[Hub]/) : Traits : Whole body water mass :

chr2:197,560,575-201,571,143

Best TWAS P=3.02e-12 · Best GWAS P=6.05e-14 conditioned to 0.00019

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TYW5 0.08 0.14 lasso 8 0.13 2.2e-15 -5.3 5.5 3.1e-08 -0.05 0.02 0.98 FALSE
2 GTEx Adipose Subcutaneous RFTN2 0.14 0.10 enet 11 0.13 5.3e-11 -6.3 -6.1 1.2e-09 0.86 0.30 0.70 FALSE
3 GTEx Brain Caudate basal ganglia TYW5 0.23 0.11 lasso 3 0.11 5.4e-04 -4.5 5.3 1.1e-07 -0.03 0.04 0.59 FALSE
4 GTEx Brain Hippocampus FTCDNL1 0.35 0.24 enet 24 0.26 9.0e-07 -3.9 -5.9 3.2e-09 -0.10 0.30 0.20 TRUE
5 GTEx Brain Nucleus accumbens basal ganglia C2orf47 0.25 0.01 lasso 3 0.00 2.8e-01 5.2 -5.7 1.2e-08 0.04 0.05 0.46 TRUE
6 GTEx Breast Mammary Tissue SF3B1 0.06 0.06 lasso 4 0.03 6.6e-03 -4.4 -5.4 8.0e-08 0.61 0.17 0.68 FALSE
7 GTEx Breast Mammary Tissue (Female) SF3B1 0.05 -0.01 lasso 3 -0.01 8.1e-01 -4.3 -5.3 9.7e-08 0.65 0.05 0.10 FALSE
8 GTEx Lung RFTN2 0.06 0.08 lasso 8 0.06 2.7e-05 -6.9 -6.8 1.1e-11 0.86 0.11 0.89 FALSE
9 GTEx Skin Sun Exposed Lower leg MARS2 0.04 0.05 enet 8 0.03 1.2e-03 -7.1 7.0 3.0e-12 -0.86 0.09 0.90 TRUE
10 GTEx Spleen RFTN2 0.11 0.03 enet 26 0.05 2.4e-02 -7.1 -6.7 2.5e-11 0.84 0.08 0.40 FALSE
11 GTEx Spleen MARS2 0.12 0.04 lasso 5 0.00 3.4e-01 -7.0 6.6 4.5e-11 -0.82 0.07 0.36 FALSE
12 GTEx Thyroid SF3B1 0.04 0.02 enet 14 0.02 2.0e-02 -4.5 -5.9 4.0e-09 0.72 0.10 0.82 FALSE
13 GTEx Thyroid PLCL1 0.04 0.01 lasso 4 0.00 2.6e-01 -6.9 -6.4 1.3e-10 0.76 0.19 0.53 FALSE
14 GTEx Thyroid RFTN2 0.04 0.01 enet 11 0.01 9.5e-02 -7.0 -6.0 1.7e-09 0.80 0.08 0.75 FALSE
15 GTEx Whole Blood PLCL1 0.08 0.08 enet 15 0.05 4.1e-05 -6.4 -6.7 1.6e-11 0.92 0.14 0.86 FALSE
16 ROSMAP Brain Pre-frontal Cortex TYW5 0.11 0.12 lasso 5 0.11 5.5e-14 -5.3 5.6 2.6e-08 -0.04 0.02 0.98 FALSE
17 ROSMAP Brain Pre-frontal Cortex C2orf69 0.07 0.04 enet 13 0.06 3.6e-08 -5.2 5.4 7.1e-08 -0.05 0.03 0.97 FALSE
18 YFS Blood PLCL1 0.10 0.10 lasso 9 0.14 1.5e-43 -6.5 -5.6 2.2e-08 0.83 0.72 0.28 FALSE
19 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PLCL1 0.04 0.00 blup 130 0.02 4.0e-03 1.7 -5.7 1.0e-08 0.65 0.05 0.38 FALSE
20 The Cancer Genome Atlas Lung Adenocarcinoma C2orf60 0.03 0.03 blup 44 0.03 1.8e-04 -5.3 5.7 1.5e-08 -0.05 0.01 0.97 FALSE
21 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C2orf60 0.04 0.05 lasso 5 0.03 2.1e-03 -5.5 5.5 4.8e-08 -0.04 0.01 0.91 FALSE
22 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RFTN2 0.05 0.01 blup 61 0.02 3.1e-02 -4.4 -6.0 2.0e-09 0.70 0.04 0.40 FALSE