TWAS hub - SOCS2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0421	0.0129	7.1e-06	0.024	0.020	0.016	0.022	0.021	3.0e-08	2.4e-07	3.8e-06	6.5e-08	1.5e-07
2	YFS	Blood	0.0590	0.0141	8.2e-11	0.036	0.037	0.030	0.038	0.035	6.8e-12	3.9e-12	2.7e-10	1.7e-12	1.5e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Sitting height	20.1	142.8	210.2	8.7	14.5
Height	17.4	335.1	476.3	13.9	21.8
Standing height	15.3	151.4	198.8	10.2	14.1
Comparative height size at age 10	12.2	67.1	73.3	7.8	8.6
Trunk fat-free mass	9.0	51.7	76.8	5.2	8.8
Trunk predicted mass	8.8	50.5	75.9	5.0	8.7
Forced expiratory volume in 1-second (FEV1), predicted	8.5	17.6	22.2	3.6	4.7
Whole body fat-free mass	7.8	44.5	67.2	4.7	8.2
Whole body water mass	7.8	44.5	67.6	4.6	8.2
Arm predicted mass (right)	7.5	38.2	57.5	4.4	7.6
Arm fat-free mass (right)	7.2	36.9	56.5	4.2	7.5
Major Depression (MDD)	7.1	8.6	13.5	-3.7	-1.9
Arm predicted mass (left)	6.6	33.4	51.8	3.9	7.2
Basal metabolic rate	6.5	35.8	54.5	4.1	7.4
Arm fat-free mass (left)	6.1	30.8	49.0	3.5	7.0
Leg fat-free mass (left)	5.9	31.1	47.7	3.8	6.9
Leg predicted mass (left)	5.9	31.3	47.5	3.9	6.9
Leg predicted mass (right)	5.9	31.3	47.8	3.8	6.9
Leg fat-free mass (right)	5.7	30.7	46.9	3.8	6.8
Fractured/broken bones in last 5 years	5.6	7.2	8.3	2.9	2.5
Heel bone mineral density (BMD) T-score, automated (left)	5.3	12.1	15.4	-3.9	-3.0
Peak expiratory flow (PEF)	5.3	12.2	20.1	2.1	4.5
Heel T-Score	5.2	41.3	52.7	-5.5	-7.3
Financial difficulties in last 2 years	4.6	6.2	10.5	-3.2	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	4.3	9.9	12.6	-3.5	-2.7
Medication: Bendroflumethiazide	4.0	6.1	6.7	2.3	2.6
Age when periods started (menarche)	3.5	8.5	10.3	2.6	3.2
Worry too long after embarrassment	3.2	5.4	7.6	-1.8	-2.8
Hand grip strength (right)	3.1	8.5	8.8	2.9	3.0
Average weekly champagne plus white wine intake	3.1	4.3	7.6	2.8	1.0
Had other major operations	3.0	3.7	3.8	-2.0	-1.9
Weight	3.0	14.7	22.7	2.6	4.8
Medication: Paracetamol	3.0	5.0	7.3	-2.7	-1.7
Leg pain on walking	3.0	3.8	5.3	-2.3	-1.5
Qualifications: NVQ or HND or HNC or equivalent	3.0	3.7	6.7	-2.6	-0.8
Frequency of depressed mood in last 2 weeks	2.9	4.1	6.0	-2.5	-1.5
Ever had hysterectomy (womb removed)	2.9	3.2	3.3	1.8	1.8
Had menopause	2.9	3.7	4.6	2.2	1.6
Eye problems/disorders: None of the above	2.9	3.3	5.8	-1.0	-2.4
Illness, injury, bereavement, stress in last 2 years	2.9	3.5	3.8	1.8	1.9
Qualifications: CSEs or equivalent	2.8	3.7	5.0	-2.2	-1.5
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.6	6.7	-2.6	-1.6
Forced expiratory volume in 1-second (FEV1)	2.8	9.3	16.5	1.4	4.1
Lung FVC	2.7	13.9	14.8	-3.9	-3.6
Forced vital capacity (FVC)	2.7	10.6	18.3	1.7	4.3
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	3.9	-1.6	-2.0
Mouth/teeth dental problems: Mouth ulcers	2.7	4.3	4.9	1.9	2.2
Ever used hormone-replacement therapy (HRT)	2.6	3.3	6.6	2.6	0.3
Diabetes (father)	2.6	3.3	5.4	1.1	2.3
