Hub : Genes

PHLDA3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.157	0.0350	4.0e-09	0.102	0.094	0.099	0.103	0.106	2.0e-12	1.5e-11	5.1e-12	1.7e-12	7.2e-13
2	GTEx	Artery Tibial	0.142	0.0489	2.8e-03	-0.002	NA	-0.004	NA	-0.004	4.9e-01	NA	9.9e-01	NA	9.4e-01
3	GTEx	Skin Sun Exposed Lower leg	0.107	0.0410	3.9e-03	0.027	NA	0.014	NA	0.031	2.6e-03	NA	2.3e-02	NA	1.3e-03
4	TCGA	Soft Tissue Sarcoma	0.054	0.0290	8.2e-03	0.010	0.027	0.002	NA	0.014	7.9e-02	9.5e-03	2.4e-01	NA	4.8e-02
5	TCGA	Uterine Corpus Endometrial Carcinoma	0.206	0.0850	7.7e-03	0.067	0.087	0.062	NA	0.063	6.2e-03	2.0e-03	8.3e-03	NA	7.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	1.2	-0.3	-0.3	-0.5	-1.1	0.2
Bipolar Disorder or Schizophrenia	0.5	1.1	3.1	-0.8	1.2	-1.8	-0.5	0.4
Depressed Affect (Nagel 2018)	2.5	5.2	16.9	4.1	-1.7	1.5	-1.6	-1.2
Depression (Nagel 2018)	0.5	0.8	2.3	1.5	-0.1	1.3	0.3	0.4
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.6	-0.8	0.9	1.9	-0.2	1.2
Neuroticism (Nagel 2018)	1.3	3.2	9.9	3.2	-0.5	0.8	-1.3	-1.8
Schizophrenia (2018)	0.7	1.5	3.5	-0.8	1.8	-1.9	0.2	0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	0.6	0.3	-0.8	-0.8	0.8	-0.4
Worry (Nagel 2018)	0.6	1.3	3.4	1.3	0.4	0.2	-1.0	-1.8
Alzheimer’s Disease (in mother)	0.4	0.5	1.6	1.3	0.4	-0.4	0.6	0.5
Alzheimer’s Disease (in father)	2.5	2.7	5.3	1.1	-2.1	0.7	-1.4	-2.3
Alzheimer’s Disease (including proxy)	0.9	1.3	2.7	1.6	-1.5	-0.5	0.2	-1.2
Crohns Disease (2017)	1.6	3.6	9.5	3.1	-0.1	2.3	-1.6	0.8
Irritable Bowel Disease (IBD)	1.0	2.5	7.7	2.8	0.5	1.8	-0.9	0.6
Ulcerative Colitis (UC)	0.4	0.7	1.6	1.3	0.8	1.0	-0.1	0.1
Major Depression (MDD)	0.4	0.5	0.8	0.7	-0.9	0.3	0.9	0.5
Reaction Time	1.2	2.2	7.2	-2.7	1.6	-0.9	-0.2	-0.7
Verbal and Numeric Reasoning (VNR)	0.4	0.8	3.1	0.2	0.2	0.8	-1.8	-0.7
Breast Cancer	1.6	3.9	11.0	-1.2	-2.1	-1.6	0.6	-3.3
Ovarian Cancer	6.8	9.1	17.5	4.2	-0.6	3.2	-3.7	-1.7
Prostate Cancer	0.7	1.0	3.0	-0.8	-1.7	-0.7	-0.1	0.9
Age at First Birth	0.1	0.2	0.4	0.1	-0.3	0.6	-0.6	-0.4
Bipolar Disorder (2011)	2.0	1.9	6.4	0.6	-0.4	-0.1	-2.5	-1.6
Body Mass Index (BMI) (2010)	0.8	1.1	4.7	0.3	-0.1	-2.2	0.4	-0.7
Coronary Artery Disease (CAD)	0.7	0.9	2.6	0.8	0.3	0.2	-1.0	-1.6
Crohns Disease (2012)	1.2	1.9	3.7	1.9	0.9	1.7	-1.5	-0.6
Mean Putamen Volume	1.5	1.7	4.6	1.4	1.0	2.2	-0.7	0.5
Fasting Glucose	0.2	0.3	1.1	0.4	0.4	-0.2	-0.1	1.1
HbA1C	1.3	1.5	2.8	-0.1	-0.9	-1.1	-1.7	-1.6
HDL Cholesterol	0.6	1.0	1.6	1.2	0.9	1.3	0.4	-1.1
LDL Cholesterol	0.1	0.1	0.3	0.5	-0.5	0.1	-0.1	-0.4
Lupus	1.1	1.6	3.3	0.8	1.5	1.0	-1.8	-0.9
Neuroticism (2016)	2.0	2.9	5.1	2.2	1.3	0.5	-2.0	-1.9
Primary Biliary Cirrhosis	0.8	1.2	4.4	0.1	1.0	0.8	-0.1	2.1
Rheumatoid Arthritis	0.4	0.5	1.6	-0.2	-1.3	-0.8	-0.3	-0.1
Schizophrenia (2014)	1.1	2.4	5.9	-1.3	1.5	-2.4	0.9	1.2
Triglycerides	0.3	0.4	2.0	0.0	0.2	-1.4	0.2	-0.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.6	0.4	0.1	-0.7	-1.6	-0.8
