Best TWAS P=2.11e-13 · Best GWAS P=3.17e-14 conditioned to 0.644
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PHLDA3 | 0.16 | 0.10 | lasso | 12 | 0.11 | 7.2e-13 | 4.5 | 5.1 | 2.8e-07 | 0.06 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | SHISA4 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.5e-03 | -6.0 | -6.6 | 3.4e-11 | -0.57 | 0.19 | 0.36 | TRUE |
| 3 | GTEx | Esophagus Muscularis | LMOD1 | 0.16 | 0.09 | enet | 9 | 0.08 | 7.8e-06 | 7.6 | -7.0 | 2.3e-12 | -0.98 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RP11-307B6.3 | 0.20 | 0.12 | lasso | 3 | 0.12 | 5.6e-08 | 7.6 | -6.9 | 6.0e-12 | -0.97 | 0.01 | 0.99 | FALSE |
| 5 | METSIM | Adipose | LMOD1 | 0.09 | 0.07 | bslmm | 496 | 0.07 | 4.8e-10 | 7.5 | -7.1 | 1.1e-12 | -0.96 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LMOD1 | 0.07 | 0.06 | blup | 59 | 0.03 | 2.1e-02 | 7.5 | -6.7 | 2.1e-11 | -0.90 | 0.01 | 0.86 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LMOD1 | 0.04 | 0.07 | enet | 6 | 0.05 | 9.4e-07 | -6.6 | -7.2 | 4.5e-13 | -0.75 | 0.23 | 0.76 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | LMOD1 | 0.04 | 0.01 | blup | 59 | 0.01 | 5.7e-02 | 7.3 | -7.3 | 2.1e-13 | -0.83 | 0.01 | 0.81 | TRUE |