TWAS hub - MLX

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.032	0.015	0.00096	0.028	0.016	0.023	0.015	0.021	0.0002	0.0042	0.00065	0.0055	0.0013
2	GTEx	Cells Transformed fibroblasts	0.040	0.019	0.00580	0.032	NA	0.000	NA	-0.003	0.0017	NA	0.33000	NA	0.6100

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Medication: Metformin	9.3	13.2	15.9	-3.2	-4.0
Arm fat mass (left)	7.5	30.8	31.0	-5.5	-5.6
Trunk fat mass	7.2	31.1	31.8	-5.5	-5.6
Weight	7.1	34.8	37.2	-6.1	-5.7
Arm fat mass (right)	7.0	28.8	29.1	-5.3	-5.4
Illnesses of father: Heart disease	6.8	9.5	9.7	-3.1	-3.0
Mouth/teeth dental problems: Loose teeth	6.4	7.5	9.2	-2.4	-3.0
Whole body fat mass	6.3	26.3	26.8	-5.1	-5.2
Hip circumference	5.7	24.3	31.6	-5.6	-4.1
Migraine (self-reported)	5.7	7.1	8.8	2.3	3.0
Trunk fat percentage	5.6	22.6	23.9	-4.6	-4.9
Leg predicted mass (left)	5.5	29.1	33.9	-5.8	-4.9
Diabetes diagnosed by doctor	5.5	9.1	10.2	-2.8	-3.2
Ovarian Cancer	5.4	7.1	8.0	-2.5	-2.8
Arm fat percentage (left)	5.4	21.5	22.8	-4.5	-4.8
Leg fat-free mass (left)	5.3	28.3	33.1	-5.8	-4.8
Arm fat percentage (right)	5.3	20.7	22.7	-4.3	-4.8
Age at First Birth	5.2	7.6	7.7	2.7	2.8
Basal metabolic rate	5.2	28.6	32.6	-5.7	-5.0
Mouth/teeth dental problems: Dentures	5.0	8.4	9.2	-3.0	-2.8
Exposure to tobacco smoke outside home	5.0	6.6	8.3	-2.2	-2.9
Alcohol intake frequency.	5.0	11.7	14.1	-3.0	-3.8
HDL Cholesterol	4.9	8.2	9.6	2.6	3.1
Blood White Count	4.7	34.9	42.5	-5.2	-6.5
Leg fat-free mass (right)	4.7	25.1	30.2	-5.5	-4.5
Leg predicted mass (right)	4.6	24.7	29.7	-5.5	-4.4
Arm fat-free mass (left)	4.6	23.3	26.5	-5.2	-4.5
Worry too long after embarrassment	4.5	7.5	7.8	2.8	2.7
Whole body water mass	4.5	25.6	30.0	-5.5	-4.6
Body fat percentage	4.4	17.3	19.1	-3.9	-4.4
Medication: Allopurinol	4.4	5.8	6.1	2.5	2.4
Whole body fat-free mass	4.4	25.3	30.0	-5.5	-4.5
Leg fat mass (right)	4.3	16.8	18.7	-3.9	-4.3
Illnesses of father: None of the above (group 1)	4.3	5.3	5.6	2.3	2.4
Leg fat mass (left)	4.2	16.6	18.2	-3.9	-4.3
Arm predicted mass (left)	4.2	21.5	24.0	-4.9	-4.3
Hypothyroidism/myxoedema (self-reported)	4.1	8.0	13.2	-3.6	-1.7
Body mass index (BMI)	4.0	17.1	17.9	-4.0	-4.2
Maternal smoking around birth	3.9	5.6	6.2	-2.2	-2.5
Schizophrenia vs Biploar Disorder	3.8	5.0	5.1	-2.3	-2.2
Qualifications: O levels/GCSEs or equivalent	3.8	6.1	6.1	2.5	2.5
Medication: Gliclazide	3.8	4.3	4.8	-2.0	-2.2
Hayfever/allergic rhinitis (self-reported)	3.7	4.9	6.1	1.9	2.5
Trunk fat-free mass	3.7	21.3	25.5	-5.0	-4.1
Trunk predicted mass	3.7	21.2	25.3	-5.0	-4.1
Arm fat-free mass (right)	3.7	19.2	22.4	-4.7	-4.0
Arm predicted mass (right)	3.7	18.9	22.3	-4.7	-3.9
Height	3.6	69.7	87.2	-9.3	-7.2
Hearing difficulty/problems: Yes	3.6	5.5	8.1	1.7	2.8
Medication: Co-codamol	3.6	4.1	4.6	-1.9	-2.1
Average weekly champagne plus white wine intake	3.5	4.8	5.7	1.9	2.4
Hand grip strength (right)	3.4	9.2	10.0	-3.2	-2.9
