TWAS hub - FNDC5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1532	0.0418	1.3e-09	0.162	NA	0.160	NA	0.156	1.1e-15	NA	1.8e-15	NA	4.1e-15
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1890	0.0680	9.6e-04	0.005	NA	-0.001	NA	-0.003	1.7e-01	NA	4.0e-01	NA	5.1e-01
3	METSIM	Adipose	0.0384	0.0194	2.3e-03	0.037	0.018	0.031	0.021	0.034	2.3e-06	0.00091	1.6e-05	0.00033	5.9e-06
4	TCGA	Breast Invasive Carcinoma	0.0171	0.0109	4.2e-03	0.007	0.007	0.000	NA	0.002	1.1e-02	0.00920	2.7e-01	NA	9.1e-02
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0313	0.0163	6.6e-04	0.036	0.021	0.029	NA	0.028	5.3e-05	0.00180	2.9e-04	NA	3.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5
Qualifications: None of the above	6.7	14.4	22.4	-4.7	-3.7	-4.1	-4.4
Miserableness	6.5	11.2	18.5	-4.3	-3.2	-3.8	-3.6
Leg fat mass (left)	5.5	21.5	35.6	-6.0	-3.6	-5.2	-5.6
Leg fat mass (right)	5.3	20.5	34.8	-5.9	-3.5	-5.0	-5.5
Taking other prescription medications	5.1	7.9	11.0	-3.2	-3.0	-3.3	-3.1
Weight	5.1	25.0	40.9	-6.4	-4.1	-5.7	-5.9
Happiness	5.1	6.1	8.9	3.0	2.3	2.8	3.0
Arm predicted mass (left)	4.9	24.8	39.3	-6.3	-4.4	-5.5	-6.0
Depressed Affect (Nagel 2018)	4.8	10.1	15.8	-4.0	-3.6	-3.4	-3.2
Waist circumference	4.8	17.6	26.1	-5.1	-3.5	-4.9	-5.0
Hearing difficulty/problems: Yes	4.7	7.3	11.8	-3.3	-1.7	-3.4	-3.3
Mood swings	4.7	8.5	13.5	-3.7	-2.6	-3.3	-3.3
Arm fat-free mass (right)	4.6	23.4	38.8	-6.2	-4.2	-5.2	-5.8
Arm fat-free mass (left)	4.6	23.2	38.2	-6.2	-4.2	-5.2	-5.8
Risk taking	4.6	6.8	16.5	-4.1	-0.6	-3.0	-2.8
Hip circumference	4.5	19.2	32.1	-5.7	-3.3	-5.0	-5.3
Body mass index (BMI)	4.4	18.6	29.7	-5.5	-3.6	-4.8	-5.2
Whole body fat mass	4.4	18.5	32.0	-5.7	-3.1	-5.0	-5.1
Arm predicted mass (right)	4.4	22.5	36.1	-6.0	-4.2	-5.2	-5.6
Arm fat mass (left)	4.4	18.0	28.8	-5.4	-3.3	-5.0	-5.1
Arm fat mass (right)	4.3	17.8	28.8	-5.4	-3.3	-4.9	-5.0
Bipolar Disorder (2011)	4.1	3.9	8.6	-2.9	1.3	-2.0	-2.3
BMI	4.0	23.0	39.6	-6.3	-3.4	-5.7	-5.6
Basal metabolic rate	4.0	21.9	34.0	-5.8	-4.2	-5.2	-5.5
Tinnitus: Yes, now most or all of the time	3.7	4.3	6.4	-2.5	-2.0	-2.4	-2.3
Trunk fat mass	3.6	15.6	27.3	-5.2	-2.7	-4.7	-4.6
Diabetes (self-reported)	3.5	5.4	9.1	-2.6	-3.0	-2.2	-2.5
Leg fat percentage (right)	3.5	12.8	22.4	-4.7	-2.9	-3.8	-4.3
Leg fat percentage (left)	3.5	12.7	22.9	-4.8	-2.8	-3.9	-4.2
Family relationship satisfaction	3.4	4.2	7.3	2.7	1.4	2.6	2.3
Whole body fat-free mass	3.4	19.4	30.1	-5.5	-4.0	-4.8	-5.2
Whole body water mass	3.4	19.3	29.5	-5.4	-4.1	-4.9	-5.2
Angina	3.2	4.2	6.4	-2.4	-2.2	-2.5	-2.1
Leg fat-free mass (left)	3.2	16.9	26.1	-5.1	-3.6	-4.7	-4.8
Leg predicted mass (left)	3.2	17.0	26.6	-5.2	-3.6	-4.7	-4.9
