Hub : Genes

DPF3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.3910	0.0540	1.6e-15	0.398	NA	0.388	NA	0.388	1.1e-31	NA	1.1e-30	NA	9.6e-31
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.1781	0.0372	0.0e+00	0.184	0.166	0.216	NA	0.221	3.1e-20	2.9e-18	7.3e-24	NA	1.6e-24
3	TCGA	Brain Lower Grade Glioma	0.0451	0.0192	8.7e-04	0.044	0.022	0.024	NA	0.030	9.0e-06	1.3e-03	8.5e-04	NA	2.1e-04
4	TCGA	Thyroid Carcinoma	0.1000	0.0310	3.2e-07	0.023	0.071	0.065	NA	0.055	2.3e-03	1.9e-07	6.5e-07	NA	4.8e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.0	1.6	6.1	2.5	0.2	0.5	0.5
Bipolar Disorder or Schizophrenia	0.7	1.7	6.1	2.5	-0.3	0.3	-0.7
Depressed Affect (Nagel 2018)	1.5	3.2	7.4	0.1	1.0	2.1	-2.7
Depression (Nagel 2018)	2.6	3.9	5.3	1.8	1.4	2.2	-2.3
Intelligence (Savage-Jansen 2018)	2.9	8.8	18.2	-0.4	-3.1	-2.7	4.3
Neuroticism (Nagel 2018)	1.0	2.4	4.4	0.8	1.3	2.1	-1.8
Schizophrenia (2018)	0.4	0.8	1.5	1.2	-0.6	-0.0	-1.2
Schizophrenia vs Biploar Disorder	2.0	2.6	4.7	0.7	1.7	1.5	-2.2
Worry (Nagel 2018)	2.3	4.9	7.5	2.4	2.1	2.7	-1.4
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	-1.1	-0.6	-0.1	1.1
Alzheimer’s Disease (in father)	0.7	0.7	1.8	-0.2	1.3	1.0	-0.1
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	-0.2	0.3	0.3	-0.0
Crohns Disease (2017)	0.1	0.3	1.0	-0.0	0.4	0.2	1.0
Irritable Bowel Disease (IBD)	0.2	0.5	1.1	0.5	0.5	0.8	1.1
Ulcerative Colitis (UC)	0.3	0.6	1.1	0.9	0.4	1.1	0.5
Major Depression (MDD)	1.2	1.4	3.8	1.9	0.3	1.0	-0.9
Reaction Time	0.4	0.8	1.3	-0.9	0.6	0.8	1.1
Verbal and Numeric Reasoning (VNR)	1.9	4.5	10.0	-1.4	-2.1	-1.4	3.2
Breast Cancer	0.5	1.2	2.1	0.7	-1.4	-1.4	-0.5
Ovarian Cancer	0.2	0.3	0.5	-0.7	0.3	0.7	0.1
Prostate Cancer	1.3	1.8	4.8	-2.2	0.7	0.8	1.1
Age at First Birth	1.4	2.1	2.9	-0.4	-1.7	-1.6	1.6
Bipolar Disorder (2011)	1.4	1.3	5.0	2.2	-0.0	0.1	0.6
Body Mass Index (BMI) (2010)	3.3	4.5	9.4	2.4	1.3	1.3	-3.1
Coronary Artery Disease (CAD)	0.6	0.8	1.9	-0.0	-1.0	-0.4	1.4
Crohns Disease (2012)	0.8	1.4	2.4	-1.0	1.5	1.1	0.9
Mean Putamen Volume	0.9	1.0	1.9	1.4	0.8	0.9	-0.9
Fasting Glucose	0.4	0.5	0.8	-0.6	0.7	0.9	0.6
HbA1C	1.5	1.6	2.3	1.5	1.5	1.0	-0.9
HDL Cholesterol	0.2	0.3	0.5	0.7	0.1	0.4	-0.6
LDL Cholesterol	1.3	2.0	2.6	-1.3	-1.6	-1.2	1.5
Lupus	0.3	0.5	1.3	0.1	1.1	0.8	0.5
Neuroticism (2016)	1.7	2.4	5.4	0.7	1.2	1.5	-2.3
Primary Biliary Cirrhosis	0.9	1.2	1.9	1.3	1.4	0.7	-0.9
Rheumatoid Arthritis	0.2	0.3	0.9	-0.3	0.2	0.3	1.0
Schizophrenia (2014)	1.0	2.2	5.5	2.3	0.6	1.2	-1.3
Triglycerides	0.7	1.2	1.8	-1.4	1.3	1.1	0.3
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.0	-1.0	1.3	1.4	-0.3
Ulcerative Colitis	0.4	0.5	1.1	0.6	0.7	1.0	0.4
