[Hub]/) : Traits : Whole body fat-free mass :

chr11:64,407,419-66,333,072

Best TWAS P=5.05e-11 · Best GWAS P=6.6e-12 conditioned to 1.93e-09

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Brain Cerebellar Hemisphere EFEMP2 0.35 0.15 enet 5 0.09 2.2e-03 5.3 5.4 7.0e-08 -0.18 0.33 0.10 TRUE
2 GTEx Colon Transverse DPF2 0.19 0.01 lasso 4 0.05 1.6e-03 4.3 6.6 5.1e-11 0.00 0.07 0.28 TRUE
3 GTEx Esophagus Mucosa DPF2 0.12 0.02 lasso 4 0.03 6.2e-03 -4.5 5.5 4.7e-08 -0.15 0.12 0.10 FALSE
4 GTEx Testis DPF2 0.20 0.09 lasso 7 0.06 9.5e-04 -4.1 5.1 2.9e-07 -0.14 0.14 0.18 FALSE
5 METSIM Adipose EFEMP2 0.07 0.05 lasso 8 0.04 4.2e-06 4.6 5.2 2.3e-07 -0.25 0.99 0.01 FALSE
6 The Cancer Genome Atlas Breast Invasive Carcinoma EFEMP2 0.04 0.02 lasso 5 0.02 1.4e-05 5.6 5.2 1.6e-07 -0.20 0.06 0.93 FALSE
7 The Cancer Genome Atlas Breast Invasive Carcinoma POLA2 0.01 0.01 blup 34 0.02 2.6e-04 -4.6 5.2 1.6e-07 -0.08 0.10 0.86 FALSE
8 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma POLA2 0.05 0.02 blup 36 0.05 2.2e-03 -4.5 5.2 2.4e-07 -0.07 0.03 0.65 FALSE
9 The Cancer Genome Atlas Glioblastoma Multiforme CTSW 0.16 0.18 enet 16 0.19 2.3e-06 4.1 -5.2 1.9e-07 0.20 0.19 0.60 FALSE
10 The Cancer Genome Atlas Glioblastoma Multiforme DKFZp761E198 0.14 0.00 blup 39 0.05 1.4e-02 -4.8 -5.4 7.2e-08 0.33 0.01 0.41 FALSE
11 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DKFZp761E198 0.07 0.02 blup 39 0.03 5.9e-04 -4.9 -5.3 1.1e-07 0.35 0.01 0.77 FALSE
12 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DPF2 0.03 0.03 lasso 2 0.03 5.6e-04 -5.3 5.4 6.0e-08 -0.06 0.00 0.95 FALSE
13 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma POLA2 0.04 0.01 lasso 3 0.02 8.7e-04 -4.9 5.1 2.7e-07 -0.09 0.17 0.57 FALSE
14 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DPF2 0.07 0.04 blup 28 0.04 2.9e-05 -5.3 5.7 1.5e-08 -0.04 0.00 0.99 FALSE
15 The Cancer Genome Atlas Brain Lower Grade Glioma DPF2 0.03 0.02 blup 28 0.02 1.2e-03 -5.3 5.9 3.1e-09 -0.04 0.00 0.96 FALSE
16 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CAPN1 0.03 0.02 blup 39 0.02 2.1e-03 -5.6 -6.4 1.4e-10 0.19 0.00 0.97 FALSE
17 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma POLA2 0.12 0.03 enet 9 0.05 2.5e-04 -5.3 5.8 6.2e-09 -0.12 0.03 0.60 FALSE
18 The Cancer Genome Atlas Soft Tissue Sarcoma POLA2 0.09 0.06 blup 34 0.08 1.4e-05 -5.7 5.9 4.2e-09 -0.15 0.01 0.98 FALSE
19 The Cancer Genome Atlas Thyroid Carcinoma DPF2 0.05 0.02 blup 29 0.03 3.7e-04 -5.3 5.9 4.3e-09 -0.03 0.00 0.95 FALSE
20 The Cancer Genome Atlas Thyroid Carcinoma FIBP 0.04 0.00 blup 45 0.02 8.0e-03 4.1 5.4 7.2e-08 -0.25 0.02 0.06 FALSE