Medication: Levothyroxine sodium	3.3	5.5	9.1	-3.0	-1.4
Diabetes (self-reported)	3.3	5.1	5.4	-2.2	-2.3
Heart disease (siblings)	3.3	4.1	5.7	-1.6	-2.4
Medication for hormone replacement therapy	3.2	3.6	4.4	-1.7	-2.1
Waist circumference	3.1	11.4	14.1	-2.9	-3.8
Knee pain experienced in last month	3.1	4.9	5.3	-2.1	-2.3
Hand grip strength (left)	3.0	8.0	9.3	-2.6	-3.1
Number of treatments/medications taken	3.0	5.4	7.1	1.9	2.7
Alcohol drinker status: Previous	3.0	3.4	5.5	-1.2	-2.3
Birth weight of first child	2.9	5.2	7.3	1.8	2.7
Type 2 Diabetes (T2D) (2018)	2.8	5.2	6.3	-2.0	-2.5
Hayfever, allergic rhinitis or eczema	2.8	6.2	7.1	2.3	2.7
Mouth/teeth dental problems	2.7	4.1	5.3	2.3	1.7
Qualifications: A levels/AS levels or equivalent	2.7	6.0	6.7	2.3	2.6
Standing height	2.7	26.4	33.4	-5.8	-4.4
Tense / ‘highly strung’	2.7	4.4	6.0	-1.7	-2.5
BMI	2.6	15.3	16.2	-3.8	-4.0
Illnesses of siblings	2.6	3.7	5.2	1.5	2.3
Alzheimer’s Disease (including proxy)	2.5	3.6	4.0	-1.8	-2.0
High blood pressure (mother)	2.5	3.5	5.8	2.4	1.1
Gout (self-reported)	2.5	3.4	3.6	1.8	1.9
Blood Eosinophil Count	2.4	18.7	19.5	-4.4	-4.2
Cardiovascular Disease	2.4	7.9	12.6	-1.8	-3.5
Diabetes (father)	2.4	2.9	3.7	-1.5	-1.9
Forced expiratory volume in 1-second (FEV1)	2.4	8.1	9.9	-2.5	-3.1
Birth weight	2.4	5.2	6.7	1.9	2.6
Comparative height size at age 10	2.4	13.1	13.3	-3.6	-3.6
Intelligence (Savage-Jansen 2018)	2.3	7.0	7.4	2.6	2.7
Impedance of leg (left)	2.3	10.9	13.9	3.7	2.8
Qualifications: None of the above	2.3	5.0	5.4	-2.3	-2.1
Glaucoma (self-reported)	2.2	2.6	3.9	2.0	1.2
Age started oral contraceptive pill	2.1	2.7	3.1	1.5	1.8
Commuting to job workplace: Cycle	2.1	2.5	2.8	1.5	1.7
Basal cell carcinoma (self-reported)	2.1	2.5	2.9	1.7	1.5
Crohns Disease (2012)	2.0	3.3	4.7	1.4	2.2
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	3.1	-1.8	-1.2
Had menopause	2.0	2.5	3.6	-1.9	-1.2
Forced vital capacity (FVC)	2.0	7.6	9.1	-2.5	-3.0
Medication: Lansoprazole	2.0	2.2	2.9	1.2	1.7
Breastfed as a baby	2.0	2.5	2.7	1.5	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	3.0	1.7	1.4
Allergy or Eczema	1.9	5.0	6.6	1.9	2.6
Hearing difficulty/problems with background noise	1.9	3.0	4.3	1.3	2.1
Leg fat percentage (right)	1.9	7.0	9.0	-2.2	-3.0
Pulse rate, automated reading	1.9	6.3	7.3	-2.3	-2.7
Bipolar Disorder (2018)	1.8	2.9	4.8	2.2	1.0
Prostate Cancer	1.8	2.5	2.8	-1.5	-1.7
Waist Hip Ratio (WHR)	1.8	8.2	16.3	4.0	0.4
Chest pain or discomfort	1.8	2.5	4.1	-2.0	-1.0
Supplements: Vitamin C	1.8	2.1	2.4	1.6	1.3
Alzheimer’s Disease (in father)	1.7	1.9	2.0	-1.4	-1.3
Hypothyroidism (self reported)	1.7	3.9	7.0	-2.6	-0.9
Falls in the last year	1.7	2.2	2.6	-1.4	-1.6
Medication: Seretide 50 evohaler	1.7	2.0	3.1	-1.8	-0.9
Illnesses of siblings: Diabetes	1.7	2.1	2.2	-1.4	-1.5
Ever had bowel cancer screening	1.7	2.0	2.9	1.0	1.7
Commuting to job workplace: Public transport	1.7	2.1	2.8	1.1	1.7
Leg fat percentage (left)	1.7	6.2	8.0	-2.1	-2.8
