TWAS hub - SPTY2D1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1840	0.0540	1.4e-04	0.142	NA	0.139	NA	0.145	1.1e-11	NA	1.8e-11	NA	6.7e-12
2	GTEx	Artery Aorta	0.1290	0.0570	9.5e-03	0.168	NA	0.164	NA	0.160	1.5e-09	NA	2.5e-09	NA	3.7e-09
3	GTEx	Cells Transformed fibroblasts	0.3130	0.0580	1.0e-10	0.266	NA	0.253	NA	0.257	5.2e-20	NA	5.7e-19	NA	2.5e-19
4	GTEx	Liver	0.3290	0.1030	2.6e-03	-0.004	NA	0.001	NA	-0.002	4.5e-01	NA	3.1e-01	NA	3.8e-01
5	TCGA	Breast Invasive Carcinoma	0.0264	0.0117	2.1e-05	0.020	0.025	0.028	NA	0.028	5.1e-05	4.8e-06	1.9e-06	NA	1.4e-06
6	TCGA	Colon Adenocarcinoma	0.0500	0.0270	2.5e-03	0.047	0.039	0.050	NA	0.053	9.8e-04	2.5e-03	7.3e-04	NA	5.2e-04
7	TCGA	Lung Adenocarcinoma	0.0600	0.0242	8.5e-06	0.066	0.052	0.053	NA	0.060	3.1e-08	9.0e-07	7.4e-07	NA	1.5e-07
8	TCGA	Lung Squamous Cell Carcinoma	0.0338	0.0173	6.7e-04	0.003	0.010	0.003	NA	0.004	1.4e-01	2.0e-02	1.2e-01	NA	9.0e-02
9	TCGA	Prostate Adenocarcinoma	0.1352	0.0395	2.8e-16	0.205	0.174	0.202	NA	0.205	4.0e-21	7.6e-18	1.0e-20	NA	4.4e-21
10	TCGA	Thyroid Carcinoma	0.1020	0.0440	4.7e-07	0.092	0.067	0.059	NA	0.092	2.8e-09	4.6e-07	2.1e-06	NA	3.2e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	5	6	7	8	9	10
LDL Cholesterol	13.7	21.7	29.7	-3.9	-5.0	-5.2	-4.8	-4.6	-5.0	-5.4	-5.0	-5.1
Sensitivity / hurt feelings	7.0	12.0	15.4	-3.5	-3.9	-3.9	-3.2	-3.4	-3.8	-3.6	-3.8	-3.8
Height	6.6	126.4	171.6	8.4	13.1	12.6	10.9	11.1	12.7	11.8	12.8	12.5
Coronary Artery Disease (CAD)	6.4	7.6	11.4	-2.9	-3.0	-2.9	-2.9	-2.6	-2.8	-3.4	-2.8	-2.8
Breast Cancer	6.2	14.8	19.3	2.9	4.0	4.2	4.4	4.2	4.3	4.0	4.2	4.2
Mouth/teeth dental problems: Dentures	5.7	9.6	12.4	-3.2	-3.2	-3.2	-3.3	-3.4	-3.3	-3.5	-3.3	-3.1
Medication: Cholesterol lowering	5.7	8.9	13.4	-3.7	-2.9	-3.1	-3.1	-3.0	-3.1	-3.5	-3.0	-3.0
Trunk predicted mass	5.5	31.6	45.2	5.9	6.7	6.0	5.0	4.9	6.2	6.2	6.2	6.0
Commuting to job workplace: Walk	5.5	5.9	9.1	1.7	2.3	2.6	2.9	3.0	2.5	2.7	2.6	2.5
Trunk fat-free mass	5.4	30.9	44.1	5.8	6.6	6.0	4.9	4.8	6.2	6.1	6.1	6.0
Sitting height	5.3	37.6	52.1	6.1	7.2	6.6	5.5	5.5	6.7	7.0	6.8	6.5
Standing height	4.7	47.0	64.3	6.9	8.0	7.3	6.4	6.6	7.5	7.4	7.5	7.2
High cholesterol (Self-reported)	4.7	8.3	13.8	-2.8	-2.8	-2.9	-3.7	-2.7	-3.3	-3.0	-3.0	-2.9
Whole body fat-free mass	4.6	26.3	38.1	5.6	6.2	5.5	4.5	4.2	5.8	5.6	5.7	5.5
Whole body water mass	4.6	26.5	38.7	5.7	6.2	5.5	4.5	4.2	5.8	5.6	5.7	5.5
Basal metabolic rate	4.1	22.5	33.2	5.3	5.8	5.0	4.1	3.8	5.4	5.1	5.3	5.0
Arm predicted mass (left)	3.9	19.9	28.7	5.3	5.4	4.7	3.6	3.6	4.9	5.0	4.8	4.6
Leg fat-free mass (left)	3.7	19.5	28.3	5.0	5.3	4.6	4.0	3.4	5.1	4.6	4.9	4.7
Arm fat-free mass (left)	3.7	19.0	28.1	4.9	5.3	4.6	3.6	3.5	4.8	4.8	4.8	4.6
Leg predicted mass (left)	3.6	19.1	27.6	4.8	5.2	4.5	4.0	3.4	5.1	4.6	4.9	4.6
Comparative height size at age 10	3.6	20.0	30.9	4.2	5.6	5.0	3.8	3.8	5.1	4.6	5.2	4.9
Financial situation satisfaction	3.5	4.3	5.9	-1.3	-2.2	-2.3	-2.4	-2.4	-2.2	-2.0	-2.3	-2.2
Arm predicted mass (right)	3.4	17.5	25.8	4.9	5.1	4.4	3.5	3.1	4.6	4.8	4.5	4.3
Hand grip strength (left)	3.3	8.6	14.5	3.1	3.8	3.1	2.1	3.0	2.8	3.8	3.0	2.9
Medication for cholesterol, blood pressure or diabetes	3.3	5.5	8.1	2.0	2.5	2.6	2.4	2.6	2.4	2.8	2.4	2.4
Arm fat-free mass (right)	3.3	16.8	25.3	4.7	5.0	4.3	3.4	3.2	4.5	4.6	4.4	4.3
Leg fat-free mass (right)	3.3	17.8	26.1	4.8	5.1	4.4	3.7	3.1	4.9	4.5	4.7	4.4
Leg predicted mass (right)	3.3	17.7	25.6	4.9	5.1	4.4	3.7	3.0	4.9	4.5	4.7	4.4
Medication: Simvastatin	3.2	4.7	8.4	-1.5	-2.0	-2.4	-2.9	-2.3	-2.4	-2.2	-2.3	-2.4
Age started oral contraceptive pill	3.2	4.0	7.2	-2.7	-2.1	-1.9	-1.9	-1.3	-2.3	-2.5	-2.1	-1.9
Eye problems/disorders: Glaucoma	3.1	3.6	5.9	0.8	2.2	2.3	1.6	1.8	2.3	1.6	2.4	2.4
