Best TWAS P=3.04e-13 · Best GWAS P=1.33e-11 conditioned to 0.607
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ACVR2B | 0.08 | 0.08 | enet | 15 | 0.09 | 9.6e-11 | -5.6 | 6.2 | 7.4e-10 | -0.88 | 0.15 | 0.85 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | EXOG | 0.10 | 0.00 | enet | 12 | 0.00 | 1.3e-01 | -6.6 | -6.2 | 4.5e-10 | 0.68 | 0.02 | 0.76 | FALSE |
| 3 | GTEx | Brain Cerebellum | EXOG | 0.19 | 0.23 | enet | 4 | 0.21 | 7.7e-07 | -6.7 | -6.7 | 2.3e-11 | 0.99 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Brain Cerebellum | ACVR2B-AS1 | 0.25 | 0.07 | lasso | 6 | 0.10 | 8.3e-04 | -6.6 | -6.6 | 4.3e-11 | 0.91 | 0.02 | 0.95 | FALSE |
| 5 | GTEx | Brain Frontal Cortex BA9 | EXOG | 0.18 | 0.08 | lasso | 4 | 0.05 | 1.7e-02 | -6.7 | -6.7 | 2.2e-11 | 0.99 | 0.02 | 0.89 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | EXOG | 0.08 | 0.06 | enet | 10 | 0.05 | 8.6e-04 | -5.8 | -7.3 | 3.0e-13 | 0.90 | 0.03 | 0.95 | TRUE |
| 7 | GTEx | Colon Transverse | XYLB | 0.08 | 0.03 | enet | 15 | 0.05 | 1.7e-03 | -6.7 | 6.4 | 1.2e-10 | -0.85 | 0.03 | 0.94 | FALSE |
| 8 | GTEx | Esophagus Mucosa | EXOG | 0.13 | 0.05 | lasso | 3 | 0.03 | 5.0e-03 | -6.6 | -6.8 | 9.3e-12 | 0.98 | 0.02 | 0.94 | FALSE |
| 9 | GTEx | Nerve Tibial | EXOG | 0.10 | 0.00 | lasso | 5 | 0.00 | 1.7e-01 | -6.6 | -5.4 | 7.5e-08 | 0.87 | 0.02 | 0.89 | FALSE |
| 10 | GTEx | Ovary | EXOG | 0.33 | 0.25 | lasso | 8 | 0.21 | 8.1e-06 | -6.3 | -6.6 | 4.3e-11 | 0.90 | 0.05 | 0.83 | FALSE |
| 11 | GTEx | Pancreas | EXOG | 0.22 | 0.08 | enet | 15 | 0.03 | 2.6e-02 | -6.7 | -5.9 | 3.7e-09 | 0.91 | 0.03 | 0.94 | FALSE |
| 12 | GTEx | Stomach | EXOG | 0.14 | 0.05 | lasso | 6 | 0.02 | 2.5e-02 | -6.7 | -6.7 | 2.0e-11 | 1.00 | 0.02 | 0.97 | FALSE |
| 13 | GTEx | Testis | EXOG | 0.35 | 0.28 | lasso | 5 | 0.26 | 8.1e-12 | -6.8 | -6.8 | 7.9e-12 | 1.00 | 0.01 | 0.99 | FALSE |
| 14 | GTEx | Thyroid | EXOG | 0.19 | 0.20 | lasso | 3 | 0.19 | 2.9e-14 | -6.6 | -6.6 | 3.8e-11 | 0.98 | 0.01 | 0.99 | FALSE |
| 15 | NTR | Blood | ACVR2B | 0.02 | 0.02 | lasso | 3 | 0.02 | 5.6e-07 | -6.3 | -6.6 | 3.4e-11 | 0.95 | 0.03 | 0.96 | FALSE |
| 16 | NTR | Blood | EXOG | 0.02 | 0.03 | lasso | 6 | 0.03 | 1.0e-09 | -5.6 | 6.0 | 2.6e-09 | -0.89 | 0.16 | 0.84 | FALSE |
| 17 | NTR | Blood | XYLB | 0.05 | 0.06 | lasso | 3 | 0.06 | 6.2e-18 | -6.3 | -6.4 | 1.8e-10 | 0.87 | 0.12 | 0.88 | FALSE |
| 18 | ROSMAP | Brain Pre-frontal Cortex | EXOG | 0.10 | 0.13 | lasso | 2 | 0.12 | 4.8e-15 | -6.6 | -6.2 | 5.6e-10 | 0.98 | 0.02 | 0.98 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | EXOG | 0.04 | 0.01 | blup | 56 | 0.03 | 2.2e-04 | -6.3 | -5.5 | 4.0e-08 | 0.82 | 0.02 | 0.85 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | XYLB | 0.03 | 0.03 | blup | 82 | 0.02 | 5.1e-03 | -6.5 | 5.8 | 5.0e-09 | -0.91 | 0.01 | 0.98 | FALSE |
| 21 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EXOG | 0.14 | 0.09 | blup | 56 | 0.09 | 9.5e-06 | -6.6 | -6.3 | 3.4e-10 | 0.88 | 0.01 | 0.99 | FALSE |
| 22 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | LOC100128640 | 0.09 | 0.05 | lasso | 2 | 0.03 | 1.7e-02 | -6.3 | 6.3 | 2.5e-10 | -0.86 | 0.02 | 0.52 | FALSE |
| 23 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | EXOG | 0.02 | 0.02 | blup | 56 | 0.01 | 1.0e-02 | -6.4 | -6.5 | 7.0e-11 | 0.96 | 0.02 | 0.86 | FALSE |
| 24 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | XYLB | 0.05 | 0.03 | lasso | 4 | 0.02 | 2.4e-03 | -6.1 | 6.2 | 6.5e-10 | -0.93 | 0.02 | 0.97 | FALSE |
| 25 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | EXOG | 0.10 | 0.02 | blup | 56 | 0.03 | 2.1e-02 | -2.5 | -5.2 | 2.2e-07 | 0.82 | 0.02 | 0.57 | FALSE |
| 26 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC100128640 | 0.08 | 0.02 | blup | 28 | 0.03 | 2.6e-04 | -6.7 | 6.0 | 1.6e-09 | -0.87 | 0.01 | 0.98 | FALSE |
| 27 | The Cancer Genome Atlas | Prostate Adenocarcinoma | XYLB | 0.05 | 0.06 | enet | 7 | 0.05 | 3.5e-06 | -6.5 | 5.9 | 3.4e-09 | -0.95 | 0.00 | 1.00 | FALSE |
| 28 | The Cancer Genome Atlas | Thyroid Carcinoma | ACVR2B | 0.02 | 0.00 | blup | 49 | 0.01 | 1.6e-02 | -6.4 | 6.4 | 1.3e-10 | -0.92 | 0.03 | 0.48 | FALSE |
| 29 | The Cancer Genome Atlas | Thyroid Carcinoma | EXOG | 0.11 | 0.05 | blup | 56 | 0.10 | 9.5e-10 | -6.6 | -5.6 | 2.0e-08 | 0.83 | 0.01 | 0.99 | FALSE |
| 30 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC100128640 | 0.07 | 0.03 | blup | 28 | 0.03 | 1.0e-03 | -6.7 | 6.4 | 1.9e-10 | -0.96 | 0.01 | 0.98 | FALSE |