Worry (Nagel 2018)	1.6	3.4	5.2	-1.3	-2.3
Neuroticism (2016)	1.6	2.4	3.6	-1.9	-1.0
Severe depression (siblings)	1.6	1.7	2.3	1.1	1.5
Impedance of leg (right)	1.6	7.9	10.7	3.3	2.3
Qualifications: CSEs or equivalent	1.6	2.0	2.2	-1.5	-1.4
Allergy	1.6	3.6	5.4	-1.4	-2.3
Prospective memory result	1.6	2.0	2.1	1.4	1.4
Lung cancer (father)	1.6	1.9	2.5	-1.1	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.1	6.5	-1.9	-2.5
Age at first live birth	1.6	2.9	4.6	2.1	1.1
Pulse wave peak to peak time	1.6	1.8	2.6	-1.6	-1.0
Osteoporosis (self-reported)	1.6	2.0	2.8	1.1	1.7
Wears glasses or contact lenses	1.6	1.8	2.6	1.0	1.6
Mother’s age at death	1.6	2.1	2.8	1.1	1.7
Number of operations (self-reported)	1.6	2.3	3.6	1.1	1.9
Body Mass Index (BMI) (2010)	1.5	2.1	2.5	-1.3	-1.6
Father’s age at death	1.5	2.0	2.2	1.3	1.5
Pulse wave reflection index	1.5	1.9	2.1	1.3	1.4
Suffer from ‘nerves’	1.5	2.4	2.9	-1.4	-1.7
Age at last live birth	1.5	2.2	3.6	1.9	0.9
Medication for cholesterol	1.5	2.3	3.7	0.9	1.9
Ever taken oral contraceptive pill	1.5	1.7	2.1	1.5	1.1
Mean Putamen Volume	1.4	1.6	2.4	-0.9	-1.6
Ulcerative Colitis	1.4	2.1	2.3	1.4	1.5
Angina	1.4	1.9	2.8	-0.9	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	2.0	-1.4	-1.3
Angina (self-reported)	1.4	1.9	2.6	-1.1	-1.6
Cholesterol lowering medication	1.4	2.1	3.5	-0.8	-1.9
Alzheimer’s Disease (in mother)	1.3	1.6	1.6	-1.3	-1.2
Blood clot in the leg (DVT)	1.3	1.7	3.0	-1.7	-0.7
High cholesterol (Self-reported)	1.3	2.3	4.2	-0.6	-2.1
Sitting height	1.2	8.6	11.4	-3.4	-2.4
Hair/balding pattern: Pattern 2	1.2	1.6	2.2	0.9	1.5
Peak expiratory flow (PEF)	1.2	2.8	3.4	-1.5	-1.8
Chronic bronchitis/emphysema (mother)	1.2	1.4	1.6	-1.3	-1.1
Forced vital capacity (FVC), Best measure	1.2	4.5	5.5	-1.9	-2.3
Number of full brothers	1.2	1.6	2.1	-1.0	-1.4
Mineral and other dietary supplements	1.2	1.6	3.0	-0.6	-1.7
Medication: Aspirin	1.2	1.6	2.8	-0.5	-1.7
Eye problems/disorders: Glaucoma	1.2	1.4	2.1	1.4	0.9
Verbal and Numeric Reasoning (VNR)	1.1	2.6	2.7	1.6	1.6
Nervous feelings	1.1	2.1	2.2	-1.5	-1.4
Overall health rating	1.1	2.3	2.5	-1.6	-1.4
Medication: Aspirin	1.1	1.4	2.6	-0.5	-1.6
Asthma (self-reported)	1.1	2.3	4.0	0.8	2.0
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.5	-1.6	-0.5
Pack years of smoking	1.1	1.6	1.8	-1.3	-1.2
Crohns Disease (2017)	1.0	2.1	3.9	0.5	2.0
LDL Cholesterol	1.0	1.6	2.7	1.6	0.7
Stomach or abdominal pain in last month	1.0	1.2	1.3	1.1	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.7	-0.0	-2.2
Length of working week for main job	1.0	1.1	1.9	-1.4	-0.6
Headache pain in last month	1.0	1.7	3.1	0.6	1.8
Number of children fathered	1.0	1.2	1.9	-1.4	-0.7
Shortness of breath walking on level ground	1.0	1.2	1.7	0.8	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	1.2	1.1	1.1
Supplements: Calcium	1.0	1.0	1.8	0.6	1.3
Pack years adult smoking proportion	0.9	1.4	1.5	-1.2	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.9	-0.2	-2.0
