Hub : Genes

NCKAP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Liver 0.501 0.1250 0.00180 -0.007 NA 0.003 NA 0.012 5.8e-01 NA 0.25000 NA 0.14000
2 ROSMAP Brain Pre-frontal Cortex 0.081 0.0268 0.00013 0.020 0.02 0.021 0.024 0.020 1.1e-03 0.0011 0.00089 0.00035 0.00110
3 TCGA Liver Hepatocellular Carcinoma 0.074 0.0450 0.00780 0.092 0.03 0.038 NA 0.070 4.2e-05 0.0140 0.00680 NA 0.00034

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.9 1.5 3.1 1.8 0.4 1.1
Bipolar Disorder or Schizophrenia 0.3 0.7 1.5 0.3 1.2 -0.7
Depressed Affect (Nagel 2018) 1.0 2.1 3.5 0.7 1.9 -1.5
Depression (Nagel 2018) 1.9 2.8 5.4 -0.1 1.7 -2.3
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.8 0.5 -1.4 0.7
Neuroticism (Nagel 2018) 2.8 6.5 10.4 -0.3 3.2 -3.0
Schizophrenia (2018) 1.0 2.1 3.5 -1.1 1.3 -1.9
Schizophrenia vs Biploar Disorder 1.7 2.2 4.5 -2.1 -0.4 -1.4
Worry (Nagel 2018) 3.8 8.0 12.6 -1.0 3.6 -3.2
Alzheimer’s Disease (in mother) 2.3 2.7 7.3 2.7 0.8 0.3
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.4 0.6 0.0
Alzheimer’s Disease (including proxy) 0.8 1.1 2.9 1.7 0.6 0.1
Crohns Disease (2017) 0.6 1.3 1.7 -1.0 -1.3 1.1
Irritable Bowel Disease (IBD) 0.8 1.8 3.0 -0.4 -1.7 1.5
Ulcerative Colitis (UC) 0.5 1.0 1.4 0.2 -1.2 1.2
Major Depression (MDD) 0.8 1.0 1.3 -1.0 0.8 -1.1
Reaction Time 1.4 2.6 6.0 -0.3 2.5 -1.3
Verbal and Numeric Reasoning (VNR) 0.1 0.1 0.2 0.4 -0.5 0.2
Breast Cancer 0.0 0.0 0.0 -0.0 -0.1 -0.2
Ovarian Cancer 0.4 0.5 0.8 -0.9 -0.5 -0.7
Prostate Cancer 0.5 0.7 1.6 -1.3 -0.6 0.4
Age at First Birth 0.6 0.9 2.2 0.1 0.6 -1.5
Bipolar Disorder (2011) 0.3 0.3 0.7 0.8 0.4 -0.0
Body Mass Index (BMI) (2010) 0.1 0.2 0.3 -0.4 0.1 -0.6
Coronary Artery Disease (CAD) 0.2 0.2 0.4 -0.4 -0.6 -0.4
Crohns Disease (2012) 0.5 0.7 2.1 0.2 -0.3 1.4
Mean Putamen Volume 0.4 0.5 0.7 -0.8 -0.8 0.1
Fasting Glucose 0.4 0.4 1.2 -1.1 0.0 -0.4
HbA1C 0.3 0.4 0.5 -0.7 0.7 -0.4
HDL Cholesterol 0.1 0.2 0.5 0.7 0.1 -0.4
LDL Cholesterol 0.1 0.2 0.2 -0.5 0.4 -0.1
Lupus 1.0 1.4 2.2 -0.8 1.5 -1.2
Neuroticism (2016) 0.8 1.2 2.6 0.4 1.6 -0.9
Primary Biliary Cirrhosis 0.6 0.9 2.1 -0.3 -0.8 1.4
Rheumatoid Arthritis 0.2 0.3 0.8 0.3 0.3 -0.9
Schizophrenia (2014) 0.4 1.0 1.5 -0.9 0.8 -1.2
Triglycerides 0.2 0.3 0.6 -0.6 0.8 0.0
Type 2 Diabetes (T2D) (2012) 1.0 1.2 3.5 0.2 1.9 -0.3
Ulcerative Colitis 1.9 2.8 5.7 2.4 -0.1 1.7
Blood Eosinophil Count 0.1 0.5 1.4 0.4 1.2 -0.3
Blood Platelet Count 1.0 11.1 12.2 -3.4 3.1 -3.5
Blood Red Count 0.2 1.7 3.9 -2.0 0.4 -1.0
Blood White Count 0.1 0.8 1.3 -1.1 0.3 -1.0
Heel T-Score 3.8 30.1 46.9 2.5 -6.1 6.8
BMI 0.1 0.8 1.3 1.1 0.7 0.8
Height 1.6 31.4 52.9 7.3 -4.3 4.8
Waist Hip Ratio (WHR) 0.1 0.2 0.6 -0.4 0.7 0.2
Systolic Blood Pressure 0.1 0.7 1.3 0.4 1.2 0.8
Smoking Status 0.1 0.3 0.6 -0.2 0.4 0.7
