Best TWAS P=3.03e-12 · Best GWAS P=2.28e-13 conditioned to 0.00128
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hypothalamus | PDE1A | 0.24 | -0.01 | enet | 21 | -0.01 | 0.75800 | 5.9 | 7.0 | 3.0e-12 | 0.59 | 0.08 | 0.21 | TRUE |
| 2 | GTEx | Liver | NCKAP1 | 0.50 | -0.01 | lasso | 10 | 0.01 | 0.14300 | 4.8 | 5.9 | 3.3e-09 | 0.11 | 0.05 | 0.08 | TRUE |
| 3 | GTEx | Skin Sun Exposed Lower leg | PDE1A | 0.11 | 0.07 | lasso | 4 | 0.04 | 0.00060 | 5.1 | -5.6 | 1.8e-08 | -0.69 | 0.14 | 0.84 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PDE1A | 0.05 | 0.04 | blup | 206 | 0.04 | 0.00005 | -4.4 | 5.2 | 2.0e-07 | 0.42 | 0.65 | 0.02 | FALSE |