Ulcerative Colitis	0.6	0.8	2.2	1.5	0.3	0.9	-0.9	0.5
Blood Eosinophil Count	0.2	1.6	4.5	-0.2	-2.1	-0.9	0.6	-1.5
Blood Platelet Count	0.2	2.2	7.1	-2.7	-0.8	-1.1	1.3	0.4
Blood Red Count	0.2	2.4	5.8	-1.1	1.4	-1.0	1.3	2.4
Blood White Count	0.9	6.5	10.0	-3.1	1.0	-2.0	2.8	3.2
Heel T-Score	0.1	0.8	2.9	-0.4	0.2	-1.7	1.0	0.2
BMI	0.6	3.7	14.4	3.8	0.3	1.1	-1.6	-0.1
Height	0.4	7.2	17.3	4.2	0.7	3.3	-2.7	-0.6
Waist Hip Ratio (WHR)	0.1	0.5	1.0	1.0	0.7	0.9	-0.3	-0.2
Systolic Blood Pressure	0.5	2.6	4.5	1.8	-1.9	-0.3	-1.3	-2.1
Smoking Status	0.8	1.9	5.9	-0.4	0.8	0.5	2.4	1.6
Allergy or Eczema	0.0	0.1	0.3	-0.2	0.1	-0.0	0.6	0.2
Cardiovascular Disease	1.9	6.1	16.0	4.0	-1.2	1.0	-2.6	-2.4
Hypothyroidism (self reported)	0.3	0.7	1.5	1.0	-0.4	0.2	-0.8	-1.2
Respiratory disease	1.7	3.8	12.7	-1.5	-0.5	-3.6	1.7	-1.0
Type 2 Diabetes (T2D) (2018)	2.7	5.0	13.0	3.6	-0.8	2.1	-1.8	-1.9
Lung FEV1/FVC ratio	1.2	6.3	12.3	2.4	-1.5	3.5	-1.0	-3.2
Lung FVC	0.3	1.6	3.7	1.2	0.1	1.2	-1.9	1.1
Neuroticism	0.5	1.2	4.8	2.2	0.5	0.2	-0.8	-0.5
Chronotype (morning person)	0.6	1.5	4.0	0.8	-1.4	0.5	-2.0	-0.7
Hair Pigment	0.0	1.1	2.5	1.0	0.9	1.1	-0.5	1.6
Tanning	0.0	0.4	0.7	0.8	-0.5	0.5	0.5	-0.8
Hand grip strength (left)	0.4	1.0	2.7	-1.2	-0.2	-0.7	1.6	-0.4
Number of treatments/medications taken	1.4	2.4	6.1	2.5	-1.3	1.4	-0.7	-1.5
Average weekly spirits intake	0.9	1.1	2.7	-0.4	-1.4	-0.6	0.4	1.6
Sensitivity / hurt feelings	0.6	1.0	2.6	1.5	-0.3	-0.2	-0.5	-1.6
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.3	1.1	0.0	0.7	0.7	-0.2
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.8	-0.0	-0.8	-0.0	-0.5
Relative age of first facial hair	0.3	0.6	1.3	0.1	-0.5	1.2	1.0	0.8
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	4.8	2.2	0.3	1.5	-0.6	-0.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.2	-0.4	0.4	-1.5	-0.1	-0.2
Ever had hysterectomy (womb removed)	1.2	1.4	5.1	-0.7	0.5	-2.2	0.9	0.4
Systolic blood pressure, automated reading	0.1	0.4	1.1	1.1	-0.9	-0.1	0.1	-0.4
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	4.2	1.3	1.4	2.0	0.4	0.6
Angina	1.3	1.8	3.7	1.0	-1.4	1.9	0.8	1.2
Medication for hormone replacement therapy	0.7	0.8	1.5	-1.2	0.7	-0.7	1.0	-0.8
Vitamin and mineral supplements	1.6	2.1	7.0	-0.1	-0.9	-0.3	1.7	2.6
Supplements: Zinc	1.9	2.0	7.8	0.2	-1.2	-0.1	-1.0	-2.8
Medication: Co-codamol	0.4	0.5	1.4	1.2	-0.7	-0.5	-0.1	-0.3
Medication: Metformin	0.7	1.0	3.1	1.8	0.7	0.9	-0.6	-0.2
Diabetes (father)	0.4	0.5	1.9	-0.2	1.4	-0.3	-0.0	0.8
Diabetes (mother)	3.0	3.8	6.3	2.5	-1.0	0.8	-2.4	-2.3
Severe depression (siblings)	1.1	1.2	4.3	-0.3	-2.1	-1.0	0.6	-0.8
Pack years adult smoking proportion	0.7	1.0	2.4	-0.2	0.6	-0.8	1.2	1.5
Impedance of leg (right)	1.5	7.4	14.4	-3.8	1.7	-2.7	3.1	1.7
Leg fat-free mass (left)	1.8	9.5	25.6	5.1	-0.1	2.9	-3.0	-2.1