Blood clot in the leg (DVT)	2.9	3.8	5.9	0.3	2.1	2.4	1.8	1.8	2.2	2.2	2.4	2.4
Mouth/teeth dental problems: Loose teeth	2.9	3.5	5.5	0.8	2.3	2.1	2.1	1.9	2.1	1.8	2.1	2.1
Mood swings	2.9	5.3	8.9	-3.0	-2.2	-2.4	-1.9	-2.6	-2.4	-2.5	-2.4	-2.3
Medication: Atorvastatin	2.8	3.5	6.4	-2.5	-1.8	-1.8	-2.1	-1.7	-2.1	-1.9	-1.9	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	4.9	1.2	1.9	2.0	1.8	1.5	2.2	1.6	2.2	2.1
Commuting to job workplace: Car/motor vehicle	2.7	3.1	5.2	-0.9	-2.3	-1.9	-1.8	-1.7	-2.0	-2.0	-1.9	-1.9
Deep venous thrombosis (DVT) (self-reported)	2.7	3.5	5.2	0.4	1.9	2.3	1.8	1.8	2.1	2.2	2.2	2.3
Type 2 Diabetes (T2D) (2012)	2.6	3.1	5.0	2.2	1.9	1.9	1.8	2.0	1.5	1.6	1.7	1.9
Cardiovascular Disease	2.6	8.6	11.2	-2.1	-3.0	-3.3	-3.3	-3.2	-3.2	-3.0	-3.2	-3.2
Triglycerides	2.4	3.9	6.0	-1.1	-2.0	-2.1	-2.1	-2.4	-2.1	-2.3	-2.1	-2.0
Worry too long after embarrassment	2.4	4.0	5.5	-1.3	-2.3	-2.3	-1.8	-1.8	-2.2	-2.2	-2.3	-2.4
Migraine (self-reported)	2.4	3.0	7.1	-1.3	-1.4	-1.7	-2.7	-1.8	-1.9	-1.9	-1.8	-1.7
Vitamin and mineral supplements	2.3	3.1	4.6	-1.4	-1.7	-1.9	-2.1	-1.8	-2.0	-1.8	-2.0	-2.0
Pulse wave reflection index	2.2	2.7	4.2	-0.1	-1.5	-2.0	-1.9	-1.4	-2.0	-1.7	-2.0	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	5.2	1.1	1.5	1.6	2.2	2.3	1.6	1.7	1.6	1.5
Pulse wave peak to peak time	2.1	2.5	3.8	1.2	1.5	1.8	2.0	1.7	1.8	1.6	1.7	1.8
Number of self-reported non-cancer illnesses	2.1	3.6	5.9	-2.4	-1.6	-1.9	-2.4	-1.7	-2.1	-1.9	-1.9	-1.9
Waist Hip Ratio (WHR)	2.0	9.0	13.7	-2.3	-3.7	-3.3	-2.8	-2.3	-3.6	-3.2	-3.5	-3.4
Weight	2.0	9.8	14.9	3.6	3.9	3.3	2.5	2.3	3.7	3.2	3.6	3.4
Heart disease (siblings)	2.0	2.5	3.3	-1.7	-1.6	-1.8	-1.6	-1.5	-1.7	-1.6	-1.6	-1.7
Systolic blood pressure, automated reading	1.9	5.4	9.2	-2.8	-3.0	-2.5	-1.9	-1.9	-2.4	-2.5	-2.5	-2.5
Hand grip strength (right)	1.9	5.1	9.1	2.3	2.9	2.3	2.0	2.1	2.2	3.0	2.3	2.2
Ovarian Cancer	1.8	2.4	3.5	-1.0	-1.7	-1.8	-1.6	-1.1	-1.9	-1.8	-1.8	-1.7
Taking other prescription medications	1.8	2.8	4.0	-1.6	-1.7	-1.8	-2.0	-1.6	-1.8	-1.9	-1.8	-1.8
Breast cancer (self-reported)	1.8	2.1	9.1	-3.0	-1.4	-1.2	-1.0	-1.1	-1.2	-1.5	-1.2	-1.1
Unable to work because of sickness or disability	1.8	2.4	5.1	-2.3	-1.3	-1.5	-1.9	-1.8	-1.2	-1.6	-1.3	-1.3
Exposure to tobacco smoke at home	1.7	1.9	4.5	-0.9	0.9	1.5	2.1	1.6	1.5	0.6	1.6	1.7
Ever taken oral contraceptive pill	1.7	1.8	3.7	-0.3	-1.4	-1.5	-1.9	-1.2	-1.5	-1.6	-1.4	-1.5
Mean Putamen Volume	1.6	1.8	4.8	2.2	1.7	1.4	0.7	1.1	1.3	1.2	1.4	1.3
Average weekly spirits intake	1.6	2.0	4.9	0.6	1.2	1.5	1.8	2.2	1.3	1.3	1.4	1.5
Supplements: Zinc	1.6	1.7	2.9	0.7	1.7	1.4	1.3	1.5	1.4	1.0	1.5	1.5
Neuroticism score	1.6	3.3	4.9	-2.0	-2.1	-2.0	-1.1	-1.7	-1.9	-2.2	-2.0	-1.9
Falls in the last year	1.6	2.2	3.3	0.1	1.7	1.8	1.6	1.6	1.5	1.5	1.6	1.8
Commuting to job workplace: Cycle	1.5	1.9	3.2	0.6	1.4	1.5	1.7	1.4	1.8	1.0	1.7	1.5
Severe depression (siblings)	1.4	1.5	2.5	-1.2	-0.8	-1.4	-1.6	-1.5	-1.2	-1.3	-1.3	-1.3
Eye problems/disorders: Cataract	1.4	1.7	2.7	0.8	1.3	1.4	1.5	1.6	1.3	1.7	1.2	1.3
Alzheimer’s Disease (in mother)	1.3	1.5	2.3	-1.3	-1.1	-1.3	-1.4	-0.9	-1.4	-1.5	-1.4	-1.4
Age at First Birth	1.3	1.9	3.9	0.2	-1.6	-1.9	-1.2	-1.3	-1.5	-1.1	-1.7	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.2	-0.8	-1.2	-1.4	-1.4	-1.5	-1.3	-1.4	-1.4	-1.4
Mother’s age at death	1.3	1.6	2.6	-0.5	-1.3	-1.4	-1.3	-1.0	-1.6	-1.5	-1.5	-1.5
Neuroticism	1.2	2.8	4.7	-2.2	-2.1	-1.7	-0.8	-1.4	-1.7	-2.2	-1.7	-1.6
Depression (self-reported)	1.2	1.5	2.1	-0.7	-1.5	-1.4	-1.3	-0.9	-1.3	-1.3	-1.4	-1.4
Medication: Lansoprazole	1.2	1.4	2.5	-1.5	-1.6	-1.2	-1.1	-1.1	-1.2	-1.3	-1.1	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	4.1	-1.2	-1.0	-1.1	-2.0	-1.3	-1.4	-0.8	-1.3	-1.1