Allergy or Eczema 0.1 0.1 0.4 0.6 -0.2 0.0
Cardiovascular Disease 2.2 7.2 9.1 -2.1 2.8 -3.0
Hypothyroidism (self reported) 0.0 0.1 0.1 -0.3 0.3 -0.3
Respiratory disease 0.7 1.6 2.7 -0.8 1.6 -1.2
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.3 0.0 0.8 -1.2
Lung FEV1/FVC ratio 0.4 2.1 3.8 0.8 -1.9 1.4
Lung FVC 0.1 0.4 0.6 -0.7 -0.0 0.8
Neuroticism 4.6 11.2 18.5 -1.1 4.3 -3.7
Chronotype (morning person) 0.9 2.2 4.5 1.0 -1.0 2.1
Hair Pigment 0.2 5.9 9.5 2.4 -1.6 3.1
Tanning 0.1 0.9 1.7 -0.9 -1.3 0.5
Hand grip strength (left) 2.3 6.0 6.4 2.5 -2.4 2.5
Number of treatments/medications taken 0.2 0.3 0.5 -0.2 0.7 -0.6
Average weekly spirits intake 0.1 0.1 0.3 -0.1 -0.6 0.1
Sensitivity / hurt feelings 0.2 0.4 0.7 0.4 0.9 -0.5
Frequency of depressed mood in last 2 weeks 2.0 2.8 5.2 1.0 2.3 -1.5
Hearing difficulty/problems: Yes 3.1 4.7 11.5 -0.1 3.4 -1.6
Relative age of first facial hair 0.1 0.2 0.4 0.5 -0.6 -0.1
Other serious medical condition/disability diagnosed by doctor 0.7 1.0 1.5 0.2 -1.2 1.2
Ever used hormone-replacement therapy (HRT) 0.8 1.0 1.7 1.0 1.3 -0.5
Ever had hysterectomy (womb removed) 0.3 0.4 0.7 0.5 -0.8 -0.3
Systolic blood pressure, automated reading 0.3 0.9 2.3 1.5 0.5 0.6
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 1.8 -1.0 1.3 -1.4
Angina 0.2 0.2 0.7 -0.0 0.1 0.8
Medication for hormone replacement therapy 1.1 1.3 2.5 -0.3 1.6 -1.1
Vitamin and mineral supplements 0.7 0.9 1.8 0.8 -0.7 1.3
Supplements: Zinc 0.8 0.9 2.0 1.4 -0.5 0.7
Medication: Co-codamol 0.5 0.6 1.1 -0.9 0.2 1.1
Medication: Metformin 1.8 2.6 4.9 0.2 1.7 -2.2
Diabetes (father) 0.2 0.2 0.3 0.6 0.4 0.5
Diabetes (mother) 2.1 2.7 4.3 -1.4 1.4 -2.1
Severe depression (siblings) 1.4 1.6 2.7 -0.5 1.4 -1.6
Pack years adult smoking proportion 0.1 0.2 0.2 0.5 0.4 0.3
Impedance of leg (right) 0.3 1.6 4.0 -2.0 -0.3 0.8
Leg fat-free mass (left) 1.6 8.7 23.0 4.8 -1.1 1.3
Trunk fat percentage 0.1 0.3 0.6 -0.8 0.5 0.1
Hand grip strength (right) 0.9 2.4 4.1 0.9 -2.0 1.5
Townsend deprivation index at recruitment 0.7 1.0 2.2 -1.5 -0.1 0.9
Current tobacco smoking 0.3 0.6 0.9 -0.9 0.9 -0.0
Average weekly fortified wine intake 1.8 2.1 3.0 1.7 -1.6 0.9
Maternal smoking around birth 1.3 1.9 5.2 -0.1 2.3 -0.7
Fed-up feelings 1.2 2.1 4.3 0.8 2.1 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 2.3 3.1 4.5 0.5 2.1 -2.1
Relative age voice broke 0.3 0.5 1.4 -0.2 -0.2 -1.2
Taking other prescription medications 0.3 0.5 0.8 0.4 0.7 -0.9
Age when periods started (menarche) 3.2 7.6 14.5 -3.8 1.3 -2.6
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 0.8 -0.8 0.7 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 3.6 8.1 13.6 0.6 -3.2 3.7
Tinnitus: Yes, but not now, but have in the past 3.2 3.4 4.7 -2.2 1.5 -1.8
