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chr16:13,697,975-15,886,243

Best TWAS P=3.56e-14 · Best GWAS P=2.13e-11 conditioned to 0.697

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	NTAN1	0.05	0.03	lasso	2	0.04	6.7e-04	-6.7	7.1	1.2e-12	-0.97	0.01	0.97	FALSE
2	GTEx	Artery Tibial	RRN3	0.11	0.06	lasso	2	0.07	2.0e-06	5.7	5.4	5.3e-08	-0.53	0.77	0.21	FALSE
3	GTEx	Cells EBV-transformed lymphocytes	RRN3	0.36	0.14	lasso	5	0.20	4.5e-07	5.7	5.9	3.1e-09	-0.65	0.19	0.77	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	RP11-958N24.1	0.22	0.02	lasso	5	0.06	4.8e-03	-2.9	5.4	6.8e-08	-0.63	0.02	0.37	FALSE
5	GTEx	Cells Transformed fibroblasts	RRN3	0.10	0.12	enet	13	0.13	6.3e-10	5.7	6.4	1.7e-10	-0.62	0.64	0.36	FALSE
6	GTEx	Colon Transverse	RRN3	0.13	0.00	lasso	5	0.00	1.9e-01	5.5	-5.4	5.9e-08	0.34	0.02	0.31	FALSE
7	GTEx	Esophagus Mucosa	RRN3	0.13	0.13	lasso	4	0.13	3.2e-09	5.5	5.3	1.2e-07	-0.55	0.78	0.22	FALSE
8	GTEx	Heart Atrial Appendage	NOMO1	0.19	0.12	lasso	6	0.10	3.7e-05	5.5	5.4	5.6e-08	-0.52	0.22	0.29	FALSE
9	GTEx	Heart Atrial Appendage	NTAN1	0.10	0.09	lasso	1	0.07	3.7e-04	5.5	5.5	4.5e-08	-0.53	0.04	0.44	FALSE
10	GTEx	Heart Left Ventricle	RRN3	0.24	0.12	lasso	7	0.17	2.2e-09	5.5	-6.3	2.5e-10	0.44	0.54	0.38	FALSE
11	GTEx	Heart Left Ventricle	NTAN1	0.09	0.04	lasso	3	0.02	2.0e-02	5.7	5.6	2.5e-08	-0.52	0.02	0.71	FALSE
12	GTEx	Muscle Skeletal	RRN3	0.18	0.03	enet	17	0.11	5.7e-11	4.2	-5.9	3.2e-09	0.39	0.18	0.70	FALSE
13	GTEx	Muscle Skeletal	NTAN1	0.12	0.07	lasso	6	0.09	1.4e-09	5.5	6.1	1.3e-09	-0.49	0.81	0.18	FALSE
14	GTEx	Nerve Tibial	NTAN1	0.07	0.00	enet	14	0.00	1.7e-01	5.7	6.3	3.2e-10	-0.21	0.02	0.18	FALSE
15	GTEx	Skin Sun Exposed Lower leg	RRN3	0.10	0.12	lasso	1	0.11	4.5e-09	5.7	5.7	1.4e-08	-0.52	0.76	0.24	FALSE
16	GTEx	Testis	RRN3	0.10	0.10	lasso	2	0.07	3.9e-04	5.7	5.7	1.4e-08	-0.53	0.11	0.15	FALSE
17	GTEx	Thyroid	RP11-65J21.3	0.35	0.32	lasso	2	0.31	2.6e-24	-5.1	-5.1	3.0e-07	-0.03	0.51	0.49	TRUE
18	NTR	Blood	NTAN1	0.01	0.00	bslmm	110	0.00	4.2e-02	5.7	6.2	5.3e-10	-0.25	0.02	0.04	FALSE
19	NTR	Blood	PDXDC1	0.12	0.12	enet	26	0.15	1.3e-46	-6.6	7.6	3.6e-14	-0.88	0.01	0.99	TRUE
20	ROSMAP	Brain Pre-frontal Cortex	NTAN1	0.12	0.10	lasso	3	0.11	1.4e-13	5.5	5.6	2.6e-08	-0.52	0.86	0.14	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	PDXDC1	0.25	0.12	enet	12	0.14	1.3e-13	-6.7	-5.1	3.0e-07	0.77	0.01	0.99	FALSE