Blood Eosinophil Count	0.9	6.8	8.1	-2.6	2.8	2.9	-2.1
Blood Platelet Count	0.5	5.4	14.4	3.8	-1.0	-0.8	-2.3
Blood Red Count	2.8	27.3	58.5	2.5	5.0	4.4	-7.6
Blood White Count	0.2	1.7	5.9	0.8	0.4	0.2	-2.4
Heel T-Score	0.1	0.8	2.7	-1.6	0.6	-0.2	0.3
BMI	4.1	23.5	50.6	5.4	3.2	2.0	-7.1
Height	0.1	1.5	2.5	0.2	1.6	1.2	1.4
Waist Hip Ratio (WHR)	0.3	1.5	3.8	-1.9	0.8	0.3	1.3
Systolic Blood Pressure	1.5	7.5	14.9	3.9	1.8	1.4	-3.1
Smoking Status	1.1	2.6	4.6	-0.3	2.2	2.1	-1.2
Allergy or Eczema	0.1	0.3	0.6	-0.8	0.2	0.1	-0.8
Cardiovascular Disease	3.3	10.8	23.4	2.2	-3.8	-4.8	0.7
Hypothyroidism (self reported)	1.1	2.4	3.9	0.0	-1.6	-1.8	2.0
Respiratory disease	1.5	3.3	4.1	-2.0	1.8	1.5	-1.9
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.2	-0.0	1.1	0.4	-0.9
Lung FEV1/FVC ratio	0.1	0.6	0.9	0.9	-0.8	0.1	1.0
Lung FVC	0.4	2.2	3.5	-1.2	1.8	1.9	-1.0
Neuroticism	3.2	7.7	12.5	1.5	3.0	3.5	-2.6
Chronotype (morning person)	1.0	2.2	7.2	-2.7	-0.1	0.6	1.1
Hair Pigment	0.1	2.9	4.2	1.1	2.1	1.9	-1.5
Tanning	0.1	1.5	5.4	-0.6	-0.3	0.1	2.3
Hand grip strength (left)	1.4	3.6	7.0	1.4	2.7	2.0	-1.1
Number of treatments/medications taken	0.5	0.9	2.1	1.2	0.0	0.3	-1.5
Average weekly spirits intake	2.7	3.4	5.0	1.8	2.2	1.9	-1.2
Sensitivity / hurt feelings	0.1	0.1	0.4	0.0	-0.1	0.5	0.6
Frequency of depressed mood in last 2 weeks	1.0	1.4	4.7	2.2	-0.2	0.1	-1.0
Hearing difficulty/problems: Yes	1.0	1.6	4.3	-0.8	-0.6	-1.0	2.1
Relative age of first facial hair	1.1	2.2	4.3	-0.5	-1.6	-1.4	2.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	-0.5	0.2	-0.1	-0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.4	-0.2	0.2	-0.1
Ever had hysterectomy (womb removed)	0.6	0.6	1.9	-1.4	0.0	0.6	0.5
Systolic blood pressure, automated reading	5.0	14.7	21.2	2.8	4.1	3.6	-4.6
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	3.6	-1.9	1.6	1.3	-0.9
Angina	0.0	0.0	0.1	-0.0	-0.3	-0.3	0.2
Medication for hormone replacement therapy	0.4	0.4	0.8	-0.8	-0.3	-0.4	0.9
Vitamin and mineral supplements	0.1	0.1	0.2	0.4	0.4	-0.1	-0.4
Supplements: Zinc	0.3	0.3	0.4	0.6	0.6	0.6	-0.1
Medication: Co-codamol	0.4	0.4	1.2	-0.1	0.7	-0.3	-1.1
Medication: Metformin	2.0	2.9	4.3	-0.0	2.1	1.9	-1.9
Diabetes (father)	0.5	0.7	1.9	-1.4	0.3	0.4	-0.8
Diabetes (mother)	1.5	1.9	3.0	-1.4	-0.7	-1.4	1.7
Severe depression (siblings)	1.1	1.2	2.4	0.2	-1.3	-0.9	1.5
Pack years adult smoking proportion	0.8	1.3	2.0	-0.2	1.4	1.1	-1.3
Impedance of leg (right)	5.1	24.8	46.3	-5.1	-4.2	-3.0	6.8
Leg fat-free mass (left)	2.9	15.3	24.7	3.9	3.9	2.5	-5.0
Trunk fat percentage	0.3	1.2	3.2	0.9	0.8	0.3	-1.8
Hand grip strength (right)	1.1	3.0	5.3	2.0	2.3	1.6	-0.5
