Best TWAS P=5.36e-09 · Best GWAS P=4.29e-10 conditioned to 0.0146
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | SP1 | 0.17 | 0.12 | lasso | 4 | 0.12 | 8.6e-05 | 4.2 | 5.5 | 3.3e-08 | -0.31 | 0.16 | 0.62 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | SP1 | 0.12 | 0.13 | lasso | 5 | 0.08 | 9.5e-05 | 4.1 | 5.2 | 2.6e-07 | -0.23 | 0.92 | 0.02 | FALSE |
| 3 | METSIM | Adipose | SOAT2 | 0.03 | 0.06 | lasso | 1 | 0.05 | 1.5e-08 | 5.1 | -5.1 | 2.7e-07 | 0.15 | 0.52 | 0.48 | FALSE |
| 4 | METSIM | Adipose | SP7 | 0.03 | 0.02 | lasso | 2 | 0.01 | 6.1e-03 | 5.1 | -5.6 | 2.1e-08 | 0.15 | 0.22 | 0.13 | TRUE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PRR13 | 0.13 | 0.04 | blup | 28 | 0.07 | 3.3e-06 | 4.1 | -5.6 | 2.2e-08 | 0.58 | 0.07 | 0.39 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PRR13 | 0.05 | 0.03 | blup | 28 | 0.04 | 4.1e-03 | 3.9 | -5.2 | 2.0e-07 | 0.47 | 0.03 | 0.06 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PRR13 | 0.07 | 0.04 | blup | 28 | 0.05 | 4.7e-06 | 3.9 | -5.8 | 5.4e-09 | 0.60 | 0.39 | 0.24 | TRUE |
| 8 | The Cancer Genome Atlas | Rectum Adenocarcinoma | PCBP2 | 0.25 | 0.04 | blup | 36 | 0.10 | 2.3e-03 | -6.2 | -5.4 | 7.7e-08 | 0.64 | 0.00 | 0.61 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | PCBP2 | 0.04 | 0.01 | enet | 6 | 0.02 | 4.8e-03 | 2.8 | -5.5 | 3.0e-08 | 0.63 | 0.01 | 0.43 | FALSE |