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.2	0.9	1.5
Happiness	0.9	1.0	1.2	1.1	0.9
Eye problems/disorders: None of the above	0.9	1.0	1.3	-0.9	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.9	-0.1	1.7
Osteoarthritis (self-reported)	0.9	1.2	2.1	0.5	1.5
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.0	0.4	1.4
Medication: Atorvastatin	0.9	1.1	1.5	-0.9	-1.2
Lupus	0.8	1.3	2.0	0.7	1.4
Ever used hormone-replacement therapy (HRT)	0.8	1.1	1.4	-1.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	1.3	-1.0	-1.1
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.2	-1.1	-0.8
Medication: Ramipril	0.8	1.1	1.9	-0.5	-1.4
Pulse wave Arterial Stiffness index	0.8	1.0	1.4	1.2	0.7
Diastolic blood pressure, automated reading	0.8	2.4	2.6	-1.5	-1.6
Unable to work because of sickness or disability	0.8	1.0	1.1	-1.0	-1.1
Heel T-Score	0.7	5.9	11.6	0.6	-3.4
Supplements: Zinc	0.7	0.7	1.1	0.6	1.0
Townsend deprivation index at recruitment	0.7	1.0	1.6	0.7	1.2
Asthma	0.7	1.4	2.7	0.3	1.6
Medication: Cholesterol lowering	0.7	1.1	2.2	0.0	-1.5
Illnesses of mother	0.7	0.9	1.7	0.4	1.3
Wheeze or whistling in the chest in last year	0.7	1.3	2.6	-1.6	0.1
Qualifications: College or University degree	0.7	2.3	2.8	1.7	1.3
Qualifications: nursing, teaching	0.7	1.0	1.6	0.7	1.3
Commuting to job workplace: Walk	0.7	0.8	0.9	0.9	0.9
Medication: Lisinopril	0.7	0.9	1.7	-0.4	-1.3
Myopia	0.7	1.0	1.4	1.2	0.8
Reaction Time	0.6	1.1	1.8	-0.6	-1.3
HbA1C	0.6	0.7	1.0	-1.0	-0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.1	-1.0	-0.4
Medication: Simvastatin	0.6	0.9	1.7	0.2	-1.3
Alcohol intake versus 10 years previously	0.6	0.9	0.9	-0.9	-0.9
Medication: Amlodipine	0.6	0.8	1.5	-0.4	-1.2
Eye problems/disorders: Cataract	0.6	0.7	1.0	1.0	0.6
Risk taking	0.6	0.9	1.7	0.3	1.3
Irritable Bowel Disease (IBD)	0.5	1.1	2.2	-0.1	1.5
Triglycerides	0.5	0.9	1.7	0.3	-1.3
Multivitamins +/- minerals	0.5	0.6	1.1	0.3	1.0
Time employed in main current job	0.5	0.6	0.6	0.8	0.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.5	-0.2	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	0.9	-0.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.3	-1.0	-1.2
Average weekly red wine intake	0.5	0.8	1.1	0.7	1.0
Number of self-reported non-cancer illnesses	0.5	0.8	0.8	0.9	0.9
Hearing aid user	0.5	0.5	0.6	0.6	0.8
Medication: Paracetamol	0.5	0.7	1.3	0.4	1.1
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.8	0.0	1.7
Impedance of whole body	0.5	2.5	3.1	1.7	1.4
Bipolar Disorder or Schizophrenia	0.4	1.1	2.2	1.5	-0.0
Depression (Nagel 2018)	0.4	0.6	0.7	-0.8	-0.8
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.0	-1.0	-0.2
Tanning	0.4	5.2	6.8	1.9	2.6
Ever had hysterectomy (womb removed)	0.4	0.5	0.5	-0.7	-0.7
Systolic blood pressure, automated reading	0.4	1.3	2.2	-0.6	-1.5
Current tobacco smoking	0.4	0.6	0.6	-0.7	-0.8
Alcohol usually taken with meals	0.4	0.7	0.9	0.7	0.9
