TWAS hub - ACVR2B-AS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2550	0.0810	6.1e-05	0.072	NA	0.046	NA	0.097	0.0038	NA	0.017	NA	0.00083
2	ROSMAP	Brain Pre-frontal Cortex	0.0522	0.0256	8.7e-03	0.016	0.013	0.010	0.016	0.016	0.0031	0.0074	0.016	0.0031	0.00350

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Impedance of arm (right)	13.5	63.0	118.8	10.9	2.7
Impedance of arm (left)	12.8	59.2	110.2	10.5	2.9
Eye problems/disorders: Cataract	9.7	11.2	19.9	1.6	4.5
Impedance of whole body	9.5	48.5	88.2	9.4	3.0
Time employed in main current job	7.4	8.5	11.6	-2.3	-3.4
Arm predicted mass (right)	6.0	30.5	56.6	-7.5	-2.1
Arm fat-free mass (right)	5.8	29.9	55.4	-7.4	-2.1
Alcohol intake frequency.	5.6	13.1	19.6	4.4	2.6
Trunk fat-free mass	5.3	30.2	53.0	-7.3	-2.7
Trunk predicted mass	5.2	29.7	52.1	-7.2	-2.7
Number of operations (self-reported)	5.1	7.6	8.5	2.6	2.9
Arm fat-free mass (left)	5.0	25.5	46.0	-6.8	-2.2
Bilateral oophorectomy (both ovaries removed)	4.9	5.7	11.0	-3.3	-0.6
Arm predicted mass (left)	4.9	24.8	45.7	-6.8	-2.0
Comparative body size at age 10	4.8	13.2	17.9	-4.2	-2.9
Schizophrenia (2014)	4.6	10.1	11.5	-3.4	-3.0
Hand grip strength (left)	4.5	11.8	16.2	-4.0	-2.7
Had major operations	4.3	5.1	6.7	1.9	2.6
Whole body water mass	4.3	24.4	43.5	-6.6	-2.3
Hand grip strength (right)	4.2	11.4	18.7	-4.3	-2.0
Whole body fat-free mass	4.2	23.8	42.5	-6.5	-2.2
Impedance of leg (right)	4.1	20.1	31.7	5.6	2.9
Impedance of leg (left)	4.1	19.9	34.0	5.8	2.4
Schizophrenia (2018)	3.7	7.8	8.2	-2.7	-2.9
Schizophrenia vs Biploar Disorder	3.7	4.8	9.1	-0.8	-3.0
Mean Putamen Volume	3.7	4.2	8.4	0.1	-2.9
Eye problems/disorders: None of the above	3.7	4.3	8.1	-0.6	-2.8
Average weekly red wine intake	3.7	5.4	8.6	-2.9	-1.5
Osteoarthritis (self-reported)	3.7	4.8	5.2	2.3	2.1
Deep venous thrombosis (DVT) (self-reported)	3.7	4.7	9.4	-0.3	3.1
Medication: Paracetamol	3.6	5.6	6.1	2.5	2.3
Ever had hysterectomy (womb removed)	3.5	3.9	6.9	-2.6	-0.9
Age when periods started (menarche)	3.3	8.0	8.3	2.9	2.8
Number of full brothers	3.3	4.1	8.1	0.3	2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.3	3.9	4.0	2.0	1.9
Basal metabolic rate	3.3	18.4	33.6	-5.8	-1.8
Chronotype (morning person)	3.2	7.3	14.7	3.8	-0.1
Maternal smoking around birth	3.2	4.6	9.1	-3.0	0.3
Falls in the last year	2.9	4.0	7.1	2.7	1.0
Medication: Bendroflumethiazide	2.9	4.4	8.7	0.2	2.9
Medication: Allopurinol	2.8	3.7	3.9	-1.9	2.0
Blood clot in the leg (DVT)	2.7	3.5	7.0	-0.3	2.6
Birth weight	2.7	5.9	9.6	-3.1	-1.4
Eye problems/disorders: Diabetes related eye disease	2.6	2.8	5.7	0.0	2.4
Diabetes (mother)	2.6	3.3	5.0	-2.2	-1.3
Number of incorrect matches in round	2.6	4.3	7.6	-2.8	-1.0
Loud music exposure frequency	2.6	2.9	5.5	2.4	0.5
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.0	4.8	-2.2	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.1	4.9	1.1	2.2
Lung FVC	2.5	12.6	16.7	-4.1	-2.9