Townsend deprivation index at recruitment	1.7	2.5	6.4	0.0	1.6	0.8	-2.5
Current tobacco smoking	0.6	1.0	2.4	-1.6	1.0	0.7	-0.5
Average weekly fortified wine intake	0.9	1.1	1.4	0.9	-1.1	-0.9	-1.2
Maternal smoking around birth	0.6	0.9	1.7	1.3	1.2	0.6	0.1
Fed-up feelings	1.6	2.8	10.4	0.4	0.6	0.6	-3.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.9	0.9	0.4	1.4	-1.2
Relative age voice broke	1.4	2.2	3.8	-0.0	-1.9	-1.6	1.6
Taking other prescription medications	0.4	0.6	1.9	-0.7	0.1	0.3	-1.4
Age when periods started (menarche)	5.0	12.1	25.3	-3.4	-2.2	-2.5	5.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.8	0.4	0.9	0.7	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.2	-0.8	1.0	1.0	1.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.3	0.8	0.2	0.7	-1.1
Qualifications: CSEs or equivalent	0.3	0.4	1.0	1.0	0.1	0.0	-0.9
Serious illness, injury or assault to yourself	0.8	0.9	1.7	-1.3	-1.2	-0.8	-0.4
High blood pressure	1.4	3.8	5.8	2.4	-1.7	-2.3	-1.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.1	-0.5	-0.7	0.3
Multivitamins +/- minerals	0.0	0.1	0.2	-0.1	-0.4	-0.1	-0.1
Stomach or abdominal pain in last month	0.3	0.3	1.0	0.2	-0.5	-0.3	1.0
Supplements: Glucosamine	1.9	2.5	3.7	-0.5	1.8	1.9	-1.6
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	1.7	-1.3	-0.3	-1.2	1.2
Medication: Atenolol	0.2	0.2	0.4	0.7	0.3	0.3	0.5
Medication: Levothyroxine sodium	0.7	1.2	1.7	1.1	-1.3	-1.2	0.7
Sitting height	0.1	0.5	1.3	1.1	0.3	-0.6	-0.4
Chronic bronchitis/emphysema (father)	1.0	1.2	1.8	-1.1	0.8	1.1	1.3
High blood pressure (mother)	0.4	0.6	1.1	0.0	-1.0	-1.1	0.4
Body mass index (BMI)	3.8	16.3	30.3	3.9	3.5	2.8	-5.5
Impedance of leg (left)	4.9	23.9	44.9	-5.3	-3.9	-2.8	6.7
Leg predicted mass (left)	2.9	15.3	24.7	4.0	3.9	2.4	-5.0
Trunk fat mass	1.1	4.8	9.5	2.0	2.1	1.2	-3.1
Waist circumference	2.0	7.3	13.2	2.1	2.8	2.0	-3.6
Number of incorrect matches in round	0.6	1.0	2.1	-0.5	0.6	1.5	-1.2
Past tobacco smoking	1.7	3.1	5.9	0.4	-2.2	-2.4	1.2
Alcohol usually taken with meals	0.2	0.3	0.7	-0.5	-0.8	-0.5	0.3
Nervous feelings	1.9	3.5	9.8	3.1	1.0	1.5	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.0	1.0	0.5	0.7	-0.6
Hearing difficulty/problems with background noise	0.3	0.5	0.6	0.4	-0.8	-0.8	0.7
Hair/balding pattern: Pattern 2	0.3	0.3	0.6	0.2	-0.5	-0.6	-0.7
Had menopause	0.1	0.1	0.4	0.0	-0.3	-0.0	-0.6
Had other major operations	0.6	0.7	2.2	0.6	0.0	-0.3	-1.5
Forced vital capacity (FVC)	0.3	1.0	1.7	-1.3	1.0	0.9	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.0	-1.4	1.0	1.0	0.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.7	0.9	-1.2	-1.3	0.5
