Best TWAS P=4.85e-10 · Best GWAS P=1.41e-09 conditioned to 0.264
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | PRDX3 | 0.27 | 0.00 | enet | 30 | 0.02 | 3.9e-02 | 4.4 | 5.3 | 9.3e-08 | 0.06 | 0.12 | 0.06 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | PRDX3 | 0.34 | 0.11 | enet | 31 | 0.12 | 1.9e-04 | 3.9 | 5.2 | 1.6e-07 | 0.21 | 0.11 | 0.08 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | FAM45A | 0.24 | 0.13 | enet | 51 | 0.09 | 2.7e-04 | 4.5 | 6.0 | 2.2e-09 | 0.19 | 0.14 | 0.09 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | CACUL1 | 0.12 | 0.08 | lasso | 4 | 0.06 | 1.2e-08 | -5.6 | 5.5 | 2.9e-08 | 0.57 | 0.03 | 0.97 | FALSE |
| 5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C10orf46 | 0.23 | 0.04 | lasso | 4 | 0.04 | 8.6e-03 | -5.6 | 6.2 | 4.8e-10 | 0.66 | 0.01 | 0.42 | TRUE |