Qualifications: CSEs or equivalent 3.3 4.3 7.6 -2.8 2.1 -1.0
Serious illness, injury or assault to yourself 0.0 0.0 0.0 -0.2 -0.1 -0.2
High blood pressure 2.9 8.0 9.1 -2.5 3.0 -3.0
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.1 0.2 0.3 0.2
Multivitamins +/- minerals 0.7 0.9 2.3 -0.0 0.6 -1.5
Stomach or abdominal pain in last month 0.4 0.6 1.0 1.0 0.7 -0.3
Supplements: Glucosamine 0.1 0.2 0.2 0.4 -0.4 -0.4
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.1 -0.7 -0.6 -1.0
Medication: Atenolol 1.5 1.9 2.5 -1.3 1.2 -1.6
Medication: Levothyroxine sodium 0.6 0.9 1.3 -0.6 1.1 -1.1
Sitting height 1.6 11.5 20.4 4.5 -2.3 3.0
Chronic bronchitis/emphysema (father) 1.3 1.5 4.0 0.7 2.0 -0.4
High blood pressure (mother) 0.8 1.1 2.9 -1.7 -0.4 -0.5
Body mass index (BMI) 0.2 0.9 1.7 1.3 1.1 0.2
Impedance of leg (left) 0.6 2.7 8.0 -2.8 -0.2 0.5
Leg predicted mass (left) 1.5 8.2 22.0 4.7 -1.0 1.2
Trunk fat mass 0.1 0.4 0.9 1.0 -0.2 0.6
Waist circumference 0.3 1.0 2.5 1.6 0.7 0.3
Number of incorrect matches in round 0.1 0.1 0.2 0.2 -0.0 -0.5
Past tobacco smoking 0.1 0.2 0.3 0.0 0.5 -0.4
Alcohol usually taken with meals 0.3 0.5 0.8 0.9 -0.8 0.4
Nervous feelings 4.4 8.3 11.1 -2.1 3.1 -3.3
Frequency of tenseness / restlessness in last 2 weeks 2.6 4.0 8.0 0.1 2.8 -2.0
Hearing difficulty/problems with background noise 2.2 3.6 8.7 1.0 3.0 -1.0
Hair/balding pattern: Pattern 2 0.9 1.1 2.8 -0.4 -1.7 0.6
Had menopause 0.4 0.5 1.2 1.1 -0.5 -0.1
Had other major operations 1.6 1.9 4.1 0.1 2.0 -1.3
Forced vital capacity (FVC) 0.9 3.6 5.2 2.3 -1.4 1.9
Heel bone mineral density (BMD) T-score, automated (right) 2.3 5.2 8.1 0.3 -2.9 2.7
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 1.9 0.9 0.4 -1.4
Qualifications: None of the above 0.1 0.3 0.7 -0.8 0.3 0.2
Financial difficulties in last 2 years 0.6 0.8 1.6 0.1 0.9 -1.3
Mouth/teeth dental problems 0.5 0.7 1.7 1.3 -0.0 0.7
Heart attack 0.5 0.7 1.7 -0.1 -1.3 0.6
Allergy 0.1 0.2 0.4 0.6 -0.5 -0.4
Pain all over the body in last month 0.0 0.0 0.0 -0.0 0.1 0.2
Diabetes (self-reported) 0.6 0.9 2.6 1.6 -0.0 -0.2
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.5 0.3 0.7 0.4
Medication: Ramipril 0.3 0.4 0.8 0.5 0.9 0.5
Medication: Simvastatin 1.1 1.7 2.7 0.6 -1.4 1.6
Fluid intelligence score 1.0 2.1 2.8 0.9 -1.6 1.7
Illnesses of siblings 0.1 0.2 0.3 -0.6 0.3 -0.3
Neuroticism score 3.6 7.6 12.0 -0.4 3.5 -3.2
Weight 1.1 5.3 13.4 3.7 -0.8 1.4
Impedance of arm (right) 1.0 4.8 13.8 -3.7 -0.7 0.1
Arm fat percentage (right) 0.1 0.5 1.5 0.2 1.2 -0.0
Trunk fat-free mass 2.7 15.5 41.0 6.4 -1.6 1.7
Hip circumference 0.5 2.0 5.3 2.3 0.5 0.6
Time employed in main current job 1.6 1.9 3.8 2.0 1.1 -0.7
Alcohol intake versus 10 years previously 1.8 2.7 7.1 -0.4 -2.7 0.9
