TWAS
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About
Usage
Models
Genes
Traits
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Traits
:
Whole body fat mass
:
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→
chr2:164,657,815-166,396,485
Best TWAS P=6.77e-13 · Best GWAS P=1.97e-15 conditioned to 0.0386
164.6M
164.8M
165M
165.2M
165.4M
165.6M
165.8M
166M
166.2M
166.4M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Muscularis
GRB14
0.14
0.09
lasso
7
0.06
0.00016
7.0
-7.2
6.8e-13
-0.46
0.26
0.49
TRUE
2
GTEx
Thyroid
COBLL1
0.07
0.05
lasso
3
0.05
0.00015
-5.5
5.6
2.2e-08
0.59
0.57
0.25
TRUE
3
The Cancer Genome Atlas
Colon Adenocarcinoma
GRB14
0.09
0.01
blup
82
0.03
0.00464
6.2
-6.1
1.3e-09
-0.54
0.02
0.64
FALSE