Qualifications: None of the above	2.4	5.1	8.3	1.2	2.1	2.5	-2.9
Financial difficulties in last 2 years	0.5	0.7	1.2	1.1	-0.3	-0.6	-1.0
Mouth/teeth dental problems	0.6	0.9	1.7	0.9	-1.3	-0.9	0.4
Heart attack	1.5	2.0	4.3	-0.9	1.5	2.1	0.6
Allergy	0.2	0.5	1.0	1.0	-0.3	0.1	0.9
Pain all over the body in last month	0.7	0.8	1.8	0.8	0.6	0.4	-1.3
Diabetes (self-reported)	1.9	2.9	5.3	0.0	2.3	1.5	-2.0
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	-0.3	-0.1	0.3	-0.1
Medication: Ramipril	0.1	0.1	0.3	-0.5	0.4	-0.3	0.1
Medication: Simvastatin	1.1	1.7	2.9	0.8	-1.7	-1.6	0.9
Fluid intelligence score	2.7	5.5	8.4	-1.1	-2.7	-2.3	2.9
Illnesses of siblings	0.8	1.2	3.2	-0.5	1.0	1.8	-0.4
Neuroticism score	1.3	2.7	3.7	1.6	1.5	1.9	-1.4
Weight	2.8	13.5	22.8	3.3	3.7	2.6	-4.8
Impedance of arm (right)	8.3	38.5	48.6	-4.9	-6.9	-5.8	7.0
Arm fat percentage (right)	0.9	3.7	9.6	2.0	0.9	0.3	-3.1
Trunk fat-free mass	3.5	20.3	25.6	4.4	4.9	3.5	-5.1
Hip circumference	1.6	6.8	13.9	2.6	2.2	1.3	-3.7
Time employed in main current job	0.3	0.3	1.1	-0.3	1.0	0.1	-0.3
Alcohol intake versus 10 years previously	2.3	3.4	6.2	0.7	2.1	1.5	-2.5
Father’s age at death	1.6	2.2	3.6	-1.0	-1.7	-1.1	1.9
Worrier / anxious feelings	0.1	0.2	0.5	0.2	-0.3	0.5	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.5	0.2	1.2	0.7	-1.2
Falls in the last year	1.2	1.6	3.4	0.6	-1.6	-1.8	-0.4
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	-0.4	0.4	0.6	0.7
Number of live births	0.7	0.9	1.1	1.0	-1.1	-1.0	-0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.4	-0.5	0.2	0.3	0.6
Pulse rate	0.4	0.6	1.8	0.8	0.4	-0.0	-1.3
Happiness	0.2	0.3	0.6	-0.6	-0.1	-0.4	0.8
Noisy workplace	1.2	1.4	3.3	-0.7	1.3	0.6	-1.8
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.8	-1.0	-0.9	-0.6	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.1	-0.4	-0.5	0.7
Mouth/teeth dental problems: Dentures	1.1	1.8	2.8	-1.7	1.5	1.3	-0.7
Asthma	1.3	2.6	4.8	-2.2	1.5	1.6	-1.0
Medication: Ibuprofen (e.g. Nurofen)	2.3	3.0	7.8	2.8	-1.1	-1.3	-1.1
Medication: Cholesterol lowering	0.0	0.0	0.1	-0.3	0.2	0.1	0.1
Depression (self-reported)	1.4	1.7	6.0	2.5	-0.7	-0.1	-0.6
Medication: Lansoprazole	0.9	1.0	1.7	-0.5	1.0	1.3	-1.1
Prospective memory result	1.7	2.1	5.3	1.5	-0.1	-0.9	-2.3
Lung cancer (father)	1.3	1.6	4.1	2.0	-0.1	-0.3	-1.4
Illnesses of mother	0.6	0.7	1.1	-0.6	1.0	1.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.3	-0.9	-0.0	0.1	1.1
Pulse wave Arterial Stiffness index	0.7	0.9	1.8	-0.4	1.0	0.8	-1.3
Impedance of arm (left)	7.7	35.5	46.9	-5.1	-6.5	-5.2	6.8
Arm fat mass (right)	2.5	10.4	21.2	3.2	2.8	1.6	-4.6