Trunk fat-free mass	3.2	18.5	28.0	-5.3	-4.1	-4.6	-5.1
Trunk predicted mass	3.1	17.8	26.9	-5.2	-4.0	-4.5	-5.0
Ovarian Cancer	3.0	4.0	7.7	2.0	1.4	2.8	2.5
Impedance of arm (right)	3.0	14.0	22.0	4.7	3.7	3.6	4.6
Alcohol intake versus 10 years previously	3.0	4.5	8.8	-3.0	-2.3	-2.0	-2.0
Medication: Cholesterol lowering	3.0	4.6	6.6	-2.2	-2.5	-2.6	-2.3
Medication: Lansoprazole	3.0	3.5	6.2	-1.8	-2.5	-2.0	-1.9
Medication: Seretide 50 evohaler	3.0	3.5	5.9	-2.2	-1.2	-2.3	-2.4
Commuting to job workplace: Public transport	3.0	3.6	7.0	-1.9	-1.0	-2.5	-2.6
Impedance of arm (left)	2.9	13.4	20.9	4.5	3.7	3.4	4.6
Alcohol intake frequency.	2.9	6.7	13.5	-3.3	-3.7	-2.1	-2.2
Diabetes diagnosed by doctor	2.9	4.7	8.5	-2.4	-2.9	-1.9	-2.5
Leg fat-free mass (right)	2.8	14.8	23.0	-4.8	-3.2	-4.5	-4.5
Medication: Aspirin	2.8	3.7	5.6	-2.2	-2.0	-2.0	-2.4
Leg predicted mass (right)	2.8	14.9	23.1	-4.8	-3.3	-4.5	-4.5
Depression (Nagel 2018)	2.7	4.1	8.3	-1.9	-2.9	-2.2	-1.9
Chronotype (morning person)	2.7	6.3	9.6	3.1	2.0	3.1	2.8
Body fat percentage	2.7	10.5	19.2	-4.4	-2.1	-3.8	-3.8
Shortness of breath walking on level ground	2.7	3.2	6.8	-2.6	-1.0	-2.4	-1.6
Medication: Atorvastatin	2.7	3.3	7.3	-1.5	-2.7	-1.6	-2.1
Illnesses of father: None of the above (group 1)	2.6	3.2	5.3	2.2	1.3	2.3	2.0
Number of treatments/medications taken	2.5	4.5	10.3	-3.2	-1.6	-2.3	-2.0
Medication for hormone replacement therapy	2.5	2.8	4.6	1.9	1.5	2.1	1.9
Qualifications: O levels/GCSEs or equivalent	2.5	4.0	9.5	3.1	1.6	1.7	2.2
Angina (self-reported)	2.4	3.2	4.9	-2.2	-1.8	-2.2	-1.8
Leg pain on walking	2.4	3.0	4.3	-2.0	-2.0	-2.1	-1.6
Friendships satisfaction	2.4	3.0	6.3	2.5	2.0	1.8	1.2
Trunk fat percentage	2.3	9.1	17.3	-4.2	-1.8	-3.6	-3.4
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	9.0	-1.8	-3.0	-1.8	-1.8
Arm fat percentage (right)	2.2	8.8	14.1	-3.8	-2.0	-3.6	-3.6
Asthma	2.2	4.3	6.6	-2.5	-2.6	-2.1	-2.1
Arm fat percentage (left)	2.2	8.9	14.4	-3.8	-2.1	-3.6	-3.6
Impedance of whole body	2.2	11.2	18.1	3.7	3.6	3.4	4.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	4.6	-2.1	-1.6	-1.9	-1.8
Had other major operations	2.1	2.5	3.9	-1.4	-2.0	-1.9	-1.7
Father’s age at death	2.1	2.8	6.7	2.6	0.7	2.1	1.5
Qualifications: College or University degree	2.1	6.7	14.1	3.8	1.3	3.1	2.8
Medication for pain relief, constipation, heartburn	2.1	3.5	9.1	3.0	1.1	2.2	1.6
Comparative height size at age 10	2.1	11.4	18.2	-4.3	-2.8	-4.0	-3.9
Supplements: Fish oil (including cod liver oil)	2.1	2.8	4.9	-2.0	-2.2	-1.6	-1.6
Irritability	2.1	3.5	6.0	-1.6	-2.0	-2.4	-2.2
Type 2 Diabetes (T2D) (2018)	2.0	3.7	5.1	-2.2	-2.0	-2.3	-2.0
Fluid intelligence score	2.0	4.3	9.2	3.0	0.7	2.6	2.2