Hair/balding pattern: Pattern 4	0.4	1.0	1.3	-0.8	-1.1
Mean time to correctly identify matches	0.4	0.7	1.0	-0.6	-1.0
Heart disease (mother)	0.4	0.5	0.9	-0.2	-0.9
Smoking status: Previous	0.4	0.7	1.2	1.1	0.3
Loneliness, isolation	0.4	0.6	0.6	0.7	0.8
Guilty feelings	0.4	0.6	0.7	0.8	0.8
Irritability	0.4	0.7	1.2	1.1	0.5
Ulcerative Colitis (UC)	0.3	0.6	1.1	-1.1	-0.1
Breast Cancer	0.3	0.6	1.2	-0.3	-1.1
Bipolar Disorder (2011)	0.3	0.3	0.3	0.6	0.5
Respiratory disease	0.3	0.6	1.1	0.4	1.1
Average weekly spirits intake	0.3	0.3	0.6	-0.8	-0.0
Relative age voice broke	0.3	0.4	0.7	-0.8	0.3
Taking other prescription medications	0.3	0.5	0.9	0.2	1.0
High blood pressure	0.3	0.8	1.4	0.4	-1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.5	0.7	0.4
Medication: Atenolol	0.3	0.3	0.6	-0.3	-0.7
Fluid intelligence score	0.3	0.7	0.8	0.8	0.9
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	0.3	-1.0
Emphysema/chronic bronchitis	0.3	0.3	0.4	-0.7	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.6	0.2	0.8
Medication: Blood pressure	0.3	0.6	1.1	1.1	-0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.5	-0.7	-0.6
Medication: Bendroflumethiazide	0.3	0.4	0.5	0.7	-0.5
Illnesses of father: High blood pressure	0.3	0.3	0.7	0.8	-0.0
Ever smoked	0.3	0.5	0.8	0.9	0.4
Average weekly beer plus cider intake	0.3	0.4	0.8	-0.2	-0.9
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.4	0.6	0.5
Ever depressed for a whole week	0.3	0.3	0.4	-0.7	-0.4
Schizophrenia (2018)	0.2	0.4	0.7	0.1	-0.8
Blood Platelet Count	0.2	2.5	4.5	2.1	0.7
Systolic Blood Pressure	0.2	0.9	1.7	0.5	-1.3
Lung FVC	0.2	1.0	1.8	-0.4	-1.4
Relative age of first facial hair	0.2	0.3	0.7	-0.8	0.0
Vitamin and mineral supplements	0.2	0.3	0.6	-0.3	-0.8
Diabetes (mother)	0.2	0.2	0.4	-0.1	-0.7
Serious illness, injury or assault to yourself	0.2	0.3	0.5	-0.7	-0.2
Supplements: Glucosamine	0.2	0.2	0.3	0.4	0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	-0.3	0.5
Past tobacco smoking	0.2	0.3	0.6	-0.8	-0.1
Had other major operations	0.2	0.2	0.3	0.5	0.4
Noisy workplace	0.2	0.2	0.4	-0.6	0.2
Comparative body size at age 10	0.2	0.4	0.7	-0.4	-0.9
Medication: Blood pressure	0.2	0.4	0.6	0.4	-0.8
Medication: Ibuprofen	0.2	0.2	0.4	0.2	0.6
Had major operations	0.2	0.2	0.3	-0.3	0.5
Family relationship satisfaction	0.2	0.2	0.3	-0.4	-0.6
Leg pain on walking	0.2	0.2	0.3	-0.4	0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	0.4	-0.6
Hypertension (Self-reported)	0.2	0.6	0.9	0.5	-1.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	0.6	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.2	-0.6
Friendships satisfaction	0.2	0.3	0.4	-0.6	-0.4
Back pain experienced in last month	0.2	0.2	0.4	-0.2	-0.7
Smoking status: Current	0.2	0.3	0.3	-0.5	-0.5
Miserableness	0.2	0.3	0.4	0.5	0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	0.7	-0.1
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	0.6	0.1
Neuroticism (Nagel 2018)	0.1	0.2	0.2	0.3	-0.5
