Best TWAS P=5.05e-11 · Best GWAS P=6.6e-12 conditioned to 1.93e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | EFEMP2 | 0.35 | 0.15 | enet | 5 | 0.09 | 2.2e-03 | 5.3 | 5.4 | 7.0e-08 | -0.18 | 0.33 | 0.10 | TRUE |
| 2 | GTEx | Colon Transverse | DPF2 | 0.19 | 0.01 | lasso | 4 | 0.05 | 1.6e-03 | 4.3 | 6.6 | 5.1e-11 | 0.00 | 0.07 | 0.28 | TRUE |
| 3 | GTEx | Esophagus Mucosa | DPF2 | 0.12 | 0.02 | lasso | 4 | 0.03 | 6.2e-03 | -4.5 | 5.5 | 4.7e-08 | -0.15 | 0.12 | 0.10 | FALSE |
| 4 | GTEx | Testis | DPF2 | 0.20 | 0.09 | lasso | 7 | 0.06 | 9.5e-04 | -4.1 | 5.1 | 2.9e-07 | -0.14 | 0.14 | 0.18 | FALSE |
| 5 | METSIM | Adipose | EFEMP2 | 0.07 | 0.05 | lasso | 8 | 0.04 | 4.2e-06 | 4.6 | 5.2 | 2.3e-07 | -0.25 | 0.99 | 0.01 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EFEMP2 | 0.04 | 0.02 | lasso | 5 | 0.02 | 1.4e-05 | 5.6 | 5.2 | 1.6e-07 | -0.20 | 0.06 | 0.93 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | POLA2 | 0.01 | 0.01 | blup | 34 | 0.02 | 2.6e-04 | -4.6 | 5.2 | 1.6e-07 | -0.08 | 0.10 | 0.86 | FALSE |
| 8 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | POLA2 | 0.05 | 0.02 | blup | 36 | 0.05 | 2.2e-03 | -4.5 | 5.2 | 2.4e-07 | -0.07 | 0.03 | 0.65 | FALSE |
| 9 | The Cancer Genome Atlas | Glioblastoma Multiforme | CTSW | 0.16 | 0.18 | enet | 16 | 0.19 | 2.3e-06 | 4.1 | -5.2 | 1.9e-07 | 0.20 | 0.19 | 0.60 | FALSE |
| 10 | The Cancer Genome Atlas | Glioblastoma Multiforme | DKFZp761E198 | 0.14 | 0.00 | blup | 39 | 0.05 | 1.4e-02 | -4.8 | -5.4 | 7.2e-08 | 0.33 | 0.01 | 0.41 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DKFZp761E198 | 0.07 | 0.02 | blup | 39 | 0.03 | 5.9e-04 | -4.9 | -5.3 | 1.1e-07 | 0.35 | 0.01 | 0.77 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DPF2 | 0.03 | 0.03 | lasso | 2 | 0.03 | 5.6e-04 | -5.3 | 5.4 | 6.0e-08 | -0.06 | 0.00 | 0.95 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | POLA2 | 0.04 | 0.01 | lasso | 3 | 0.02 | 8.7e-04 | -4.9 | 5.1 | 2.7e-07 | -0.09 | 0.17 | 0.57 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DPF2 | 0.07 | 0.04 | blup | 28 | 0.04 | 2.9e-05 | -5.3 | 5.7 | 1.5e-08 | -0.04 | 0.00 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DPF2 | 0.03 | 0.02 | blup | 28 | 0.02 | 1.2e-03 | -5.3 | 5.9 | 3.1e-09 | -0.04 | 0.00 | 0.96 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CAPN1 | 0.03 | 0.02 | blup | 39 | 0.02 | 2.1e-03 | -5.6 | -6.4 | 1.4e-10 | 0.19 | 0.00 | 0.97 | FALSE |
| 17 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | POLA2 | 0.12 | 0.03 | enet | 9 | 0.05 | 2.5e-04 | -5.3 | 5.8 | 6.2e-09 | -0.12 | 0.03 | 0.60 | FALSE |
| 18 | The Cancer Genome Atlas | Soft Tissue Sarcoma | POLA2 | 0.09 | 0.06 | blup | 34 | 0.08 | 1.4e-05 | -5.7 | 5.9 | 4.2e-09 | -0.15 | 0.01 | 0.98 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | DPF2 | 0.05 | 0.02 | blup | 29 | 0.03 | 3.7e-04 | -5.3 | 5.9 | 4.3e-09 | -0.03 | 0.00 | 0.95 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | FIBP | 0.04 | 0.00 | blup | 45 | 0.02 | 8.0e-03 | 4.1 | 5.4 | 7.2e-08 | -0.25 | 0.02 | 0.06 | FALSE |