3.0 5.8 -0.2 2.4 2.0 -1.6 2.3 -0.3
Average weekly red wine intake 1.5 2.3 4.0 0.1 -2.0 -1.8 1.6 -1.9 0.7
Handedness (chirality/laterality): Left-handed 0.5 0.7 2.6 -0.2 0.9 -0.0 -0.2 0.7 1.6
Mood swings 1.9 3.4 7.9 1.4 2.8 1.7 -2.3 1.3 0.7
Loneliness, isolation 0.9 1.2 2.2 0.9 1.5 1.5 -1.4 0.4 0.2
Long-standing illness, disability or infirmity 0.6 1.0 5.0 -0.5 -0.6 -0.3 -0.0 -0.3 2.2
Ever had bowel cancer screening 0.6 0.7 1.0 0.7 -1.0 -1.0 0.6 -0.9 0.6
Diabetes diagnosed by doctor 0.1 0.1 0.3 -0.6 0.5 0.0 0.1 -0.1 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 0.8 -0.8 0.7 0.4 -0.3 0.9 -0.2
Friendships satisfaction 0.7 0.9 2.5 0.2 0.6 1.6 -1.0 0.8 0.8
Qualifications: nursing, teaching 1.7 2.6 5.1 2.3 -1.0 -2.2 0.5 -1.9 1.0
Commuting to job workplace: Walk 0.1 0.2 0.6 0.3 -0.0 0.4 -0.2 -0.1 -0.8
Eye problems/disorders: Cataract 1.0 1.2 4.7 -2.2 -0.8 0.2 0.8 0.4 -1.0
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 3.1 0.4 -1.8 -1.4 1.3 -1.6 -0.3
Medication for cholesterol 0.3 0.5 0.9 1.0 -0.9 0.1 -0.9 -0.5 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.8 -0.9 0.9 0.7 0.8 0.5 -0.1
Back pain experienced in last month 0.2 0.3 0.7 0.4 -0.4 -0.8 -0.2 -0.5 0.7
Mineral and other dietary supplements 0.8 1.1 2.3 0.9 1.5 0.8 -1.1 0.5 -1.1
Breast cancer (self-reported) 1.4 1.6 3.3 1.8 -1.4 -1.3 0.4 -1.4 0.7
Asthma (self-reported) 1.0 2.0 6.8 -2.6 -1.2 -1.1 1.5 -0.3 -0.0
Osteoporosis (self-reported) 0.3 0.3 0.7 0.5 0.4 0.4 -0.9 0.4 -0.8
Osteoarthritis (self-reported) 1.0 1.3 3.1 1.2 -0.7 -1.3 0.5 -1.8 1.0
Medication: Aspirin 0.5 0.6 1.3 -0.5 0.2 -1.1 1.0 -0.6 0.9
Medication: Gliclazide 0.7 0.8 1.6 -0.8 1.0 1.1 -0.5 1.2 0.2
Illnesses of father: None of the above (group 1) 0.7 0.9 1.6 0.2 0.9 1.2 -1.0 1.3 -0.7
Smoking status: Current 0.3 0.5 1.5 1.1 0.5 0.3 -1.2 0.0 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 3.8 -1.9 0.4 0.1 1.2 0.5 0.9
Whole body water mass 0.2 0.9 1.6 -0.9 0.8 1.1 -0.7 1.3 0.8
Leg predicted mass (right) 0.3 1.6 3.1 -0.9 1.3 1.7 -1.1 1.8 0.2
Arm fat mass (left) 0.5 2.3 4.4 -0.4 1.9 1.8 -1.3 2.1 -0.2
Number of self-reported non-cancer illnesses 0.6 1.0 4.2 -2.1 0.1 0.7 -0.1 1.2 -0.3
Average weekly champagne plus white wine intake 0.5 0.7 1.8 0.6 0.5 1.3 -1.1 0.4 -0.8
Miserableness 0.9 1.5 3.3 1.4 1.3 1.8 -1.3 0.6 -0.2
Guilty feelings 0.5 0.8 3.0 1.7 0.3 0.1 -0.5 -0.3 1.0
Wears glasses or contact lenses 0.9 1.0 1.8 0.9 -1.3 -1.3 0.7 -0.7 1.0
Ever taken oral contraceptive pill 1.7 1.9 5.4 -2.1 0.4 0.9 -0.0 0.5 -2.3
Hearing aid user 7.3 8.3 21.8 4.2 2.3 1.5 -4.7 1.2 1.0
Mother’s age at death 1.4 1.8 2.9 1.5 -1.2 -1.7 0.6 -1.6 1.0
Financial situation satisfaction 0.4 0.4 1.2 -0.1 -1.1 -0.3 0.5 -0.9 -0.6
Tinnitus: Yes, now most or all of the time 1.8 2.1 5.0 0.5 1.2 2.2 -1.6 1.6 -0.7
Commuting to job workplace: Public transport 1.3 1.6 3.3 -0.6 1.0 1.8 -0.8 1.7 -1.1