Medication: Amlodipine	2.6	3.6	4.7	2.2	1.6
Forced vital capacity (FVC), Best measure	2.6	9.5	15.0	2.0	3.9
Depressed Affect (Nagel 2018)	2.5	5.3	7.0	-2.6	-1.9
Glaucoma (self-reported)	2.5	2.9	3.9	1.4	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.2	5.2	-1.1	-2.3
Ever depressed for a whole week	2.4	3.0	5.2	-2.3	-0.9
Loneliness, isolation	2.3	3.1	5.1	-1.1	-2.3
Illnesses of father: High blood pressure	2.3	2.9	4.5	-2.1	-1.1
Hip circumference	2.2	9.6	13.8	2.3	3.7
Blood clot in the leg (DVT)	2.2	2.8	3.8	-2.0	-1.4
Fed-up feelings	2.1	3.8	5.0	-2.2	-1.6
Bilateral oophorectomy (both ovaries removed)	2.1	2.5	4.3	2.1	0.8
Ulcerative Colitis (UC)	2.0	3.8	4.5	-2.1	-1.8
Hand grip strength (left)	2.0	5.2	5.5	2.3	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.4	10.9	1.4	3.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	4.6	-1.2	-2.2
Eye problems/disorders: Glaucoma	2.0	2.4	3.7	1.0	1.9
Heart disease (siblings)	2.0	2.4	2.8	-1.7	-1.4
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	3.7	-1.9	-1.1
Neuroticism score	1.8	3.7	5.3	-2.3	-1.4
Birth weight	1.8	3.8	5.7	2.4	1.4
Guilty feelings	1.8	2.7	3.0	-1.6	-1.7
Blood Eosinophil Count	1.7	12.9	13.8	-3.5	-3.7
Waist Hip Ratio (WHR)	1.7	7.5	8.4	-2.6	-2.9
Systolic blood pressure, automated reading	1.7	5.0	6.7	-1.9	-2.6
Medication: Seretide 50 evohaler	1.7	1.9	2.4	1.5	1.2
Ever had prostate specific antigen (PSA) test	1.7	1.9	2.2	-1.3	-1.5
Commuting to job workplace: Cycle	1.7	2.0	2.2	-1.4	-1.5
Sensitivity / hurt feelings	1.6	2.8	4.3	-1.2	-2.1
Medication: Ramipril	1.6	2.0	2.5	-1.6	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	2.8	-1.7	-1.0
Illnesses of father: None of the above (group 1)	1.6	2.0	3.6	1.9	0.7
Financial situation satisfaction	1.6	1.9	3.8	-2.0	0.2
Leg fat percentage (left)	1.6	5.8	6.9	-2.2	-2.6
Relative age of first facial hair	1.5	3.0	4.6	1.2	2.1
Exposure to tobacco smoke at home	1.5	1.7	2.7	0.9	1.6
Leg fat percentage (right)	1.5	5.4	6.4	-2.1	-2.5
Medication: Aspirin	1.5	2.0	2.6	1.6	1.2
Pain experienced in last month	1.5	2.5	4.6	2.2	0.6
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	2.7	-1.6	-1.1
Neuroticism (Nagel 2018)	1.4	3.4	4.3	-2.1	-1.6
Ulcerative Colitis	1.4	2.1	2.6	-1.2	-1.6
BMI	1.4	8.4	9.0	-3.0	-2.8
Medication: Atenolol	1.4	1.7	3.2	1.8	0.5
Hair/balding pattern: Pattern 3	1.4	2.0	2.5	-1.6	-1.3
Depression (self-reported)	1.4	1.6	1.8	-1.4	-1.2
Medication: Ibuprofen	1.4	1.7	2.5	-1.6	-1.0
Supplements: Vitamin C	1.4	1.6	1.8	1.3	1.2
Mood swings	1.4	2.5	3.4	-1.9	-1.2
Risk taking	1.4	2.0	2.9	-1.7	-1.1
Chronotype (morning person)	1.3	3.1	3.3	-1.7	-1.8
Relative age voice broke	1.3	2.0	2.1	1.4	1.4
Arm fat percentage (right)	1.3	5.1	6.7	-1.9	-2.6
Overall health rating	1.3	2.7	4.1	-2.0	-1.1
Arm fat percentage (left)	1.3	5.1	6.4	-2.0	-2.5
Medication: Blood pressure	1.3	2.5	3.1	1.3	1.8
Medication: Metformin	1.2	1.6	3.3	-1.8	0.1
Chronic bronchitis/emphysema (father)	1.2	1.5	1.7	-1.3	-1.1
