[Hub]/) : Traits : Whole body fat-free mass : ← →

chr6:129,638,583-132,080,991

Best TWAS P=2.99e-66 · Best GWAS P=1.32e-59 conditioned to 0.0442

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
28	GTEx	Thyroid	L3MBTL3	0.40	0.39	enet	9	0.43	2.8e-35	16.2	17.2	3.0e-66	0.90	0.01	0.99	TRUE
33	ROSMAP	Brain Pre-frontal Cortex	EPB41L2	0.12	0.12	blup	522	0.10	6.5e-13	2.8	5.2	2.3e-07	-0.01	0.94	0.00	TRUE
13	GTEx	Lung	L3MBTL3	0.37	0.34	lasso	4	0.38	4.1e-30	16.2	17.0	4.1e-65	0.89	0.00	1.00	FALSE
2	GTEx	Adipose Visceral Omentum	L3MBTL3	0.14	0.12	lasso	2	0.15	2.8e-08	16.2	17.0	1.1e-64	0.90	0.01	0.99	FALSE
14	GTEx	Lung	RP11-73O6.3	0.15	0.08	lasso	5	0.12	2.2e-09	16.2	16.9	2.5e-64	0.91	0.01	0.99	FALSE
16	GTEx	Pancreas	L3MBTL3	0.32	0.17	lasso	4	0.23	4.4e-10	16.2	16.9	2.8e-64	0.88	0.01	0.99	FALSE
29	GTEx	Thyroid	RP11-73O6.3	0.18	0.15	lasso	3	0.20	2.3e-15	14.9	16.9	4.3e-64	0.91	0.02	0.98	FALSE
5	GTEx	Breast Mammary Tissue (Male)	L3MBTL3	0.31	0.24	lasso	6	0.23	5.5e-06	16.2	16.9	5.2e-64	0.91	0.01	0.96	FALSE
15	GTEx	Nerve Tibial	L3MBTL3	0.30	0.23	lasso	4	0.22	2.3e-15	16.2	16.8	1.4e-63	0.87	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	L3MBTL3	0.20	0.08	lasso	4	0.09	1.1e-07	16.2	16.8	2.4e-63	0.89	0.01	0.99	FALSE
3	GTEx	Breast Mammary Tissue	L3MBTL3	0.31	0.25	lasso	7	0.23	2.8e-12	16.2	16.8	2.5e-63	0.89	0.00	1.00	FALSE
22	GTEx	Small Intestine Terminal Ileum	L3MBTL3	0.37	0.20	lasso	4	0.17	1.3e-04	16.2	16.8	4.3e-63	0.86	0.01	0.95	FALSE
30	GTEx	Whole Blood	L3MBTL3	0.22	0.20	lasso	9	0.20	5.1e-18	16.2	16.7	1.2e-62	0.86	0.01	0.99	FALSE
11	GTEx	Colon Transverse	RP11-73O6.3	0.19	0.09	lasso	2	0.06	1.2e-03	16.2	16.7	1.9e-62	0.88	0.01	0.98	FALSE
23	GTEx	Spleen	L3MBTL3	0.64	0.34	enet	14	0.48	6.4e-14	13.9	16.7	2.3e-62	0.88	0.03	0.97	FALSE
31	GTEx	Whole Blood	RP11-73O6.3	0.15	0.06	lasso	8	0.04	1.1e-04	16.2	16.7	2.6e-62	0.85	0.01	0.97	FALSE
4	GTEx	Breast Mammary Tissue	RP11-73O6.3	0.27	0.22	lasso	9	0.22	1.5e-11	16.2	16.6	9.8e-62	0.85	0.01	0.99	FALSE
10	GTEx	Colon Transverse	L3MBTL3	0.27	0.13	lasso	8	0.20	8.0e-10	16.2	16.5	2.0e-61	0.87	0.01	0.99	FALSE
19	GTEx	Prostate	L3MBTL3	0.35	0.27	lasso	5	0.17	5.9e-05	16.2	16.5	2.1e-61	0.87	0.01	0.96	FALSE
21	GTEx	Skin Sun Exposed Lower leg	L3MBTL3	0.25	0.25	lasso	9	0.24	1.4e-19	16.2	16.5	5.1e-61	0.86	0.01	0.99	FALSE
8	GTEx	Breast Mammary Tissue (Female)	RP11-73O6.3	0.29	0.08	lasso	5	0.10	5.7e-04	13.9	16.4	2.0e-60	0.85	0.02	0.94	FALSE
7	GTEx	Breast Mammary Tissue (Female)	L3MBTL3	0.30	0.13	lasso	5	0.14	4.5e-05	12.1	16.4	2.9e-60	0.86	0.01	0.97	FALSE
12	GTEx	Esophagus Mucosa	L3MBTL3	0.26	0.18	lasso	2	0.23	2.7e-15	13.9	16.3	2.2e-59	0.82	0.02	0.98	FALSE
26	GTEx	Stomach	RP11-73O6.3	0.21	0.12	lasso	6	0.06	5.9e-04	16.0	16.1	4.5e-58	0.89	0.03	0.88	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	L3MBTL3	0.26	0.12	lasso	4	0.12	4.0e-07	12.7	16.0	2.2e-57	0.79	0.01	0.99	FALSE
6	GTEx	Breast Mammary Tissue (Male)	RP11-73O6.3	0.33	0.17	lasso	4	0.12	1.3e-03	16.2	15.7	1.2e-55	0.84	0.02	0.87	FALSE
27	GTEx	Testis	L3MBTL3	0.41	0.22	lasso	8	0.30	9.2e-14	16.2	15.6	7.2e-55	0.78	0.00	1.00	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	L3MBTL3	0.28	0.08	lasso	10	0.03	4.4e-02	16.2	15.6	7.5e-55	0.86	0.02	0.91	FALSE
25	GTEx	Stomach	L3MBTL3	0.36	0.18	enet	27	0.20	1.1e-09	16.0	15.6	1.3e-54	0.85	0.02	0.98	FALSE
24	GTEx	Spleen	RP11-73O6.3	0.45	0.43	enet	21	0.42	7.7e-12	14.0	15.4	2.5e-53	0.80	0.12	0.88	FALSE
17	GTEx	Pituitary	L3MBTL3	0.45	0.31	lasso	8	0.29	5.1e-08	12.1	14.4	3.8e-47	0.74	0.03	0.96	FALSE
35	YFS	Blood	L3MBTL3	0.28	0.22	blup	614	0.27	1.2e-88	13.9	13.3	3.1e-40	0.67	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	L3MBTL3	0.06	0.01	blup	114	0.04	4.0e-03	13.9	13.0	7.6e-39	0.78	0.05	0.66	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	L3MBTL3	0.14	0.07	blup	609	0.08	3.8e-10	16.2	13.0	2.3e-38	0.67	0.01	0.99	FALSE
32	METSIM	Adipose	L3MBTL3	0.13	0.12	enet	22	0.12	4.8e-18	13.9	12.7	4.8e-37	0.68	0.99	0.01	FALSE
18	GTEx	Pituitary	RP11-73O6.3	0.48	0.07	lasso	7	0.16	8.2e-05	12.1	12.2	4.8e-34	0.62	0.04	0.90	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	L3MBTL3	0.05	0.00	blup	114	0.01	1.0e-02	10.5	6.6	3.0e-11	0.51	0.02	0.29	FALSE