Hair/balding pattern: Pattern 2	2.5	3.2	5.7	0.8	2.4
Prospective memory result	2.4	2.9	5.6	-0.5	-2.4
Gout (self-reported)	2.4	3.3	6.1	-0.7	2.5
Leg fat-free mass (right)	2.4	12.7	21.7	-4.7	-1.9
Leg predicted mass (right)	2.4	12.8	22.3	-4.7	-1.8
Type 2 Diabetes (T2D) (2012)	2.3	2.6	4.6	2.1	-0.8
Leg fat-free mass (left)	2.2	11.8	21.3	-4.6	-1.5
Leg predicted mass (left)	2.2	11.8	21.6	-4.7	-1.4
Medication: Paracetamol	2.2	3.6	5.0	1.5	2.2
Illnesses of father: Heart disease	2.1	2.9	5.3	-0.6	2.3
Mouth/teeth dental problems: Mouth ulcers	2.1	3.4	3.8	1.9	1.7
Stomach or abdominal pain in last month	2.0	2.5	4.9	-2.2	-0.2
Ever taken oral contraceptive pill	2.0	2.2	3.0	-1.2	-1.7
BMI	1.9	11.2	22.4	-4.7	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	4.0	2.0	0.6
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	3.6	-1.9	-1.2
Medication: Gliclazide	1.9	2.1	4.1	0.3	2.0
Bipolar Disorder or Schizophrenia	1.7	4.2	5.4	-2.3	-1.7
Alzheimer’s Disease (in father)	1.7	1.9	3.0	-1.7	-0.9
Medication: Simvastatin	1.7	2.5	2.9	1.5	1.7
Medication: Amlodipine	1.7	2.4	4.2	-0.9	2.0
Mouth/teeth dental problems: Loose teeth	1.7	2.0	2.6	-1.6	-1.2
Trunk fat percentage	1.6	6.6	7.8	2.8	2.3
Relative age voice broke	1.6	2.4	4.5	2.1	-0.5
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	2.1	1.4	-1.2
Heart attack	1.6	2.0	3.9	0.4	2.0
Fluid intelligence score	1.6	3.4	4.8	-2.2	1.4
Illnesses of siblings	1.6	2.3	3.9	2.0	0.8
Breastfed as a baby	1.6	2.0	3.5	1.9	0.8
Exposure to tobacco smoke outside home	1.6	2.1	4.1	0.5	2.0
Worry too long after embarrassment	1.6	2.7	4.9	-2.2	-0.7
Number of full sisters	1.6	2.0	3.9	2.0	0.2
Depressed Affect (Nagel 2018)	1.5	3.1	3.3	1.7	1.8
Taking other prescription medications	1.5	2.3	3.4	1.1	1.8
Multivitamins +/- minerals	1.5	1.9	3.7	-0.4	1.9
Medication: Ramipril	1.5	1.9	3.7	0.2	1.9
Miserableness	1.5	2.6	5.1	0.4	2.3
Myopia	1.5	2.2	2.3	1.5	-1.5
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.6	0.3	1.9
Sensitivity / hurt feelings	1.4	2.3	4.6	-0.3	2.1
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	5.0	-2.2	1.3
Number of live births	1.4	2.0	3.2	1.8	0.9
Illnesses of siblings: Diabetes	1.4	1.8	2.4	-1.1	-1.5
Alcohol drinker status: Never	1.4	1.6	2.3	1.5	1.0
Age at First Birth	1.3	1.9	2.9	1.7	0.9
Triglycerides	1.3	2.1	4.2	0.2	2.0
Systolic blood pressure, automated reading	1.3	3.9	5.0	-2.2	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	5.7	-2.4	0.3
High blood pressure	1.3	3.5	5.8	-1.1	2.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	4.2	0.4	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	3.3	-1.8	-0.1
Illnesses of father: None of the above (group 1)	1.3	1.6	2.3	0.9	-1.5
Financial situation satisfaction	1.3	1.6	3.2	1.8	0.1
Commuting to job workplace: Public transport	1.3	1.6	2.0	-1.1	-1.4
Vascular/heart problems diagnosed by doctor	1.3	3.4	6.5	0.6	-2.5
Alzheimer’s Disease (including proxy)	1.2	1.7	2.6	-0.9	-1.6
