Hub : Genes

TMEM54

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.046 0.020 0.00140 -0.002 0.016 -0.001 0.015 -0.001 6.0e-01 0.0045 4.9e-01 0.0048 5.3e-01
2 GTEx Thyroid 0.103 0.041 0.00011 0.087 NA 0.071 NA 0.072 3.6e-07 NA 4.2e-06 NA 3.3e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.5 2.4 4.8 -0.0 2.2
Bipolar Disorder or Schizophrenia 0.8 2.0 4.0 0.1 2.0
Depressed Affect (Nagel 2018) 3.4 7.2 8.4 -2.4 2.9
Depression (Nagel 2018) 0.4 0.6 0.8 -0.7 0.9
Intelligence (Savage-Jansen 2018) 0.9 2.9 4.1 1.3 -2.0
Neuroticism (Nagel 2018) 0.3 0.6 1.1 -0.4 1.1
Schizophrenia (2018) 0.2 0.3 0.6 0.1 0.8
Schizophrenia vs Biploar Disorder 1.3 1.7 1.9 1.4 -1.3
Worry (Nagel 2018) 1.3 2.7 3.6 1.4 -1.9
Alzheimer’s Disease (in mother) 1.6 1.9 3.5 -0.5 1.9
Alzheimer’s Disease (in father) 0.1 0.1 0.1 0.0 0.4
Alzheimer’s Disease (including proxy) 0.8 1.2 2.3 -0.2 1.5
Crohns Disease (2017) 0.5 1.1 1.8 1.3 -0.7
Irritable Bowel Disease (IBD) 0.2 0.6 0.9 -1.0 0.5
Ulcerative Colitis (UC) 2.9 5.5 9.3 -3.0 1.3
Major Depression (MDD) 2.1 2.6 4.9 2.2 -0.6
Reaction Time 0.2 0.4 0.7 0.8 -0.4
Verbal and Numeric Reasoning (VNR) 1.4 3.4 4.2 1.6 -2.1
Breast Cancer 0.6 1.4 1.6 -1.0 -1.3
Ovarian Cancer 3.4 4.5 8.4 0.8 -2.9
Prostate Cancer 0.5 0.7 1.2 -0.4 -1.1
Age at First Birth 0.3 0.5 0.9 -1.0 -0.1
Bipolar Disorder (2011) 5.5 5.3 8.3 -1.6 2.9
Body Mass Index (BMI) (2010) 2.2 3.0 4.8 -2.2 1.1
Coronary Artery Disease (CAD) 0.2 0.2 0.2 -0.5 0.5
Crohns Disease (2012) 0.5 0.8 1.5 1.2 -0.4
Mean Putamen Volume 0.4 0.4 0.8 0.9 0.2
Fasting Glucose 1.3 1.6 1.7 -1.2 1.3
HbA1C 4.3 4.8 6.9 -2.6 1.6
HDL Cholesterol 0.4 0.6 1.2 0.1 1.1
LDL Cholesterol 0.6 0.9 1.8 1.4 0.1
Lupus 0.2 0.3 0.3 -0.4 0.6
Neuroticism (2016) 0.5 0.7 0.8 0.8 0.9
Primary Biliary Cirrhosis 0.5 0.7 0.8 0.7 0.9
Rheumatoid Arthritis 0.0 0.0 0.1 -0.1 -0.2
Schizophrenia (2014) 0.3 0.7 1.5 -0.0 1.2
Triglycerides 0.7 1.1 1.3 -1.1 0.9
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.0 -0.6 1.0
Ulcerative Colitis 1.5 2.2 3.5 -1.9 1.0
Blood Eosinophil Count 0.9 6.7 7.7 2.8 2.4
Blood Platelet Count 0.6 6.8 11.0 -3.3 1.6
Blood Red Count 0.6 5.8 11.0 3.3 0.8
Blood White Count 0.1 0.9 1.9 -0.1 1.4
Heel T-Score 0.2 1.7 3.2 0.4 -1.8
BMI 7.0 40.5 55.4 -7.4 5.1
Height 1.3 24.2 29.8 -5.5 4.3
Waist Hip Ratio (WHR) 0.1 0.3 0.6 -0.2 0.8
Systolic Blood Pressure 1.1 5.5 11.0 3.3 0.3
Smoking Status 3.2 7.7 10.0 -3.2 2.3
Allergy or Eczema 1.2 3.0 6.1 2.5 -0.2
Cardiovascular Disease 0.5 1.7 2.9 1.7 0.7
Hypothyroidism (self reported) 2.4 5.6 6.6 -2.6 2.1