Father’s age at death 0.8 1.0 1.9 1.4 0.4 -1.0
Worrier / anxious feelings 2.6 4.9 9.9 -0.2 3.1 -2.2
Frequency of tiredness / lethargy in last 2 weeks 1.2 1.9 3.4 0.7 1.4 -1.8
Falls in the last year 0.4 0.5 0.7 -0.8 0.7 0.6
Hair/balding pattern: Pattern 3 2.4 3.6 9.0 -0.9 1.0 -3.0
Number of live births 0.0 0.0 0.1 0.2 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1) 1.1 3.7 6.0 2.4 -1.6 1.7
Pulse rate 0.4 0.6 1.7 -1.3 0.1 0.4
Happiness 0.8 1.0 1.8 0.1 1.4 -1.0
Noisy workplace 1.7 2.1 6.0 -0.3 0.5 -2.4
Qualifications: A levels/AS levels or equivalent 1.7 3.7 7.4 2.7 -0.5 1.9
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 0.9 0.9 1.0 -0.0
Mouth/teeth dental problems: Dentures 0.5 0.9 1.4 -1.2 0.9 -0.8
Asthma 0.8 1.5 1.7 -1.3 1.3 -1.1
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.1 4.3 0.5 2.1 -1.3
Medication: Cholesterol lowering 0.1 0.1 0.2 0.5 -0.2 0.4
Depression (self-reported) 1.7 2.1 4.3 -0.8 1.1 -2.1
Medication: Lansoprazole 1.1 1.3 2.5 1.6 -0.1 1.1
Prospective memory result 0.1 0.1 0.3 -0.1 0.3 -0.5
Lung cancer (father) 0.5 0.6 1.3 0.1 -1.1 0.7
Illnesses of mother 1.0 1.3 3.0 -1.7 0.8 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.1 6.5 2.5 -0.8 1.4
Pulse wave Arterial Stiffness index 0.7 0.9 2.0 1.4 0.3 -0.7
Impedance of arm (left) 1.4 6.3 17.7 -4.2 -1.0 -0.2
Arm fat mass (right) 0.3 1.2 3.2 1.8 0.4 0.5
Trunk predicted mass 2.7 15.5 41.0 6.4 -1.6 1.7
Standing height 1.9 19.0 31.5 5.6 -4.1 2.9
Length of working week for main job 0.2 0.2 0.4 0.7 -0.4 0.3
Exposure to tobacco smoke at home 0.6 0.6 1.8 0.3 -0.2 1.3
Breastfed as a baby 5.9 7.4 8.9 2.9 -3.0 2.3
Tense / ‘highly strung’ 4.9 8.2 14.8 -0.1 3.8 -3.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 1.9 0.2 -0.1 -1.4
Hair/balding pattern: Pattern 4 1.5 3.5 5.5 2.4 -0.6 2.2
Birth weight of first child 0.6 1.0 1.6 1.3 -0.8 0.9
Peak expiratory flow (PEF) 1.0 2.4 3.7 0.9 -1.9 1.7
Pulse wave reflection index 0.9 1.1 2.3 1.5 -1.0 -0.0
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.6 -0.5 0.8 -0.3
Loud music exposure frequency 2.2 2.4 4.7 0.1 1.6 -2.2
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.4 0.5 0.7 -0.2
Mouth/teeth dental problems: Bleeding gums 1.2 1.5 1.8 -1.3 1.4 -1.0
Blood clot in the leg (DVT) 0.2 0.2 0.4 -0.7 0.0 0.4
Medication: Paracetamol 1.7 2.8 3.2 1.7 1.8 -1.5
Headache pain in last month 1.0 1.7 2.0 -1.1 1.4 -1.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.4 0.6 -0.5 0.6
Glaucoma (self-reported) 3.1 3.7 5.3 1.1 -2.3 2.1
Gout (self-reported) 0.2 0.3 1.0 -0.1 1.0 0.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.2 -0.5 -0.3 -0.3
Medication: Amlodipine 0.2 0.3 0.5 -0.6 0.7 0.2
Medication: Ventolin 100micrograms inhaler 1.8 2.3 3.5 -1.8 -0.2 -1.9
Birth weight 0.3 0.7 1.3 1.1 -0.5 0.7