Number of treatments/medications taken	1.2	2.2	4.3	0.2	2.1
Medication: Metformin	1.2	1.7	3.1	-0.5	1.8
Body mass index (BMI)	1.2	4.9	9.4	-3.1	0.6
Tense / ‘highly strung’	1.2	2.0	3.7	-1.9	-0.6
Osteoporosis (self-reported)	1.2	1.4	2.8	1.7	0.3
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.1	-1.8	-0.2
Illnesses of father: High blood pressure	1.2	1.5	2.1	-1.4	0.9
Pack years of smoking	1.2	1.8	3.5	-1.9	0.1
Heel T-Score	1.1	9.1	12.8	-3.6	2.3
Cardiovascular Disease	1.1	3.6	7.1	0.5	2.7
Hypothyroidism (self reported)	1.1	2.6	4.3	-0.9	2.1
Medication: Lansoprazole	1.1	1.3	1.7	1.3	0.9
Pulse wave reflection index	1.1	1.3	2.6	1.6	0.3
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	3.4	-1.0	1.8
Forced vital capacity (FVC), Best measure	1.1	3.8	4.2	-1.9	-2.0
Body fat percentage	1.1	4.5	5.7	1.8	2.4
Medication for pain relief, constipation, heartburn	1.1	1.8	2.2	-1.5	-1.2
Medication: Blood pressure	1.1	2.0	4.0	-0.3	2.0
Medication: Omeprazole	1.1	1.3	2.3	0.6	1.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.6	-1.6	0.1
Hypertension (Self-reported)	1.1	3.0	5.1	-1.0	2.3
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.4	1.6	-0.4
Risk taking	1.1	1.6	3.1	0.4	1.8
Ovarian Cancer	1.0	1.4	1.8	1.3	1.0
Blood Platelet Count	1.0	11.5	19.1	2.0	4.4
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	1.5	1.2	0.9
Weight	1.0	4.7	9.4	-3.1	-0.4
Health satisfaction	1.0	1.3	2.4	0.6	1.5
Diabetes diagnosed by doctor	1.0	1.6	3.3	0.0	1.8
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.0	1.4	-0.7
Cholesterol lowering medication	1.0	1.4	2.9	1.7	-0.1
Body Mass Index (BMI) (2010)	0.9	1.2	1.5	-1.2	-1.0
Pack years adult smoking proportion	0.9	1.4	2.7	-1.6	0.2
Forced vital capacity (FVC)	0.9	3.3	4.3	-2.1	-1.5
Medication: Cholesterol lowering	0.9	1.4	2.9	-0.0	1.7
Leg fat mass (right)	0.9	3.3	4.8	-2.2	1.3
Comparative height size at age 10	0.9	4.7	6.8	-1.6	-2.6
Medication: Aspirin	0.9	1.2	1.3	-1.0	1.2
HbA1C	0.8	0.8	1.7	1.3	0.1
Ulcerative Colitis	0.8	1.1	2.1	-0.3	-1.5
Type 2 Diabetes (T2D) (2018)	0.8	1.6	3.0	0.4	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.6	1.3	0.5
Hair/balding pattern: Pattern 4	0.8	1.9	3.6	1.9	0.4
Birth weight of first child	0.8	1.4	2.8	-1.7	-0.1
Peak expiratory flow (PEF)	0.8	2.0	3.6	-1.9	-0.6
Shortness of breath walking on level ground	0.8	1.0	1.2	-0.9	-1.1
Medication: Seretide 50 evohaler	0.8	0.9	1.7	0.4	1.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.4	1.2	0.5
Arm fat percentage (left)	0.8	3.0	4.4	1.2	2.1
Age started oral contraceptive pill	0.8	1.0	1.7	-0.5	-1.3
Leg fat mass (left)	0.8	3.1	5.0	-2.2	1.1
Alzheimer’s Disease (in mother)	0.7	0.8	1.3	0.5	-1.1
Verbal and Numeric Reasoning (VNR)	0.7	1.8	2.2	-1.2	1.5
Frequency of depressed mood in last 2 weeks	0.7	0.9	1.8	0.3	1.3
Relative age of first facial hair	0.7	1.4	2.0	1.4	-0.9
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.2	-1.1	0.8
Arm fat percentage (right)	0.7	2.9	3.3	1.5	1.8
