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chr17:41,946,180-43,913,030

Best TWAS P=1.48e-18 · Best GWAS P=4e-20 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	DCAKD	0.21	0.09	lasso	6	0.14	6.1e-12	5.8	6.4	1.5e-10	-0.35	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	ACBD4	0.10	0.06	enet	8	0.06	1.8e-05	-7.3	-8.2	1.8e-16	0.52	0.52	0.36	FALSE
3	GTEx	Adrenal Gland	PLEKHM1	0.21	0.00	enet	20	0.08	1.0e-03	4.5	6.1	8.6e-10	-0.13	0.08	0.13	FALSE
4	GTEx	Artery Aorta	NMT1	0.14	0.08	lasso	2	0.12	3.9e-07	-4.8	-5.8	5.9e-09	0.50	0.92	0.04	FALSE
5	GTEx	Artery Aorta	DCAKD	0.22	0.16	enet	26	0.19	1.1e-10	-4.3	7.5	7.7e-14	-0.46	0.92	0.07	FALSE
6	GTEx	Artery Aorta	GJC1	0.24	0.16	lasso	6	0.14	2.2e-08	5.1	5.6	1.9e-08	-0.02	1.00	0.00	TRUE
7	GTEx	Artery Coronary	NMT1	0.13	0.06	enet	7	0.11	1.5e-04	5.8	-7.2	8.7e-13	0.53	0.12	0.25	TRUE
8	GTEx	Artery Tibial	NMT1	0.11	0.09	lasso	5	0.10	6.3e-08	-5.0	-6.2	4.3e-10	0.36	0.98	0.01	FALSE
9	GTEx	Artery Tibial	DCAKD	0.27	0.21	lasso	8	0.20	6.6e-16	-4.3	5.3	1.3e-07	-0.43	1.00	0.00	FALSE
10	GTEx	Artery Tibial	ACBD4	0.10	0.09	lasso	2	0.08	4.8e-07	-7.4	-7.4	1.7e-13	0.58	0.80	0.12	FALSE
11	GTEx	Artery Tibial	HEXIM1	0.13	0.08	lasso	2	0.05	1.8e-04	5.7	5.7	1.4e-08	-0.58	0.80	0.16	FALSE
12	GTEx	Brain Cerebellar Hemisphere	ACBD4	0.43	0.12	lasso	8	0.18	1.7e-05	-6.8	-6.0	1.5e-09	0.37	0.11	0.43	FALSE
13	GTEx	Brain Cerebellar Hemisphere	CTD-2020K17.4	0.23	0.02	enet	20	0.11	1.1e-03	-6.7	-6.3	2.5e-10	0.46	0.03	0.16	FALSE
14	GTEx	Brain Cerebellum	ADAM11	0.17	0.19	enet	8	0.18	4.4e-06	4.2	5.7	1.4e-08	-0.13	0.48	0.03	FALSE
15	GTEx	Brain Cerebellum	DCAKD	0.40	0.06	enet	20	0.24	1.4e-07	-4.3	5.9	4.3e-09	-0.39	0.80	0.06	FALSE
16	GTEx	Brain Cerebellum	ACBD4	0.40	0.06	lasso	8	0.17	1.0e-05	6.3	-6.2	5.7e-10	0.27	0.09	0.14	FALSE
17	GTEx	Brain Hippocampus	CCDC43	0.23	0.09	enet	9	0.16	1.8e-04	-6.8	5.7	1.3e-08	-0.46	0.05	0.29	FALSE
18	GTEx	Breast Mammary Tissue	KANSL1	0.31	0.00	enet	9	0.11	2.6e-06	3.2	-6.0	1.5e-09	0.08	0.00	0.00	TRUE
19	GTEx	Breast Mammary Tissue	DCAKD	0.16	0.13	lasso	7	0.13	2.9e-07	-5.8	5.6	2.5e-08	-0.59	0.92	0.08	FALSE
20	GTEx	Breast Mammary Tissue (Male)	DCAKD	0.36	0.29	lasso	8	0.33	1.4e-08	-4.3	5.9	4.6e-09	-0.58	0.42	0.44	FALSE
21	GTEx	Breast Mammary Tissue (Female)	PLCD3	0.15	0.14	enet	12	0.12	2.1e-04	-6.8	5.2	2.3e-07	-0.32	0.10	0.05	FALSE
22	GTEx	Breast Mammary Tissue (Female)	FZD2	0.10	0.08	lasso	2	0.05	1.1e-02	5.7	5.9	3.4e-09	-0.07	0.04	0.13	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	GJC1	0.34	0.33	lasso	4	0.33	2.3e-11	5.1	5.2	1.7e-07	0.01	1.00	0.00	FALSE
24	GTEx	Cells Transformed fibroblasts	PLCD3	0.23	0.04	lasso	5	0.08	1.3e-06	2.5	6.0	1.5e-09	-0.48	0.95	0.01	FALSE