Peak expiratory flow (PEF)	2.0	4.7	8.1	-2.9	-2.1	-2.3	-2.4
Pulse wave reflection index	2.0	2.4	4.3	1.5	1.8	2.1	1.5
Medication: Paracetamol	2.0	3.1	8.9	-3.0	-0.7	-2.0	-1.4
Cholesterol lowering medication	2.0	3.0	5.8	-1.1	-1.9	-2.4	-2.1
Pain all over the body in last month	1.9	2.1	5.3	-0.9	-0.5	-2.3	-2.0
Medication: Simvastatin	1.9	2.7	6.0	-1.4	-1.5	-2.5	-1.8
Qualifications: A levels/AS levels or equivalent	1.9	4.2	9.8	3.1	1.1	2.4	2.1
Illnesses of father: Heart disease	1.9	2.6	5.8	-1.4	-1.6	-2.4	-1.7
Medication: Co-codamol	1.8	2.1	7.5	-0.8	-2.7	-0.9	-1.1
Diabetes (father)	1.8	2.2	4.0	-2.0	-0.2	-2.0	-1.8
Pulse wave Arterial Stiffness index	1.8	2.1	5.0	1.0	2.2	1.6	1.3
Pulse wave peak to peak time	1.8	2.2	5.3	-1.1	-2.3	-1.7	-1.2
Medication: Aspirin	1.8	2.4	3.9	-1.8	-1.7	-1.6	-2.0
Mineral and other dietary supplements	1.8	2.4	5.0	1.8	2.2	1.1	1.7
Unable to work because of sickness or disability	1.8	2.3	4.0	-1.7	-2.0	-1.6	-1.3
Supplements: Calcium	1.8	2.0	3.3	-1.7	-1.8	-1.4	-1.5
Medication: Levothyroxine sodium	1.7	2.9	4.0	-1.8	-1.9	-2.0	-1.9
Medication: Paracetamol	1.7	2.9	9.5	-3.1	0.0	-1.9	-1.1
Hypothyroidism/myxoedema (self-reported)	1.7	3.4	4.8	-2.1	-2.2	-2.1	-1.9
Exposure to tobacco smoke outside home	1.7	2.3	4.2	-1.7	-0.6	-2.0	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.8	-0.7	-1.9	-1.9	-1.8
Asthma (self-reported)	1.7	3.4	4.8	-2.1	-2.2	-2.0	-2.0
Frequency of depressed mood in last 2 weeks	1.6	2.2	4.6	-1.5	-2.1	-1.7	-1.1
Maternal smoking around birth	1.6	2.4	5.7	-2.4	0.2	-1.9	-1.5
Number of operations (self-reported)	1.6	2.4	4.9	-1.8	-2.2	-1.5	-1.2
Respiratory disease	1.5	3.3	5.2	-2.2	-2.3	-1.7	-1.9
Diabetes (mother)	1.5	2.0	4.2	-1.6	-2.0	-1.1	-1.5
Supplements: Glucosamine	1.5	1.9	3.4	-1.6	-1.4	-1.3	-1.8
Noisy workplace	1.5	1.8	5.1	-2.3	-0.5	-1.3	-1.5
Birth weight of first child	1.5	2.7	4.7	-2.2	-0.9	-1.8	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	4.0	1.2	0.8	1.6	2.0
Severe depression (siblings)	1.4	1.6	4.6	1.2	0.5	1.3	2.1
Mouth/teeth dental problems	1.4	2.1	4.0	2.0	1.4	1.4	1.6
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	3.3	1.5	1.6	1.8	1.8
Gout (self-reported)	1.4	1.9	4.5	-0.7	-2.1	-1.5	-1.6
Mouth/teeth dental problems: Loose teeth	1.4	1.7	2.8	-1.4	-1.2	-1.7	-1.5
Medication: Allopurinol	1.4	1.9	3.4	-0.9	-1.4	-1.8	-1.9
Qualifications: nursing, teaching	1.4	2.2	6.0	2.5	0.6	1.3	1.7
Commuting to job workplace: Walk	1.4	1.5	3.8	0.9	0.7	2.0	1.5
Medication: Gliclazide	1.4	1.6	4.3	-0.8	-2.1	-1.1	-1.5
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.6	-0.7	-1.4	-1.5	-1.9
Pack years of smoking	1.4	2.1	4.8	-2.2	-1.3	-1.1	-1.7
Age when periods started (menarche)	1.3	3.1	5.5	2.0	1.6	1.8	2.4