Trunk fat percentage	0.3	1.1	3.1	1.2	1.8	-0.4	0.6	0.7
Hand grip strength (right)	0.3	0.8	3.3	-0.7	-0.1	-0.4	1.8	-0.4
Townsend deprivation index at recruitment	2.0	2.8	4.0	-1.5	1.8	-2.0	1.6	1.5
Current tobacco smoking	0.5	0.8	1.9	0.1	0.9	0.9	1.4	0.8
Average weekly fortified wine intake	3.1	3.6	5.4	2.0	-0.8	2.0	-1.9	-2.3
Maternal smoking around birth	1.4	2.0	4.8	2.2	-0.2	1.7	-1.6	-0.3
Fed-up feelings	1.9	3.4	11.9	3.5	-0.3	1.8	-1.3	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.2	1.5	-1.0	1.4	0.1	-0.4
Relative age voice broke	0.9	1.3	6.0	0.3	-2.5	-0.1	-0.1	-0.8
Taking other prescription medications	0.6	0.9	2.5	1.6	-1.3	0.4	0.0	-0.2
Age when periods started (menarche)	0.2	0.6	1.8	-0.5	0.1	-1.3	0.1	-1.0
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	4.5	-0.9	-0.1	-2.1	0.6	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.5	-0.9	1.5	-1.9	-0.7	-1.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.2	-0.4	-0.3	-0.4	-0.4
Qualifications: CSEs or equivalent	0.6	0.8	2.1	-0.2	-1.0	-1.4	-0.1	-1.0
Serious illness, injury or assault to yourself	0.5	0.6	1.6	1.3	-0.2	0.1	-0.8	-0.7
High blood pressure	1.2	3.5	7.7	2.8	-0.5	0.4	-1.8	-2.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.8	-0.9	0.4	0.4	-0.1	-0.2
Multivitamins +/- minerals	0.9	1.2	3.4	0.1	-0.9	0.6	-1.2	-1.9
Stomach or abdominal pain in last month	0.4	0.4	1.5	-0.1	1.2	-0.6	0.5	0.0
Supplements: Glucosamine	1.8	2.4	9.7	0.2	0.1	-0.1	-1.5	-3.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.8	-0.3	1.0	-0.5	1.2	2.0
Medication: Atenolol	0.6	0.8	2.3	0.4	1.5	1.0	-0.1	0.7
Medication: Levothyroxine sodium	0.4	0.7	2.4	-0.5	0.3	-1.6	0.7	-0.5
Sitting height	0.2	1.1	2.4	1.5	0.4	1.1	-1.1	-0.7
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	0.1	-0.6	-0.3	-0.2	-0.9
High blood pressure (mother)	1.0	1.4	3.4	1.8	-0.2	1.8	-0.7	-0.1
Body mass index (BMI)	0.6	2.5	10.3	3.2	0.6	1.2	-0.5	-0.0
Impedance of leg (left)	1.6	7.7	14.7	-3.8	1.8	-2.7	2.9	2.2
Leg predicted mass (left)	1.8	9.6	26.1	5.1	-0.0	2.9	-3.0	-2.1
Trunk fat mass	0.4	1.9	6.6	2.6	1.5	0.7	-0.4	0.2
Waist circumference	0.9	3.2	10.3	3.2	1.3	1.7	-0.9	0.1
Number of incorrect matches in round	0.5	0.9	3.0	-0.3	0.7	-0.1	-0.9	-1.7
Past tobacco smoking	0.7	1.3	2.6	1.0	-1.3	0.3	-1.6	-1.2
Alcohol usually taken with meals	0.7	1.2	1.8	-0.4	-1.2	1.1	-1.4	-1.2
Nervous feelings	0.4	0.7	2.9	-0.6	-0.3	-0.1	0.3	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	0.0	-0.3	-0.2	0.8	-0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.4	-0.4	0.1	0.4	-0.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.0	-0.5	-0.4	-1.0	-0.2	-1.0
Had menopause	0.5	0.7	2.5	-0.3	1.6	-0.5	0.7	0.0
Had other major operations	0.2	0.2	0.7	-0.2	0.3	0.2	0.6	0.8
Forced vital capacity (FVC)	1.0	4.0	11.9	2.3	-0.5	1.1	-3.5	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.4	-0.9	0.6	-1.6	-0.6	-0.7
