TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Whole body fat-free mass
:
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→
chr10:119,742,699-121,632,800
Best TWAS P=4.85e-10 · Best GWAS P=1.41e-09 conditioned to 0.264
120M
120.5M
121M
121.5M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Pheochromocytoma and Paraganglioma
C10orf46
0.23
0.04
lasso
4
0.04
8.6e-03
-5.6
6.2
4.8e-10
0.66
0.01
0.42
TRUE
3
GTEx
Esophagus Gastroesophageal Junction
FAM45A
0.24
0.13
enet
51
0.09
2.7e-04
4.5
6.0
2.2e-09
0.19
0.14
0.09
TRUE
4
ROSMAP
Brain Pre-frontal Cortex
CACUL1
0.12
0.08
lasso
4
0.06
1.2e-08
-5.6
5.5
2.9e-08
0.57
0.03
0.97
FALSE
1
GTEx
Breast Mammary Tissue
PRDX3
0.27
0.00
enet
30
0.02
3.9e-02
4.4
5.3
9.3e-08
0.06
0.12
0.06
FALSE
2
GTEx
Breast Mammary Tissue (Female)
PRDX3
0.34
0.11
enet
31
0.12
1.9e-04
3.9
5.2
1.6e-07
0.21
0.11
0.08
FALSE