Age at first live birth	1.3	2.3	5.3	2.3	-0.5	1.8	1.7
Hearing aid user	1.3	1.5	3.9	-1.3	-0.6	-1.3	-2.0
Verbal and Numeric Reasoning (VNR)	1.2	2.9	6.1	2.5	0.9	2.4	1.4
Ever had hysterectomy (womb removed)	1.2	1.3	2.5	-1.3	-0.6	-1.5	-1.6
Medication: Metformin	1.2	1.7	2.5	-1.5	-1.6	-1.2	-1.5
Medication: Ventolin 100micrograms inhaler	1.2	1.6	3.6	-1.2	-1.1	-1.3	-1.9
Average weekly champagne plus white wine intake	1.2	1.6	4.9	-2.2	0.5	-1.1	-1.4
Heart disease (siblings)	1.2	1.5	2.8	-1.7	-0.9	-1.5	-1.2
Bipolar Disorder (2018)	1.1	1.7	3.2	-1.8	1.5	-0.8	-1.6
Fasting Glucose	1.1	1.3	3.5	-0.4	-0.5	-1.9	-1.6
Hypothyroidism (self reported)	1.1	2.5	3.7	-1.8	-1.6	-1.9	-1.8
Hand grip strength (left)	1.1	2.9	5.9	2.2	0.8	2.4	1.7
Sitting height	1.1	7.6	12.5	-3.5	-2.3	-3.1	-3.3
Mouth/teeth dental problems: Dentures	1.1	1.9	5.8	-2.4	-0.8	-1.0	-1.5
Ever smoked	1.1	2.0	3.6	-1.5	-1.2	-1.6	-1.9
Age started oral contraceptive pill	1.1	1.3	4.0	2.0	-0.0	1.1	1.3
Major Depression (MDD)	1.0	1.2	3.9	1.5	2.0	-0.1	0.2
Lung FVC	1.0	5.2	11.4	2.2	1.1	2.9	3.4
Impedance of leg (left)	1.0	4.9	8.5	2.1	2.4	2.4	2.9
Nervous feelings	1.0	1.9	3.4	1.7	1.1	1.8	1.4
Illnesses of mother	1.0	1.2	2.5	1.0	0.7	1.6	1.4
Health satisfaction	1.0	1.4	2.9	1.2	1.7	1.0	1.2
Age at last live birth	1.0	1.4	3.2	1.8	-0.7	1.3	1.3
Loneliness, isolation	1.0	1.4	2.4	-1.5	-1.4	-1.4	-0.6
Bipolar Disorder or Schizophrenia	0.9	2.2	4.4	-2.0	0.1	-1.6	-2.1
Ulcerative Colitis (UC)	0.9	1.8	3.6	-1.7	-1.1	-1.9	-1.1
Schizophrenia (2014)	0.9	2.1	2.8	-1.6	-1.4	-1.7	-1.7
Ulcerative Colitis	0.9	1.4	3.4	-1.9	-0.4	-1.7	-0.7
Height	0.9	17.5	25.8	-5.1	-3.3	-5.1	-5.0
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	2.6	0.6	1.6	0.9	1.0
Pack years adult smoking proportion	0.9	1.4	3.5	-1.9	-1.0	-0.9	-1.3
Impedance of leg (right)	0.9	4.6	7.6	2.2	2.0	2.5	2.8
Chronic bronchitis/emphysema (father)	0.9	1.0	3.9	-2.0	-0.9	-0.6	-0.0
Birth weight	0.9	2.0	4.8	-0.9	-2.2	-1.5	-1.5
Neuroticism (Nagel 2018)	0.8	1.8	2.7	-1.6	-1.5	-1.6	-1.3
Neuroticism (2016)	0.8	1.1	2.3	-1.1	-0.5	-1.4	-1.5
Townsend deprivation index at recruitment	0.8	1.1	2.0	-1.4	-0.0	-1.3	-1.2
Glaucoma (self-reported)	0.8	0.9	3.0	0.4	1.7	0.7	0.9
Wheeze or whistling in the chest in last year	0.8	1.4	2.8	-1.6	0.0	-1.3	-1.7
Eye problems/disorders: None of the above	0.8	0.9	1.8	-0.9	-1.4	-1.2	-0.6
Chest pain or discomfort	0.8	1.2	3.3	-0.7	-1.8	-1.1	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.6	-1.2	-0.9	-1.0	-1.0
Osteoporosis (self-reported)	0.8	1.0	2.6	-1.6	-1.1	-0.6	-1.0
Ever taken oral contraceptive pill	0.8	0.9	3.6	-0.4	-1.9	-0.4	-0.6
Intelligence (Savage-Jansen 2018)	0.7	2.1	4.9	1.8	0.8	2.2	1.2
