Best TWAS P=7.66e-09 · Best GWAS P=2.02e-08 conditioned to 0.319
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ZDHHC4 | 0.29 | 0.09 | enet | 19 | 0.13 | 7.5e-08 | 4.4 | -5.8 | 7.7e-09 | 0.42 | 0.62 | 0.33 | TRUE |
| 2 | GTEx | Nerve Tibial | ZNF12 | 0.16 | 0.10 | enet | 7 | 0.15 | 5.3e-11 | 5.2 | -5.6 | 2.1e-08 | 0.44 | 0.04 | 0.96 | FALSE |
| 3 | GTEx | Nerve Tibial | PMS2CL | 0.19 | 0.04 | enet | 10 | 0.08 | 2.0e-06 | 3.8 | -5.5 | 3.3e-08 | 0.52 | 0.04 | 0.95 | FALSE |
| 4 | GTEx | Thyroid | PMS2CL | 0.10 | 0.07 | lasso | 3 | 0.07 | 6.5e-06 | 5.5 | -5.6 | 2.1e-08 | 0.42 | 0.01 | 0.98 | TRUE |
| 5 | GTEx | Whole Blood | RP11-611L7.1 | 0.08 | 0.03 | lasso | 4 | 0.02 | 6.7e-03 | 5.3 | -5.7 | 1.4e-08 | 0.36 | 0.04 | 0.90 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF12 | 0.05 | 0.02 | blup | 32 | 0.02 | 7.1e-04 | 5.5 | -5.2 | 1.9e-07 | 0.21 | 0.00 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PMS2CL | 0.14 | 0.10 | lasso | 2 | 0.07 | 1.5e-03 | 5.0 | -5.2 | 2.4e-07 | 0.42 | 0.01 | 0.78 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF12 | 0.07 | 0.02 | blup | 32 | 0.05 | 2.8e-05 | -3.4 | -5.3 | 1.4e-07 | 0.50 | 0.01 | 0.96 | FALSE |