Respiratory disease 1.2 2.7 5.0 0.7 2.2
Type 2 Diabetes (T2D) (2018) 2.5 4.6 5.4 -2.3 2.0
Lung FEV1/FVC ratio 0.7 3.6 3.7 -1.9 -1.9
Lung FVC 1.4 7.3 14.3 -0.6 -3.8
Neuroticism 0.1 0.2 0.3 -0.5 0.4
Chronotype (morning person) 2.4 5.6 7.2 2.0 -2.7
Hair Pigment 0.0 0.7 1.3 0.2 -1.1
Tanning 0.1 1.0 1.8 -0.3 -1.4
Hand grip strength (left) 0.9 2.3 3.4 -1.1 -1.9
Number of treatments/medications taken 1.6 2.8 3.5 -1.5 1.9
Average weekly spirits intake 2.2 2.7 3.9 -2.0 1.2
Sensitivity / hurt feelings 0.3 0.5 0.6 -0.8 0.6
Frequency of depressed mood in last 2 weeks 0.6 0.9 1.3 -0.7 1.1
Hearing difficulty/problems: Yes 4.4 6.7 10.1 -1.8 3.2
Relative age of first facial hair 1.0 2.1 3.3 -1.8 0.9
Other serious medical condition/disability diagnosed by doctor 0.0 0.1 0.1 -0.1 0.3
Ever used hormone-replacement therapy (HRT) 1.1 1.4 1.9 1.4 -1.0
Ever had hysterectomy (womb removed) 1.0 1.1 1.2 -1.1 1.0
Systolic blood pressure, automated reading 0.3 0.9 1.2 0.8 1.1
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 -0.2 -0.5
Angina 1.3 1.8 2.2 -1.5 1.1
Medication for hormone replacement therapy 2.4 2.7 3.2 1.8 -1.5
Vitamin and mineral supplements 0.3 0.4 0.7 0.3 -0.8
Supplements: Zinc 1.5 1.6 1.8 1.2 -1.3
Medication: Co-codamol 0.8 0.9 1.9 -1.4 -0.1
Medication: Metformin 2.5 3.5 5.2 -2.3 1.3
Diabetes (father) 1.9 2.4 3.0 -1.3 1.7
Diabetes (mother) 2.6 3.3 6.3 -2.5 0.6
Severe depression (siblings) 1.4 1.5 2.4 0.8 -1.6
Pack years adult smoking proportion 1.7 2.6 3.1 -1.4 1.8
Impedance of leg (right) 3.0 14.4 22.5 4.7 -2.5
Leg fat-free mass (left) 7.8 41.5 61.5 -7.8 4.7
Trunk fat percentage 3.2 12.7 13.0 -3.5 3.6
Hand grip strength (right) 0.2 0.4 0.4 -0.7 -0.7
Townsend deprivation index at recruitment 1.8 2.5 3.3 -1.3 1.8
Current tobacco smoking 1.0 1.7 2.7 -1.6 0.8
Average weekly fortified wine intake 0.4 0.4 0.8 0.1 -0.9
Maternal smoking around birth 1.4 2.1 3.7 -0.7 1.9
Fed-up feelings 0.7 1.2 2.3 0.2 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.8 4.7 -0.9 2.2
Relative age voice broke 1.9 2.8 5.2 -2.3 0.7
Taking other prescription medications 3.5 5.4 9.4 -1.2 3.1
Age when periods started (menarche) 1.4 3.5 6.5 -0.6 -2.6
Bilateral oophorectomy (both ovaries removed) 2.3 2.6 3.5 1.9 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.4 -0.6 0.4
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 0.3 0.3
Qualifications: CSEs or equivalent 0.8 1.1 2.1 -1.4 -0.1
Serious illness, injury or assault to yourself 1.4 1.7 2.8 1.7 0.9