HbA1C	0.7	0.8	1.5	-0.5	-1.0	-1.2	-1.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	3.6	0.4	-1.9	0.1	-0.4
Past tobacco smoking	0.7	1.4	2.6	1.6	0.7	1.3	1.4
Hearing difficulty/problems with background noise	0.7	1.2	3.1	-0.9	-1.8	-0.7	-1.3
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.8	1.3	1.1	1.0	0.8
Illnesses of siblings	0.7	0.9	2.7	1.2	1.6	0.4	0.6
Depression (self-reported)	0.7	0.9	2.3	1.2	-0.5	0.6	1.5
Emphysema/chronic bronchitis	0.7	0.8	2.5	-0.4	-1.6	-1.0	-0.6
Overall health rating	0.7	1.5	2.5	-1.6	-0.9	-1.4	-1.4
Osteoarthritis (self-reported)	0.7	0.9	1.6	-1.1	-0.7	-1.3	-1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.5	-1.6	-0.9	-1.0	-0.5
Fractured/broken bones in last 5 years	0.7	0.9	2.3	-0.9	1.5	-1.1	-0.4
Schizophrenia (2018)	0.6	1.3	1.9	-1.2	-1.1	-1.4	-1.4
Schizophrenia vs Biploar Disorder	0.6	0.9	2.2	1.2	-1.5	0.3	0.7
Prostate Cancer	0.6	0.9	2.3	1.5	-0.0	1.1	1.0
Primary Biliary Cirrhosis	0.6	0.9	1.4	-0.9	-0.9	-1.2	-1.1
Stomach or abdominal pain in last month	0.6	0.7	1.9	-0.4	1.4	0.8	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.8	-0.5	1.7	0.1	0.7
Prospective memory result	0.6	0.7	1.4	0.9	0.2	1.2	1.2
Standing height	0.6	5.9	10.7	-3.3	-2.0	-2.9	-2.6
Tense / ‘highly strung’	0.6	1.0	2.3	0.9	0.9	1.1	1.5
Comparative body size at age 10	0.6	1.6	4.0	-0.7	-2.0	-1.4	-1.3
Medication: Ibuprofen	0.6	0.8	2.2	-1.2	1.5	-0.2	0.2
Medication: Omeprazole	0.6	0.7	1.3	-0.9	-1.0	-1.2	-0.7
Heart disease (mother)	0.6	0.7	2.2	-0.8	-0.8	-1.5	-0.3
Suffer from ‘nerves’	0.6	1.0	2.0	1.1	0.7	1.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	5.4	0.6	0.3	0.7	2.3
High cholesterol (Self-reported)	0.6	1.1	2.6	-0.2	-0.8	-1.6	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.0	-0.9	-1.0	-1.0	-0.9
Basal cell carcinoma (self-reported)	0.6	0.8	3.7	-0.1	-1.9	-0.1	-0.3
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	-1.0	0.8	-0.7	-1.0
Triglycerides	0.5	0.8	1.4	-1.2	0.0	-1.2	-1.1
Blood Eosinophil Count	0.5	3.7	7.5	-1.4	-2.2	-2.2	-2.7
Fed-up feelings	0.5	1.0	1.8	-1.3	-0.5	-1.3	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.4	-1.2	-1.0	-0.8	-0.8
Hair/balding pattern: Pattern 3	0.5	0.7	2.9	0.3	1.7	0.4	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.8	0.3	1.7	0.5	0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.4	-0.8	0.5	-1.2	-0.6
Ever had bowel cancer screening	0.5	0.6	0.9	-1.0	-0.9	-1.0	-0.4
Medication: Bendroflumethiazide	0.5	0.7	2.4	-0.6	-1.5	-0.4	-0.8
Worry (Nagel 2018)	0.4	0.9	1.9	1.2	0.5	1.0	1.4
HDL Cholesterol	0.4	0.6	2.2	-0.1	-0.6	-0.6	-1.5
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.9	-0.7	0.8	-1.0	-0.6
Smoking Status	0.4	1.1	2.9	-1.7	-0.0	-1.1	-1.1