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	3.6	1.9	-1.0	1.1	-1.7	-1.7
Qualifications: None of the above	1.3	2.8	7.9	-1.5	1.3	-1.3	2.8	0.7
Financial difficulties in last 2 years	0.7	0.9	3.6	0.2	1.0	1.9	0.1	-0.3
Mouth/teeth dental problems	1.0	1.6	3.4	0.9	-0.6	1.9	-1.8	-0.6
Heart attack	0.5	0.6	0.9	1.0	-0.9	-0.5	0.6	0.7
Allergy	0.2	0.4	0.7	0.8	-0.7	0.8	-0.3	0.5
Pain all over the body in last month	0.2	0.2	0.7	-0.0	0.5	0.1	0.8	0.2
Diabetes (self-reported)	2.1	3.2	10.2	3.2	0.8	1.1	-0.7	-1.9
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.5	-0.9	0.5	-1.0	-1.9	-1.4
Medication: Ramipril	0.6	0.7	2.1	0.3	-1.4	0.1	1.1	0.4
Medication: Simvastatin	0.1	0.2	0.4	0.3	-0.6	0.4	-0.1	-0.3
Fluid intelligence score	0.3	0.7	1.5	-0.5	1.2	0.3	-1.2	-0.4
Illnesses of siblings	1.0	1.4	4.2	-0.9	-0.9	-2.0	-0.1	-1.1
Neuroticism score	1.1	2.3	5.3	2.3	-1.2	0.1	-1.2	-1.8
Weight	1.1	5.4	17.3	4.2	0.8	2.3	-1.8	-0.4
Impedance of arm (right)	0.6	3.0	9.9	-3.1	0.9	-1.6	1.1	0.7
Arm fat percentage (right)	0.3	1.3	4.2	2.1	1.3	0.6	0.2	0.5
Trunk fat-free mass	1.8	10.5	25.7	5.1	-0.4	3.5	-3.4	-1.9
Hip circumference	0.4	1.9	6.2	2.5	1.1	1.4	-0.7	0.1
Time employed in main current job	1.8	2.1	3.2	1.3	1.6	0.9	-1.5	-1.8
Alcohol intake versus 10 years previously	1.3	1.9	6.7	-0.3	0.6	-0.8	1.4	2.6
Father’s age at death	0.3	0.4	0.7	-0.8	-0.9	0.4	-0.1	0.8
Worrier / anxious feelings	0.2	0.5	0.8	0.6	-0.9	0.6	-0.6	-0.6
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	12.7	3.6	-0.0	1.9	-0.9	-0.8
Falls in the last year	2.4	3.3	6.5	1.9	2.5	2.1	-0.1	1.3
Hair/balding pattern: Pattern 3	0.8	1.1	1.9	-0.9	1.0	-0.1	1.4	1.4
Number of live births	0.1	0.2	0.5	0.1	-0.7	0.3	-0.2	-0.6
Forced expiratory volume in 1-second (FEV1)	2.1	7.2	15.0	3.1	-1.1	2.2	-3.9	-2.3
Pulse rate	0.3	0.4	1.5	-0.6	0.4	-1.2	0.4	0.3
Happiness	0.4	0.5	0.9	0.4	0.9	-0.9	0.4	-0.7
Noisy workplace	0.7	0.9	3.0	-0.2	0.4	-1.1	0.2	-1.7
Qualifications: A levels/AS levels or equivalent	1.3	2.9	7.6	0.5	-1.5	0.4	-2.8	-2.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.1	-0.4	-0.1	-0.4	-0.5	-1.0
Mouth/teeth dental problems: Dentures	1.5	2.5	5.0	-0.1	0.9	-1.7	2.2	1.9
Asthma	1.1	2.1	7.5	-0.9	-0.5	-2.7	0.8	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	4.2	1.8	-0.4	2.0	-1.2	0.0
Medication: Cholesterol lowering	0.4	0.5	1.3	0.8	-0.7	1.2	-0.5	0.0
Depression (self-reported)	0.0	0.0	0.0	-0.1	-0.0	-0.0	0.0	0.2
Medication: Lansoprazole	0.8	0.9	2.2	1.0	-0.7	1.5	0.2	0.8
Prospective memory result	1.3	1.6	3.5	-1.1	0.1	-1.9	1.7	-0.4
Lung cancer (father)	0.3	0.3	1.1	1.0	-0.2	0.5	-0.1	0.4
Illnesses of mother	0.6	0.8	2.2	-1.5	0.9	-0.7	0.6	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	9.0	18.1	3.2	-2.1	2.6	-4.3	-2.4
Pulse wave Arterial Stiffness index	0.8	0.9	3.1	-0.3	-1.8	-0.3	0.5	-1.0