Trunk predicted mass	3.6	20.3	25.6	4.3	5.0	3.6	-5.1
Standing height	0.0	0.4	1.2	-0.5	1.1	0.1	0.6
Length of working week for main job	1.3	1.4	5.4	-2.3	0.4	0.1	0.4
Exposure to tobacco smoke at home	0.0	0.1	0.1	-0.2	0.3	-0.3	0.2
Breastfed as a baby	1.8	2.2	3.3	-1.8	-1.3	-1.0	1.7
Tense / ‘highly strung’	1.3	2.2	7.6	2.8	0.2	0.9	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.8	1.3	-1.1	-0.6	0.7
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.0	0.4	0.3	0.5
Birth weight of first child	0.5	0.8	1.3	0.9	0.9	0.7	-1.1
Peak expiratory flow (PEF)	0.5	1.1	2.1	-0.4	1.4	1.4	-0.5
Pulse wave reflection index	0.6	0.7	1.0	-1.0	-0.8	-0.9	0.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	4.3	2.1	0.0	-0.3	-0.5
Loud music exposure frequency	1.9	2.1	4.5	-0.9	-2.1	-1.3	1.2
Qualifications: O levels/GCSEs or equivalent	2.7	4.3	7.2	-1.6	-2.0	-1.8	2.7
Mouth/teeth dental problems: Bleeding gums	1.7	2.3	6.4	2.5	-0.2	-0.3	-1.6
Blood clot in the leg (DVT)	3.0	3.9	8.1	-2.8	-1.7	-1.8	1.3
Medication: Paracetamol	1.8	3.0	8.7	2.9	1.2	-0.2	-1.3
Headache pain in last month	2.0	3.5	5.3	2.3	2.0	1.5	-1.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	-0.2	0.4	1.0	0.4
Glaucoma (self-reported)	0.5	0.5	1.1	1.1	0.4	0.9	0.3
Gout (self-reported)	3.4	4.7	9.2	-0.4	-2.8	-3.0	1.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	1.8	0.9	-1.3	-0.9	1.0
Medication: Amlodipine	2.0	2.8	7.1	1.8	0.8	0.0	-2.7
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.5	-1.2	1.5	1.9	-0.4
Birth weight	1.6	3.4	5.2	-1.8	2.2	2.3	-0.7
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.5	-0.7	0.2	0.1	-0.2
High blood pressure (siblings)	1.2	1.8	3.7	0.2	-0.9	-1.9	1.6
Forced vital capacity (FVC), Best measure	0.3	1.1	2.5	-1.6	0.6	0.4	1.1
Body fat percentage	0.5	1.9	5.0	1.0	1.1	0.7	-2.2
Leg fat percentage (right)	1.0	3.6	6.7	1.1	2.0	1.7	-2.6
Arm fat-free mass (right)	4.3	22.2	28.8	4.1	5.4	4.0	-5.2
Exposure to tobacco smoke outside home	0.3	0.3	1.0	1.0	0.5	-0.1	-0.1
Comparative body size at age 10	3.4	9.3	13.5	3.3	2.7	2.3	-3.7
Number of full brothers	0.3	0.4	0.9	-1.0	0.6	0.5	0.2
Worry too long after embarrassment	0.2	0.4	0.6	0.8	0.5	0.4	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.5	1.6	0.3	1.1	-1.3
Wheeze or whistling in the chest in last year	0.7	1.2	3.9	-2.0	0.8	0.6	-0.2
Number of children fathered	1.5	1.7	3.9	2.0	1.0	0.3	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	2.8	3.3	4.5	-0.7	-2.0	-2.0	2.1
Age at first live birth	1.1	1.9	2.4	-1.5	-1.3	-1.2	1.5
Pulse wave peak to peak time	0.6	0.7	1.6	0.4	-0.7	-0.6	1.3
Health satisfaction	0.2	0.3	0.5	0.7	-0.4	-0.7	-0.4
