Best TWAS P=3.63e-10 · Best GWAS P=5.57e-08 conditioned to 0.827
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | DCAF4 | 0.23 | 0.07 | enet | 30 | 0.13 | 4.3e-07 | 4.6 | 5.8 | 6.3e-09 | 0.77 | 0.01 | 0.98 | FALSE |
| 2 | GTEx | Colon Sigmoid | DCAF4 | 0.30 | 0.10 | lasso | 9 | 0.11 | 1.3e-04 | 5.4 | 6.1 | 9.4e-10 | 0.89 | 0.01 | 0.95 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | DCAF4 | 0.18 | 0.01 | enet | 10 | 0.06 | 3.0e-03 | 5.4 | 6.3 | 3.6e-10 | 0.85 | 0.01 | 0.89 | TRUE |
| 4 | GTEx | Esophagus Mucosa | ZFYVE1 | 0.10 | 0.00 | lasso | 7 | 0.00 | 2.0e-01 | 5.4 | 5.9 | 3.3e-09 | 0.80 | 0.03 | 0.89 | FALSE |
| 5 | GTEx | Pancreas | DCAF4 | 0.20 | 0.15 | lasso | 4 | 0.14 | 2.4e-06 | 5.4 | 5.3 | 1.1e-07 | 0.98 | 0.00 | 0.99 | FALSE |
| 6 | GTEx | Spleen | DCAF4 | 0.47 | 0.12 | enet | 10 | 0.19 | 1.5e-05 | 4.5 | 5.7 | 1.2e-08 | 0.75 | 0.04 | 0.93 | FALSE |
| 7 | NTR | Blood | DCAF4 | 0.04 | 0.03 | lasso | 6 | 0.03 | 6.5e-09 | 5.4 | 5.6 | 2.3e-08 | 0.96 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | DPF3 | 0.10 | 0.02 | blup | 210 | 0.07 | 1.9e-07 | -2.6 | -5.3 | 8.6e-08 | -0.56 | 0.49 | 0.44 | FALSE |