Impedance of arm (left)	1.0	4.5	12.6	-3.5	0.7	-2.4	1.8	0.7
Arm fat mass (right)	0.6	2.6	9.8	3.1	1.2	1.1	-0.8	-0.0
Trunk predicted mass	1.8	10.2	25.5	5.0	-0.3	3.4	-3.3	-1.8
Standing height	0.5	4.5	9.4	2.5	0.5	2.4	-3.1	-1.1
Length of working week for main job	1.5	1.6	3.0	-0.4	1.5	0.6	1.7	1.5
Exposure to tobacco smoke at home	0.5	0.6	1.3	1.1	0.0	0.9	0.1	-0.9
Breastfed as a baby	1.0	1.3	2.0	-1.3	0.9	-1.3	1.4	0.4
Tense / ‘highly strung’	0.2	0.3	1.2	0.4	0.2	0.3	-0.0	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.7	0.5	-0.8	-1.3	0.3	-1.1
Hair/balding pattern: Pattern 4	0.5	1.3	4.2	-0.9	-0.9	-2.0	0.5	-0.4
Birth weight of first child	0.9	1.7	3.6	1.4	1.3	0.1	-1.9	-1.0
Peak expiratory flow (PEF)	3.2	7.4	13.1	2.9	-1.8	1.6	-3.6	-3.1
Pulse wave reflection index	0.6	0.7	1.0	-1.0	-0.9	-0.7	0.9	-0.7
Ever highly irritable/argumentative for 2 days	1.6	1.9	5.8	2.4	-0.9	1.0	-0.9	-0.9
Loud music exposure frequency	0.6	0.7	3.0	0.3	-1.7	-0.1	0.5	-0.4
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.6	1.6	-0.9	0.5	-1.6	-1.3
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.9	0.2	-1.6	-1.0	-1.1	-1.7
Blood clot in the leg (DVT)	0.4	0.6	1.2	0.7	0.8	0.6	-0.4	1.1
Medication: Paracetamol	2.5	4.2	13.1	3.6	-1.0	1.9	-1.8	-0.4
Headache pain in last month	1.7	3.0	7.3	2.7	-0.6	2.3	-1.1	-0.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.2	-1.8	0.6	-0.9	0.9	0.7
Glaucoma (self-reported)	0.9	1.1	2.9	-1.0	-0.2	-1.2	0.0	-1.7
Gout (self-reported)	0.9	1.2	2.0	-1.2	-1.4	-1.3	0.7	0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	1.0	0.1	-0.2	-0.5	-0.1	-1.0
Medication: Amlodipine	0.2	0.3	0.7	0.5	-0.2	0.6	0.2	0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	0.8	-0.3	-1.2	-0.1	-0.3
Birth weight	1.1	2.4	4.8	2.2	-1.2	0.4	-1.8	-1.6
Chronic bronchitis/emphysema (mother)	1.1	1.3	4.0	-0.8	-1.0	-0.8	0.5	2.0
High blood pressure (siblings)	0.4	0.5	1.1	1.1	-0.9	0.2	-0.5	-0.6
Forced vital capacity (FVC), Best measure	1.0	3.8	11.4	1.9	-1.5	1.2	-3.4	-0.7
Body fat percentage	0.4	1.7	3.8	1.4	2.0	-0.2	1.1	1.2
Leg fat percentage (right)	0.7	2.5	4.6	1.0	1.9	-0.4	2.2	1.6
Arm fat-free mass (right)	1.4	7.1	20.3	4.5	0.4	2.5	-2.7	-1.2
Exposure to tobacco smoke outside home	0.8	1.1	3.5	-0.3	0.9	-0.8	0.8	1.9
Comparative body size at age 10	0.1	0.2	0.5	-0.1	-0.1	0.6	-0.3	-0.7
Number of full brothers	0.6	0.7	1.5	-0.7	0.2	-0.6	1.2	1.1
Worry too long after embarrassment	1.4	2.3	5.0	2.2	-0.4	1.3	-1.0	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.6	0.1	-0.7	0.2	-0.7
Wheeze or whistling in the chest in last year	1.3	2.4	4.6	-1.4	1.1	-1.3	2.1	1.6
Number of children fathered	0.4	0.4	0.9	-0.9	-0.5	-1.0	0.5	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.0	-0.7	-1.4	-0.3	-0.8	-0.3
Age at first live birth	0.7	1.2	4.6	0.3	-0.2	-0.1	-1.1	-2.1
Pulse wave peak to peak time	0.9	1.0	2.7	0.6	1.6	0.7	-1.0	0.8