Wheeze or whistling in the chest in last year	1.2	2.1	2.6	1.6	1.3
Medication for cholesterol	1.2	1.8	2.4	-1.1	-1.5
Crohns Disease (2012)	1.1	1.8	2.7	0.9	1.6
Comparative body size at age 10	1.1	2.9	4.6	2.1	1.1
Mouth/teeth dental problems: Loose teeth	1.1	1.3	1.9	-1.4	-0.8
Medication for pain relief, constipation, heartburn	1.1	1.9	3.0	1.7	0.8
Medication: Aspirin	1.1	1.4	1.6	1.2	1.1
Medication: Paracetamol	1.1	1.7	1.9	-1.4	-1.2
Unable to work because of sickness or disability	1.1	1.4	1.7	1.0	1.3
Depression (Nagel 2018)	1.0	1.4	2.7	-1.6	-0.5
Intelligence (Savage-Jansen 2018)	1.0	3.1	3.5	1.6	1.9
Diabetes (mother)	1.0	1.3	2.5	-1.6	0.4
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.0	1.4	0.5
Qualifications: College or University degree	1.0	3.1	4.1	2.0	1.5
Coronary Artery Disease (CAD)	0.9	1.1	2.1	-1.4	-0.3
Smoking Status	0.9	2.0	2.9	-1.7	-1.1
Neuroticism	0.9	2.2	3.5	-1.9	-0.9
Body mass index (BMI)	0.9	3.8	4.7	-2.2	-1.7
Number of full brothers	0.9	1.2	2.2	-0.5	-1.5
Had major operations	0.9	1.1	2.1	0.2	-1.5
Smoking status: Previous	0.9	1.3	1.5	-1.0	-1.2
Friendships satisfaction	0.9	1.1	2.2	-0.1	1.5
Vitamin and mineral supplements	0.8	1.0	1.8	-0.5	-1.4
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.6	-1.3	0.5
Diabetes (self-reported)	0.8	1.2	2.3	-1.5	0.0
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.1	-1.4	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.9	-1.4	-0.2
Illnesses of father: Heart disease	0.8	1.1	1.8	1.3	0.7
Diabetes diagnosed by doctor	0.8	1.2	2.4	-1.5	0.3
Medication: Gliclazide	0.8	0.9	1.3	-1.1	-0.8
Miserableness	0.8	1.3	2.0	-1.4	-0.8
Age started oral contraceptive pill	0.8	1.0	1.8	0.5	1.3
Irritable Bowel Disease (IBD)	0.7	1.6	2.4	-1.6	-0.9
Mean Putamen Volume	0.7	0.8	0.9	0.9	0.9
HDL Cholesterol	0.7	1.1	1.1	-1.1	-1.0
LDL Cholesterol	0.7	1.1	1.6	1.2	0.9
Severe depression (siblings)	0.7	0.8	1.3	-0.6	-1.1
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.2	1.5	1.0
Asthma	0.7	1.4	2.2	-1.5	-0.7
Pulse wave Arterial Stiffness index	0.7	0.9	0.9	0.9	0.9
Osteoarthritis (self-reported)	0.7	0.9	1.0	-0.8	-1.0
Number of self-reported non-cancer illnesses	0.7	1.2	1.4	-1.2	-1.0
Myopia	0.7	1.1	1.5	-1.2	0.8
Age at First Birth	0.6	0.9	1.3	1.2	0.7
Allergy or Eczema	0.6	1.5	3.0	-0.2	1.7
Pack years adult smoking proportion	0.6	0.8	1.6	-0.4	-1.2
Average weekly fortified wine intake	0.6	0.7	0.9	1.0	0.7
Maternal smoking around birth	0.6	0.9	1.5	-0.5	-1.2
High blood pressure	0.6	1.6	2.2	1.5	1.0
Allergy	0.6	1.3	2.5	1.6	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	0.8	-0.7	-0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	1.5	0.8	1.2
Number of full sisters	0.6	0.8	1.5	0.0	-1.2
Family relationship satisfaction	0.6	0.7	1.2	-1.1	0.5
Breast cancer (self-reported)	0.6	0.7	1.0	-1.0	-0.6
Osteoporosis (self-reported)	0.6	0.7	1.3	1.1	0.4
Ever taken oral contraceptive pill	0.6	0.6	1.0	-1.0	-0.6
Commuting to job workplace: Public transport	0.6	0.7	1.4	1.2	0.2
Fasting Glucose	0.5	0.6	0.7	-0.8	0.8
