Best TWAS P=9.38e-20 · Best GWAS P=1.31e-24 conditioned to 0.0378
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | COBLL1 | 0.05 | 0.01 | lasso | 6 | 0.03 | 0.00033 | -6.4 | 5.3 | 9.8e-08 | 0.41 | 0.40 | 0.06 | TRUE |
| 2 | GTEx | Esophagus Muscularis | GRB14 | 0.14 | 0.09 | lasso | 7 | 0.06 | 0.00016 | 8.9 | -9.1 | 9.4e-20 | -0.46 | 0.29 | 0.42 | TRUE |
| 3 | GTEx | Thyroid | COBLL1 | 0.07 | 0.05 | lasso | 3 | 0.05 | 0.00015 | -6.9 | 6.9 | 5.5e-12 | 0.59 | 0.57 | 0.25 | TRUE |
| 4 | METSIM | Adipose | GRB14 | 0.04 | 0.00 | bslmm | 376 | 0.01 | 0.01630 | -2.6 | -5.3 | 1.4e-07 | -0.26 | 0.12 | 0.13 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | GRB14 | 0.09 | 0.01 | blup | 82 | 0.03 | 0.00464 | 8.4 | -6.7 | 2.6e-11 | -0.54 | 0.02 | 0.64 | FALSE |