25	GTEx	Cells Transformed fibroblasts	GJC1	0.41	0.40	enet	32	0.44	8.7e-36	5.0	5.2	1.6e-07	-0.02	1.00	0.00	TRUE
26	GTEx	Cells Transformed fibroblasts	HEXIM1	0.11	0.10	lasso	2	0.08	1.6e-06	5.7	5.7	1.2e-08	-0.58	0.73	0.20	FALSE
27	GTEx	Colon Transverse	DCAKD	0.28	0.18	lasso	8	0.26	1.5e-12	-4.3	5.8	7.3e-09	-0.41	0.99	0.01	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	NMT1	0.24	0.21	lasso	4	0.22	2.8e-08	4.6	-7.1	1.7e-12	0.54	0.52	0.44	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	DCAKD	0.42	0.36	lasso	7	0.37	3.8e-14	-5.8	5.9	3.5e-09	-0.58	0.96	0.04	FALSE
30	GTEx	Esophagus Mucosa	ADAM11	0.19	0.14	lasso	4	0.12	1.2e-08	5.7	5.7	1.2e-08	-0.07	0.99	0.00	FALSE
31	GTEx	Esophagus Mucosa	DCAKD	0.33	0.32	enet	20	0.35	5.6e-24	-4.3	5.6	2.1e-08	-0.51	1.00	0.00	FALSE
32	GTEx	Esophagus Mucosa	ACBD4	0.14	0.10	lasso	4	0.10	4.5e-07	6.2	-6.7	2.7e-11	0.13	0.59	0.08	FALSE
33	GTEx	Esophagus Muscularis	DCAKD	0.27	0.29	lasso	5	0.30	2.1e-18	-4.3	5.1	3.0e-07	-0.47	1.00	0.00	FALSE
34	GTEx	Heart Left Ventricle	DCAKD	0.17	0.17	lasso	3	0.17	2.3e-09	-4.3	5.8	8.0e-09	-0.55	0.98	0.01	FALSE
35	GTEx	Lung	HIGD1B	0.09	0.04	lasso	3	0.04	2.2e-04	5.6	-5.5	4.9e-08	-0.01	0.78	0.01	FALSE
36	GTEx	Lung	DCAKD	0.22	0.05	enet	27	0.10	5.2e-08	4.5	5.6	2.3e-08	-0.44	0.96	0.03	FALSE
37	GTEx	Muscle Skeletal	PLCD3	0.18	0.10	enet	8	0.10	1.7e-10	6.2	6.5	7.2e-11	-0.12	1.00	0.00	FALSE
38	GTEx	Muscle Skeletal	DCAKD	0.12	0.06	enet	16	0.07	9.9e-08	-5.8	6.5	8.2e-11	-0.54	0.88	0.12	FALSE
39	GTEx	Nerve Tibial	DCAKD	0.35	0.29	enet	21	0.30	1.6e-21	4.6	5.6	2.4e-08	-0.42	1.00	0.00	FALSE
40	GTEx	Nerve Tibial	ACBD4	0.21	0.10	lasso	5	0.11	4.2e-08	-6.8	-8.1	4.2e-16	0.47	0.92	0.07	FALSE
41	GTEx	Pancreas	NMT1	0.19	0.12	enet	18	0.07	8.0e-04	-4.8	-5.2	1.7e-07	0.27	0.33	0.09	FALSE
42	GTEx	Prostate	NMT1	0.43	0.28	lasso	6	0.25	5.3e-07	4.7	-5.1	2.8e-07	0.36	0.58	0.11	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	DCAKD	0.30	0.21	lasso	6	0.20	5.0e-11	-5.8	6.3	3.2e-10	-0.58	1.00	0.00	FALSE
44	GTEx	Skin Sun Exposed Lower leg	DCAKD	0.33	0.20	enet	30	0.31	2.4e-26	-4.3	5.9	4.3e-09	-0.27	1.00	0.00	TRUE
45	GTEx	Skin Sun Exposed Lower leg	ACBD4	0.06	0.05	lasso	4	0.02	3.8e-03	6.3	-8.1	7.1e-16	0.33	0.19	0.08	FALSE
46	GTEx	Stomach	DCAKD	0.29	0.17	enet	25	0.20	9.4e-10	-4.3	6.8	1.2e-11	-0.48	0.57	0.42	FALSE
47	GTEx	Thyroid	PLCD3	0.12	0.01	enet	20	0.07	8.2e-06	6.2	5.7	1.2e-08	-0.04	0.77	0.01	TRUE
48	GTEx	Thyroid	DCAKD	0.25	0.26	enet	17	0.27	9.4e-21	-5.8	5.5	4.8e-08	-0.57	1.00	0.00	FALSE
49	GTEx	Thyroid	ACBD4	0.20	0.16	enet	23	0.15	1.2e-11	-7.2	-8.8	1.5e-18	0.51	1.00	0.00	TRUE
50	METSIM	Adipose	C17orf104	0.05	0.02	bslmm	404	0.04	4.2e-06	5.0	-5.8	4.8e-09	0.11	0.91	0.00	FALSE
51	YFS	Blood	FZD2	0.15	0.12	bslmm	362	0.13	1.8e-39	5.7	5.3	1.1e-07	-0.08	0.64	0.36	FALSE