Sensitivity / hurt feelings	0.4	0.7	1.7	-1.3	0.3	-1.1	-0.7
Hair/balding pattern: Pattern 2	0.4	0.5	1.7	-1.3	-0.1	-0.7	-0.7
Allergy	0.4	0.9	1.5	1.0	1.2	1.2	0.7
Neuroticism score	0.4	0.7	1.6	-1.2	-0.8	-1.0	-0.7
Exposure to tobacco smoke at home	0.4	0.5	1.1	-1.1	-0.7	-0.2	-0.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.8	-0.9	-0.7	-0.7	-0.8
Medication: Blood pressure	0.4	0.7	1.6	-0.6	-1.3	-0.8	-1.0
Mean time to correctly identify matches	0.4	0.8	3.1	-0.6	-1.8	-0.7	-0.5
Had major operations	0.4	0.4	1.3	-0.3	-1.1	-0.6	-0.6
Knee pain experienced in last month	0.4	0.7	1.7	-1.3	-1.0	-0.6	-0.3
Average weekly red wine intake	0.4	0.6	1.9	1.4	0.4	0.9	-0.2
Number of self-reported non-cancer illnesses	0.4	0.8	1.4	-0.8	-1.2	-0.9	-1.0
Eye problems/disorders: Glaucoma	0.4	0.4	1.3	0.4	1.2	0.5	0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.2	-0.7	-1.1	-0.6	-0.6
Alcohol drinker status: Previous	0.4	0.5	1.0	-1.0	-0.7	-0.7	-0.6
Reaction Time	0.3	0.6	2.6	0.1	-1.6	-0.5	-0.1
Breast Cancer	0.3	0.6	1.3	0.2	1.1	0.6	1.2
Age at First Birth	0.3	0.4	1.1	0.6	-1.1	0.5	-0.2
Body Mass Index (BMI) (2010)	0.3	0.5	1.1	-1.1	-0.9	-0.4	-0.6
Mean Putamen Volume	0.3	0.3	1.2	1.1	0.2	0.6	0.3
Blood Red Count	0.3	2.5	4.0	-2.0	-1.6	-1.7	-1.9
Systolic Blood Pressure	0.3	1.4	5.2	1.0	2.3	0.5	0.6
Neuroticism	0.3	0.7	1.7	-1.3	-0.1	-1.1	-0.6
Average weekly spirits intake	0.3	0.4	1.5	-0.1	-0.3	-0.5	-1.2
Supplements: Zinc	0.3	0.3	1.1	0.5	-0.3	0.2	1.1
Current tobacco smoking	0.3	0.5	0.9	-0.9	0.9	-0.7	-0.4
Multivitamins +/- minerals	0.3	0.4	1.4	-0.4	-1.2	-0.2	-0.6
Number of incorrect matches in round	0.3	0.5	1.4	0.6	0.3	0.8	1.2
Heart attack	0.3	0.4	0.7	-0.8	-0.8	-0.5	-0.5
Falls in the last year	0.3	0.4	1.7	-0.0	1.3	0.2	0.7
Number of live births	0.3	0.4	1.2	1.1	-0.7	0.5	0.3
Length of working week for main job	0.3	0.3	1.2	0.1	1.1	0.4	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.4	0.3	1.2	0.1	0.4
High blood pressure (siblings)	0.3	0.4	1.2	0.3	-1.1	0.6	0.5
Number of children fathered	0.3	0.3	1.1	-1.1	0.3	-0.1	-0.5
Smoking status: Previous	0.3	0.5	1.2	-1.1	-0.2	-0.8	-0.8
Eye problems/disorders: Cataract	0.3	0.4	1.0	0.4	1.0	0.7	0.3
Financial situation satisfaction	0.3	0.4	1.2	1.1	0.5	0.6	0.6
Average weekly beer plus cider intake	0.3	0.5	1.6	0.3	0.7	1.3	0.5
Pain experienced in last month	0.3	0.6	1.7	1.3	-1.0	0.4	-0.3
Crohns Disease (2017)	0.2	0.5	1.3	0.2	1.1	0.5	0.9
Irritable Bowel Disease (IBD)	0.2	0.4	1.2	-1.1	0.2	-0.8	-0.1
Blood Platelet Count	0.2	2.3	5.1	-1.4	-1.4	-1.6	-2.2
Blood White Count	0.2	1.2	2.3	-1.3	-0.4	-1.5	-1.4
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	0.8	0.7	0.4	0.1