Health satisfaction	2.2	2.9	10.0	3.2	-0.5	1.1	-1.2	-1.2
Shortness of breath walking on level ground	0.4	0.5	0.9	0.6	0.9	-0.4	0.9	0.7
Qualifications: College or University degree	0.8	2.6	4.8	-1.6	-2.2	-0.3	-2.0	-1.2
Eye problems/disorders: None of the above	1.4	1.6	3.2	-0.6	-1.3	-1.8	1.1	1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.0	1.0	0.5	0.7	-0.1	0.4
Emphysema/chronic bronchitis	0.2	0.2	0.5	-0.3	0.6	-0.7	0.1	0.2
Medication for pain relief, constipation, heartburn	2.5	4.2	12.3	-3.5	0.6	-2.3	1.7	0.3
Neck or shoulder pain in last month	0.5	0.7	2.1	1.1	-0.7	0.0	-1.4	0.0
Medication: Blood pressure	0.5	0.8	2.5	1.6	0.4	1.0	-0.5	-0.2
Angina (self-reported)	1.5	2.0	4.9	1.1	-1.5	2.2	0.6	1.2
Migraine (self-reported)	0.7	0.9	2.0	1.4	-0.3	1.4	-0.7	-0.2
Medication: Ibuprofen	2.5	3.0	6.0	2.4	-0.2	2.4	-1.6	-0.8
Medication: Allopurinol	0.8	1.1	2.6	-1.0	-0.8	-0.4	1.6	0.9
Medication: Omeprazole	0.6	0.7	1.4	1.0	1.2	0.9	0.3	0.2
Medication: Seretide 50 evohaler	0.7	0.8	2.7	-1.1	-0.4	-0.1	1.6	0.4
Mean time to correctly identify matches	1.3	2.5	8.2	-2.9	1.7	-0.8	0.9	0.3
Heart disease (mother)	1.4	1.8	3.6	0.9	-1.5	-0.6	-1.2	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	0.9	-0.0	-0.9	-0.3	-0.4
Whole body fat mass	0.6	2.4	8.5	2.9	1.5	0.9	-0.2	0.3
Leg fat mass (right)	0.8	3.0	10.7	3.3	1.6	1.2	0.1	0.5
Arm predicted mass (right)	1.5	7.8	21.1	4.6	0.4	2.8	-2.7	-1.6
Pulse rate, automated reading	0.4	1.3	4.2	1.1	0.1	-0.2	-1.0	-2.0
Alcohol intake frequency.	0.4	1.0	2.4	0.5	0.3	0.4	1.5	1.4
Comparative height size at age 10	0.1	0.7	1.3	1.1	-0.1	0.3	-1.1	1.0
Number of full sisters	0.6	0.8	2.2	-0.1	-1.1	-1.5	-0.5	-0.3
Suffer from ‘nerves’	1.4	2.1	6.1	1.6	-0.1	0.0	-1.4	-2.5
Overall health rating	0.9	2.0	8.4	2.9	0.2	0.6	-0.6	-0.9
Chest pain or discomfort	0.8	1.2	2.7	0.3	0.3	0.6	1.6	1.6
Had major operations	0.6	0.7	1.8	-1.4	-0.1	0.7	0.8	0.8
Age at last live birth	0.5	0.7	1.2	0.9	-0.3	1.1	-0.5	-1.0
Family relationship satisfaction	0.5	0.6	1.0	-0.7	-0.3	-0.9	1.0	-0.9
Leg pain on walking	0.7	0.9	2.2	0.7	0.2	1.5	1.1	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	0.7	0.3	0.2	0.8	0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.5	-0.7	0.7	0.2	0.5	-0.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.9	0.1	1.1	-0.3	1.0	2.0
Medication: Aspirin	0.5	0.7	2.4	1.6	-0.5	0.2	-0.7	-0.5
Supplements: Vitamin C	2.4	2.8	6.6	0.9	1.6	-0.1	-2.1	-2.6
Knee pain experienced in last month	0.5	0.8	3.1	-0.5	0.4	-1.8	0.7	-0.3
Hypertension (Self-reported)	1.3	3.5	7.9	2.8	-0.8	0.4	-1.9	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.2	7.1	2.3	0.2	2.7	-1.1	-1.6
Illnesses of father: Heart disease	1.6	2.2	4.6	1.2	-2.0	-0.7	-0.7	-2.1
Illnesses of siblings: Diabetes	1.1	1.3	5.4	0.4	0.3	0.3	0.9	2.3