Fasting Glucose	0.1	0.1	0.1	0.3	-0.3
Schizophrenia (2014)	0.1	0.2	0.3	0.4	-0.6
Blood Red Count	0.1	1.1	2.2	0.3	-1.5
Sensitivity / hurt feelings	0.1	0.2	0.4	0.6	0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.2	-0.4
Average weekly fortified wine intake	0.1	0.1	0.3	-0.5	0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	0.6	-0.1
Number of incorrect matches in round	0.1	0.2	0.3	0.2	0.5
Heart attack	0.1	0.2	0.3	0.6	-0.0
Neuroticism score	0.1	0.3	0.4	0.7	0.4
Worrier / anxious feelings	0.1	0.1	0.2	0.5	0.2
Depression (self-reported)	0.1	0.1	0.2	0.5	-0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.5	-0.2
Medication: Paracetamol	0.1	0.2	0.3	0.2	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	-0.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	-0.4	0.4
Health satisfaction	0.1	0.2	0.3	-0.5	-0.2
Neck or shoulder pain in last month	0.1	0.1	0.2	0.1	0.5
Medication: Omeprazole	0.1	0.2	0.2	-0.5	-0.3
Number of full sisters	0.1	0.1	0.2	0.4	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	-0.0	-0.7
Financial situation satisfaction	0.1	0.1	0.1	-0.3	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.2	0.3
Alcohol drinker status: Never	0.1	0.1	0.1	0.2	0.3
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.4	0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	-0.2	-0.3
Pain experienced in last month	0.1	0.1	0.2	0.4	-0.0
Major Depression (MDD)	0.0	0.0	0.1	-0.0	-0.2
Coronary Artery Disease (CAD)	0.0	0.0	0.0	-0.1	-0.2
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.0	0.1
Rheumatoid Arthritis	0.0	0.0	0.1	0.1	0.2
Smoking Status	0.0	0.0	0.1	-0.2	0.0
Lung FEV1/FVC ratio	0.0	0.2	0.3	0.6	0.1
Neuroticism	0.0	0.0	0.0	0.1	-0.2
Chronotype (morning person)	0.0	0.0	0.1	-0.1	-0.2
Hair Pigment	0.0	0.3	0.4	0.6	0.4
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	0.2	0.3
Fed-up feelings	0.0	0.0	0.1	-0.1	-0.3
Age when periods started (menarche)	0.0	0.0	0.0	0.1	0.1
Financial difficulties in last 2 years	0.0	0.0	0.0	0.2	-0.2
Pain all over the body in last month	0.0	0.1	0.1	-0.2	-0.2
Impedance of arm (right)	0.0	0.1	0.2	0.5	0.3
Number of live births	0.0	0.0	0.0	-0.2	-0.1
Pulse rate	0.0	0.1	0.1	-0.3	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	0.2	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.0	0.2
Impedance of arm (left)	0.0	0.0	0.0	0.1	0.1
Exposure to tobacco smoke at home	0.0	0.0	0.0	0.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.3	0.2
Loud music exposure frequency	0.0	0.0	0.0	-0.2	0.1
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.0	0.1	0.2
High blood pressure (siblings)	0.0	0.1	0.1	0.3	-0.2
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	-0.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.0	0.2
Mood swings	0.0	0.1	0.1	0.4	0.2
Long-standing illness, disability or infirmity	0.0	0.0	0.0	-0.1	0.1
Breast cancer (self-reported)	0.0	0.0	0.1	-0.3	0.1

Hub : Genes

MLX

Models

Trait associations