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.7 0.8 -0.4 0.2
High blood pressure (siblings) 0.6 0.9 1.7 -1.3 0.8 -0.6
Forced vital capacity (FVC), Best measure 0.7 2.4 5.4 2.3 -0.5 1.2
Body fat percentage 0.0 0.2 0.4 -0.3 0.7 0.2
Leg fat percentage (right) 0.2 0.8 1.5 0.8 1.2 0.6
Arm fat-free mass (right) 2.6 13.1 34.3 5.9 -1.5 1.7
Exposure to tobacco smoke outside home 5.9 7.8 10.7 -3.3 2.5 -2.6
Comparative body size at age 10 0.8 2.3 4.8 1.3 -2.2 0.7
Number of full brothers 4.7 5.9 8.8 3.0 -1.5 2.5
Worry too long after embarrassment 1.2 2.1 3.0 1.0 1.5 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 1.8 1.2 0.4 -1.3
Wheeze or whistling in the chest in last year 1.0 1.7 4.7 -0.3 2.2 -0.6
Number of children fathered 2.8 3.1 5.2 -0.7 1.9 -2.3
Reason for reducing amount of alcohol drunk: Health precaution 6.7 7.9 13.1 -2.2 2.4 -3.6
Age at first live birth 0.1 0.1 0.2 -0.5 -0.4 -0.1
Pulse wave peak to peak time 0.8 0.9 1.3 -1.1 -0.6 1.0
Health satisfaction 0.6 0.8 1.8 1.4 0.6 -0.5
Shortness of breath walking on level ground 3.7 4.3 7.2 -1.8 2.7 -1.6
Qualifications: College or University degree 1.0 3.0 7.9 2.8 -0.7 0.8
Eye problems/disorders: None of the above 1.1 1.3 2.5 -1.1 1.6 -0.5
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.6 0.3 0.4 -1.6
Emphysema/chronic bronchitis 0.1 0.1 0.4 -0.6 -0.0 -0.1
Medication for pain relief, constipation, heartburn 2.2 3.8 6.3 -0.1 -2.3 2.5
Neck or shoulder pain in last month 0.5 0.7 1.8 1.3 0.5 -0.1
Medication: Blood pressure 0.7 1.3 2.1 -1.1 0.8 -1.4
Angina (self-reported) 0.2 0.2 0.7 0.2 0.0 0.8
Migraine (self-reported) 1.2 1.5 2.4 1.6 -0.4 1.4
Medication: Ibuprofen 2.1 2.6 5.2 -0.0 2.3 -1.6
Medication: Allopurinol 0.0 0.1 0.1 0.3 0.2 -0.2
Medication: Omeprazole 3.8 4.6 7.8 -0.0 2.8 -2.4
Medication: Seretide 50 evohaler 1.8 2.1 6.1 -2.5 0.1 -0.5
Mean time to correctly identify matches 0.7 1.3 2.5 -0.2 1.6 -1.2
Heart disease (mother) 0.3 0.4 0.6 0.6 -0.5 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.1 -0.7 -1.1 -0.4
Whole body fat mass 0.3 1.1 2.3 1.5 -0.3 0.9
Leg fat mass (right) 0.4 1.7 4.4 2.1 0.4 0.8
Arm predicted mass (right) 2.5 12.5 33.1 5.8 -1.3 1.7
Pulse rate, automated reading 0.2 0.7 1.6 -1.3 0.3 0.5
Alcohol intake frequency. 0.5 1.0 3.1 -1.8 0.2 -0.2
Comparative height size at age 10 2.8 15.4 36.6 6.0 -2.1 2.3
Number of full sisters 0.2 0.3 0.6 -0.3 0.2 -0.8
Suffer from ‘nerves’ 3.1 4.9 8.7 -0.6 2.4 -3.0
Overall health rating 0.2 0.5 1.1 -0.4 0.2 -1.1
Chest pain or discomfort 0.0 0.0 0.0 -0.2 0.2 0.1
Had major operations 1.1 1.3 3.0 0.9 -1.7 0.5
Age at last live birth 1.2 1.8 3.3 -1.8 1.2 -0.7
Family relationship satisfaction 0.1 0.2 0.3 0.5 -0.5 0.1