Shortness of breath walking on level ground	0.9	1.1	3.3	-1.8	-0.6	-0.8	0.2
Qualifications: College or University degree	0.5	1.6	3.9	-1.2	-0.7	-0.7	2.0
Eye problems/disorders: None of the above	1.5	1.7	4.5	-0.5	-1.4	-0.4	2.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.9	-0.5	1.4	1.2	0.4
Emphysema/chronic bronchitis	0.6	0.7	1.5	-0.8	0.8	-0.3	-1.2
Medication for pain relief, constipation, heartburn	0.6	1.1	3.0	-1.7	-0.7	-0.3	0.9
Neck or shoulder pain in last month	0.7	1.1	2.6	-1.6	0.7	0.4	1.0
Medication: Blood pressure	0.5	0.9	3.0	0.6	0.6	-0.2	-1.7
Angina (self-reported)	0.1	0.1	0.2	0.5	-0.2	-0.1	0.2
Migraine (self-reported)	1.5	1.8	2.2	1.0	-1.4	-1.4	1.5
Medication: Ibuprofen	2.8	3.4	8.2	2.9	-1.4	-1.1	-1.5
Medication: Allopurinol	0.4	0.6	1.1	-0.8	-0.6	-1.1	-0.4
Medication: Omeprazole	1.9	2.2	3.4	-1.8	1.5	1.9	-0.1
Medication: Seretide 50 evohaler	1.4	1.6	3.5	-0.7	-1.5	-1.9	0.5
Mean time to correctly identify matches	0.5	0.9	1.4	-1.2	0.3	0.8	1.2
Heart disease (mother)	0.6	0.7	1.4	0.8	-0.4	-1.2	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	0.5	0.8	0.2	0.1
Whole body fat mass	1.9	8.0	15.6	2.4	2.7	1.8	-3.9
Leg fat mass (right)	2.2	8.4	14.0	2.5	2.9	2.2	-3.7
Arm predicted mass (right)	4.5	23.3	32.7	3.9	5.7	4.2	-5.3
Pulse rate, automated reading	0.1	0.5	1.5	-0.3	-0.3	-0.4	-1.2
Alcohol intake frequency.	0.7	1.5	4.2	0.9	0.4	1.0	-2.0
Comparative height size at age 10	0.3	1.7	2.4	-1.3	1.5	1.1	-1.2
Number of full sisters	3.8	4.6	11.9	-1.4	-1.5	-1.5	3.5
Suffer from ‘nerves’	1.2	1.9	6.6	2.6	0.1	0.1	-0.9
Overall health rating	1.0	2.2	5.2	1.9	0.3	-0.1	-2.3
Chest pain or discomfort	0.5	0.7	1.7	1.3	0.5	0.2	-1.0
Had major operations	0.4	0.5	1.9	-1.4	-0.0	-0.3	-0.2
Age at last live birth	0.9	1.3	2.0	-0.6	-1.4	-1.4	1.1
Family relationship satisfaction	3.0	3.7	5.5	-2.0	-1.7	-1.5	2.3
Leg pain on walking	0.1	0.1	0.3	-0.6	-0.1	-0.0	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	-0.3	0.1	0.5	-0.7
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.8	1.7	-0.9	-0.5	-0.9
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	5.2	-0.0	2.3	2.2	-1.0
Medication: Aspirin	0.3	0.3	0.9	-0.4	-0.4	-0.3	0.9
Supplements: Vitamin C	0.2	0.2	0.6	-0.4	0.5	0.8	0.1
Knee pain experienced in last month	1.3	1.9	6.4	0.6	0.0	-1.0	-2.5
Hypertension (Self-reported)	1.4	4.0	6.4	2.5	-1.9	-2.3	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.3	8.0	-0.2	2.2	2.8	-0.5
Illnesses of father: Heart disease	1.1	1.6	4.0	-1.2	-0.6	-0.7	2.0
Illnesses of siblings: Diabetes	0.6	0.7	1.8	-1.1	0.0	-0.1	-1.3
Smoking status: Previous	2.4	3.5	4.9	1.2	2.0	2.2	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.9	-0.5	1.0	0.4	0.1