High blood pressure 0.3 0.9 1.8 1.3 -0.3
Hayfever, allergic rhinitis or eczema 1.7 3.6 7.2 2.7 -0.2
Multivitamins +/- minerals 0.1 0.2 0.2 -0.5 0.3
Stomach or abdominal pain in last month 0.7 0.8 1.6 1.3 0.3
Supplements: Glucosamine 1.3 1.7 1.8 -1.4 1.3
Diverticular disease/diverticulitis (self-reported) 1.4 1.7 3.2 -1.8 -0.4
Medication: Atenolol 0.1 0.2 0.2 -0.5 -0.4
Medication: Levothyroxine sodium 1.7 2.9 3.6 -1.9 1.5
Sitting height 1.7 12.4 17.9 -4.2 2.6
Chronic bronchitis/emphysema (father) 1.4 1.6 2.4 -1.6 0.9
High blood pressure (mother) 1.4 1.9 3.4 1.9 -0.7
Body mass index (BMI) 7.3 30.9 40.3 -6.3 4.6
Impedance of leg (left) 2.8 13.4 21.3 4.6 -2.4
Leg predicted mass (left) 7.8 41.4 60.5 -7.8 4.7
Trunk fat mass 6.0 25.9 30.8 -5.5 4.6
Waist circumference 8.0 29.2 38.7 -6.2 4.4
Number of incorrect matches in round 1.2 1.9 3.7 1.9 -0.4
Past tobacco smoking 2.9 5.3 6.1 2.1 -2.5
Alcohol usually taken with meals 0.4 0.7 1.4 -1.2 -0.2
Nervous feelings 1.7 3.2 3.8 1.6 -1.9
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.1 2.1 -1.4 1.4
Hearing difficulty/problems with background noise 0.7 1.2 2.3 -0.1 1.5
Hair/balding pattern: Pattern 2 0.2 0.2 0.2 -0.5 0.4
Had menopause 0.0 0.0 0.1 -0.1 0.3
Had other major operations 3.1 3.8 6.3 -2.5 1.1
Forced vital capacity (FVC) 1.7 6.4 12.6 -3.5 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.6 -0.8 0.4
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.5 1.2 0.4
Qualifications: None of the above 5.5 11.9 14.4 -3.1 3.8
Financial difficulties in last 2 years 0.6 0.8 1.6 -1.3 0.3
Mouth/teeth dental problems 0.4 0.6 1.2 0.2 -1.1
Heart attack 0.1 0.2 0.3 0.3 0.5
Allergy 0.7 1.6 2.0 -1.4 -1.1
Pain all over the body in last month 2.1 2.2 4.5 0.1 2.1
Diabetes (self-reported) 5.5 8.5 12.2 -3.5 2.2
Hayfever/allergic rhinitis (self-reported) 3.0 4.0 7.0 2.6 -1.0
Medication: Ramipril 0.8 1.0 1.6 0.7 1.3
Medication: Simvastatin 1.5 2.2 2.3 -1.4 1.5
Fluid intelligence score 2.4 5.0 6.8 1.8 -2.6
Illnesses of siblings 0.2 0.3 0.3 -0.5 -0.6
Neuroticism score 0.6 1.3 2.0 -1.4 0.8
Weight 9.8 48.4 67.8 -8.2 5.4
Impedance of arm (right) 9.0 41.9 69.7 8.3 -3.8
Arm fat percentage (right) 2.5 10.0 11.5 -2.9 3.4
Trunk fat-free mass 8.5 48.8 78.9 -8.9 4.3
Hip circumference 8.9 38.5 51.0 -7.1 5.1
Time employed in main current job 1.1 1.3 1.8 1.3 -0.9
Alcohol intake versus 10 years previously 2.6 3.9 5.9 -2.4 1.4
Father’s age at death 1.6 2.2 2.4 1.4 -1.5
Worrier / anxious feelings 0.2 0.4 0.7 -0.1 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 1.6 -0.5 1.3
