TWAS
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Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Whole body fat-free mass
:
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→
chr2:182,305,254-184,594,404
Best TWAS P=1.31e-12 · Best GWAS P=6.14e-14 conditioned to 0.00081
182.5M
183M
183.5M
184M
184.5M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Brain Hypothalamus
PDE1A
0.24
-0.01
enet
21
-0.01
0.75800
6.0
7.1
1.3e-12
0.59
0.08
0.20
TRUE
2
GTEx
Liver
NCKAP1
0.50
-0.01
lasso
10
0.01
0.14300
4.8
6.0
2.3e-09
0.11
0.05
0.08
TRUE
3
GTEx
Skin Sun Exposed Lower leg
PDE1A
0.11
0.07
lasso
4
0.04
0.00060
5.3
-5.8
7.3e-09
-0.69
0.14
0.85
FALSE
4
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
PDE1A
0.05
0.04
blup
206
0.04
0.00005
-4.4
5.2
1.7e-07
0.42
0.65
0.02
FALSE