Best TWAS P=5.09e-23 · Best GWAS P=6.53e-27 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC441454 | 0.05 | 0.01 | lasso | 3 | 0.02 | 1.5e-03 | 6.0 | 6.7 | 2.4e-11 | 0.04 | 0.04 | 0.57 | FALSE |
| 2 | GTEx | Artery Tibial | RP11-435O5.5 | 0.09 | 0.04 | lasso | 2 | 0.02 | 7.3e-03 | 10.1 | -9.9 | 5.1e-23 | -0.95 | 0.02 | 0.94 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | CDC14B | 0.16 | 0.02 | enet | 21 | 0.02 | 3.7e-02 | 8.2 | -7.1 | 1.8e-12 | -0.02 | 0.06 | 0.88 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | AAED1 | 0.17 | 0.02 | lasso | 3 | 0.04 | 2.4e-02 | 8.2 | 7.3 | 3.1e-13 | 0.02 | 0.04 | 0.52 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | RP11-435O5.5 | 0.14 | 0.04 | lasso | 4 | 0.02 | 7.9e-03 | 5.2 | -5.4 | 6.2e-08 | -0.60 | 0.36 | 0.03 | TRUE |
| 6 | GTEx | Heart Atrial Appendage | RP11-435O5.4 | 0.18 | 0.00 | lasso | 5 | 0.00 | 6.2e-01 | 2.7 | -5.3 | 1.0e-07 | -0.10 | 0.04 | 0.43 | TRUE |
| 7 | GTEx | Liver | PTCH1 | 0.25 | 0.06 | enet | 11 | 0.03 | 4.9e-02 | 9.7 | 6.3 | 3.6e-10 | 0.26 | 0.16 | 0.06 | FALSE |
| 8 | GTEx | Nerve Tibial | HSD17B3 | 0.14 | 0.00 | enet | 20 | 0.00 | 2.4e-01 | 7.9 | 6.1 | 8.6e-10 | 0.05 | 0.08 | 0.44 | FALSE |
| 9 | GTEx | Nerve Tibial | ZNF367 | 0.10 | 0.05 | lasso | 3 | 0.02 | 7.9e-03 | 8.5 | 7.7 | 1.2e-14 | 0.04 | 0.02 | 0.97 | FALSE |
| 10 | GTEx | Spleen | PTCH1 | 0.33 | 0.08 | lasso | 8 | 0.18 | 1.9e-05 | -0.1 | 5.4 | 7.9e-08 | 0.28 | 0.17 | 0.10 | TRUE |
| 11 | GTEx | Testis | HABP4 | 0.19 | 0.22 | lasso | 9 | 0.21 | 1.1e-09 | 8.3 | 8.3 | 1.3e-16 | 0.04 | 0.06 | 0.94 | FALSE |
| 12 | GTEx | Thyroid | CDC14B | 0.15 | 0.10 | lasso | 5 | 0.08 | 5.3e-07 | 7.9 | -8.0 | 1.4e-15 | -0.04 | 0.22 | 0.78 | FALSE |
| 13 | NTR | Blood | PTCH1 | 0.04 | 0.02 | blup | 433 | 0.02 | 4.1e-08 | 7.1 | 6.0 | 1.8e-09 | 0.09 | 0.98 | 0.00 | TRUE |
| 14 | YFS | Blood | HABP4 | 0.08 | 0.09 | enet | 24 | 0.11 | 5.9e-34 | 8.3 | -8.0 | 1.6e-15 | -0.09 | 0.04 | 0.96 | FALSE |
| 15 | YFS | Blood | PTCH1 | 0.09 | 0.05 | lasso | 8 | 0.05 | 1.2e-15 | 7.1 | 7.9 | 3.7e-15 | 0.42 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CDC14B | 0.02 | 0.01 | lasso | 1 | 0.01 | 3.0e-03 | 8.4 | -8.4 | 3.7e-17 | -0.04 | 0.02 | 0.61 | FALSE |
| 17 | The Cancer Genome Atlas | Glioblastoma Multiforme | CDC14B | 0.16 | 0.17 | blup | 41 | 0.19 | 2.6e-06 | 8.2 | -7.4 | 9.4e-14 | -0.01 | 0.04 | 0.93 | FALSE |
| 18 | The Cancer Genome Atlas | Glioblastoma Multiforme | HABP4 | 0.08 | 0.06 | blup | 44 | 0.05 | 1.6e-02 | 7.8 | -8.5 | 1.3e-17 | -0.06 | 0.03 | 0.49 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HABP4 | 0.02 | 0.02 | blup | 44 | 0.02 | 7.1e-03 | 8.2 | 8.5 | 2.4e-17 | 0.04 | 0.03 | 0.68 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CDC14B | 0.03 | 0.02 | blup | 42 | 0.02 | 2.1e-03 | 8.2 | -8.4 | 4.6e-17 | -0.04 | 0.03 | 0.67 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CDC14B | 0.05 | 0.06 | lasso | 5 | 0.06 | 6.5e-07 | 8.2 | -7.6 | 3.5e-14 | -0.04 | 0.06 | 0.94 | FALSE |
| 22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HABP4 | 0.05 | 0.08 | lasso | 5 | 0.08 | 6.9e-09 | 7.8 | -7.9 | 1.9e-15 | -0.05 | 0.09 | 0.91 | FALSE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PTCH1 | 0.02 | 0.01 | blup | 54 | 0.02 | 1.1e-03 | 8.7 | -8.7 | 4.9e-18 | -0.86 | 0.02 | 0.73 | FALSE |
| 24 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CDC14B | 0.08 | 0.02 | blup | 41 | 0.04 | 1.0e-03 | 6.0 | -8.7 | 4.2e-18 | -0.08 | 0.02 | 0.60 | TRUE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | CDC14B | 0.05 | 0.07 | blup | 42 | 0.08 | 4.8e-08 | 8.3 | -8.2 | 2.6e-16 | -0.03 | 0.04 | 0.96 | FALSE |