Leg pain on walking 1.0 1.3 1.9 -0.7 1.4 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.6 0.2 0.8 -0.3
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.3 0.5 0.5 -0.4
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.0 -1.0 -0.7 0.3
Medication: Aspirin 0.7 0.9 2.6 -1.6 0.1 -0.3
Supplements: Vitamin C 0.1 0.1 0.1 0.2 0.1 0.4
Knee pain experienced in last month 1.7 2.7 6.5 2.6 0.5 1.1
Hypertension (Self-reported) 3.3 9.2 12.3 -2.2 3.5 -3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.6 4.2 2.1 0.4 0.6
Illnesses of father: Heart disease 1.3 1.8 2.7 -1.7 0.2 -1.7
Illnesses of siblings: Diabetes 1.7 2.1 6.2 2.5 0.2 0.4
Smoking status: Previous 0.2 0.3 0.6 0.2 -0.8 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 2.6 1.6 0.9 -0.4
Whole body fat-free mass 2.4 13.6 35.6 6.0 -1.5 1.7
Leg fat-free mass (right) 1.5 7.8 20.7 4.5 -1.1 1.1
Arm fat percentage (left) 0.1 0.4 1.1 -0.2 1.0 -0.1
Average weekly red wine intake 1.2 1.8 4.3 2.1 -0.6 0.9
Handedness (chirality/laterality): Left-handed 0.4 0.4 0.5 -0.6 0.7 -0.6
Mood swings 0.1 0.1 0.2 -0.4 0.2 -0.3
Loneliness, isolation 2.3 3.2 4.8 -0.6 2.2 -2.1
Long-standing illness, disability or infirmity 0.1 0.1 0.3 -0.0 0.6 -0.3
Ever had bowel cancer screening 0.1 0.2 0.3 -0.2 0.4 -0.5
Diabetes diagnosed by doctor 0.4 0.6 0.8 0.7 0.6 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.4 0.5 1.2 -0.4
Friendships satisfaction 0.7 0.9 1.1 1.0 -0.8 1.0
Qualifications: nursing, teaching 0.5 0.8 1.3 1.1 -0.8 0.7
Commuting to job workplace: Walk 0.3 0.4 0.5 -0.7 0.4 -0.6
Eye problems/disorders: Cataract 1.1 1.2 2.0 0.5 -1.2 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 1.6 1.3 -0.8 1.1
Medication for cholesterol 0.6 0.9 1.9 0.5 -1.4 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.3 0.1 1.1 -1.1
Back pain experienced in last month 1.7 2.5 3.4 1.7 -1.2 1.8
Mineral and other dietary supplements 0.5 0.7 1.2 1.1 0.9 -0.3
Breast cancer (self-reported) 0.9 1.1 1.6 1.3 -0.3 1.2
Asthma (self-reported) 0.8 1.5 2.5 -1.6 1.2 -0.9
Osteoporosis (self-reported) 1.9 2.3 2.7 -1.5 1.4 -1.6
Osteoarthritis (self-reported) 0.4 0.5 1.1 1.1 0.5 -0.1
Medication: Aspirin 0.9 1.2 3.0 -1.7 0.4 -0.6
Medication: Gliclazide 0.3 0.4 0.6 -0.8 -0.0 -0.7
Illnesses of father: None of the above (group 1) 2.3 2.8 3.6 1.8 -1.3 1.9
Smoking status: Current 0.3 0.5 0.8 -0.8 0.9 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.8 0.2 1.7 -0.4
Whole body water mass 2.3 13.1 34.9 5.9 -1.4 1.6
Leg predicted mass (right) 1.5 7.9 21.0 4.6 -1.2 1.2
Arm fat mass (left) 0.3 1.3 3.3 1.8 0.3 0.6
Number of self-reported non-cancer illnesses 1.6 2.7 5.2 0.0 2.3 -1.7
Average weekly champagne plus white wine intake 0.1 0.1 0.3 -0.1 -0.0 -0.5
Miserableness 3.1 5.3 10.0 -1.0 3.2 -2.2
Guilty feelings 5.1 7.7 12.7 1.0 3.6 -3.1