HbA1C	0.5	0.5	0.5	0.7	0.7
Rheumatoid Arthritis	0.5	0.7	0.9	0.9	0.8
Hypothyroidism (self reported)	0.5	1.1	1.4	-0.9	1.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.7	-1.3	0.4
Hearing difficulty/problems: Yes	0.5	0.8	1.5	1.2	-0.2
Medication: Co-codamol	0.5	0.5	0.9	0.9	0.5
Townsend deprivation index at recruitment	0.5	0.7	0.8	-0.7	-0.9
Serious illness, injury or assault to yourself	0.5	0.6	0.8	-0.9	-0.6
Multivitamins +/- minerals	0.5	0.6	1.1	-1.0	0.4
Impedance of leg (left)	0.5	2.5	5.1	0.2	-2.2
Fluid intelligence score	0.5	1.0	2.0	-1.4	-0.1
Time employed in main current job	0.5	0.5	0.7	-0.9	-0.6
Lung cancer (father)	0.5	0.6	1.1	-0.2	-1.0
Body fat percentage	0.5	1.9	3.0	-0.9	-1.7
Medication: Blood pressure	0.5	0.8	1.1	1.1	0.7
Suffer from ‘nerves’	0.5	0.8	1.1	-1.1	0.6
Hypertension (Self-reported)	0.5	1.3	1.8	1.4	0.9
Mineral and other dietary supplements	0.5	0.7	1.0	1.0	0.7
Asthma (self-reported)	0.5	1.1	1.4	-1.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.4	-1.2	-0.9
Hearing aid user	0.5	0.5	1.0	-0.3	-1.0
Mother’s age at death	0.5	0.7	1.3	1.2	0.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	1.1	0.0
Number of operations (self-reported)	0.5	0.7	1.2	-0.5	-1.1
Ovarian Cancer	0.4	0.6	0.8	-0.9	0.6
Neuroticism (2016)	0.4	0.6	0.9	-1.0	0.4
Blood White Count	0.4	3.2	3.5	-1.9	-1.7
Impedance of leg (right)	0.4	1.8	3.5	0.3	-1.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.5	0.6	0.7
High blood pressure (mother)	0.4	0.5	1.0	-1.0	0.2
Trunk fat mass	0.4	1.9	2.4	1.1	1.6
Past tobacco smoking	0.4	0.7	0.9	0.9	0.7
Alcohol usually taken with meals	0.4	0.7	1.0	0.6	-1.0
Hair/balding pattern: Pattern 2	0.4	0.5	0.6	-0.6	0.8
Impedance of arm (right)	0.4	1.8	2.1	1.5	-1.2
Happiness	0.4	0.5	0.9	0.4	0.9
Impedance of arm (left)	0.4	1.7	2.1	1.1	-1.5
Hair/balding pattern: Pattern 4	0.4	0.9	1.8	-0.4	-1.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.6	0.6	0.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	0.2	1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	-0.3	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	0.8	-0.8	0.9
Number of children fathered	0.4	0.4	0.8	-0.1	0.9
Emphysema/chronic bronchitis	0.4	0.4	0.6	-0.8	-0.5
Migraine (self-reported)	0.4	0.5	0.8	0.5	-0.9
Mean time to correctly identify matches	0.4	0.7	1.3	1.2	0.3
Pulse rate, automated reading	0.4	1.2	2.3	-1.5	-0.2
Chest pain or discomfort	0.4	0.6	0.7	0.8	-0.8
Knee pain experienced in last month	0.4	0.6	1.1	-1.0	-0.4
High cholesterol (Self-reported)	0.4	0.7	1.2	-1.1	-0.4
Impedance of whole body	0.4	2.1	2.9	1.2	-1.7
Lupus	0.3	0.4	0.8	-0.9	-0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	-0.1	-0.8
Blood Red Count	0.3	3.0	4.5	1.2	2.1
Lung FEV1/FVC ratio	0.3	1.4	1.6	1.1	1.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	0.5	-0.8
Taking other prescription medications	0.3	0.5	0.8	-0.9	-0.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.7	-0.6	0.9
