Best TWAS P=1.25e-08 · Best GWAS P=6.59e-08 conditioned to 0.657
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | MLX | 0.03 | 0.03 | enet | 12 | 0.02 | 6.5e-04 | -5.4 | -5.5 | 4.3e-08 | 0.94 | 0.02 | 0.97 | FALSE |
2 | GTEx | Adipose Subcutaneous | HSD17B1P1 | 0.06 | 0.09 | enet | 6 | 0.09 | 4.0e-08 | -5.1 | -5.7 | 1.2e-08 | 0.92 | 0.03 | 0.97 | TRUE |
3 | GTEx | Brain Cerebellum | HSD17B1P1 | 0.17 | 0.16 | lasso | 4 | 0.20 | 1.7e-06 | -5.4 | -5.3 | 1.1e-07 | 0.95 | 0.04 | 0.94 | FALSE |
4 | GTEx | Breast Mammary Tissue | TUBG2 | 0.15 | 0.06 | enet | 18 | 0.08 | 4.5e-05 | -5.1 | -5.3 | 1.4e-07 | 0.94 | 0.02 | 0.98 | FALSE |
5 | GTEx | Breast Mammary Tissue | CNTNAP1 | 0.06 | 0.03 | lasso | 2 | 0.05 | 9.9e-04 | -5.2 | 5.2 | 1.6e-07 | -0.98 | 0.02 | 0.94 | FALSE |
6 | GTEx | Colon Sigmoid | TUBG2 | 0.16 | 0.04 | lasso | 5 | 0.05 | 6.7e-03 | -5.4 | -5.2 | 2.4e-07 | 0.99 | 0.02 | 0.91 | FALSE |
7 | GTEx | Esophagus Muscularis | HSD17B1P1 | 0.08 | 0.03 | lasso | 3 | 0.01 | 6.8e-02 | -5.1 | -5.3 | 1.3e-07 | 0.96 | 0.03 | 0.88 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | NAGLU | 0.08 | 0.06 | enet | 9 | 0.09 | 5.8e-08 | 3.8 | -5.2 | 1.5e-07 | 0.84 | 0.02 | 0.97 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | CNTNAP1 | 0.06 | 0.05 | blup | 27 | 0.03 | 7.3e-03 | -5.3 | 5.5 | 3.5e-08 | -0.95 | 0.01 | 0.95 | FALSE |
10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NAGLU | 0.13 | 0.02 | enet | 8 | 0.04 | 1.6e-05 | 3.8 | -5.5 | 4.1e-08 | 0.78 | 0.01 | 0.87 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | CNTNAP1 | 0.06 | 0.05 | lasso | 1 | 0.04 | 6.8e-06 | -5.2 | 5.2 | 2.4e-07 | -0.97 | 0.00 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CNTNAP1 | 0.06 | 0.04 | blup | 27 | 0.04 | 8.9e-05 | -5.2 | 5.2 | 2.0e-07 | -0.92 | 0.00 | 0.99 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | CNTNAP1 | 0.04 | 0.03 | blup | 27 | 0.05 | 2.7e-05 | -5.1 | 5.2 | 2.5e-07 | -0.89 | 0.01 | 0.97 | FALSE |