Lung cancer (father)	0.7	0.8	1.5	0.4	-1.2
Leg fat percentage (right)	0.7	2.5	4.9	-0.2	2.2
Medication: Ibuprofen	0.7	0.8	1.0	0.8	1.0
Heart disease (mother)	0.7	0.9	1.4	0.6	1.2
Pulse rate, automated reading	0.7	2.1	2.8	-1.2	-1.7
Back pain experienced in last month	0.7	1.1	2.2	-1.5	-0.0
Number of self-reported non-cancer illnesses	0.7	1.2	2.5	-0.1	1.6
High cholesterol (Self-reported)	0.7	1.2	1.3	1.0	1.2
Irritability	0.7	1.3	1.9	1.4	0.8
Heart disease (siblings)	0.7	0.8	1.4	-1.2	0.5
Reaction Time	0.6	1.1	2.1	0.2	-1.4
Bipolar Disorder (2011)	0.6	0.6	1.0	-1.0	0.3
Lupus	0.6	0.9	0.9	-0.9	0.9
Blood White Count	0.6	4.7	9.4	-0.2	3.1
Medication: Co-codamol	0.6	0.7	1.3	0.0	1.2
Townsend deprivation index at recruitment	0.6	0.8	0.9	-0.8	1.0
Chronic bronchitis/emphysema (father)	0.6	0.7	0.8	0.7	-0.9
Waist circumference	0.6	2.0	3.3	-1.8	0.9
Financial difficulties in last 2 years	0.6	0.8	1.4	-0.3	1.2
Mouth/teeth dental problems: Dentures	0.6	1.0	1.1	0.9	1.1
Asthma	0.6	1.3	2.5	-1.6	-0.0
Illnesses of mother	0.6	0.7	1.2	0.4	1.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.4	-0.2	1.2
Glaucoma (self-reported)	0.6	0.8	1.3	-0.5	-1.1
Family relationship satisfaction	0.6	0.8	1.5	0.3	1.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.0	-1.0	-0.8
Ever had bowel cancer screening	0.6	0.7	0.9	0.7	0.9
Medication: Aspirin	0.6	0.8	1.5	-0.3	1.2
Leg fat percentage (left)	0.6	2.0	4.0	-0.1	2.0
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.2	0.5	1.1
Unable to work because of sickness or disability	0.6	0.8	1.6	-0.0	-1.3
Ulcerative Colitis (UC)	0.5	0.9	1.6	-0.4	-1.3
Primary Biliary Cirrhosis	0.5	0.7	0.8	-0.9	-0.8
Lung FEV1/FVC ratio	0.5	2.6	4.3	0.9	2.1
Average weekly spirits intake	0.5	0.6	1.2	-1.1	-0.2
Hearing difficulty/problems: Yes	0.5	0.7	1.3	1.2	-0.3
Medication for hormone replacement therapy	0.5	0.5	1.0	1.0	-0.3
Diabetes (father)	0.5	0.6	0.8	-0.9	0.6
Severe depression (siblings)	0.5	0.5	0.8	-0.9	-0.5
Supplements: Glucosamine	0.5	0.6	0.7	0.8	0.8
Sitting height	0.5	3.5	6.4	0.7	-2.5
Nervous feelings	0.5	0.8	1.6	-0.2	-1.3
Alcohol intake versus 10 years previously	0.5	0.7	1.5	1.2	0.0
Father’s age at death	0.5	0.7	1.3	-0.1	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	1.7	-1.3	-1.2
Length of working week for main job	0.5	0.6	0.8	-0.9	0.6
Medication: Ventolin 100micrograms inhaler	0.5	0.6	0.6	0.8	-0.8
Number of children fathered	0.5	0.6	1.1	-1.1	-0.3
Mood swings	0.5	0.8	1.7	-0.1	1.3
Loneliness, isolation	0.5	0.7	1.2	0.5	1.1
Friendships satisfaction	0.5	0.6	0.6	0.8	0.8
Commuting to job workplace: Walk	0.5	0.6	0.7	0.8	0.7
Asthma (self-reported)	0.5	1.0	2.0	-1.4	-0.0
Commuting to job workplace: Cycle	0.5	0.6	0.9	0.6	0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.9	0.6	1.0
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	1.1	-0.3
Irritable Bowel Disease (IBD)	0.4	0.9	1.7	-0.1	-1.3
Breast Cancer	0.4	0.9	1.8	-0.2	-1.3
Height	0.4	6.9	13.8	-0.2	-3.7