Supplements: Glucosamine	0.3	0.4	0.7	-0.8	-0.3
Medication: Levothyroxine sodium	0.3	0.5	0.7	-0.6	0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.5	-0.7	-0.4
Mouth/teeth dental problems	0.3	0.4	0.6	-0.8	-0.6
Pain all over the body in last month	0.3	0.4	0.6	-0.8	0.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.1	0.9
Illnesses of siblings	0.3	0.4	0.7	0.3	-0.8
Worrier / anxious feelings	0.3	0.5	0.6	-0.8	-0.7
Pulse rate	0.3	0.4	0.6	-0.5	-0.8
Noisy workplace	0.3	0.4	0.4	-0.6	-0.7
Prospective memory result	0.3	0.4	0.8	0.9	-0.2
Length of working week for main job	0.3	0.4	0.6	0.8	0.3
Pulse wave reflection index	0.3	0.4	0.5	-0.4	-0.7
Medication: Omeprazole	0.3	0.4	0.5	-0.5	0.7
Eye problems/disorders: Cataract	0.3	0.3	0.4	0.6	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.6	-0.8	-0.2
Ever smoked	0.3	0.5	0.5	-0.7	-0.7
Average weekly beer plus cider intake	0.3	0.5	0.6	-0.6	0.8
Irritability	0.3	0.5	1.0	-1.0	-0.2
Diastolic blood pressure, automated reading	0.3	1.0	1.1	1.1	0.9
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.6	0.2	0.8
Alcohol drinker status: Previous	0.3	0.3	0.7	0.8	0.1
Pack years of smoking	0.3	0.4	0.7	-0.3	-0.8
Schizophrenia (2018)	0.2	0.3	0.7	0.2	0.8
Worry (Nagel 2018)	0.2	0.4	0.4	-0.6	0.6
Reaction Time	0.2	0.3	0.5	0.3	-0.7
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	-0.6	0.2
Primary Biliary Cirrhosis	0.2	0.3	0.5	-0.3	0.7
Triglycerides	0.2	0.4	0.5	0.5	0.7
Cardiovascular Disease	0.2	0.8	1.0	0.7	1.0
Respiratory disease	0.2	0.3	0.7	-0.8	-0.2
Average weekly spirits intake	0.2	0.3	0.4	-0.3	0.7
Supplements: Zinc	0.2	0.2	0.3	-0.6	0.3
Stomach or abdominal pain in last month	0.2	0.3	0.5	-0.7	0.3
Number of incorrect matches in round	0.2	0.4	0.7	0.9	0.0
Nervous feelings	0.2	0.3	0.5	0.7	0.2
Qualifications: None of the above	0.2	0.3	0.6	-0.3	-0.8
Alcohol intake versus 10 years previously	0.2	0.2	0.5	0.1	-0.7
Number of live births	0.2	0.3	0.5	-0.7	0.2
Medication: Lansoprazole	0.2	0.3	0.5	0.7	0.2
Illnesses of mother	0.2	0.3	0.4	0.6	-0.5
Whole body fat mass	0.2	0.9	1.5	0.5	1.2
Alcohol intake frequency.	0.2	0.4	0.7	-0.8	-0.2
Age at last live birth	0.2	0.3	0.6	-0.8	0.2
Qualifications: nursing, teaching	0.2	0.3	0.5	0.7	0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.4	-0.7	-0.3
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.4	-0.6	-0.4
Medication: Lisinopril	0.2	0.3	0.5	0.7	0.3
Supplements: Calcium	0.2	0.2	0.2	-0.4	0.5
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	-0.3	-0.5
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.4	0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	-0.1	0.7
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.5	0.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.1	-0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.5	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	-0.5	-0.2
Crohns Disease (2017)	0.1	0.3	0.5	-0.2	0.7
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	-0.1	0.7
