Best TWAS P=1.83e-10 · Best GWAS P=0.000152 conditioned to 0.000129
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP1-283E3.4 | 0.65 | 0.14 | lasso | 9 | 0.33 | 5.1e-28 | -3.2 | -5.6 | 2.8e-08 | -0.03 | 0.01 | 0.15 | FALSE |
| 2 | GTEx | Artery Aorta | RP1-283E3.4 | 0.60 | 0.12 | lasso | 9 | 0.27 | 3.2e-15 | -3.2 | -5.2 | 1.6e-07 | -0.09 | 0.01 | 0.08 | FALSE |
| 3 | GTEx | Artery Tibial | RP1-283E3.4 | 0.66 | 0.09 | lasso | 6 | 0.38 | 4.9e-31 | -3.2 | -5.4 | 7.9e-08 | -0.09 | 0.02 | 0.13 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | RP1-283E3.4 | 0.59 | 0.13 | lasso | 8 | 0.29 | 3.0e-22 | 2.9 | -5.5 | 3.3e-08 | 0.00 | 0.02 | 0.08 | FALSE |
| 5 | GTEx | Esophagus Mucosa | RP1-283E3.4 | 0.53 | 0.12 | enet | 20 | 0.22 | 4.1e-15 | -3.2 | -5.9 | 4.4e-09 | 0.04 | 0.01 | 0.15 | FALSE |
| 6 | GTEx | Esophagus Muscularis | RP1-283E3.4 | 0.46 | 0.14 | enet | 23 | 0.24 | 1.6e-14 | -3.2 | -6.4 | 1.8e-10 | -0.01 | 0.01 | 0.14 | TRUE |
| 7 | GTEx | Lung | RP1-283E3.4 | 0.58 | 0.07 | lasso | 7 | 0.34 | 8.8e-27 | -3.2 | -5.3 | 9.3e-08 | -0.13 | 0.02 | 0.12 | FALSE |
| 8 | GTEx | Muscle Skeletal | SLC35E2B | 0.35 | 0.06 | lasso | 4 | 0.19 | 3.2e-18 | -3.0 | 5.5 | 3.0e-08 | 0.07 | 0.02 | 0.09 | FALSE |
| 9 | GTEx | Muscle Skeletal | RP1-283E3.4 | 0.51 | 0.12 | lasso | 6 | 0.29 | 2.4e-28 | -3.2 | -5.4 | 5.5e-08 | -0.08 | 0.01 | 0.15 | FALSE |
| 10 | GTEx | Muscle Skeletal | RP11-345P4.10 | 0.54 | 0.06 | lasso | 7 | 0.29 | 4.7e-29 | -3.0 | 5.4 | 7.2e-08 | 0.10 | 0.02 | 0.08 | FALSE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | RP1-283E3.4 | 0.48 | 0.12 | lasso | 5 | 0.31 | 1.1e-17 | -3.2 | -5.6 | 2.4e-08 | 0.03 | 0.01 | 0.07 | FALSE |
| 12 | GTEx | Thyroid | RP1-283E3.4 | 0.59 | 0.04 | lasso | 10 | 0.22 | 3.8e-17 | -3.2 | -6.0 | 2.0e-09 | -0.03 | 0.01 | 0.11 | FALSE |