Smoking status: Previous	0.6	0.9	2.2	-1.1	0.6	-0.2	1.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted	4.0	8.2	15.4	3.0	-1.4	2.1	-3.9	-3.2
Whole body fat-free mass	1.8	10.1	26.4	5.1	-0.2	3.2	-3.2	-1.9
Leg fat-free mass (right)	1.7	8.9	23.5	4.8	-0.2	2.8	-3.1	-1.8
Arm fat percentage (left)	0.3	1.2	3.6	1.9	1.4	0.3	0.4	0.3
Average weekly red wine intake	1.0	1.5	3.7	0.1	-0.0	0.8	-1.7	-1.9
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.0	-1.0	-0.4	0.1	-0.4	1.0
Mood swings	2.2	4.1	9.4	3.1	-1.1	1.1	-2.0	-2.0
Loneliness, isolation	1.9	2.6	6.0	2.4	-2.3	0.7	-0.2	-1.1
Long-standing illness, disability or infirmity	0.7	1.1	4.7	2.2	0.2	0.4	-0.0	-0.7
Ever had bowel cancer screening	0.9	1.0	2.3	-0.8	0.2	-1.4	0.2	-1.5
Diabetes diagnosed by doctor	2.1	3.5	11.7	3.4	-0.1	1.3	-1.2	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.5	1.2	0.7	0.5	-0.3	-1.0
Friendships satisfaction	0.6	0.8	1.7	-0.4	-0.9	-1.3	0.4	-1.0
Qualifications: nursing, teaching	1.1	1.8	3.2	-0.0	-1.8	-0.8	-1.4	-1.7
Commuting to job workplace: Walk	0.1	0.2	0.5	-0.0	-0.3	-0.1	0.7	0.4
Eye problems/disorders: Cataract	1.2	1.3	2.5	0.0	1.6	1.1	-1.1	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	4.6	-2.1	1.0	-1.6	1.2	-0.3
Medication for cholesterol	0.5	0.8	2.5	-0.3	-0.6	1.0	-0.1	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.7	-1.0	-0.8	0.4	0.8	1.9
Back pain experienced in last month	3.0	4.3	10.3	3.2	-0.2	0.3	-2.8	-1.9
Mineral and other dietary supplements	1.3	1.7	4.5	0.9	0.9	1.3	0.9	2.1
Breast cancer (self-reported)	0.1	0.1	0.2	0.5	0.2	-0.1	-0.2	0.5
Asthma (self-reported)	1.1	2.1	7.3	-0.8	-0.6	-2.7	0.8	-1.2
Osteoporosis (self-reported)	2.3	2.8	5.0	-2.0	0.3	-1.4	1.7	2.2
Osteoarthritis (self-reported)	0.6	0.8	2.3	1.5	-0.6	-0.4	1.0	0.2
Medication: Aspirin	0.4	0.6	2.0	1.4	-0.4	-0.2	-0.6	-0.4
Medication: Gliclazide	0.3	0.4	1.1	-0.1	0.7	0.1	0.5	1.0
Illnesses of father: None of the above (group 1)	1.4	1.7	4.3	-1.3	1.2	-0.8	0.8	2.1
Smoking status: Current	0.5	0.8	1.9	0.2	0.7	0.9	1.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	9.5	0.8	-1.5	1.0	-3.1	-1.6
Whole body water mass	1.8	10.4	27.1	5.2	-0.2	3.1	-3.3	-2.0
Leg predicted mass (right)	1.8	9.4	24.5	5.0	-0.2	2.9	-3.2	-1.9
Arm fat mass (left)	0.6	2.6	9.6	3.1	1.2	1.2	-0.7	-0.1
Number of self-reported non-cancer illnesses	0.8	1.4	4.1	2.0	-0.8	0.6	-0.7	-1.1
Average weekly champagne plus white wine intake	1.7	2.3	8.9	-3.0	0.3	-1.2	1.0	0.4
Miserableness	1.7	2.9	6.0	2.4	-1.6	0.2	-1.2	-2.1
Guilty feelings	1.3	2.0	3.4	1.8	-1.1	-0.1	-1.7	-1.5
Wears glasses or contact lenses	0.7	0.9	2.5	0.7	0.0	1.6	-0.8	-0.8
Ever taken oral contraceptive pill	0.3	0.3	0.8	-0.3	-0.9	0.5	0.6	-0.4
Hearing aid user	0.2	0.3	0.7	-0.1	-0.7	-0.8	0.2	-0.2
Mother’s age at death	0.6	0.7	2.2	-0.6	-0.3	-1.5	0.8	-0.7
Financial situation satisfaction	4.1	5.1	10.8	3.3	-0.8	2.5	-2.0	-1.9
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	-0.8	-0.6	-0.2	0.7	0.1