Age at first live birth	1.2	2.2	6.3	2.5	-0.9	-1.4	-1.3	-2.4	-1.0	-0.7	-1.2	-1.4
Eye problems/disorders: None of the above	1.2	1.4	2.2	-1.1	-1.5	-1.5	-0.9	-0.9	-1.3	-1.2	-1.4	-1.4
Had major operations	1.2	1.4	2.2	0.5	-1.3	-1.4	-1.0	-1.4	-1.2	-1.5	-1.3	-1.4
Neuroticism (Nagel 2018)	1.1	2.5	3.9	-2.0	-1.7	-1.7	-1.1	-1.7	-1.6	-1.8	-1.7	-1.7
Townsend deprivation index at recruitment	1.1	1.6	3.3	-0.0	1.8	1.3	1.2	1.1	1.5	1.1	1.5	1.4
Number of incorrect matches in round	1.1	1.8	2.8	-0.1	1.6	1.6	1.3	1.4	1.6	1.0	1.6	1.7
Hip circumference	1.1	4.8	7.6	2.3	2.7	2.3	1.8	1.4	2.8	2.1	2.6	2.5
Worrier / anxious feelings	1.1	2.1	3.5	-0.9	-1.5	-1.6	-1.3	-1.9	-1.5	-1.5	-1.6	-1.6
Ever highly irritable/argumentative for 2 days	1.1	1.4	2.8	-1.3	-1.0	-1.4	-0.7	-1.3	-1.0	-1.7	-1.2	-1.3
Glaucoma (self-reported)	1.1	1.2	2.1	1.2	1.3	1.3	0.3	0.9	1.3	0.9	1.4	1.4
Medication for cholesterol	1.1	1.7	2.4	0.8	1.3	1.5	1.5	1.1	1.4	1.6	1.5	1.4
Vascular/heart problems diagnosed by doctor	1.1	2.9	4.0	1.6	1.9	1.9	1.8	2.0	1.7	1.7	1.7	1.8
Cholesterol lowering medication	1.1	1.6	3.3	0.0	-0.8	-1.4	-1.8	-1.1	-1.6	-0.9	-1.6	-1.6
Depressed Affect (Nagel 2018)	1.0	2.0	3.6	-1.4	-1.2	-1.6	-1.2	-1.9	-1.4	-1.6	-1.5	-1.5
Worry (Nagel 2018)	1.0	2.2	3.2	-1.7	-1.8	-1.6	-1.2	-1.3	-1.6	-1.5	-1.6	-1.6
Primary Biliary Cirrhosis	1.0	1.5	2.6	0.4	1.5	1.3	1.3	1.6	1.4	0.9	1.4	1.4
Systolic Blood Pressure	1.0	4.9	8.9	-3.0	-2.7	-2.4	-1.7	-1.8	-2.3	-2.1	-2.4	-2.3
Supplements: Glucosamine	1.0	1.3	2.1	-1.4	-1.0	-1.1	-1.4	-1.3	-1.1	-1.5	-1.0	-1.0
Impedance of leg (left)	1.0	5.1	8.1	-1.9	-2.8	-2.5	-2.1	-1.4	-2.8	-2.0	-2.7	-2.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.2	0.4	1.4	1.1	1.5	1.4	1.1	1.2	1.1	1.1
Ever had prostate specific antigen (PSA) test	1.0	1.1	3.3	-1.8	-1.0	-0.9	-1.0	-0.6	-1.1	-1.3	-0.9	-0.9
Supplements: Calcium	1.0	1.1	1.7	0.5	1.2	1.2	1.1	1.3	1.2	0.8	1.3	1.2
Blood Red Count	0.9	8.3	11.8	-2.2	-3.2	-3.2	-3.4	-2.4	-3.4	-2.6	-3.3	-3.3
Forced vital capacity (FVC)	0.9	3.5	8.3	2.9	2.6	1.7	1.3	1.3	1.9	2.0	1.8	1.6
Prospective memory result	0.9	1.1	5.0	-0.4	-0.8	-1.1	-1.1	-2.2	-0.6	-1.2	-0.8	-0.9
Illnesses of mother	0.9	1.1	2.0	0.7	1.2	1.3	0.7	1.4	1.1	1.0	1.2	1.2
Health satisfaction	0.9	1.1	1.9	0.6	1.4	1.2	1.0	0.8	1.3	1.0	1.3	1.2
Medication: Blood pressure	0.9	1.6	2.5	-1.4	-1.3	-1.4	-1.2	-1.6	-1.2	-1.4	-1.2	-1.3
Medication: Omeprazole	0.9	1.0	1.5	0.6	1.0	1.2	1.0	1.0	1.1	1.2	1.2	1.2
Commuting to job workplace: Public transport	0.9	1.1	2.0	0.3	1.4	1.3	0.9	0.5	1.3	1.2	1.2	1.3
Risk taking	0.9	1.3	2.4	1.1	1.2	1.2	1.1	1.3	1.1	1.6	1.1	1.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.6	-0.4	1.1	1.2	1.3	1.0	1.2	0.9	1.2	1.3
Depression (Nagel 2018)	0.8	1.1	2.1	-0.3	0.9	1.1	1.4	1.4	1.3	0.8	1.3	1.2
Major Depression (MDD)	0.8	1.0	2.0	0.5	1.4	1.1	0.9	0.7	1.4	0.5	1.3	1.2
Hair/balding pattern: Pattern 3	0.8	1.2	2.1	-1.0	-1.2	-1.1	-1.4	-1.4	-1.2	-0.9	-1.1	-1.1
Pulse wave Arterial Stiffness index	0.8	0.9	1.7	-0.7	-0.7	-1.1	-1.3	-0.9	-1.1	-1.0	-1.0	-1.0
Gout (self-reported)	0.8	1.1	2.2	0.2	-1.0	-1.1	-1.4	-1.5	-1.1	-1.0	-1.1	-1.2
High blood pressure (siblings)	0.8	1.1	3.2	-1.8	-1.0	-0.8	-1.3	-1.0	-0.9	-1.2	-0.8	-0.7
Qualifications: College or University degree	0.8	2.5	4.0	1.3	1.6	1.7	1.8	2.0	1.6	1.6	1.7	1.6
Neck or shoulder pain in last month	0.8	1.1	2.2	0.4	1.5	1.2	0.7	0.6	1.3	0.9	1.4	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.5	1.0	1.0	1.1	1.2	0.7	1.1	0.9	1.1	1.1
Osteoarthritis (self-reported)	0.8	1.1	4.8	-2.2	-0.9	-0.7	-0.8	-0.7	-0.8	-1.4	-0.7	-0.7
Leg fat percentage (left)	0.8	2.9	4.8	-0.8	-1.7	-2.0	-1.9	-2.2	-1.6	-1.6	-1.8	-1.9
Pain experienced in last month	0.8	1.3	2.9	-0.1	-1.7	-1.3	-0.6	-1.0	-1.3	-1.0	-1.4	-1.4