Smoking Status	0.4	1.0	1.8	-1.4	-0.4
Fed-up feelings	0.4	0.8	1.4	0.4	1.2
Qualifications: CSEs or equivalent	0.4	0.5	0.9	-0.9	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.1	-1.1	0.1
Qualifications: None of the above	0.4	0.8	0.9	0.9	0.9
Diabetes (self-reported)	0.4	0.6	1.2	0.0	1.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	1.8	-1.4	-0.8
Exposure to tobacco smoke at home	0.4	0.4	0.7	0.8	0.4
Emphysema/chronic bronchitis	0.4	0.4	0.8	0.9	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.1	-1.1	-0.7
Wears glasses or contact lenses	0.4	0.4	0.8	-0.9	0.0
Medication: Lisinopril	0.4	0.5	0.8	-0.9	0.5
Alcohol drinker status: Previous	0.4	0.5	1.0	0.1	1.0
Depression (Nagel 2018)	0.3	0.5	0.8	0.9	0.3
Neuroticism (Nagel 2018)	0.3	0.8	0.9	0.9	0.9
Coronary Artery Disease (CAD)	0.3	0.3	0.6	-0.2	-0.8
HDL Cholesterol	0.3	0.6	0.9	0.5	-0.9
LDL Cholesterol	0.3	0.5	0.9	0.1	0.9
Rheumatoid Arthritis	0.3	0.4	0.8	0.9	-0.1
Allergy or Eczema	0.3	0.7	1.3	1.1	0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	0.0	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.5	-0.7	-0.6
Medication: Atenolol	0.3	0.3	0.5	-0.7	0.4
Medication: Levothyroxine sodium	0.3	0.6	1.1	-0.0	1.1
Past tobacco smoking	0.3	0.6	1.1	1.1	0.1
Hearing difficulty/problems with background noise	0.3	0.4	0.5	0.7	0.6
Hair/balding pattern: Pattern 3	0.3	0.5	1.0	-1.0	-0.1
Pulse rate	0.3	0.5	0.6	-0.8	-0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	0.7	-0.8	0.8
Arm fat mass (right)	0.3	1.1	1.5	-1.2	0.8
Qualifications: College or University degree	0.3	0.9	1.7	-1.3	-0.3
Mean time to correctly identify matches	0.3	0.6	1.3	-0.0	-1.1
Whole body fat mass	0.3	1.2	1.8	-0.8	1.4
Suffer from ‘nerves’	0.3	0.4	0.8	0.1	-0.9
Chest pain or discomfort	0.3	0.4	0.6	0.8	-0.5
Age at last live birth	0.3	0.5	0.9	1.0	-0.1
Arm fat mass (left)	0.3	1.3	1.7	-1.3	0.9
Average weekly champagne plus white wine intake	0.3	0.4	0.5	-0.7	-0.5
Mother’s age at death	0.3	0.3	0.6	-0.8	0.3
Medication: Blood pressure	0.3	0.6	1.3	0.0	1.1
Bipolar Disorder (2018)	0.2	0.4	0.6	-0.4	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.0	-0.7	1.0
Crohns Disease (2017)	0.2	0.4	0.6	0.6	-0.7
Prostate Cancer	0.2	0.2	0.4	0.6	0.4
Fasting Glucose	0.2	0.2	0.4	-0.6	0.3
Blood Red Count	0.2	2.2	4.2	-2.0	-0.4
Neuroticism	0.2	0.6	1.1	-0.0	1.0
Vitamin and mineral supplements	0.2	0.3	0.6	0.1	-0.8
Current tobacco smoking	0.2	0.3	0.3	-0.5	0.5
Average weekly fortified wine intake	0.2	0.3	0.5	0.7	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.7	-0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.3	0.4	0.5
Trunk fat mass	0.2	1.0	1.8	0.4	1.4
Alcohol usually taken with meals	0.2	0.4	0.7	-0.3	0.9
Neuroticism score	0.2	0.5	0.7	-0.5	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.5	-0.3	-0.7
Depression (self-reported)	0.2	0.3	0.5	-0.7	-0.2
Standing height	0.2	2.1	4.2	-0.1	-2.0
High blood pressure (siblings)	0.2	0.2	0.5	-0.7	0.0
