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chr17:3,208,350-6,068,117

Best TWAS P=5.71e-09 · Best GWAS P=2e-08 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	ROSMAP	Brain Pre-frontal Cortex	RPAIN	0.06	0.06	lasso	3	0.06	3.1e-08	5.5	-5.8	5.7e-09	-0.98	0.00	1.00	TRUE
2	GTEx	Artery Coronary	RP11-810M2.2	0.30	0.02	lasso	4	0.02	8.5e-02	5.3	5.6	1.7e-08	-0.03	0.02	0.79	TRUE
5	GTEx	Esophagus Gastroesophageal Junction	GP1BA	0.35	0.16	lasso	11	0.18	5.9e-07	3.9	5.6	2.6e-08	0.56	0.25	0.60	FALSE
3	GTEx	Brain Putamen basal ganglia	AC012146.7	0.30	0.03	enet	23	0.03	7.6e-02	3.8	-5.6	2.7e-08	-0.45	0.08	0.24	FALSE
11	The Cancer Genome Atlas	Thyroid Carcinoma	RABEP1	0.04	0.03	enet	5	0.03	1.5e-03	-4.6	-5.5	4.0e-08	-0.67	0.09	0.82	FALSE
4	GTEx	Esophagus Gastroesophageal Junction	DHX33	0.12	0.08	lasso	5	0.07	1.8e-03	5.6	-5.5	4.9e-08	-0.96	0.02	0.96	FALSE
1	GTEx	Adrenal Gland	RABEP1	0.13	0.03	lasso	13	0.02	7.2e-02	-4.4	-5.4	8.2e-08	-0.80	0.03	0.83	FALSE
7	GTEx	Muscle Skeletal	ZZEF1	0.11	0.01	lasso	3	0.01	1.9e-02	5.3	5.3	1.0e-07	-0.01	0.02	0.96	FALSE
10	The Cancer Genome Atlas	Glioblastoma Multiforme	RABEP1	0.23	0.13	blup	79	0.15	3.4e-05	4.5	-5.3	1.2e-07	-0.77	0.06	0.83	FALSE
6	GTEx	Esophagus Muscularis	RABEP1	0.13	0.09	lasso	10	0.10	2.1e-06	5.6	-5.3	1.3e-07	-0.94	0.02	0.98	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	RABEP1	0.20	0.22	bslmm	546	0.20	7.4e-25	4.5	-5.1	3.1e-07	-0.75	0.49	0.49	FALSE