Falls in the last year 0.3 0.5 0.7 0.9 0.4
Hair/balding pattern: Pattern 3 0.2 0.3 0.4 0.6 0.4
Number of live births 0.4 0.6 0.8 0.6 -0.9
Forced expiratory volume in 1-second (FEV1) 1.6 5.4 8.2 -2.9 -1.6
Pulse rate 0.0 0.1 0.2 -0.1 0.4
Happiness 2.0 2.4 3.2 1.3 -1.8
Noisy workplace 2.2 2.7 5.1 -0.5 2.3
Qualifications: A levels/AS levels or equivalent 1.2 2.7 2.9 1.6 -1.7
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.8 0.1 -0.9
Mouth/teeth dental problems: Dentures 0.5 0.8 1.2 -0.6 1.1
Asthma 1.7 3.3 6.6 0.0 2.6
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.3 -0.2 -0.5
Medication: Cholesterol lowering 2.2 3.5 5.1 -1.4 2.3
Depression (self-reported) 2.2 2.7 4.7 2.2 -0.7
Medication: Lansoprazole 4.8 5.5 6.2 -2.5 2.2
Prospective memory result 0.8 1.0 1.8 -0.5 -1.4
Lung cancer (father) 0.1 0.1 0.3 -0.5 -0.1
Illnesses of mother 1.8 2.3 2.3 -1.5 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.6 9.9 -3.1 -1.1
Pulse wave Arterial Stiffness index 1.4 1.6 2.4 -0.9 -1.6
Impedance of arm (left) 7.9 36.5 58.7 7.7 -3.8
Arm fat mass (right) 6.8 28.0 34.1 -5.8 4.7
Trunk predicted mass 8.3 47.4 76.9 -8.8 4.2
Standing height 1.7 17.0 27.6 -5.2 2.5
Length of working week for main job 1.6 1.8 3.4 -1.9 -0.3
Exposure to tobacco smoke at home 2.4 2.7 4.7 -2.2 0.9
Breastfed as a baby 0.5 0.6 1.0 -0.5 -1.0
Tense / ‘highly strung’ 0.7 1.1 1.8 0.7 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 0.7 -0.7 0.8
Hair/balding pattern: Pattern 4 0.9 2.2 3.9 0.8 -2.0
Birth weight of first child 1.8 3.3 5.5 -1.1 2.4
Peak expiratory flow (PEF) 3.5 8.2 10.5 -3.2 2.4
Pulse wave reflection index 0.6 0.7 1.3 0.4 -1.1
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.4 -0.2 0.7
Loud music exposure frequency 0.2 0.2 0.2 -0.4 -0.5
Qualifications: O levels/GCSEs or equivalent 2.7 4.3 4.7 2.0 -2.2
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.1 0.1 -0.4
Blood clot in the leg (DVT) 0.8 1.0 1.0 -1.0 1.0
Medication: Paracetamol 0.3 0.5 0.7 0.9 0.5
Headache pain in last month 0.0 0.0 0.1 0.1 0.3
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 2.8 1.1 -1.7
Glaucoma (self-reported) 0.1 0.1 0.3 -0.5 -0.1
Gout (self-reported) 1.5 2.0 2.2 -1.5 1.3
Hypothyroidism/myxoedema (self-reported) 2.4 4.6 5.1 -2.2 2.0
Medication: Amlodipine 1.0 1.4 2.6 1.6 -0.5
Medication: Ventolin 100micrograms inhaler 1.3 1.6 2.8 -0.7 1.7
Birth weight 1.1 2.3 2.8 -1.4 1.7
Chronic bronchitis/emphysema (mother) 0.5 0.6 0.9 0.9 0.5
High blood pressure (siblings) 0.5 0.7 1.1 1.0 -0.5