52	YFS	Blood	HEXIM2	0.02	0.01	bslmm	279	0.01	1.0e-05	5.8	-6.3	2.4e-10	0.61	0.58	0.37	TRUE
53	YFS	Blood	NMT1	0.02	0.01	lasso	6	0.01	5.0e-03	6.4	-7.0	1.9e-12	0.37	0.28	0.03	FALSE
54	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC644172	0.08	0.00	blup	79	0.04	3.2e-04	2.8	5.3	8.6e-08	-0.51	0.07	0.27	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC644172	0.14	0.07	enet	10	0.12	1.2e-23	1.6	5.2	1.5e-07	-0.35	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	MGC57346	0.02	0.00	blup	62	0.02	2.2e-05	1.8	5.3	1.5e-07	-0.53	0.04	0.59	FALSE
57	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LOC644172	0.19	-0.01	blup	81	0.03	1.3e-02	1.8	6.0	2.7e-09	-0.47	0.02	0.56	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DCAKD	0.07	0.07	lasso	4	0.07	1.4e-08	-5.8	7.0	2.6e-12	-0.56	0.06	0.94	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACBD4	0.08	0.04	enet	9	0.04	6.9e-06	-7.2	-7.0	3.2e-12	0.50	0.95	0.01	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC644172	0.04	0.00	enet	15	0.02	4.0e-03	-9.2	6.2	6.2e-10	-0.60	0.00	0.76	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	NMT1	0.08	0.04	blup	83	0.05	3.5e-06	-4.3	-5.5	3.1e-08	0.37	0.96	0.02	FALSE
62	The Cancer Genome Atlas	Lung Adenocarcinoma	NMT1	0.04	0.00	blup	81	0.01	1.9e-02	-4.8	-6.6	3.5e-11	0.27	0.03	0.70	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	PLCD3	0.04	0.01	blup	64	0.01	2.3e-02	6.2	-6.0	1.7e-09	0.27	0.05	0.08	FALSE
64	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HEXIM1	0.06	0.01	blup	47	0.03	3.3e-03	3.0	5.8	7.2e-09	-0.24	0.01	0.10	FALSE
65	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NMT1	0.23	0.08	blup	82	0.12	1.1e-05	4.6	-7.2	7.7e-13	0.55	0.05	0.90	FALSE
66	The Cancer Genome Atlas	Prostate Adenocarcinoma	ACBD4	0.04	0.01	enet	7	0.03	2.2e-04	4.5	-6.6	3.2e-11	0.44	0.09	0.14	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC644172	0.15	0.01	blup	77	0.06	1.0e-06	6.4	6.1	1.3e-09	-0.40	0.19	0.29	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	NMT1	0.09	0.08	lasso	3	0.09	1.1e-09	4.6	-5.4	8.4e-08	0.46	0.91	0.09	FALSE
69	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC644172	0.20	0.01	enet	12	0.06	4.5e-03	-3.2	5.4	8.5e-08	-0.47	0.06	0.08	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	C17orf104	0.07	0.02	blup	37	0.04	6.2e-05	5.7	-5.2	2.0e-07	0.09	0.01	0.98	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	HEXIM1	0.05	0.05	blup	47	0.04	8.5e-05	-9.2	8.4	5.1e-17	-0.84	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Thyroid Carcinoma	NMT1	0.18	0.19	enet	20	0.20	3.8e-19	-4.8	-5.8	8.7e-09	0.40	1.00	0.00	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	PLCD3	0.24	0.16	lasso	5	0.20	2.8e-19	6.2	6.9	6.2e-12	-0.15	1.00	0.00	FALSE