Crohns Disease (2012)	0.7	1.2	3.5	1.9	0.6	0.9	1.6	1.2	1.0	0.7	0.9	0.8
HDL Cholesterol	0.7	1.2	2.8	-0.8	-1.7	-1.2	-1.1	-0.5	-1.1	-1.3	-1.1	-1.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.7	-0.4	-0.7	-1.2	-1.0	-1.3	-0.8	-0.7	-1.0	-1.1
Maternal smoking around birth	0.7	1.0	3.3	1.1	1.8	0.9	0.2	0.8	1.0	1.2	1.0	0.9
High blood pressure	0.7	1.9	3.1	-1.3	-1.5	-1.5	-1.5	-1.8	-1.2	-1.3	-1.3	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.4	-1.0	-1.0	-1.0	-1.2	-0.8	-1.1	-0.9	-1.0	-1.0
Medication: Amlodipine	0.7	1.0	1.8	-1.0	-0.8	-1.1	-0.7	-1.4	-0.9	-1.3	-1.0	-1.0
Medication: Seretide 50 evohaler	0.7	0.8	1.8	0.1	-0.8	-0.9	-0.7	-1.3	-0.9	-1.0	-1.0	-1.0
Illnesses of father: Heart disease	0.7	0.9	2.2	-0.4	-1.5	-1.0	-0.8	-0.5	-0.9	-1.4	-1.0	-1.0
Diastolic blood pressure, automated reading	0.7	2.3	4.6	-1.4	-2.1	-1.7	-1.0	-1.5	-1.3	-1.6	-1.6	-1.7
Ever depressed for a whole week	0.7	0.9	1.4	-0.8	-0.8	-1.1	-1.0	-0.6	-1.1	-0.8	-1.1	-1.2
Impedance of whole body	0.7	3.8	6.1	-1.8	-2.5	-2.2	-1.4	-1.2	-2.3	-2.1	-2.3	-2.3
Alzheimer’s Disease (including proxy)	0.6	0.9	1.4	-0.0	-0.9	-1.1	-1.0	-1.1	-0.9	-1.2	-1.1	-1.2
Lung FVC	0.6	2.9	5.0	-0.9	-1.4	-1.8	-2.1	-2.2	-1.9	-1.7	-1.9	-1.9
Number of treatments/medications taken	0.6	1.0	4.1	-2.0	-0.7	-0.9	-0.9	-0.8	-0.8	-1.3	-0.8	-0.8
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.4	0.6	0.9	0.9	1.2	0.9	1.0	0.9	1.0	1.0
Medication for hormone replacement therapy	0.6	0.7	2.1	-1.0	-0.8	-0.9	-0.5	-0.8	-0.6	-1.5	-0.7	-0.8
Diabetes (father)	0.6	0.7	1.3	1.1	0.7	0.9	0.5	0.7	1.0	0.8	1.0	1.0
Serious illness, injury or assault to yourself	0.6	0.8	1.5	-0.2	0.8	1.0	0.8	0.6	1.2	1.0	1.1	1.2
Hair/balding pattern: Pattern 2	0.6	0.8	2.0	1.0	0.7	0.8	1.4	1.4	0.8	0.5	0.7	0.7
Heart attack	0.6	0.8	1.1	-0.8	-0.7	-0.9	-1.0	-1.0	-1.0	-1.0	-1.0	-0.9
Illnesses of siblings	0.6	0.8	2.9	1.7	0.8	0.8	1.0	0.8	0.7	1.1	0.6	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.2	0.3	-0.9	-1.0	-0.9	-0.6	-1.1	-0.7	-1.0	-1.0
Asthma	0.6	1.1	3.3	-1.8	-0.5	-0.9	-0.8	-1.1	-1.3	-1.2	-1.1	-1.0
Tense / ‘highly strung’	0.6	1.0	1.7	-0.7	-1.1	-1.1	-0.8	-0.8	-1.3	-0.9	-1.2	-1.2
Age at last live birth	0.6	0.9	6.0	2.4	0.8	0.2	0.7	-0.5	0.7	0.7	0.4	0.2
Hypertension (Self-reported)	0.6	1.7	3.6	-1.1	-1.4	-1.4	-1.6	-1.9	-1.1	-1.3	-1.2	-1.3
Average weekly red wine intake	0.6	0.9	1.8	1.0	0.9	1.1	1.1	1.3	0.8	0.6	1.0	1.1
Loneliness, isolation	0.6	0.9	1.3	0.6	1.1	1.0	1.1	1.0	1.1	0.9	1.0	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.1	0.5	1.4	0.8	0.4	0.7	0.9	0.9	0.9	0.8
Friendships satisfaction	0.6	0.7	1.6	0.6	1.0	0.7	1.1	1.3	0.9	1.0	0.8	0.7
Back pain experienced in last month	0.6	0.8	2.3	-0.6	1.5	1.0	0.4	0.5	1.0	0.9	1.1	1.1
Illnesses of father: None of the above (group 1)	0.6	0.8	2.4	1.3	0.8	0.6	0.8	0.7	0.8	1.5	0.7	0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.1	-1.0	-0.8	-0.9	-0.8	-0.8	-1.1	-0.9	-1.0	-0.9
Schizophrenia (2018)	0.5	1.1	2.2	-0.5	-1.0	-1.2	-1.2	-0.7	-1.5	-1.1	-1.3	-1.3
Crohns Disease (2017)	0.5	1.1	2.8	1.7	0.9	1.1	1.3	0.9	1.2	0.5	1.1	1.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	-0.4	1.2	1.1	0.5	-0.1	1.1	0.7	1.1	1.2
Neuroticism (2016)	0.5	0.8	2.1	-0.9	-0.1	-0.8	-1.3	-1.4	-0.6	-1.0	-0.6	-0.8
Blood Eosinophil Count	0.5	4.1	6.7	0.1	2.0	2.4	2.4	2.4	2.3	1.5	2.4	2.6
Chronotype (morning person)	0.5	1.2	2.3	0.5	0.9	1.2	1.1	0.8	1.5	1.0	1.4	1.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.8	-1.3	-0.5	-0.7	-0.9	-0.3	-0.8	-0.8	-0.8	-0.8
Medication: Metformin	0.5	0.8	2.1	1.5	0.7	0.8	0.9	0.6	1.0	0.8	0.9	0.8
Impedance of leg (right)	0.5	2.6	4.3	-1.8	-2.1	-1.7	-1.2	-0.5	-2.1	-1.4	-1.9	-1.9