Vitamin and mineral supplements	0.2	0.3	0.7	0.8	0.6	0.3	0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.6	-0.1	-0.5	-0.7
Serious illness, injury or assault to yourself	0.2	0.2	0.6	-0.8	-0.3	-0.6	0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.7	0.3	-0.8	-0.6	-0.3
High blood pressure (mother)	0.2	0.3	1.0	1.0	-0.0	0.2	0.6
Had menopause	0.2	0.3	0.7	-0.8	-0.7	-0.1	-0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.0	0.1	-0.5	-1.0	-0.3
Medication: Ramipril	0.2	0.2	0.5	-0.7	0.2	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	2.2	0.1	0.4	0.6	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.5	-0.5	0.2	0.6
Lung cancer (father)	0.2	0.2	0.4	-0.7	-0.5	0.4	0.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	1.0	0.1	0.5	1.0
Headache pain in last month	0.2	0.4	1.4	-0.8	1.2	0.1	0.1
Number of full brothers	0.2	0.3	0.6	-0.8	0.8	0.4	-0.1
Worry too long after embarrassment	0.2	0.3	1.1	-0.1	1.0	0.4	0.3
Neck or shoulder pain in last month	0.2	0.3	1.1	-1.1	-0.1	-0.4	-0.0
Migraine (self-reported)	0.2	0.2	0.6	-0.0	-0.1	0.6	0.8
Number of full sisters	0.2	0.3	0.7	0.3	0.5	0.8	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.6	-0.4	0.5	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.6	-0.7	-0.0	0.9
Breast cancer (self-reported)	0.2	0.2	0.7	0.4	-0.9	-0.1	0.1
Medication: Blood pressure	0.2	0.4	0.9	0.7	1.0	0.6	0.3
Alcohol drinker status: Never	0.2	0.2	1.0	0.1	-1.0	0.3	0.3
Ever depressed for a whole week	0.2	0.3	0.6	0.6	0.8	-0.6	0.2
Commuting to job workplace: Cycle	0.2	0.3	1.4	-0.0	-1.2	-0.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.8	-0.6	-0.1	-0.3	-0.9
Alzheimer’s Disease (in father)	0.1	0.2	0.3	0.5	0.5	0.4	0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	-0.3	0.5	-0.3	-0.6
Crohns Disease (2012)	0.1	0.2	0.8	0.3	0.9	0.0	0.4
LDL Cholesterol	0.1	0.2	0.5	0.1	-0.7	-0.4	-0.4
Rheumatoid Arthritis	0.1	0.1	0.3	0.1	-0.5	0.3	0.2
Cardiovascular Disease	0.1	0.3	0.8	0.1	0.4	-0.9	-0.9
Lung FEV1/FVC ratio	0.1	0.3	1.0	0.1	0.7	-0.2	1.0
Hair Pigment	0.1	3.0	6.2	2.5	1.3	2.0	1.7
Tanning	0.1	1.6	2.6	1.6	0.7	1.6	1.6
Relative age of first facial hair	0.1	0.1	0.6	0.1	0.8	0.3	0.0
Systolic blood pressure, automated reading	0.1	0.4	1.3	-0.6	0.5	-0.4	-1.1
Hand grip strength (right)	0.1	0.3	0.7	0.7	-0.4	0.8	0.3
Relative age voice broke	0.1	0.1	0.3	0.3	-0.6	0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	-0.0	-0.7	-0.2	-0.5
Qualifications: CSEs or equivalent	0.1	0.1	0.1	-0.3	0.3	-0.3	0.3
High blood pressure	0.1	0.3	0.5	0.7	0.7	0.5	-0.2
Medication: Atenolol	0.1	0.1	0.3	0.6	-0.1	-0.1	-0.0
Alcohol usually taken with meals	0.1	0.1	0.4	0.3	-0.4	0.3	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.3	-0.1	-0.3	-0.5	-0.5