Whole body fat-free mass	3.6	20.6	28.6	4.3	4.9	3.3	-5.3
Leg fat-free mass (right)	3.1	16.6	26.9	4.0	4.1	2.6	-5.2
Arm fat percentage (left)	0.9	3.5	9.0	1.9	1.0	0.5	-3.0
Average weekly red wine intake	1.6	2.3	5.0	-1.4	-0.8	-1.3	2.2
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.6	-0.0	-1.3	-1.2	0.9
Mood swings	0.1	0.2	0.4	0.4	-0.6	-0.1	-0.6
Loneliness, isolation	0.1	0.2	0.3	-0.5	-0.4	0.3	-0.6
Long-standing illness, disability or infirmity	0.6	0.9	2.5	0.7	0.7	0.4	-1.6
Ever had bowel cancer screening	0.4	0.5	0.7	0.8	0.5	0.6	-0.8
Diabetes diagnosed by doctor	1.2	1.9	3.5	-0.0	1.9	1.2	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.4	-0.0	-1.2	-1.1	0.4
Friendships satisfaction	2.7	3.4	8.8	-1.1	-1.4	-1.3	3.0
Qualifications: nursing, teaching	0.8	1.3	2.8	-0.5	-1.0	-1.1	1.7
Commuting to job workplace: Walk	0.4	0.4	1.1	-0.7	0.1	-0.3	1.0
Eye problems/disorders: Cataract	0.6	0.7	1.8	-0.8	0.1	-0.6	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.6	-0.6	-0.3	-0.6	0.8
Medication for cholesterol	0.9	1.4	2.1	-1.0	1.4	1.2	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.5	-0.2	0.2	-0.4
Back pain experienced in last month	1.6	2.3	3.7	1.8	1.2	0.8	-1.9
Mineral and other dietary supplements	3.0	4.0	7.7	1.3	-2.5	-2.8	0.8
Breast cancer (self-reported)	2.6	3.0	7.2	2.2	-0.4	-0.4	-2.7
Asthma (self-reported)	1.2	2.4	4.5	-2.1	1.4	1.4	-1.0
Osteoporosis (self-reported)	1.3	1.6	2.9	-1.7	0.6	1.1	1.4
Osteoarthritis (self-reported)	0.7	1.0	2.0	-1.0	0.7	0.7	-1.4
Medication: Aspirin	0.7	0.9	1.8	-0.8	-0.9	-0.7	1.3
Medication: Gliclazide	0.6	0.6	1.7	-1.3	-0.6	-0.4	0.6
Illnesses of father: None of the above (group 1)	1.2	1.5	3.1	0.8	1.1	1.0	-1.8
Smoking status: Current	0.8	1.3	3.7	-1.9	0.9	0.7	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.5	0.9	0.7	1.2	0.5
Whole body water mass	3.6	20.8	29.3	4.3	4.9	3.4	-5.4
Leg predicted mass (right)	3.1	16.8	27.6	4.0	4.1	2.6	-5.2
Arm fat mass (left)	2.5	10.1	18.4	3.0	3.0	2.0	-4.3
Number of self-reported non-cancer illnesses	0.9	1.6	3.4	0.2	-1.7	-1.9	-0.0
Average weekly champagne plus white wine intake	1.1	1.5	3.7	1.9	0.7	1.1	-0.7
Miserableness	0.4	0.8	1.9	0.1	0.5	1.0	-1.4
Guilty feelings	1.6	2.5	3.5	0.6	1.8	1.9	-1.7
Wears glasses or contact lenses	4.4	5.1	8.1	-0.4	2.8	2.9	-2.0
Ever taken oral contraceptive pill	0.3	0.3	0.8	-0.7	0.2	0.0	0.9
Hearing aid user	0.2	0.2	0.4	-0.6	0.5	0.4	0.2
Mother’s age at death	0.7	0.9	2.2	0.7	-1.5	-0.8	0.6
Financial situation satisfaction	0.2	0.2	0.5	0.2	0.2	-0.6	-0.7
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.2	-0.8	-0.6	-0.0	1.1