Age when periods started (menarche)	0.5	1.1	6.2	2.5	0.7	0.7	0.4	1.1	0.5	1.4	0.5	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.2	1.5	0.9	0.4	0.6	1.0	0.2	0.6	0.3	0.3
Medication: Ramipril	0.5	0.7	1.3	-1.1	-1.0	-0.8	-0.6	-0.4	-1.0	-0.8	-0.9	-0.8
Time employed in main current job	0.5	0.6	2.0	0.7	-0.7	-0.7	-1.4	-0.5	-0.9	-0.5	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	5.0	2.2	1.9	1.0	0.5	0.5	1.2	1.4	1.1	0.9
Happiness	0.5	0.6	1.4	-0.3	0.7	0.6	1.2	1.2	0.5	1.1	0.4	0.5
Forced vital capacity (FVC), Best measure	0.5	1.7	6.9	2.6	1.8	0.9	0.4	0.4	1.2	1.4	1.1	0.8
Body fat percentage	0.5	1.9	3.7	-0.4	-1.4	-1.6	-1.6	-1.9	-1.1	-1.5	-1.4	-1.6
Wheeze or whistling in the chest in last year	0.5	0.9	1.5	-0.1	1.1	1.1	1.2	1.2	0.8	1.0	0.9	1.1
Number of children fathered	0.5	0.5	1.8	1.3	0.8	0.7	0.3	0.2	0.8	0.5	0.7	0.8
Chest pain or discomfort	0.5	0.7	1.3	0.1	0.8	0.9	1.2	1.0	0.9	0.9	0.8	0.9
Supplements: Vitamin C	0.5	0.6	0.9	0.4	0.8	0.8	0.9	0.8	0.8	0.8	0.9	0.9
Asthma (self-reported)	0.5	0.9	2.5	-1.6	-0.5	-0.8	-0.7	-1.0	-1.2	-1.1	-1.0	-0.9
Osteoporosis (self-reported)	0.5	0.6	1.2	-0.7	1.1	0.9	0.7	0.2	0.9	0.8	0.9	0.9
Fractured/broken bones in last 5 years	0.5	0.7	2.3	-0.8	0.5	0.8	1.5	1.2	0.6	0.6	0.7	0.8
Ulcerative Colitis	0.4	0.6	0.9	0.6	-0.7	-0.8	-1.0	-0.7	-0.9	-0.8	-0.9	-0.9
Hearing difficulty/problems: Yes	0.4	0.6	1.0	0.5	0.9	0.8	0.4	0.9	1.0	0.2	1.0	0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.8	-1.3	0.6	0.7	0.2	0.5	0.7	0.4	0.8	0.9
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	-0.3	-0.7	-0.8	-0.8	0.1	-0.9	-0.3	-0.9	-0.9
Medication: Co-codamol	0.4	0.4	1.1	0.4	1.0	0.6	-0.5	-0.4	0.7	0.8	0.7	0.7
Trunk fat percentage	0.4	1.6	3.3	-0.2	-1.2	-1.5	-1.4	-1.8	-0.9	-1.4	-1.2	-1.4
Qualifications: CSEs or equivalent	0.4	0.6	4.5	2.1	0.2	0.2	0.5	0.5	0.3	0.7	0.2	0.1
Chronic bronchitis/emphysema (father)	0.4	0.5	4.0	-2.0	-0.0	0.0	-0.6	0.3	-0.3	-0.4	-0.0	0.0
Alcohol usually taken with meals	0.4	0.6	1.4	-0.8	-1.2	-0.6	-0.8	-0.0	-1.0	-1.0	-0.7	-0.6
Financial difficulties in last 2 years	0.4	0.6	2.1	0.4	-0.8	-0.9	-0.6	-1.5	-0.6	-0.4	-0.7	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	6.7	2.6	1.5	0.6	0.1	-0.1	0.9	1.3	0.7	0.5
Leg fat percentage (right)	0.4	1.5	2.4	-0.8	-1.3	-1.5	-1.4	-1.6	-1.1	-1.2	-1.3	-1.4
Guilty feelings	0.4	0.5	1.3	-0.0	1.2	0.7	0.8	0.5	0.9	0.6	0.9	0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	-1.0	0.6	0.8	0.6	0.8	0.8	0.3	0.7	0.9
Ever smoked	0.4	0.7	2.4	-0.8	-0.7	-0.7	-0.8	-1.1	-0.6	-1.5	-0.6	-0.6
Basal cell carcinoma (self-reported)	0.4	0.5	2.0	0.1	0.4	0.6	0.6	1.4	0.4	1.0	0.5	0.5
Alcohol drinker status: Previous	0.4	0.4	1.6	-0.9	-0.7	-0.5	-0.5	-0.7	-0.4	-1.3	-0.4	-0.4
Alzheimer’s Disease (in father)	0.3	0.3	1.6	1.3	-0.4	-0.4	-0.2	-0.9	0.1	0.2	-0.2	-0.4
Rheumatoid Arthritis	0.3	0.4	1.9	1.4	0.4	0.3	0.4	-0.5	0.7	0.6	0.5	0.4
Blood White Count	0.3	2.0	3.8	-1.9	-1.8	-1.6	-0.6	-1.1	-1.5	-1.2	-1.6	-1.5
BMI	0.3	1.6	5.0	2.2	1.3	1.1	0.9	0.7	1.4	1.3	1.3	1.2
Smoking Status	0.3	0.7	2.5	-1.6	0.9	0.7	0.9	0.6	0.7	-0.1	0.7	0.8
Respiratory disease	0.3	0.6	1.2	-1.0	-0.2	-0.7	-0.9	-1.1	-0.9	-0.7	-0.8	-0.8
Lung FEV1/FVC ratio	0.3	1.5	3.5	0.5	1.6	1.3	0.9	1.3	1.3	1.9	1.2	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	0.4	0.3	0.7	0.8	0.9	0.7	0.6	0.7	0.8
Relative age voice broke	0.3	0.5	1.8	0.8	1.3	0.7	0.1	-0.2	0.8	0.8	0.8	0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.4	0.8	-0.2	-0.5	-1.2	-0.4	-0.5	-0.5	-0.4	-0.6
Stomach or abdominal pain in last month	0.3	0.4	1.3	1.1	1.1	0.5	0.2	0.4	0.6	0.5	0.6	0.4
High blood pressure (mother)	0.3	0.4	3.7	1.9	-0.1	-0.1	0.1	0.1	-0.0	0.5	-0.0	-0.1
Past tobacco smoking	0.3	0.5	1.6	1.1	0.5	0.6	0.6	0.9	0.4	1.3	0.4	0.5