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	-0.7	0.4
Neck or shoulder pain in last month	0.2	0.3	0.5	-0.7	-0.3
Migraine (self-reported)	0.2	0.2	0.4	0.6	0.3
Knee pain experienced in last month	0.2	0.3	0.6	-0.0	0.8
Smoking status: Current	0.2	0.4	0.6	-0.8	0.4
Guilty feelings	0.2	0.3	0.4	-0.4	-0.6
Medication: Atorvastatin	0.2	0.3	0.5	0.7	0.2
Fractured/broken bones in last 5 years	0.2	0.2	0.3	-0.2	0.6
Pain experienced in last month	0.2	0.3	0.6	0.2	-0.8
Neuroticism (2016)	0.1	0.1	0.2	0.0	-0.5
Blood Eosinophil Count	0.1	0.8	1.7	1.3	0.1
Waist Hip Ratio (WHR)	0.1	0.6	0.7	0.7	0.9
Angina	0.1	0.1	0.2	-0.4	0.2
Supplements: Zinc	0.1	0.1	0.2	-0.2	0.4
Had menopause	0.1	0.2	0.3	0.2	-0.6
Had other major operations	0.1	0.1	0.1	0.2	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	0.2	0.5
Allergy	0.1	0.1	0.2	0.5	-0.2
Pain all over the body in last month	0.1	0.1	0.1	0.3	0.0
Hip circumference	0.1	0.6	1.0	-1.0	0.4
Worrier / anxious feelings	0.1	0.1	0.2	-0.4	0.1
Happiness	0.1	0.1	0.2	0.4	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.1	0.6
Headache pain in last month	0.1	0.2	0.4	0.7	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	-0.1	-0.3
Age at first live birth	0.1	0.1	0.2	0.2	-0.5
Supplements: Vitamin C	0.1	0.1	0.1	-0.3	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	0.4	0.2
Qualifications: nursing, teaching	0.1	0.2	0.3	0.4	0.5
Medication for cholesterol	0.1	0.1	0.2	-0.4	-0.1
Mineral and other dietary supplements	0.1	0.1	0.1	0.2	-0.3
Breast cancer (self-reported)	0.1	0.1	0.1	-0.1	0.4
Hearing aid user	0.1	0.1	0.2	0.2	-0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.2	0.5
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.0	0.4
Ever smoked	0.1	0.2	0.3	-0.6	-0.3
Diastolic blood pressure, automated reading	0.1	0.3	0.5	-0.7	-0.5
Supplements: Calcium	0.1	0.2	0.3	0.0	-0.6
Worry (Nagel 2018)	0.0	0.1	0.1	-0.3	-0.3
Major Depression (MDD)	0.0	0.0	0.1	-0.3	0.0
Crohns Disease (2012)	0.0	0.1	0.1	0.3	0.1
Systolic Blood Pressure	0.0	0.2	0.5	-0.7	0.1
Respiratory disease	0.0	0.1	0.1	0.1	-0.4
Hair Pigment	0.0	1.2	1.3	1.1	1.1
Tanning	0.0	0.2	0.4	-0.3	0.6
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	-0.0	-0.3
High blood pressure (mother)	0.0	0.0	0.0	0.2	-0.0
Mouth/teeth dental problems	0.0	0.0	0.1	-0.2	0.0
Noisy workplace	0.0	0.0	0.0	-0.2	0.2
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	-0.2	0.2
Pulse wave peak to peak time	0.0	0.0	0.1	0.1	-0.3
Angina (self-reported)	0.0	0.1	0.1	-0.3	0.2
Overall health rating	0.0	0.0	0.1	-0.2	-0.1
Leg pain on walking	0.0	0.0	0.0	0.1	-0.1
Smoking status: Previous	0.0	0.0	0.0	-0.0	0.2
Long-standing illness, disability or infirmity	0.0	0.1	0.1	0.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	-0.3	0.0
Average weekly beer plus cider intake	0.0	0.0	0.0	-0.0	0.1
Ever depressed for a whole week	0.0	0.0	0.0	-0.0	-0.2

Hub : Genes

ACVR2B-AS1

Models

Trait associations