Forced vital capacity (FVC), Best measure 1.6 5.8 11.6 -3.4 -0.1
Body fat percentage 3.7 14.8 15.4 -3.9 3.8
Leg fat percentage (right) 4.9 17.6 22.5 -4.7 3.6
Arm fat-free mass (right) 12.4 63.7 99.4 -10.0 5.3
Exposure to tobacco smoke outside home 2.7 3.5 3.7 -1.8 1.9
Comparative body size at age 10 0.5 1.3 2.0 -0.8 1.4
Number of full brothers 1.5 1.9 3.5 -1.9 0.6
Worry too long after embarrassment 0.1 0.2 0.3 -0.5 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 1.9 -0.3 1.4
Wheeze or whistling in the chest in last year 2.0 3.6 5.9 -1.1 2.4
Number of children fathered 0.0 0.0 0.0 -0.1 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 1.4 -0.7 -1.2
Age at first live birth 1.4 2.5 4.7 0.5 -2.2
Pulse wave peak to peak time 1.1 1.3 2.3 0.5 1.5
Health satisfaction 1.3 1.7 3.0 1.7 -0.6
Shortness of breath walking on level ground 2.4 2.8 2.9 -1.7 1.7
Qualifications: College or University degree 2.4 7.7 8.8 2.6 -3.0
Eye problems/disorders: None of the above 0.0 0.1 0.1 0.3 -0.2
Mouth/teeth dental problems: Loose teeth 1.7 2.0 2.4 -1.3 1.6
Emphysema/chronic bronchitis 1.0 1.1 2.2 -1.5 0.2
Medication for pain relief, constipation, heartburn 0.5 0.8 1.5 -0.4 -1.2
Neck or shoulder pain in last month 0.5 0.7 1.0 -0.5 1.0
Medication: Blood pressure 0.4 0.7 0.9 -0.9 0.7
Angina (self-reported) 1.1 1.4 2.1 -1.5 0.8
Migraine (self-reported) 0.4 0.5 0.8 0.4 -0.9
Medication: Ibuprofen 0.1 0.2 0.3 -0.6 -0.1
Medication: Allopurinol 1.6 2.1 2.3 -1.4 1.5
Medication: Omeprazole 0.3 0.3 0.4 -0.6 0.6
Medication: Seretide 50 evohaler 2.9 3.4 6.5 -0.4 2.6
Mean time to correctly identify matches 0.5 1.0 1.8 1.4 -0.5
Heart disease (mother) 0.4 0.5 0.7 0.8 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.4 -0.3 -0.6
Whole body fat mass 7.4 30.7 37.0 -6.1 4.9
Leg fat mass (right) 8.6 33.3 41.2 -6.4 5.0
Arm predicted mass (right) 12.0 61.1 95.8 -9.8 5.1
Pulse rate, automated reading 0.1 0.4 0.6 0.4 0.8
Alcohol intake frequency. 0.5 1.2 1.7 -0.8 1.3
Comparative height size at age 10 2.9 15.7 17.8 -4.2 3.7
Number of full sisters 0.8 1.0 1.9 -0.2 -1.4
Suffer from ‘nerves’ 1.4 2.2 2.8 1.3 -1.7
Overall health rating 0.7 1.4 2.6 0.4 1.6
Chest pain or discomfort 0.4 0.6 0.7 -0.7 0.9
Had major operations 1.2 1.5 2.9 1.7 -0.0
Age at last live birth 0.7 1.0 1.9 -0.3 -1.4
Family relationship satisfaction 1.6 2.0 2.8 -1.1 -1.7
Leg pain on walking 2.4 3.0 4.0 -2.0 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.2 -0.4 0.5
Commuting to job workplace: Car/motor vehicle 0.4 0.5 0.6 0.6 0.8