Blood Platelet Count	0.1	0.9	1.3	0.6	-1.2
Systolic Blood Pressure	0.1	0.7	1.0	0.6	-1.0
Hair Pigment	0.1	2.6	3.7	-1.2	-1.9
Number of treatments/medications taken	0.1	0.1	0.1	-0.3	0.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.5	-0.1
Trunk fat percentage	0.1	0.5	1.0	-0.2	-1.0
Current tobacco smoking	0.1	0.2	0.3	-0.6	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.3	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	-0.7	-0.2
Medication: Simvastatin	0.1	0.1	0.2	0.1	-0.4
Father’s age at death	0.1	0.2	0.3	-0.2	0.5
Falls in the last year	0.1	0.1	0.2	-0.1	0.4
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.4	0.0
Breastfed as a baby	0.1	0.1	0.2	0.5	-0.1
Birth weight of first child	0.1	0.3	0.5	0.1	0.7
Loud music exposure frequency	0.1	0.2	0.2	-0.5	-0.3
Gout (self-reported)	0.1	0.1	0.2	0.4	-0.1
High blood pressure (siblings)	0.1	0.1	0.2	-0.5	0.0
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.1	0.4
Health satisfaction	0.1	0.1	0.1	-0.3	0.3
Shortness of breath walking on level ground	0.1	0.2	0.2	-0.4	0.4
Medication: Allopurinol	0.1	0.1	0.2	0.5	-0.1
Heart disease (mother)	0.1	0.2	0.3	-0.2	-0.6
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.4	-0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.4	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.2	-0.5	-0.3
Ever had bowel cancer screening	0.1	0.2	0.3	-0.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.4	0.1
Commuting to job workplace: Walk	0.1	0.2	0.2	0.4	-0.3
Alcohol drinker status: Never	0.1	0.1	0.3	0.5	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.5	-0.7	-0.2
Cholesterol lowering medication	0.1	0.1	0.2	-0.4	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.0	0.0	-0.1	0.2
Tanning	0.0	0.2	0.3	0.1	-0.5
Angina	0.0	0.1	0.1	-0.0	-0.3
Medication for hormone replacement therapy	0.0	0.0	0.0	-0.1	-0.1
Waist circumference	0.0	0.2	0.3	-0.6	0.0
Hearing difficulty/problems with background noise	0.0	0.1	0.1	-0.0	0.4
Heart attack	0.0	0.0	0.0	0.0	-0.2
Arm fat mass (right)	0.0	0.1	0.3	-0.5	0.1
Tense / ‘highly strung’	0.0	0.0	0.0	-0.1	0.0
Headache pain in last month	0.0	0.0	0.0	-0.1	0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.0	0.0	0.1
Age at first live birth	0.0	0.0	0.0	-0.2	-0.0
Pulse wave peak to peak time	0.0	0.1	0.1	-0.3	0.2
Neck or shoulder pain in last month	0.0	0.0	0.1	0.2	0.1
Angina (self-reported)	0.0	0.0	0.0	0.2	0.1
Leg fat mass (right)	0.0	0.1	0.2	-0.3	0.4
Average weekly red wine intake	0.0	0.0	0.0	0.1	-0.2
Long-standing illness, disability or infirmity	0.0	0.0	0.0	-0.1	-0.0
Back pain experienced in last month	0.0	0.1	0.1	-0.3	0.1
Smoking status: Current	0.0	0.0	0.1	-0.1	0.2
Arm fat mass (left)	0.0	0.2	0.2	-0.3	0.5
Wears glasses or contact lenses	0.0	0.0	0.0	-0.2	0.1
Medication: Atorvastatin	0.0	0.0	0.1	-0.3	0.0
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.1	-0.2
Leg fat mass (left)	0.0	0.1	0.1	-0.4	0.3

Hub : Genes

SOCS2

Models

Trait associations