Best TWAS P=4.96e-10 · Best GWAS P=7.65e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SPTY2D1 | 0.18 | 0.14 | lasso | 5 | 0.14 | 6.7e-12 | -5.6 | 5.7 | 1.6e-08 | 0.54 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Aorta | SPTY2D1 | 0.13 | 0.17 | enet | 10 | 0.16 | 2.5e-09 | 5.8 | 6.2 | 5.0e-10 | 0.97 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | SPTY2D1 | 0.31 | 0.27 | lasso | 6 | 0.26 | 2.5e-19 | 5.6 | 5.5 | 4.7e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | SPTY2D1-AS1 | 0.14 | 0.12 | lasso | 6 | 0.11 | 9.0e-09 | 5.6 | 5.1 | 2.9e-07 | 0.99 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | SPTY2D1 | 0.06 | 0.07 | lasso | 2 | 0.06 | 1.5e-07 | 5.8 | 5.8 | 6.9e-09 | 1.00 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SPTY2D1 | 0.03 | 0.00 | blup | 43 | 0.01 | 2.0e-02 | 5.8 | 5.6 | 2.6e-08 | 0.93 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SPTY2D1 | 0.14 | 0.20 | lasso | 3 | 0.20 | 4.4e-21 | 5.8 | 5.7 | 1.2e-08 | 1.00 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | SPTY2D1 | 0.10 | 0.09 | lasso | 3 | 0.09 | 3.2e-09 | 5.6 | 5.5 | 4.2e-08 | 1.00 | 0.01 | 0.99 | FALSE |