TWAS
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Traits
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Whole body fat mass
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chr10:103,746,504-105,282,664
Best TWAS P=5.31e-08 · Best GWAS P=3.49e-07 conditioned to 0.0144
103.8M
104M
104.2M
104.4M
104.6M
104.8M
105M
105.2M
0
2
4
6
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Brain Cerebellum
ARL3
0.20
0.09
enet
32
0.07
3.7e-03
5.1
5.4
5.3e-08
0.57
0.05
0.87
TRUE
5
The Cancer Genome Atlas
Bladder Urothelial Carcinoma
AS3MT
0.06
0.09
enet
6
0.07
1.3e-06
4.7
-5.3
9.6e-08
-0.80
0.04
0.95
FALSE
4
ROSMAP
Brain Pre-frontal Cortex
CYP17A1-AS1
0.15
0.18
lasso
6
0.19
1.3e-23
5.1
5.3
1.4e-07
0.81
0.02
0.98
FALSE
3
GTEx
Nerve Tibial
CYP17A1-AS1
0.14
0.08
lasso
6
0.06
7.2e-05
4.9
5.2
2.0e-07
0.82
0.02
0.97
FALSE
2
GTEx
Breast Mammary Tissue (Female)
CYP17A1-AS1
0.14
0.01
lasso
11
0.00
4.7e-01
4.1
5.1
3.0e-07
0.60
0.04
0.37
FALSE