Wears glasses or contact lenses 1.7 1.9 3.3 1.2 -1.1 1.8
Ever taken oral contraceptive pill 0.8 0.9 2.0 -0.8 1.4 -0.1
Hearing aid user 0.1 0.1 0.2 -0.3 0.1 0.4
Mother’s age at death 0.4 0.5 0.8 0.1 -0.9 -0.8
Financial situation satisfaction 1.4 1.8 2.0 -1.2 1.4 -1.4
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.3 1.5 -0.5 0.3
Commuting to job workplace: Public transport 0.5 0.6 0.9 -1.0 -0.9 -0.0
Eye problems/disorders: Glaucoma 0.9 1.0 1.6 0.4 -1.3 1.1
Medication: Blood pressure 0.6 1.1 1.9 -1.1 1.4 -0.5
Pain type(s) experienced in last month: Hip pain 1.8 2.2 4.2 2.1 1.5 -0.3
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.7 -0.8 -0.1 0.8
High cholesterol (Self-reported) 0.2 0.3 0.6 0.6 -0.7 0.0
Medication: Bendroflumethiazide 3.9 6.0 12.7 -3.6 1.3 -1.9
Medication: Paracetamol 1.1 1.7 3.2 1.8 1.1 -0.9
Medication: Lisinopril 0.5 0.6 1.4 -0.6 1.2 -0.3
Medication: Atorvastatin 0.2 0.2 0.6 -0.8 -0.2 -0.2
Illnesses of father: High blood pressure 1.0 1.3 1.5 -1.2 1.0 -1.2
Alcohol drinker status: Never 0.3 0.4 0.9 -1.0 0.4 -0.2
Ever smoked 0.1 0.2 0.5 -0.3 -0.2 -0.7
Basal metabolic rate 2.0 11.1 29.7 5.5 -1.1 1.5
Leg fat percentage (left) 0.2 0.8 2.3 0.3 1.5 0.3
Arm fat-free mass (left) 2.6 13.2 36.0 6.0 -1.0 1.6
Number of operations (self-reported) 1.3 2.0 3.7 0.2 1.5 -1.9
Average weekly beer plus cider intake 1.0 1.4 2.4 -1.1 1.5 -0.8
Irritability 5.4 9.2 14.6 0.0 3.8 -3.6
Risk taking 0.3 0.5 1.3 -0.3 -1.1 -0.1
Ever had prostate specific antigen (PSA) test 2.4 2.8 4.8 1.3 1.4 -2.2
Fractured/broken bones in last 5 years 0.8 1.1 2.2 -1.5 0.4 -0.9
Age started oral contraceptive pill 0.5 0.6 1.7 -0.0 -1.3 0.4
Diastolic blood pressure, automated reading 0.7 2.1 5.0 0.6 2.2 -1.0
Ever depressed for a whole week 2.2 2.7 6.7 0.7 1.0 -2.6
Unable to work because of sickness or disability 0.3 0.4 0.8 0.4 -0.4 0.9
Commuting to job workplace: Cycle 1.4 1.7 3.5 0.1 1.9 -1.3
Myopia 1.2 1.7 3.1 -0.9 -1.8 1.1
Vascular/heart problems diagnosed by doctor 2.5 6.8 7.7 2.6 -2.4 2.8
Cholesterol lowering medication 0.6 0.9 1.4 -1.2 -0.9 0.7
Medication: Omeprazole (e.g. Zanprol) 2.0 2.4 4.2 0.9 2.1 -1.5
Pain experienced in last month 2.0 3.3 8.0 -2.8 0.2 -1.4
Supplements: Calcium 0.1 0.1 0.1 0.1 0.2 0.4
Basal cell carcinoma (self-reported) 2.2 2.6 3.0 -1.5 1.7 -1.6
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.8 -0.1 -0.9 0.1
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.5 -0.4 -0.4 0.7
Heart disease (siblings) 1.1 1.3 3.2 -0.2 -1.8 0.8
Alcohol drinker status: Previous 0.2 0.2 0.4 -0.6 0.4 0.1
Pack years of smoking 0.1 0.2 0.5 0.1 -0.1 0.7
Impedance of whole body 1.2 6.1 18.1 -4.2 -0.6 -0.1
Leg fat mass (left) 0.4 1.4 3.4 1.9 0.6 0.7
Arm predicted mass (left) 2.6 13.0 35.0 5.9 -1.1 1.7