Best TWAS P=2.84e-10 · Best GWAS P=7.23e-10 conditioned to 2.83e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AMZ1 | 0.19 | 0.12 | enet | 22 | 0.13 | 5.7e-16 | 5.0 | 5.9 | 4.3e-09 | 0.00 | 0.10 | 0.90 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | GNA12 | 0.46 | 0.51 | lasso | 5 | 0.50 | 7.9e-19 | -5.7 | -5.5 | 3.2e-08 | -0.03 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Whole Blood | GNA12 | 0.09 | 0.01 | enet | 4 | 0.00 | 3.3e-01 | -5.3 | -5.6 | 2.6e-08 | -0.02 | 0.02 | 0.90 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | AMZ1 | 0.09 | 0.05 | lasso | 6 | 0.04 | 2.4e-06 | -5.3 | 6.3 | 2.8e-10 | 0.02 | 0.05 | 0.95 | TRUE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | AMZ1 | 0.18 | 0.05 | blup | 69 | 0.05 | 1.4e-02 | 3.6 | -5.6 | 1.6e-08 | -0.02 | 0.01 | 0.59 | FALSE |