Best TWAS P=2.39e-09 · Best GWAS P=9.62e-25 conditioned to 3.37e-20
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | RMND1 | 0.34 | 0.09 | lasso | 6 | 0.19 | 4.8e-13 | 4.8 | -5.4 | 5.3e-08 | -0.01 | 1.00 | 0.00 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | SYNE1 | 0.12 | 0.01 | blup | 875 | 0.05 | 6.9e-07 | 1.0 | 5.3 | 9.0e-08 | 0.26 | 0.64 | 0.08 | TRUE |
| 3 | YFS | Blood | RGS17 | 0.10 | 0.11 | enet | 11 | 0.11 | 6.3e-33 | 5.3 | 5.2 | 2.5e-07 | -0.01 | 0.01 | 0.99 | FALSE |
| 4 | YFS | Blood | RMND1 | 0.06 | 0.06 | lasso | 12 | 0.05 | 6.5e-16 | 5.2 | -5.7 | 1.5e-08 | -0.01 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RGS17 | 0.02 | 0.02 | enet | 5 | 0.02 | 1.8e-04 | 5.3 | -5.2 | 1.8e-07 | 0.02 | 0.01 | 0.98 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RMND1 | 0.02 | 0.00 | blup | 57 | 0.01 | 3.1e-03 | 4.6 | -5.6 | 2.3e-08 | -0.02 | 0.00 | 0.61 | FALSE |
| 7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RMND1 | 0.16 | 0.10 | lasso | 7 | 0.12 | 1.6e-06 | 5.2 | -6.0 | 2.4e-09 | -0.02 | 0.02 | 0.98 | TRUE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | RMND1 | 0.11 | 0.09 | lasso | 4 | 0.10 | 2.9e-06 | 5.1 | -5.2 | 2.5e-07 | 0.01 | 0.38 | 0.57 | FALSE |
| 9 | The Cancer Genome Atlas | Esophageal Carcinoma | RMND1 | 0.12 | 0.09 | enet | 9 | 0.10 | 4.2e-04 | 4.2 | -5.3 | 1.2e-07 | -0.03 | 0.08 | 0.28 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RMND1 | 0.07 | 0.06 | blup | 58 | 0.09 | 1.4e-10 | 5.2 | -5.9 | 3.8e-09 | 0.01 | 0.18 | 0.82 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RMND1 | 0.09 | 0.10 | lasso | 4 | 0.10 | 1.6e-11 | 4.9 | -5.4 | 5.4e-08 | 0.03 | 0.56 | 0.44 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C6orf211 | 0.05 | 0.03 | lasso | 3 | 0.04 | 6.3e-05 | 4.7 | -5.2 | 1.9e-07 | -0.01 | 0.06 | 0.92 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | RMND1 | 0.05 | 0.06 | lasso | 2 | 0.07 | 4.3e-08 | 6.3 | -6.0 | 2.4e-09 | -0.04 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RMND1 | 0.16 | 0.15 | enet | 7 | 0.09 | 2.7e-03 | 6.3 | -5.5 | 3.1e-08 | -0.04 | 0.00 | 0.95 | FALSE |
| 15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RMND1 | 0.06 | 0.04 | blup | 57 | 0.06 | 4.9e-05 | 4.4 | -5.9 | 3.9e-09 | -0.03 | 0.03 | 0.88 | FALSE |