Commuting to job workplace: Public transport	0.8	1.0	2.3	-0.6	1.5	0.6	-0.9
Eye problems/disorders: Glaucoma	1.0	1.2	2.5	1.6	0.8	1.1	-0.6
Medication: Blood pressure	1.9	3.6	5.5	2.2	-2.3	-2.0	-0.1
Pain type(s) experienced in last month: Hip pain	1.3	1.6	3.4	-1.9	1.5	0.3	-0.7
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.3	-0.5	1.6	2.1	-0.9
High cholesterol (Self-reported)	1.2	2.2	4.2	-0.3	-1.5	-2.1	1.4
Medication: Bendroflumethiazide	0.5	0.7	1.4	0.3	-1.2	-1.2	0.2
Medication: Paracetamol	2.3	3.5	11.3	3.4	0.7	-0.1	-1.5
Medication: Lisinopril	0.9	1.1	1.8	0.6	-1.2	-1.4	-1.0
Medication: Atorvastatin	0.2	0.2	0.5	-0.4	0.3	0.1	-0.7
Illnesses of father: High blood pressure	2.7	3.3	6.5	1.2	-2.3	-2.6	0.1
Alcohol drinker status: Never	0.1	0.2	0.3	-0.5	-0.5	-0.3	0.1
Ever smoked	1.3	2.2	4.7	-1.0	1.7	2.2	-0.2
Basal metabolic rate	3.5	19.5	28.3	4.2	4.7	3.2	-5.3
Leg fat percentage (left)	1.2	4.3	7.8	1.0	2.2	1.9	-2.8
Arm fat-free mass (left)	4.8	24.4	32.2	4.2	5.7	4.0	-5.6
Number of operations (self-reported)	0.6	0.9	2.2	-1.1	0.3	-0.4	-1.5
Average weekly beer plus cider intake	0.1	0.1	0.3	0.3	0.2	-0.2	0.6
Irritability	0.6	1.1	2.9	-0.2	1.0	1.7	-0.6
Risk taking	0.8	1.1	2.1	-0.3	-1.4	-0.7	1.4
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.5	-1.6	-0.5	-1.0	1.2
Fractured/broken bones in last 5 years	1.7	2.2	4.3	0.2	-2.1	-2.0	0.3
Age started oral contraceptive pill	0.6	0.7	2.3	-1.5	0.1	0.3	0.7
Diastolic blood pressure, automated reading	1.4	4.4	8.2	1.1	-2.8	-2.9	0.7
Ever depressed for a whole week	3.3	4.1	5.5	1.9	-2.3	-2.3	1.3
Unable to work because of sickness or disability	0.9	1.2	1.8	-1.1	1.3	0.8	-1.0
Commuting to job workplace: Cycle	1.3	1.6	3.7	-1.5	0.3	0.2	1.9
Myopia	0.8	1.1	3.1	-0.9	-0.6	-0.3	1.8
Vascular/heart problems diagnosed by doctor	1.3	3.6	6.6	-2.6	1.4	1.9	1.5
Cholesterol lowering medication	1.5	2.2	4.1	0.5	-2.0	-2.0	0.8
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.0	-1.4	0.9	1.0	0.1
Pain experienced in last month	0.9	1.5	3.4	-0.8	-1.8	-0.8	1.2
Supplements: Calcium	0.4	0.4	1.2	-0.4	0.1	1.1	-0.6
Basal cell carcinoma (self-reported)	1.4	1.7	3.5	0.1	1.9	0.5	-1.8
Heart attack/myocardial infarction (self-reported)	1.9	2.4	5.2	-1.0	1.8	2.3	0.6
Deep venous thrombosis (DVT) (self-reported)	2.6	3.3	7.5	-2.7	-1.5	-1.6	1.0
Heart disease (siblings)	1.8	2.2	5.2	2.3	-1.0	-1.5	0.1
Alcohol drinker status: Previous	2.3	2.6	4.3	0.1	2.1	1.9	-1.6
Pack years of smoking	1.1	1.6	2.4	-0.1	1.6	1.3	-1.5
Impedance of whole body	6.9	35.2	54.0	-5.5	-5.9	-4.7	7.3
Leg fat mass (left)	2.3	9.0	15.0	2.2	3.2	2.4	-3.9
Arm predicted mass (left)	4.8	24.2	32.8	3.9	5.7	4.2	-5.6