Nervous feelings	0.3	0.5	1.9	-1.4	-0.7	-0.6	-0.3	-0.9	-0.5	-0.5	-0.6	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	-1.1	-1.0	-0.7	-0.1	-0.5	-0.6	-1.1	-0.6	-0.5
Fluid intelligence score	0.3	0.7	0.9	-0.3	0.8	0.8	0.9	0.9	0.9	0.8	1.0	0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.7	1.3	0.8	0.6	1.3	0.3	0.7	0.9	0.6	0.5
Impedance of arm (left)	0.3	1.6	2.8	-1.7	-1.7	-1.4	-0.3	-0.5	-1.3	-1.6	-1.3	-1.4
Breastfed as a baby	0.3	0.4	0.8	0.5	0.4	0.9	0.3	0.8	0.7	0.5	0.8	0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	0.3	-0.5	-1.1	-0.3	-0.8	-0.8	-0.5	-1.0	-1.1
Birth weight	0.3	0.6	2.2	1.5	0.4	0.7	0.4	1.0	0.6	1.0	0.6	0.7
Exposure to tobacco smoke outside home	0.3	0.3	0.9	0.3	0.4	0.6	0.9	0.7	0.6	0.5	0.6	0.7
Medication for pain relief, constipation, heartburn	0.3	0.4	3.5	1.9	-0.4	-0.3	-0.1	-0.1	-0.4	0.2	-0.4	-0.5
Heart disease (mother)	0.3	0.3	1.0	-1.0	-0.5	-0.6	-0.6	-0.2	-0.6	-0.3	-0.6	-0.5
Leg pain on walking	0.3	0.4	1.4	-1.2	0.6	0.6	0.6	-0.0	0.8	-0.1	0.7	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	3.0	1.7	1.1	0.3	0.1	0.4	0.4	0.7	0.4	0.2
Arm fat percentage (left)	0.3	1.1	2.8	-0.3	-0.9	-1.2	-1.0	-1.7	-0.7	-1.4	-0.9	-1.1
Diabetes diagnosed by doctor	0.3	0.5	1.5	1.2	0.8	0.5	0.3	0.0	0.8	0.8	0.7	0.6
Medication: Gliclazide	0.3	0.4	0.7	0.7	0.8	0.7	0.2	0.3	0.6	0.6	0.7	0.7
Smoking status: Current	0.3	0.4	1.2	-1.1	0.7	0.6	0.8	1.0	0.4	0.1	0.5	0.6
Medication: Blood pressure	0.3	0.5	0.7	-0.8	-0.8	-0.8	-0.6	-0.8	-0.6	-0.7	-0.7	-0.7
Medication: Lisinopril	0.3	0.4	2.2	-1.5	-0.4	-0.5	-0.7	-0.8	-0.3	-0.3	-0.3	-0.3
Illnesses of father: High blood pressure	0.3	0.4	0.7	-0.9	-0.4	-0.5	-0.8	-0.7	-0.6	-0.5	-0.6	-0.6
Irritability	0.3	0.6	1.9	-1.4	-0.8	-0.6	0.0	-0.2	-0.7	-1.2	-0.7	-0.6
Bipolar Disorder (2018)	0.2	0.4	0.8	0.5	0.7	0.5	0.4	0.7	0.9	0.7	0.8	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	4.1	-2.0	-0.1	0.3	0.2	0.7	-0.1	-0.5	0.2	0.4
Schizophrenia vs Biploar Disorder	0.2	0.3	1.0	0.5	-0.5	-0.5	-0.1	-1.0	-0.6	-0.8	-0.5	-0.5
Reaction Time	0.2	0.4	1.4	-0.5	-0.7	-0.7	-0.8	-1.2	-0.5	-0.5	-0.6	-0.6
Prostate Cancer	0.2	0.3	1.3	-1.2	-1.1	-0.3	0.2	0.3	-0.2	-0.6	-0.3	-0.2
Fasting Glucose	0.2	0.2	1.5	0.1	-0.1	-0.0	-0.7	-1.2	-0.1	-0.2	0.0	-0.1
Relative age of first facial hair	0.2	0.5	1.3	0.4	1.1	0.8	0.3	0.1	0.9	1.0	0.8	0.8
Angina	0.2	0.3	0.8	-0.9	-0.5	-0.5	-0.5	-0.1	-0.5	-0.5	-0.5	-0.4
Diabetes (mother)	0.2	0.2	0.8	0.5	0.9	0.4	-0.4	0.0	0.4	0.5	0.4	0.3
Pack years adult smoking proportion	0.2	0.3	0.7	-0.0	0.4	0.7	0.8	0.5	0.8	0.3	0.6	0.8
Current tobacco smoking	0.2	0.3	1.7	-1.3	0.5	0.5	0.6	0.8	0.2	-0.0	0.3	0.5
Average weekly fortified wine intake	0.2	0.3	0.5	0.6	-0.6	-0.4	-0.1	0.2	-0.7	-0.7	-0.6	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	2.9	1.7	0.8	0.2	-0.4	0.0	0.4	0.2	0.3	0.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	-0.7	-0.3	-0.6	-0.2	-0.7	-0.7	-0.8	-0.7	-0.7
Multivitamins +/- minerals	0.2	0.3	0.9	1.0	0.2	0.3	0.8	0.2	0.5	0.6	0.5	0.3
Medication: Atenolol	0.2	0.2	0.4	-0.6	0.6	0.5	0.5	0.5	0.5	0.2	0.5	0.6
Hearing difficulty/problems with background noise	0.2	0.4	0.9	-0.9	0.9	0.5	0.3	0.1	0.8	0.3	0.7	0.6
Had menopause	0.2	0.3	1.4	-1.2	-0.4	-0.0	0.2	0.3	0.0	-0.9	-0.0	0.1
Mouth/teeth dental problems	0.2	0.3	1.0	0.1	0.2	0.5	0.8	1.0	0.5	0.5	0.6	0.5
Impedance of arm (right)	0.2	0.8	1.7	-1.3	-1.3	-0.9	-0.0	-0.1	-0.8	-1.3	-0.8	-0.9
Arm fat percentage (right)	0.2	0.6	1.9	-0.1	-0.7	-0.9	-0.8	-1.4	-0.4	-1.2	-0.6	-0.8
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.8	0.4	0.3	-0.0	-0.8	0.7	0.1	0.6	0.5
Number of live births	0.2	0.3	0.9	0.9	0.0	0.4	0.6	0.6	0.5	0.1	0.5	0.5
Noisy workplace	0.2	0.2	1.0	-1.0	-0.5	-0.2	-0.4	-0.4	-0.3	-0.6	-0.3	-0.2
