Best TWAS P=1.02e-09 · Best GWAS P=3.36e-09 conditioned to 0.000945
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | METTL21A | 0.10 | 0.02 | lasso | 4 | 0.02 | 1.6e-02 | -4.8 | 5.7 | 1.4e-08 | 0.32 | 0.20 | 0.18 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CREB1 | 0.15 | 0.00 | enet | 7 | 0.00 | 2.8e-01 | -4.8 | -6.1 | 1.0e-09 | -0.50 | 0.14 | 0.42 | TRUE |
| 3 | GTEx | Esophagus Mucosa | METTL21A | 0.10 | 0.10 | enet | 9 | 0.12 | 1.8e-08 | -4.8 | 5.1 | 2.9e-07 | 0.57 | 0.49 | 0.50 | FALSE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CREB1 | 0.03 | 0.01 | blup | 64 | 0.01 | 2.5e-02 | -5.1 | -5.3 | 1.3e-07 | -0.49 | 0.11 | 0.46 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FAM119A | 0.04 | 0.02 | blup | 51 | 0.03 | 1.0e-06 | -4.6 | 5.3 | 1.1e-07 | 0.64 | 0.03 | 0.96 | FALSE |