Best TWAS P=8.31e-11 · Best GWAS P=1.48e-11 conditioned to 0.0333
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | RP11-529H20.6 | 0.20 | 0.14 | lasso | 4 | 0.18 | 6.4e-10 | -4.6 | -5.2 | 2.5e-07 | 0.05 | 0.09 | 0.88 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | BTBD7 | 0.16 | 0.01 | lasso | 8 | 0.04 | 3.6e-04 | -5.7 | 5.5 | 4.5e-08 | -0.02 | 0.15 | 0.82 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | RPS6KA5 | 0.08 | 0.07 | lasso | 2 | 0.06 | 5.3e-05 | -6.2 | 6.4 | 1.7e-10 | -0.89 | 0.04 | 0.94 | FALSE |
| 4 | GTEx | Colon Sigmoid | RIN3 | 0.24 | 0.17 | lasso | 6 | 0.11 | 9.3e-05 | 6.6 | -6.5 | 8.3e-11 | 0.03 | 0.00 | 0.99 | TRUE |
| 5 | GTEx | Colon Sigmoid | RPS6KA5 | 0.16 | 0.09 | lasso | 5 | 0.08 | 7.1e-04 | -5.1 | -5.1 | 2.7e-07 | 0.81 | 0.04 | 0.89 | FALSE |
| 6 | GTEx | Esophagus Muscularis | RIN3 | 0.17 | 0.05 | lasso | 6 | 0.06 | 1.6e-04 | 5.7 | -6.0 | 2.5e-09 | 0.00 | 0.04 | 0.83 | FALSE |
| 7 | GTEx | Prostate | RP11-529H20.6 | 0.28 | 0.00 | lasso | 5 | 0.05 | 2.5e-02 | -4.6 | -5.2 | 1.5e-07 | 0.07 | 0.06 | 0.49 | TRUE |
| 8 | GTEx | Spleen | C14orf159 | 0.30 | 0.21 | lasso | 5 | 0.21 | 3.6e-06 | -5.5 | 6.4 | 1.4e-10 | -0.81 | 0.07 | 0.44 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | RIN3 | 0.05 | 0.00 | blup | 163 | 0.01 | 6.0e-02 | -3.0 | -5.8 | 4.9e-09 | -0.05 | 0.03 | 0.06 | TRUE |
| 10 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | BTBD7 | 0.11 | 0.03 | blup | 72 | 0.02 | 8.0e-02 | -5.7 | 5.7 | 1.3e-08 | -0.01 | 0.02 | 0.82 | TRUE |