Arm fat mass (right)	0.2	0.9	2.9	1.7	1.2	0.8	0.5	0.0	1.3	0.7	1.1	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.3	-0.5	-0.4	-0.8	-0.7	-0.5	-0.6	-0.4	-0.5
Hair/balding pattern: Pattern 4	0.2	0.6	1.6	-0.0	-0.2	-0.9	-1.2	-1.1	-0.6	-0.8	-0.6	-0.8
Birth weight of first child	0.2	0.4	1.5	-0.7	-0.1	-0.4	-1.2	-0.9	-0.6	-0.3	-0.5	-0.4
Peak expiratory flow (PEF)	0.2	0.5	1.3	0.7	1.1	0.7	0.6	0.6	0.7	0.4	0.8	0.7
Headache pain in last month	0.2	0.4	0.8	0.9	0.4	0.7	0.6	0.6	0.7	0.2	0.7	0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.6	0.5	-0.2	-0.5	-0.6	-0.8	-0.6	-0.5	-0.5	-0.6
Number of full brothers	0.2	0.3	2.5	1.6	0.2	0.1	-0.3	0.5	-0.1	0.3	0.0	-0.1
Medication: Allopurinol	0.2	0.3	0.6	-0.6	-0.7	-0.4	-0.5	-0.7	-0.5	-0.8	-0.4	-0.3
Mean time to correctly identify matches	0.2	0.3	1.4	-1.2	-0.5	-0.4	-0.3	-0.6	-0.2	-0.7	-0.2	-0.2
Overall health rating	0.2	0.5	1.0	-0.5	0.9	0.9	0.5	0.4	0.9	0.3	0.9	1.0
Medication: Aspirin	0.2	0.2	1.8	-1.4	-0.0	-0.0	-0.2	-0.3	0.1	-0.6	0.1	0.2
Smoking status: Previous	0.2	0.2	0.8	-0.7	-0.3	-0.4	-0.5	-0.9	-0.2	-0.8	-0.2	-0.3
Qualifications: nursing, teaching	0.2	0.3	0.9	1.0	0.5	0.4	0.6	-0.3	0.7	0.7	0.5	0.4
Mineral and other dietary supplements	0.2	0.3	0.8	0.7	-0.9	-0.6	-0.6	-0.5	-0.5	-0.0	-0.6	-0.6
Medication: Aspirin	0.2	0.3	2.2	-1.5	-0.0	0.1	0.1	-0.2	0.3	-0.5	0.2	0.4
Arm fat mass (left)	0.2	0.8	2.3	1.5	1.2	0.7	0.6	0.1	1.2	0.7	1.0	0.8
Miserableness	0.2	0.3	1.5	-0.1	-0.1	-0.6	-0.5	-1.2	-0.4	-0.7	-0.5	-0.6
Hearing aid user	0.2	0.3	0.9	0.1	0.9	0.4	0.1	0.9	0.4	0.4	0.6	0.4
Medication: Bendroflumethiazide	0.2	0.3	1.6	0.1	-0.0	0.3	1.3	0.6	0.5	0.7	0.3	0.4
Average weekly beer plus cider intake	0.2	0.3	0.8	0.9	0.3	0.5	0.4	-0.2	0.7	0.6	0.4	0.5
Pack years of smoking	0.2	0.3	0.7	-0.3	0.2	0.6	0.8	0.5	0.6	0.1	0.5	0.7
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	-0.1	-0.3	-0.6	-0.6	-0.0	-0.6	-0.4	-0.5	-0.7
Ulcerative Colitis (UC)	0.1	0.2	0.7	0.3	-0.2	-0.3	-0.8	-0.6	-0.6	-0.5	-0.4	-0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.3	-1.2	-0.6	-0.4	-0.3	-0.2	-0.5	-0.6	-0.4	-0.3
HbA1C	0.1	0.1	0.3	-0.5	0.5	0.2	-0.3	-0.1	0.3	-0.3	0.2	0.3
Lupus	0.1	0.2	0.5	-0.7	0.6	0.5	0.5	0.3	0.5	0.0	0.5	0.5
Schizophrenia (2014)	0.1	0.2	0.5	0.2	-0.2	-0.6	-0.4	0.1	-0.7	-0.5	-0.6	-0.6
Blood Platelet Count	0.1	0.6	5.2	-2.3	-0.4	-0.3	-0.3	-0.6	-0.3	-0.6	-0.3	-0.2
Hypothyroidism (self reported)	0.1	0.2	0.7	-0.9	0.1	0.3	-0.5	-0.1	0.3	-0.4	0.4	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	2.2	1.5	0.0	-0.0	-0.2	0.1	0.1	0.1	0.1	-0.0
Fed-up feelings	0.1	0.1	0.5	0.4	0.3	-0.3	-0.0	-0.7	-0.1	-0.3	-0.2	-0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	-0.2	0.3	0.3	0.2	0.2	0.2	0.1	0.4	0.3
Medication: Levothyroxine sodium	0.1	0.1	0.6	-0.1	0.1	0.3	0.4	0.8	0.3	-0.2	0.3	0.3
Trunk fat mass	0.1	0.4	2.1	1.5	0.7	0.2	0.1	-0.4	0.8	0.3	0.6	0.3
Waist circumference	0.1	0.3	0.6	0.6	0.6	0.5	0.3	0.1	0.8	0.5	0.7	0.7
Had other major operations	0.1	0.1	0.3	-0.5	0.5	0.4	0.1	0.3	0.3	0.0	0.4	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	2.2	1.5	0.3	-0.1	-0.5	-0.4	0.2	-0.2	0.1	-0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	-0.6	-0.2	-0.3	0.1	-0.2	-0.2	-0.3	-0.3	-0.4
Qualifications: None of the above	0.1	0.3	0.8	-0.9	0.5	0.6	0.4	0.8	0.5	0.3	0.6	0.6
Allergy	0.1	0.1	0.4	0.6	-0.1	0.2	0.2	0.4	0.5	0.4	0.4	0.3
Pain all over the body in last month	0.1	0.1	0.3	0.1	-0.0	-0.2	-0.6	-0.5	-0.2	-0.1	-0.2	-0.2
Diabetes (self-reported)	0.1	0.1	0.7	0.8	0.1	-0.1	-0.2	-0.6	0.3	0.4	0.1	-0.1
Father’s age at death	0.1	0.1	0.4	-0.1	0.2	-0.1	-0.6	-0.4	-0.1	-0.5	-0.0	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	0.1	0.3	0.1	0.5	0.3	0.3	0.6	0.2	0.1
Lung cancer (father)	0.1	0.1	0.3	0.2	-0.0	0.1	-0.4	0.3	-0.1	0.6	-0.0	-0.0