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.0 -1.0 -0.4
Medication: Aspirin 2.5 3.3 3.3 -1.8 1.8
Supplements: Vitamin C 0.0 0.0 0.1 0.2 -0.1
Knee pain experienced in last month 0.1 0.2 0.3 -0.6 0.1
Hypertension (Self-reported) 0.4 1.0 1.8 1.3 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 1.7 -0.0 1.3
Illnesses of father: Heart disease 0.4 0.5 1.0 0.0 1.0
Illnesses of siblings: Diabetes 1.0 1.3 1.9 -1.4 0.8
Smoking status: Previous 1.9 2.9 3.5 -1.5 1.9
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.5 4.9 -2.2 0.3
Whole body fat-free mass 8.9 50.9 79.7 -8.9 4.7
Leg fat-free mass (right) 7.3 38.9 57.9 -7.6 4.5
Arm fat percentage (left) 2.9 11.4 12.0 -3.5 3.3
Average weekly red wine intake 0.2 0.3 0.6 -0.7 -0.1
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.5 -0.5 0.7
Mood swings 3.9 7.0 11.1 -1.7 3.3
Loneliness, isolation 2.7 3.7 6.8 -2.6 0.8
Long-standing illness, disability or infirmity 0.4 0.5 0.9 0.4 -1.0
Ever had bowel cancer screening 0.3 0.3 0.4 0.7 0.4
Diabetes diagnosed by doctor 3.1 5.2 5.7 -2.4 2.2
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 3.2 -1.8 0.4
Friendships satisfaction 0.9 1.1 2.0 1.4 -0.6
Qualifications: nursing, teaching 3.3 5.1 6.0 2.0 -2.4
Commuting to job workplace: Walk 0.0 0.0 0.0 -0.2 -0.1
Eye problems/disorders: Cataract 0.7 0.8 1.4 -1.2 0.4
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.0 -0.3 -1.4
Medication for cholesterol 2.9 4.4 6.6 -2.6 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 1.6 1.3 -0.3
Back pain experienced in last month 0.0 0.0 0.1 -0.0 0.2
Mineral and other dietary supplements 2.8 3.8 4.0 2.0 -1.9
Breast cancer (self-reported) 0.0 0.0 0.0 -0.1 -0.1
Asthma (self-reported) 1.5 3.1 6.1 0.1 2.5
Osteoporosis (self-reported) 1.0 1.3 1.4 -1.2 1.1
Osteoarthritis (self-reported) 0.6 0.7 1.2 1.1 0.5
Medication: Aspirin 3.0 3.9 4.2 -1.9 2.0
Medication: Gliclazide 0.4 0.5 0.8 -0.4 0.9
Illnesses of father: None of the above (group 1) 2.2 2.7 5.4 0.2 -2.3
Smoking status: Current 0.9 1.5 2.5 -1.6 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.7 3.7 6.2 -1.1 -2.5
Whole body water mass 8.8 50.2 78.3 -8.8 4.7
Leg predicted mass (right) 7.3 39.1 58.1 -7.6 4.5
Arm fat mass (left) 6.7 27.5 33.6 -5.8 4.6
Number of self-reported non-cancer illnesses 1.0 1.8 2.1 1.4 1.2
Average weekly champagne plus white wine intake 1.2 1.7 3.2 -0.3 1.8
Miserableness 6.5 11.3 14.5 -2.9 3.8
Guilty feelings 0.1 0.1 0.2 -0.2 0.5
Wears glasses or contact lenses 0.1 0.1 0.2 0.3 0.4