Commuting to job workplace: Public transport	0.8	0.9	2.2	-0.4	-1.5	-1.5	0.1	0.2
Eye problems/disorders: Glaucoma	1.3	1.5	2.9	-1.7	-0.3	-1.4	-0.1	-1.6
Medication: Blood pressure	0.3	0.6	2.0	0.7	0.1	-1.4	0.2	-0.6
Pain type(s) experienced in last month: Hip pain	1.6	2.0	7.1	2.7	-0.9	1.0	-0.7	-0.9
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.2	-0.2	-0.9	-0.1	-0.9	-1.8
High cholesterol (Self-reported)	0.3	0.6	1.1	1.0	-0.7	0.4	-0.2	-1.0
Medication: Bendroflumethiazide	0.3	0.5	2.0	0.5	0.1	-0.2	-0.6	-1.4
Medication: Paracetamol	2.7	4.1	11.9	3.5	-1.6	2.0	-1.5	0.1
Medication: Lisinopril	1.0	1.3	3.4	1.9	0.7	-0.5	-1.2	-0.9
Medication: Atorvastatin	1.1	1.4	3.5	0.3	0.2	1.9	1.2	1.4
Illnesses of father: High blood pressure	0.7	0.8	2.4	0.5	-0.5	1.5	-0.7	-0.8
Alcohol drinker status: Never	0.1	0.1	0.3	-0.1	0.5	0.4	0.2	0.2
Ever smoked	0.6	1.1	1.7	-0.9	1.1	0.5	1.3	1.3
Basal metabolic rate	1.7	9.2	25.6	5.1	0.2	3.0	-3.0	-1.6
Leg fat percentage (left)	0.7	2.6	4.2	1.1	2.1	-0.3	2.0	1.9
Arm fat-free mass (left)	1.4	7.2	20.3	4.5	0.4	2.7	-2.6	-1.0
Number of operations (self-reported)	0.6	0.9	2.3	-0.3	1.2	0.1	1.5	0.9
Average weekly beer plus cider intake	0.8	1.1	3.5	-0.5	-1.9	-1.1	0.6	-0.5
Irritability	0.2	0.4	1.6	1.3	-0.6	-0.1	0.0	0.3
Risk taking	1.3	1.9	4.9	1.3	0.2	2.2	-1.5	-0.7
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.8	1.4	-0.4	0.1	-1.2	-1.1
Fractured/broken bones in last 5 years	0.1	0.1	0.4	-0.6	-0.0	0.1	0.2	0.6
Age started oral contraceptive pill	0.5	0.7	1.6	0.6	-0.8	1.3	-0.2	0.8
Diastolic blood pressure, automated reading	0.4	1.2	1.6	1.2	0.2	-1.2	1.3	-1.1
Ever depressed for a whole week	0.3	0.4	0.8	0.8	-0.2	-0.3	-0.3	-0.9
Unable to work because of sickness or disability	2.9	3.8	5.4	2.2	2.2	2.3	-1.4	-1.4
Commuting to job workplace: Cycle	1.6	1.9	5.5	0.7	-1.2	0.4	-1.3	-2.3
Myopia	1.1	1.6	3.6	0.7	-1.9	-0.0	-0.7	-1.8
Vascular/heart problems diagnosed by doctor	1.3	3.6	8.7	-3.0	0.6	-0.4	1.7	2.4
Cholesterol lowering medication	1.3	1.9	5.0	2.2	0.5	1.7	-0.5	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.8	1.9	0.6	0.9	-0.6	-0.9
Pain experienced in last month	0.7	1.2	3.1	-1.8	1.2	0.1	0.9	0.7
Supplements: Calcium	0.1	0.1	0.2	-0.2	0.4	-0.2	-0.1	-0.1
Basal cell carcinoma (self-reported)	1.5	1.8	5.0	-1.9	0.1	-2.2	0.5	0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.6	0.9	0.9	-1.0	-0.3	0.7	0.9
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	0.5	0.8	0.4	-0.3	0.8
Heart disease (siblings)	1.2	1.4	6.1	-0.5	2.5	0.7	-0.1	0.6
Alcohol drinker status: Previous	0.4	0.5	1.7	0.1	-0.1	0.1	0.9	1.3
Pack years of smoking	0.5	0.8	2.0	0.0	0.4	-0.8	1.0	1.4
Impedance of whole body	1.4	7.0	18.5	-4.3	1.2	-2.9	2.3	1.3
Leg fat mass (left)	0.8	3.3	11.4	3.4	1.7	1.3	-0.1	0.6
Arm predicted mass (left)	1.6	8.1	22.8	4.8	0.5	3.1	-2.6	-1.0