Length of working week for main job	0.1	0.1	0.4	-0.5	-0.2	0.1	0.5	0.6	0.1	-0.0	0.0	0.2
Loud music exposure frequency	0.1	0.1	0.3	0.0	-0.5	-0.3	0.1	0.1	-0.2	-0.1	-0.3	-0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.9	0.9	0.4	0.3	0.1	-0.2	0.4	0.4	0.4	0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.6	-0.8	0.2	0.3	-0.1	0.4	0.3	-0.2	0.4	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.7	-0.6	0.2	-0.0	-0.8	-0.6	-0.2	-0.4	-0.0	-0.1
Medication: Ibuprofen	0.1	0.1	0.3	-0.5	-0.6	-0.3	-0.5	-0.1	-0.4	-0.3	-0.3	-0.2
Whole body fat mass	0.1	0.5	2.3	1.5	0.8	0.4	0.2	-0.2	0.9	0.6	0.7	0.5
Leg fat mass (right)	0.1	0.5	1.8	1.3	0.9	0.5	0.5	0.1	0.9	0.7	0.8	0.6
Pulse rate, automated reading	0.1	0.3	0.6	-0.5	-0.8	-0.6	-0.6	-0.3	-0.6	-0.5	-0.6	-0.7
Alcohol intake frequency.	0.1	0.2	0.9	-0.9	-0.2	-0.1	-0.4	-0.5	0.2	-0.6	0.1	0.1
Number of full sisters	0.1	0.1	0.6	-0.4	0.5	0.4	-0.2	0.1	0.2	0.8	0.3	0.3
Suffer from ‘nerves’	0.1	0.1	0.2	0.0	-0.2	-0.4	-0.3	-0.0	-0.4	-0.0	-0.3	-0.4
Family relationship satisfaction	0.1	0.2	0.4	0.3	0.6	0.2	0.6	-0.2	0.5	0.5	0.3	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.8	0.9	-0.1	0.1	0.2	-0.0	-0.0	0.1	-0.0	-0.0
Knee pain experienced in last month	0.1	0.2	1.0	-1.0	0.1	0.3	-0.3	-0.3	0.3	0.1	0.3	0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.5	0.4	0.1	-0.5	0.1	0.1	-0.4	0.2	0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.7	-0.5	0.8	0.1	0.4	0.1	0.3	0.4	0.2	0.2
Long-standing illness, disability or infirmity	0.1	0.1	1.0	-1.0	0.0	-0.1	-0.2	-0.1	0.3	-0.6	0.2	0.1
Ever had bowel cancer screening	0.1	0.2	0.7	-0.3	0.1	0.2	0.8	0.9	0.1	0.0	0.2	0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.5	0.6	0.7	0.1	0.1	0.3	0.1	0.3	0.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.6	0.0	0.8	0.2	-0.2	0.3	0.0	0.1	0.1	0.1
Average weekly champagne plus white wine intake	0.1	0.1	0.6	-0.6	0.1	0.2	0.8	0.0	0.3	0.1	0.2	0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.0	0.4	0.3	0.5	0.3	0.6	0.1	0.5	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.7	-0.8	0.6	0.3	0.5	0.4	0.1	-0.3	0.2	0.2
Alcohol drinker status: Never	0.1	0.2	0.6	-0.8	-0.6	-0.2	0.4	0.2	-0.3	-0.4	-0.3	-0.2
Leg fat mass (left)	0.1	0.3	2.0	1.4	0.6	0.2	0.1	-0.2	0.6	0.5	0.5	0.3
Irritable Bowel Disease (IBD)	0.0	0.1	0.7	0.8	0.1	0.1	-0.2	-0.2	-0.0	-0.5	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.1	0.0	-0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.4	1.2	0.8	1.1	0.4	0.1	0.3	0.6	0.7	0.6	0.5
Allergy or Eczema	0.0	0.1	0.7	-0.9	0.1	0.1	0.2	-0.1	-0.0	-0.4	0.0	0.1
Hair Pigment	0.0	0.3	0.5	-0.6	-0.7	0.5	0.6	0.6	-0.7	-0.5	-0.1	0.6
Tanning	0.0	0.4	1.6	0.2	-0.3	-0.6	-1.3	-0.6	-0.6	-0.0	-0.6	-0.7
Body mass index (BMI)	0.0	0.2	0.8	0.6	0.1	-0.2	-0.5	-0.9	0.2	-0.2	0.1	-0.0
Pulse rate	0.0	0.0	0.2	-0.4	0.1	0.0	-0.2	-0.2	-0.1	-0.0	0.0	-0.1
Medication: Paracetamol	0.0	0.0	0.2	-0.0	0.2	0.1	-0.4	-0.2	0.1	0.1	0.1	0.1
Comparative body size at age 10	0.0	0.1	0.2	0.4	0.1	0.4	0.3	-0.0	0.4	-0.2	0.4	0.4
Shortness of breath walking on level ground	0.0	0.0	0.0	0.2	0.1	0.0	0.2	-0.2	0.1	0.0	0.0	0.0
Emphysema/chronic bronchitis	0.0	0.0	0.2	-0.4	-0.3	-0.1	-0.1	0.1	-0.0	-0.2	-0.1	0.0
Angina (self-reported)	0.0	0.1	0.4	-0.6	-0.2	-0.1	-0.1	0.2	-0.2	-0.1	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.2	-0.4	0.1	-0.2	-0.4	-0.2	-0.1	0.0	-0.1	-0.2
Wears glasses or contact lenses	0.0	0.0	0.2	-0.4	-0.1	0.1	0.1	-0.0	0.4	-0.1	0.2	0.1
Medication: Paracetamol	0.0	0.1	0.1	0.2	0.3	0.2	-0.3	-0.0	0.4	0.1	0.3	0.3
Number of operations (self-reported)	0.0	0.0	0.2	-0.1	0.2	-0.1	-0.5	-0.1	-0.1	-0.3	-0.0	-0.1
Myopia	0.0	0.1	0.2	0.2	0.0	-0.3	-0.5	-0.0	-0.4	-0.2	-0.3	-0.3

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