Ever taken oral contraceptive pill 1.0 1.1 2.2 -1.5 0.0
Hearing aid user 1.5 1.7 3.0 -0.6 1.7
Mother’s age at death 1.3 1.6 3.1 1.8 -0.1
Financial situation satisfaction 0.4 0.5 0.9 -0.9 -0.4
Tinnitus: Yes, now most or all of the time 2.2 2.6 4.7 -0.7 2.2
Commuting to job workplace: Public transport 6.1 7.3 11.5 -1.7 3.4
Eye problems/disorders: Glaucoma 0.2 0.2 0.4 -0.2 -0.7
Medication: Blood pressure 2.6 4.9 7.8 2.8 -1.4
Pain type(s) experienced in last month: Hip pain 0.9 1.1 1.4 -0.9 1.2
Supplements: Fish oil (including cod liver oil) 3.3 4.3 5.0 -1.9 2.2
High cholesterol (Self-reported) 0.2 0.3 0.5 0.7 0.5
Medication: Bendroflumethiazide 0.1 0.2 0.2 0.4 -0.4
Medication: Paracetamol 0.2 0.2 0.4 0.2 0.6
Medication: Lisinopril 0.1 0.1 0.1 -0.4 -0.0
Medication: Atorvastatin 0.5 0.6 1.0 -0.5 1.0
Illnesses of father: High blood pressure 0.2 0.2 0.4 -0.1 0.6
Alcohol drinker status: Never 0.1 0.2 0.3 0.1 -0.6
Ever smoked 2.9 5.1 5.3 -2.2 2.3
Basal metabolic rate 9.5 52.5 79.6 -8.9 5.0
Leg fat percentage (left) 4.8 17.3 21.6 -4.6 3.6
Arm fat-free mass (left) 11.1 56.3 83.9 -9.2 5.3
Number of operations (self-reported) 0.4 0.6 0.6 -0.8 0.7
Average weekly beer plus cider intake 0.6 0.8 1.5 -1.2 0.3
Irritability 2.3 3.9 4.5 -1.8 2.1
Risk taking 6.9 10.1 11.0 -3.3 3.0
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.3 -0.7 1.1
Fractured/broken bones in last 5 years 0.8 1.1 1.3 0.9 1.1
Age started oral contraceptive pill 1.7 2.1 2.2 1.4 -1.5
Diastolic blood pressure, automated reading 0.6 1.8 2.2 -1.5 1.2
Ever depressed for a whole week 0.2 0.2 0.5 -0.0 0.7
Unable to work because of sickness or disability 1.6 2.1 3.4 -0.9 1.8
Commuting to job workplace: Cycle 0.7 0.8 1.6 -1.3 0.3
Myopia 0.3 0.4 0.8 0.9 -0.1
Vascular/heart problems diagnosed by doctor 0.3 0.9 1.8 -1.4 0.2
Cholesterol lowering medication 0.1 0.2 0.3 -0.1 0.6
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.2 -0.4 0.4
Pain experienced in last month 0.1 0.1 0.2 -0.4 -0.3
Supplements: Calcium 1.8 2.0 2.0 -1.4 1.4
Basal cell carcinoma (self-reported) 0.3 0.3 0.6 -0.8 0.3
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.2 0.1 0.4
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 1.5 -0.9 1.2
Heart disease (siblings) 0.5 0.7 1.1 0.5 1.1
Alcohol drinker status: Previous 0.4 0.4 0.7 -0.4 0.8
Pack years of smoking 2.2 3.2 4.0 -1.5 2.0
Impedance of whole body 5.9 29.8 48.6 7.0 -3.3
Leg fat mass (left) 8.8 34.5 41.6 -6.5 5.2
Arm predicted mass (left) 11.6 58.8 87.0 -9.3 5.5