TWAS
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Models
Genes
Traits
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Traits
:
Whole body fat-free mass
:
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→
chr12:93,110,493-94,675,142
Best TWAS P=1.73e-20 · Best GWAS P=4.31e-45 conditioned to 1.37e-23
93.2M
93.4M
93.6M
93.8M
94M
94.2M
94.4M
94.6M
0
10
20
30
40
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Breast Mammary Tissue (Male)
MRPL42
0.21
-0.01
lasso
2
-0.01
6.0e-01
9.4
-9.3
1.7e-20
-0.48
0.05
0.06
TRUE
3
YFS
Blood
SOCS2
0.06
0.04
bslmm
444
0.04
1.7e-12
6.8
8.2
2.3e-16
0.01
1.00
0.00
TRUE
2
GTEx
Muscle Skeletal
MRPL42
0.07
0.02
lasso
3
0.04
1.5e-04
-5.4
-5.5
2.9e-08
-0.17
0.69
0.01
TRUE
4
YFS
Blood
UBE2N
0.02
0.00
bslmm
424
0.01
3.6e-03
11.9
5.4
6.2e-08
0.38
0.06
0.26
FALSE
5
The Cancer Genome Atlas
Prostate Adenocarcinoma
MRPL42
0.07
0.03
blup
49
0.03
1.4e-04
-3.2
5.3
9.4e-08
0.21
0.26
0.58
FALSE