Eye problems/disorders: Glaucoma 1.9 2.2 5.1 0.3 2.2 1.6 -1.4 1.8 -0.6
Medication: Blood pressure 0.3 0.6 1.9 -0.6 0.2 -0.5 0.9 -0.3 1.4
Pain type(s) experienced in last month: Hip pain 1.0 1.3 2.6 -0.8 -1.1 -1.4 1.6 -1.0 0.4
Supplements: Fish oil (including cod liver oil) 2.7 3.6 5.3 -1.4 -2.3 -2.3 2.0 -1.7 1.3
High cholesterol (Self-reported) 1.2 2.1 5.0 -0.1 1.9 1.2 -1.6 2.2 0.4
Medication: Bendroflumethiazide 0.3 0.5 1.8 -0.3 -0.5 -0.7 0.5 -0.1 1.3
Medication: Paracetamol 0.3 0.4 0.8 0.9 -0.7 -0.2 -0.4 -0.7 -0.8
Medication: Lisinopril 0.6 0.8 1.7 -1.1 -0.9 -0.6 1.3 -0.3 0.7
Medication: Atorvastatin 1.0 1.3 4.7 -2.2 0.4 -0.0 1.5 0.6 -0.5
Illnesses of father: High blood pressure 1.2 1.5 2.7 0.7 -1.6 -1.4 1.1 -1.6 0.0
Alcohol drinker status: Never 0.4 0.5 1.0 0.1 -0.6 -0.8 0.1 -0.9 1.0
Ever smoked 0.3 0.5 1.0 0.5 0.2 1.0 -0.8 0.3 -1.0
Basal metabolic rate 0.2 1.3 2.5 -0.9 1.1 1.4 -0.9 1.6 0.7
Leg fat percentage (left) 0.6 2.2 5.2 -1.0 2.0 1.6 -0.9 2.3 -0.1
Arm fat-free mass (left) 0.1 0.6 1.0 -0.7 0.6 0.9 -0.6 1.0 0.8
Number of operations (self-reported) 0.2 0.3 0.8 -0.9 -0.6 -0.4 0.4 -0.5 -0.2
Average weekly beer plus cider intake 0.4 0.6 1.5 -1.2 -0.9 0.0 0.7 0.7 -0.4
Irritability 0.8 1.4 3.5 1.2 1.9 1.0 -0.9 1.0 0.7
Risk taking 1.4 2.0 7.2 -2.7 -1.5 0.9 0.9 0.6 -1.0
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.4 0.6 -1.1 -1.0 0.4 -1.2 -0.7
Fractured/broken bones in last 5 years 0.7 0.9 2.2 0.1 1.4 1.0 0.0 0.4 -1.5
Age started oral contraceptive pill 1.4 1.8 5.1 2.2 1.2 0.6 -1.8 0.2 0.9
Diastolic blood pressure, automated reading 1.1 3.4 6.0 -2.5 -2.2 -1.3 2.3 -1.3 -0.8
Ever depressed for a whole week 0.4 0.5 0.7 -0.7 -0.8 -0.8 0.5 -0.7 0.5
Unable to work because of sickness or disability 0.3 0.4 0.9 -0.4 -0.7 -0.6 0.5 -0.4 0.9
Commuting to job workplace: Cycle 1.9 2.3 8.3 2.9 1.0 -0.3 -1.8 -0.3 0.9
Myopia 0.1 0.1 0.4 -0.6 -0.0 0.1 -0.2 0.5 -0.1
Vascular/heart problems diagnosed by doctor 0.6 1.5 7.4 2.7 0.5 0.1 -1.2 -0.3 0.4
Cholesterol lowering medication 0.9 1.3 3.4 -0.2 1.8 0.8 -0.6 1.6 1.0
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.3 -0.4 -0.5 -0.1 -0.0 0.0 -0.5
Pain experienced in last month 2.1 3.5 6.6 0.8 2.3 1.9 -1.8 2.6 1.1
Supplements: Calcium 0.5 0.5 1.7 -1.3 -0.4 0.3 0.3 1.0 -0.1
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 0.1 0.5 0.4 -0.3 0.3 -0.4
Heart attack/myocardial infarction (self-reported) 0.5 0.7 2.5 -1.0 -0.0 0.7 0.3 0.3 -1.6
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 4.4 -1.4 -1.4 -1.1 2.1 -1.5 -1.0
Heart disease (siblings) 1.5 1.8 2.9 -1.5 1.1 1.7 -0.8 1.5 -1.3
Alcohol drinker status: Previous 0.3 0.4 1.5 -1.2 0.3 0.5 0.5 0.3 -0.4
Pack years of smoking 1.6 2.3 4.2 -0.7 1.5 1.5 -1.2 1.8 -2.1
Impedance of whole body 0.1 0.3 1.0 -0.0 0.7 0.5 -0.2 1.0 0.0
Leg fat mass (left) 0.6 2.2 5.0 -1.0 1.9 1.6 -1.1 2.2 0.3
Arm predicted mass (left) 0.1 0.6 1.3 -1.1 0.5 0.9 -0.3 1.0 0.6