Best TWAS P=7.11e-09 · Best GWAS P=1.13e-12 conditioned to 3.5e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | STK33 | 0.18 | 0.18 | lasso | 9 | 0.20 | 3.8e-24 | -5.0 | 5.8 | 7.1e-09 | -0.83 | 0.91 | 0.09 | TRUE |
| 2 | GTEx | Brain Caudate basal ganglia | RP11-152H18.3 | 0.23 | 0.01 | enet | 1 | 0.06 | 1.1e-02 | -5.2 | -5.2 | 2.2e-07 | 0.69 | 0.04 | 0.67 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | STK33 | 0.05 | 0.03 | lasso | 2 | 0.03 | 2.5e-04 | -5.3 | 5.2 | 2.0e-07 | -0.53 | 0.48 | 0.10 | FALSE |
| 4 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ST5 | 0.41 | 0.02 | blup | 128 | 0.13 | 2.3e-05 | 3.1 | -5.2 | 2.6e-07 | 0.58 | 0.03 | 0.62 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | STK33 | 0.14 | 0.08 | lasso | 6 | 0.10 | 1.0e-09 | -5.0 | 5.6 | 2.6e-08 | -0.66 | 0.98 | 0.02 | FALSE |