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.0	0.3	-0.6	0.0
Time employed in main current job	0.1	0.2	0.6	0.0	0.8	-0.2	-0.4
Worrier / anxious feelings	0.1	0.1	0.4	0.6	-0.0	0.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.9	-0.2	-0.2	-0.1	0.9
Breastfed as a baby	0.1	0.1	0.3	0.5	0.4	-0.2	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.8	-0.1	0.1	-0.9	-0.5
Loud music exposure frequency	0.1	0.2	0.4	0.4	0.7	0.2	0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.6	-0.0	0.2	0.8	0.5
Blood clot in the leg (DVT)	0.1	0.1	0.4	-0.3	-0.1	-0.2	-0.6
Medication: Amlodipine	0.1	0.1	0.3	0.5	0.3	0.0	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.2	0.6	-0.8	-0.5	-0.4	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	-0.2	-0.5	-0.7	0.0
Pulse rate, automated reading	0.1	0.4	1.1	-1.0	0.4	-0.7	-0.4
Supplements: Vitamin C	0.1	0.1	0.3	-0.2	0.5	0.2	0.2
Hypertension (Self-reported)	0.1	0.3	0.7	0.8	0.9	0.3	-0.3
Illnesses of siblings: Diabetes	0.1	0.2	0.3	-0.6	-0.5	0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.6	-0.8	0.7	-0.3	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.5	0.2	0.1	-0.5
Long-standing illness, disability or infirmity	0.1	0.2	0.8	-0.4	-0.3	-0.2	0.9
Medication for cholesterol	0.1	0.2	0.9	-0.9	0.0	-0.3	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.5	0.3	-0.1	0.5	0.7
Back pain experienced in last month	0.1	0.2	0.7	-0.4	-0.0	-0.8	0.2
Smoking status: Current	0.1	0.2	0.5	-0.6	0.7	-0.3	-0.2
Wears glasses or contact lenses	0.1	0.1	0.5	0.7	-0.3	-0.1	-0.3
Mother’s age at death	0.1	0.1	0.4	0.6	-0.1	0.1	-0.3
Medication: Lisinopril	0.1	0.1	0.2	0.4	0.5	-0.2	-0.4
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.5	0.5	-0.1	-0.2
Diastolic blood pressure, automated reading	0.1	0.2	0.6	-0.6	0.5	-0.0	-0.8
Vascular/heart problems diagnosed by doctor	0.1	0.1	0.4	-0.7	-0.2	-0.0	0.5
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.2	-0.2	0.1	-0.1
Lupus	0.0	0.1	0.2	-0.2	0.0	0.5	-0.0
Heel T-Score	0.0	0.3	1.1	-1.0	-0.6	-0.0	0.4
Waist Hip Ratio (WHR)	0.0	0.2	0.5	-0.3	0.3	-0.7	-0.7
Allergy or Eczema	0.0	0.1	0.3	-0.5	0.4	-0.4	0.2
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	-0.0	-0.3	-0.3	0.1
Average weekly fortified wine intake	0.0	0.0	0.0	-0.0	-0.2	0.0	0.0
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	-0.0	0.3	-0.2	0.4
Forced vital capacity (FVC)	0.0	0.1	0.4	-0.6	-0.2	-0.1	0.4
Pulse rate	0.0	0.0	0.1	-0.2	0.0	-0.2	-0.3
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.2	0.1	0.2	0.0	-0.4
Guilty feelings	0.0	0.1	0.2	-0.0	0.2	-0.4	-0.2
Myopia	0.0	0.1	0.1	0.3	-0.4	-0.1	0.4

Hub : Genes

FNDC5

Models

Trait associations